Cancer-Associated Protein Kinase C Mutations Reveal Kinase’s Role as Tumor Suppressor
Antal, Corina E., Hudson, Andrew M., Kang, Emily, Zanca, Ciro, Wirth, Christopher, Stephenson, Natalie L., Trotter, Eleanor W., Gallegos, Lisa L., Miller, Crispin J., Furnari, Frank B., Hunter, Tony, Brognard, John, Newton, Alexandra C.
Published in Cell (29.01.2015)
Published in Cell (29.01.2015)
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Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors
Marusiak, Anna A, Edwards, Zoe C, Hugo, Willy, Trotter, Eleanor W, Girotti, Maria R, Stephenson, Natalie L, Kong, Xiangju, Gartside, Michael G, Fawdar, Shameem, Hudson, Andrew, Breitwieser, Wolfgang, Hayward, Nicholas K, Marais, Richard, Lo, Roger S, Brognard, John
Published in Nature communications (22.05.2014)
Published in Nature communications (22.05.2014)
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Targeted genetic dependency screen facilitates identification of actionable mutations in FGFR4, MAP3K9, and PAK5 in lung cancer
Fawdar, Shameem, Trotter, Eleanor W., Li, Yaoyong, Stephenson, Natalie L., Hanke, Franziska, Marusiak, Anna A., Edwards, Zoe C., Ientile, Sara, Waszkowycz, Bohdan, Miller, Crispin J., Brognard, John
Published in Proceedings of the National Academy of Sciences - PNAS (23.07.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (23.07.2013)
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Somatically mutated ABL1 is an actionable and essential NSCLC survival gene
Testoni, Ewelina, Stephenson, Natalie L, Torres‐Ayuso, Pedro, Marusiak, Anna A, Trotter, Eleanor W, Hudson, Andrew, Hodgkinson, Cassandra L, Morrow, Christopher J, Dive, Caroline, Brognard, John
Published in EMBO molecular medicine (01.02.2016)
Published in EMBO molecular medicine (01.02.2016)
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Improved Production and Biophysical Analysis of Recombinant Silicatein-α
Sparkes, Emily I, Kettles, Rachel A, Egedeuzu, Chisom S, Stephenson, Natalie L, Caslin, Stephanie A, Tabatabaei Dakhili, S Yasin, Wong, Lu Shin
Published in Biomolecules (Basel, Switzerland) (20.08.2020)
Published in Biomolecules (Basel, Switzerland) (20.08.2020)
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Protein kinase Cα gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation
Callender, Julia A., Yang, Yimin, Lordén, Gema, Stephenson, Natalie L., Jones, Alexander C., Brognard, John, Newton, Alexandra C.
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2018)
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Recurrent MLK4 Loss-of-Function Mutations Suppress JNK Signaling to Promote Colon Tumorigenesis
Marusiak, Anna A, Stephenson, Natalie L, Baik, Hayeon, Trotter, Eleanor W, Li, Yaoyong, Blyth, Karen, Mason, Susan, Chapman, Phil, Puto, Lorena A, Read, Jon A, Brassington, Claire, Pollard, Hannah K, Phillips, Chris, Green, Isabelle, Overman, Ross, Collier, Matthew, Testoni, Ewelina, Miller, Crispin J, Hunter, Tony, Sansom, Owen J, Brognard, John
Published in Cancer research (Chicago, Ill.) (01.02.2016)
Published in Cancer research (Chicago, Ill.) (01.02.2016)
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Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases
Hudson, Andrew M, Stephenson, Natalie L, Li, Cynthia, Trotter, Eleanor, Fletcher, Adam J, Katona, Gitta, Bieniasz-Krzywiec, Patrycja, Howell, Matthew, Wirth, Chris, Furney, Simon, Miller, Crispin J, Brognard, John
Published in Science signaling (17.04.2018)
Published in Science signaling (17.04.2018)
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Abstract 4408: Mutant ABL1 is a genetic dependency in non-small cell lung cancer amenable to pharmacological intervention
Torres-Ayuso, PEDRO, Testoni, Ewelina, Stephenson, Natalie L., Marusiak, Anna A., Trotter, Eleanor W., Hudson, Andrew, Hodgkinson, Cassandra L., Morrow, Christopher J., Dive, Caroline, Brognard, John
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Protein kinase Ca gain-of-function variant in Alzheimer’s disease displays enhanced catalysis by a mechanism that evades down-regulation
Callender, Julia A, Yang, Yimin, Lordén, Gema, Stephenson, Natalie L, Jones, Alexander C, Brognard, John, Newton, Alexandra C
Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2018)
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Published in Proceedings of the National Academy of Sciences - PNAS (12.06.2018)
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Abstract 125: Protein kinase C loss-of-function mutations in cancer reveal role as tumor suppressor
Antal, Corina E., Hudson, Andrew M., Kang, Emily, Zanca, Ciro, Wirth, Christopher, Stephenson, Natalie L., Trotter, Eleanor W., Gallegos, Lisa L., Miller, Crispin, Furnari, Frank, Hunter, Tony, Brognard, John, Newton, Alexandra C.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Somatically mutated ABL 1 is an actionable and essential NSCLC survival gene
Testoni, Ewelina, Stephenson, Natalie L, Torres‐Ayuso, Pedro, Marusiak, Anna A, Trotter, Eleanor W, Hudson, Andrew, Hodgkinson, Cassandra L, Morrow, Christopher J, Dive, Caroline, Brognard, John
Published in EMBO molecular medicine (01.02.2016)
Published in EMBO molecular medicine (01.02.2016)
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