Genotype and Subtype Profiling of PSI-7977 as a Nucleotide Inhibitor of Hepatitis C Virus
Lam, Angela M, Espiritu, Christine, Bansal, Shalini, Micolochick Steuer, Holly M, Niu, Congrong, Zennou, Veronique, Keilman, Meg, Zhu, Yuao, Lan, Shuiyun, Otto, Michael J, Furman, Phillip A
Published in Antimicrobial Agents and Chemotherapy (01.06.2012)
Published in Antimicrobial Agents and Chemotherapy (01.06.2012)
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Mechanism of Activation of PSI-7851 and Its Diastereoisomer PSI-7977
Murakami, Eisuke, Tolstykh, Tatiana, Bao, Haiying, Niu, Congrong, Steuer, Holly M. Micolochick, Bao, Donghui, Chang, Wonsuk, Espiritu, Christine, Bansal, Shalini, Lam, Angela M., Otto, Michael J., Sofia, Michael J., Furman, Phillip A.
Published in The Journal of biological chemistry (05.11.2010)
Published in The Journal of biological chemistry (05.11.2010)
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Preclinical Profile of AB-423, an Inhibitor of Hepatitis B Virus Pregenomic RNA Encapsidation
Mani, Nagraj, Cole, Andrew G, Phelps, Janet R, Ardzinski, Andrzej, Cobarrubias, Kyle D, Cuconati, Andrea, Dorsey, Bruce D, Evangelista, Ellen, Fan, Kristi, Guo, Fang, Guo, Haitao, Guo, Ju-Tao, Harasym, Troy O, Kadhim, Salam, Kultgen, Steven G, Lee, Amy C H, Li, Alice H L, Long, Quanxin, Majeski, Sara A, Mao, Richeng, McClintock, Kevin D, Reid, Stephen P, Rijnbrand, Rene, Snead, Nicholas M, Micolochick Steuer, Holly M, Stever, Kim, Tang, Sunny, Wang, Xiaohe, Zhao, Qiong, Sofia, Michael J
Published in Antimicrobial agents and chemotherapy (01.06.2018)
Published in Antimicrobial agents and chemotherapy (01.06.2018)
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PSI-7851, a Pronucleotide of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine Monophosphate, Is a Potent and Pan-Genotype Inhibitor of Hepatitis C Virus Replication
LAM, Angela M, MURAKAMI, Eisuke, MORREY, John D, SMEE, Donald F, FRICK, David N, HECK, Julie A, PEIYUAN WANG, NAGARATHNAM, Dhanapalan, ROSS, Bruce S, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, ESPIRITU, Christine, MICOLOCHICK STEUER, Holly M, NIU, Congrong, KEILMAN, Meg, HAIYING BAO, ZENNOU, Veronique, BOURNE, Nigel, JULANDER, Justin G
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
Published in Antimicrobial Agents and Chemotherapy (01.08.2010)
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Hepatitis C Virus Nucleotide Inhibitors PSI-352938 and PSI-353661 Exhibit a Novel Mechanism of Resistance Requiring Multiple Mutations within Replicon RNA
LAM, Angela M, ESPIRITU, Christine, BANSAL, Shalini, MICOLOCHICK STEUER, Holly M, ZENNOU, Veronique, OTTO, Michael J, FURMAN, Phillip A
Published in Journal of Virology (01.12.2011)
Published in Journal of Virology (01.12.2011)
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Mechanism of Activation of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase
MURAKAMI, Eisuke, HAIYING BAO, FURMAN, Phillip A, RAMESH, Mangala, MCBRAYER, Tamara R, WHITAKER, Tony, MICOLOCHICK STEUER, Holly M, SCHINAZI, Raymond F, STUYVER, Lieven J, OBIKHOD, Aleksandr, OTTO, Michael J
Published in Antimicrobial Agents and Chemotherapy (01.02.2007)
Published in Antimicrobial Agents and Chemotherapy (01.02.2007)
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Inhibition of Hepatitis C Virus Replicon RNA Synthesis by PSI-352938, a Cyclic Phosphate Prodrug of β-d-2′-Deoxy-2′-α-Fluoro-2′-β-C-Methylguanosine
