Designer enzymes for glycosphingolipid synthesis by directed evolution
Withers, Stephen G, Hancock, Susan M, Rich, Jamie R, Caines, Matthew E C, Strynadka, Natalie C J
Published in Nature chemical biology (01.07.2009)
Published in Nature chemical biology (01.07.2009)
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Journal Article
Fungal Glycolipid Hydrolase Inhibitors and Their Effect on Cryptococcus neoformans
Santana, Andres G., Tysoe, Christina, Hu, Guanggan, Kronstad, James, Goddard‐Borger, Ethan D., Withers, Stephen G.
Published in Chembiochem : a European journal of chemical biology (01.02.2017)
Published in Chembiochem : a European journal of chemical biology (01.02.2017)
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Journal Article
Comprehensive characterization of sphingolipid ceramide N-deacylase for the synthesis and fatty acid remodeling of glycosphingolipids
Han, Yun-Bin, Wu, Lie, Rich, Jamie R., Huang, Feng-Tao, Withers, Stephen G., Feng, Yan, Yang, Guang-Yu
Published in Applied microbiology and biotechnology (01.08.2015)
Published in Applied microbiology and biotechnology (01.08.2015)
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Journal Article
Development of New and Selective Trypanosoma cruzi trans-Sialidase Inhibitors from Sulfonamide Chalcones and Their Derivatives
Kim, Jin Hyo, Ryu, Hyung Won, Shim, Jae Hoon, Park, Ki Hun, Withers, Stephen G
Published in Chembiochem : a European journal of chemical biology (12.10.2009)
Published in Chembiochem : a European journal of chemical biology (12.10.2009)
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Journal Article
Unambiguous Determination of the Ionization State of a Glycoside Hydrolase Active Site Lysine by 1H−15N Heteronuclear Correlation Spectroscopy
Poon, David K. Y, Schubert, Mario, Au, Jason, Okon, Mark, Withers, Stephen G, McIntosh, Lawrence P
Published in Journal of the American Chemical Society (06.12.2006)
Published in Journal of the American Chemical Society (06.12.2006)
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Crystal structure of the family 7 endoglucanase I (Cel7B) from Humicola insolens at 2.2 A resolution and identification of the catalytic nucleophile by trapping of the covalent glycosyl-enzyme intermediate
MacKenzie, L F, Sulzenbacher, G, Divne, C, Jones, T A, Wöldike, H F, Schülein, M, Withers, S G, Davies, G J
Published in Biochemical journal (15.10.1998)
Published in Biochemical journal (15.10.1998)
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Journal Article
Mechanistic Analysis of Trehalose Synthase from Mycobacterium smegmatis
Zhang, Ran, Pan, Yuan T., He, Shouming, Lam, Michael, Brayer, Gary D., Elbein, Alan D., Withers, Stephen G.
Published in The Journal of biological chemistry (14.10.2011)
Published in The Journal of biological chemistry (14.10.2011)
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A new type of pharmacological chaperone for G M1 -gangliosidosis related human lysosomal β-galactosidase: N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols
Schalli, Michael, Weber, Patrick, Tysoe, Christina, Pabst, Bettina M, Thonhofer, Martin, Paschke, Eduard, Stütz, Arnold E, Tschernutter, Marion, Windischhofer, Werner, Withers, Stephen G
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
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Journal Article
C-5a-substituted validamine type glycosidase inhibitors
Schalli, Michael, Wolfsgruber, Andreas, Gonzalez Santana, Andres, Tysoe, Christina, Fischer, Roland, Stütz, Arnold E., Thonhofer, Martin, Withers, Stephen G.
Published in Carbohydrate research (22.02.2017)
Published in Carbohydrate research (22.02.2017)
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Journal Article
Chemoenzymatic synthesis of 6‐phospho‐cyclophellitol as a novel probe of 6‐phospho‐β‐glucosidases
Kwan, David H., Jin, Yi, Jiang, Jianbing, Chen, Hong‐Ming, Kötzler, Miriam P., Overkleeft, Herman S., Davies, Gideon J., Withers, Stephen G., Ferguson, Stuart
Published in FEBS letters (01.02.2016)
Published in FEBS letters (01.02.2016)
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Journal Article
N-Substituted 5-amino-1-hydroxymethyl-cyclopentanetriols: A new family of activity promotors for a GM1-gangliosidosis related human lysosomal β-galactosidase mutant
Schalli, Michael, Tysoe, Christina, Fischer, Roland, Pabst, Bettina M., Thonhofer, Martin, Paschke, Eduard, Rappitsch, Tanja, Stütz, Arnold E., Tschernutter, Marion, Windischhofer, Werner, Withers, Stephen G.
Published in Carbohydrate research (18.04.2017)
Published in Carbohydrate research (18.04.2017)
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Journal Article
Mechanistic Insights into the 1,3-Xylanases: Useful Enzymes for Manipulation of Algal Biomass
Goddard-Borger, Ethan D, Sakaguchi, Keishi, Reitinger, Stephan, Watanabe, Nobuhisa, Ito, Makoto, Withers, Stephen G
Published in Journal of the American Chemical Society (29.02.2012)
Published in Journal of the American Chemical Society (29.02.2012)
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Journal Article
Mutational analysis in the glycone binding pocket of Dalbergia cochinchinensis β-glucosidase to increase catalytic efficiency toward mannosides
Ratananikom, Khakhanang, Choengpanya, Khuanjarat, Tongtubtim, Nusra, Charoenrat, Theppanya, Withers, Stephen G., Kongsaeree, Prachumporn T.
Published in Carbohydrate research (24.05.2013)
Published in Carbohydrate research (24.05.2013)
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Journal Article
Transition-State Mimicry by Glycosidase Inhibitors: A Critical Kinetic Analysis
Wicki, Jacqueline, Williams, Spencer J, Withers, Stephen G
Published in Journal of the American Chemical Society (18.04.2007)
Published in Journal of the American Chemical Society (18.04.2007)
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