LAM, Angela M, ESPIRITU, Christine, VESELENAK, Ronald L, GANAPATI REDDY, P, CHANG, Wonsuk, JINFA DU, NAGARATHNAM, Dhanapalan, SOFIA, Michael J, OTTO, Michael J, FURMAN, Phillip A, MURAKAMI, Eisuke, ZENNOU, Veronique, BANSAL, Shalini, MICOLOCHICK STEUER, Holly M, CONGRONG NIU, KEILMAN, Meg, HAIYING BAO, BOURNE, Nigel
Published in Antimicrobial Agents and Chemotherapy (01.06.2011)
Published in Antimicrobial Agents and Chemotherapy (01.06.2011)
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Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA
Liu, Fei, Lee, Amy C. H, Guo, Fang, Kondratowicz, Andrew S, Micolochick Steuer, Holly M, Miller, Angela, Bailey, Lauren D, Wang, Xiaohe, Chen, Shuai, Kultgen, Steven G, Cuconati, Andrea, Cole, Andrew G, Gotchev, Dimitar, Dorsey, Bruce D, Rijnbrand, Rene, Lam, Angela M, Sofia, Michael J, Gao, Min
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Published in Journal of virology (25.08.2021)
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Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein
Mani, Nagraj, Cole, Andrew G., Phelps, Janet R., Ardzinski, Andrzej, Burns, Robbin, Chiu, Tim, Cuconati, Andrea, Dorsey, Bruce D., Evangelista, Ellen, Fan, Kristi, Guo, Fang, Harasym, Troy O., Kadhim, Salam, Kowalski, Roseann, Kultgen, Steven G., Lee, Amy C.H., Li, Alice H., Majeski, Sara A., Miller, Angela, Pasetka, Chris, Reid, Stephen P., Rijnbrand, Rene, Micolochick Steuer, Holly M., Stever, Kim, Tang, Sunny, Teng, Xiaowei, Wang, Xiaohe, Sofia, Michael J.
Published in Antiviral research (01.01.2022)
Published in Antiviral research (01.01.2022)
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Discovery of a Novel Class of Potent HCV NS4B Inhibitors: SAR Studies on Piperazinone Derivatives
Kakarla, Ramesh, Liu, Jian, Naduthambi, Devan, Chang, Wonsuk, Mosley, Ralph T., Bao, Donghui, Steuer, Holly M. Micolochick, Keilman, Meg, Bansal, Shalini, Lam, Angela M., Seibel, William, Neilson, Sandra, Furman, Phillip A., Sofia, Michael J.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators
Mesaros, Eugen F., Cole, Andrew G., Kultgen, Steven G., Mani, Nagraj, Fan, Kristi Yi, Dugan, Benjamin J., Ardzinski, Andrzej, Stever, Kim, Steuer, Holly M. Micolochick, Graves, Ingrid, Tang, Sunny, Harasym, Troy O., Lam, Angela M., Thi, Emily P., Dorsey, Bruce D., Sofia, Michael J.
Published in ACS medicinal chemistry letters (12.09.2024)
Published in ACS medicinal chemistry letters (12.09.2024)
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Use of 2′-Spirocyclic Ethers in HCV Nucleoside Design
Du, Jinfa, Chun, Byoung-Kwon, Mosley, Ralph T., Bansal, Shalini, Bao, Haiying, Espiritu, Christine, Lam, Angela M., Murakami, Eisuke, Niu, Congrong, Micolochick Steuer, Holly M., Furman, Phillip A., Sofia, Michael J.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Evaluation of the in vitro anti-HBV activity of clevudine in combination with other nucleoside/ nucleotide inhibitors
CONGRONG NIU, HAIYING BAO, TOLSTYKH, Tatiana, MICOLOCHICK STEUER, Holly M, MURAKAMI, Eisuke, KORBA, Brent, FURMAN, Phillip A
Published in Antiviral therapy (01.01.2010)
Published in Antiviral therapy (01.01.2010)
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Control of Hepatitis B Virus with Imdusiran, a Small Interfering RNA Therapeutic
Thi, Emily P., Ye, Xin, Snead, Nicholas M., Lee, Amy C. H., Micolochick Steuer, Holly M., Ardzinski, Andrzej, Graves, Ingrid E., Espiritu, Christine, Cuconati, Andrea, Abbott, Cory, Jarosz, Agnes, Teng, Xiaowei, Paratala, Bhavna, McClintock, Kevin, Harasym, Troy, Rijnbrand, Rene, Lam, Angela M., Sofia, Michael J.
Published in ACS infectious diseases (11.10.2024)
Published in ACS infectious diseases (11.10.2024)
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The Mechanism of Action of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine Involves a Second Metabolic Pathway Leading to β-d-2′-Deoxy-2′-Fluoro-2′-C-Methyluridine 5′-Triphosphate, a Potent Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase
Murakami, Eisuke, Niu, Congrong, Bao, Haiying, Micolochick Steuer, Holly M, Whitaker, Tony, Nachman, Tammy, Sofia, Michael A, Wang, Peiyuan, Otto, Michael J, Furman, Phillip A
Published in Antimicrobial Agents and Chemotherapy (01.02.2008)
Published in Antimicrobial Agents and Chemotherapy (01.02.2008)
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β-d-2′-α-F-2′-β-C-Methyl-6-O-substituted 3′,5′-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: A structure–activity relationship study
Du, Jinfa, Bao, Donghui, Chun, Byoung-Kwon, Jiang, Ying, Ganapati Reddy, P., Zhang, Hai-Ren, Ross, Bruce S., Bansal, Shalini, Bao, Haiying, Espiritu, Christine, Lam, Angela M., Murakami, Eisuke, Niu, Congrong, Micolochick Steuer, Holly M., Furman, Phillip A., Otto, Michael J., Sofia, Michael J.
Published in Bioorganic & medicinal chemistry letters (15.09.2012)
Published in Bioorganic & medicinal chemistry letters (15.09.2012)
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Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
Sofia, Michael J, Bao, Donghui, Chang, Wonsuk, Du, Jinfa, Nagarathnam, Dhanapalan, Rachakonda, Suguna, Reddy, P. Ganapati, Ross, Bruce S, Wang, Peiyuan, Zhang, Hai-Ren, Bansal, Shalini, Espiritu, Christine, Keilman, Meg, Lam, Angela M, Steuer, Holly M. Micolochick, Niu, Congrong, Otto, Michael J, Furman, Phillip A
Published in Journal of medicinal chemistry (14.10.2010)
Published in Journal of medicinal chemistry (14.10.2010)
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Mechanism of Action of (-)-(2R,4R)-1-(2-hydroxymethyl-1,3-dioxolan-4-yl)thymine as an anti-HIV agent
Murakami, Eisuke, Bao, Haiying, Basavapathruni, Aravind, Bailey, Christopher M, Du, Jinfa, Steuer, Holly M Micolochick, Niu, Congrong, Whitaker, Tony, Anderson, Karen S, Otto, Michael J, Furman, Phillip A
Published in Antiviral chemistry & chemotherapy (01.04.2007)
Published in Antiviral chemistry & chemotherapy (01.04.2007)
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Discovery of C‑Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV‑2
Mesaros, Eugen F., Dugan, Benjamin J., Gao, Min, Sheraz, Muhammad, McGovern-Gooch, Kayleigh, Xu, Fran, Fan, Kristi Yi, Nguyen, Duyan, Kultgen, Steven G., Lindstrom, Aaron, Stever, Kim, Tercero, Breanna, Binder, Randall J., Liu, Fei, Micolochick Steuer, Holly M., Mani, Nagraj, Harasym, Troy O., Thi, Emily P., Cuconati, Andrea, Dorsey, Bruce D., Cole, Andrew G., Lam, Angela M., Sofia, Michael J.
Published in ACS infectious diseases (10.05.2024)
Published in ACS infectious diseases (10.05.2024)
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Synthesis of Stable Isotope Labeled Analogs of the Anti-Hepatitis C Virus Nucleotide Prodrugs PSI-7977 and PSI-352938
Chun, Byoung-Kwon, Du, Jinfa, Zhang, Hai-Ren, Chang, Wonsuk, Ross, Bruce S., Jiang, Ying, Bao, Donghui, Espiritu, Christine L., Keilman, Meg, Steuer, Holly M. Micolochick, Furman, Phillip A., Sofia, Michael J.
Published in Nucleosides, nucleotides & nucleic acids (01.11.2011)
Published in Nucleosides, nucleotides & nucleic acids (01.11.2011)
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