Search Results - "Steinmetzer, Torsten" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells

by Bestle, Dorothea, Heindl, Miriam Ruth, Limburg, Hannah, Van Lam van, Thuy, Pilgram, Oliver, Moulton, Hong, Stein, David A, Hardes, Kornelia, Eickmann, Markus, Dolnik, Olga, Rohde, Cornelius, Klenk, Hans-Dieter, Garten, Wolfgang, Steinmetzer, Torsten, Böttcher-Friebertshäuser, Eva
Published in Life science alliance (01.09.2020)

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Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism

Structure of the unliganded form of the proprotein convertase furin suggests activation by a substrate-induced mechanism

by Dahms, Sven O., Arciniega, Marcelino, Steinmetzer, Torsten, Huber, Robert, Than, Manuel E.
Published in Proceedings of the National Academy of Sciences - PNAS (04.10.2016)

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Ligand Binding Stepwise Disrupts Water Network in Thrombin: Enthalpic and Entropic Changes Reveal Classical Hydrophobic Effect

Ligand Binding Stepwise Disrupts Water Network in Thrombin: Enthalpic and Entropic Changes Reveal Classical Hydrophobic Effect

by Biela, Adam, Sielaff, Frank, Terwesten, Felix, Heine, Andreas, Steinmetzer, Torsten, Klebe, Gerhard
Published in Journal of medicinal chemistry (12.07.2012)

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In vitro testing of host-targeting small molecule antiviral matriptase/TMPRSS2 inhibitors in 2D and 3D cell-based assays

In vitro testing of host-targeting small molecule antiviral matriptase/TMPRSS2 inhibitors in 2D and 3D cell-based assays

by van Eijk, Nicholas, Schmacke, Luna C., Steinmetzer, Torsten, Pilgram, Oliver, Poór, Miklós, Pászti-Gere, Erzsébet
Published in Biomedicine & pharmacotherapy (01.12.2023)

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Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation

Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation

by Meyer, Daniela, Sielaff, Frank, Hammami, Maya, Böttcher-Friebertshäuser, Eva, Garten, Wolfgang, Steinmetzer, Torsten
Published in Biochemical journal (01.06.2013)

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PK/PD investigation of antiviral host matriptase/TMPRSS2 inhibitors in cell models

PK/PD investigation of antiviral host matriptase/TMPRSS2 inhibitors in cell models

by Gamba, Dávid, van Eijk, Nicholas, Lányi, Katalin, Monostory, Katalin, Steinmetzer, Torsten, Marosi, András, Rácz, Anita, Bajusz, Dávid, Kruhl, Diana, Böttcher-Friebertshäuser, Eva, Pászti-Gere, Erzsébet
Published in Scientific reports (18.07.2024)

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Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage

Novel proteolytic activation of Ebolavirus glycoprotein GP by TMPRSS2 and cathepsin L at an uncharted position can compensate for furin cleavage

by Bestle, Dorothea, Bittel, Linda, Werner, Anke-Dorothee, Kämper, Lennart, Dolnik, Olga, Krähling, Verena, Steinmetzer, Torsten, Böttcher-Friebertshäuser, Eva
Published in Virus research (01.09.2024)

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Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

by Böttcher-Friebertshäuser, Eva, Freuer, Catharina, Sielaff, Frank, Schmidt, Sarah, Eickmann, Markus, Uhlendorff, Jennifer, Steinmetzer, Torsten, Klenk, Hans-Dieter, Garten, Wolfgang
Published in Journal of Virology (01.06.2010)

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Matriptase, HAT, and TMPRSS2 Activate the Hemagglutinin of H9N2 Influenza A Viruses

Matriptase, HAT, and TMPRSS2 Activate the Hemagglutinin of H9N2 Influenza A Viruses

by Baron, Joanna, Tarnow, Carolin, Mayoli-Nüssle, Deborah, Schilling, Eva, Meyer, Daniela, Hammami, Maya, Schwalm, Folker, Steinmetzer, Torsten, Guan, Yi, Garten, Wolfgang, Klenk, Hans-Dieter, Böttcher-Friebertshäuser, Eva
Published in Journal of Virology (01.02.2013)

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Highly Potent Inhibitors of Proprotein Convertase Furin as Potential Drugs for Treatment of Infectious Diseases

Highly Potent Inhibitors of Proprotein Convertase Furin as Potential Drugs for Treatment of Infectious Diseases

by Becker, Gero L., Lu, Yinghui, Hardes, Kornelia, Strehlow, Boris, Levesque, Christine, Lindberg, Iris, Sandvig, Kirsten, Bakowsky, Udo, Day, Robert, Garten, Wolfgang, Steinmetzer, Torsten
Published in The Journal of biological chemistry (22.06.2012)

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A New Strategy for the Development of Highly Potent and Selective Plasmin Inhibitors

A New Strategy for the Development of Highly Potent and Selective Plasmin Inhibitors

by Saupe, Sebastian M, Steinmetzer, Torsten
Published in Journal of medicinal chemistry (09.02.2012)

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Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effect

Exposure of human intestinal epithelial cells and primary human hepatocytes to trypsin-like serine protease inhibitors with potential antiviral effect

by Pászti-Gere, Erzsébet, Pomothy, Judit, Jerzsele, Ákos, Pilgram, Oliver, Steinmetzer, Torsten
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2021)

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3-Amidinophenylalanine-derived matriptase inhibitors can modulate hepcidin production in vitro

3-Amidinophenylalanine-derived matriptase inhibitors can modulate hepcidin production in vitro

by Pászti-Gere, Erzsébet, Szombath, Gergely, Gütschow, Michael, Steinmetzer, Torsten, Székács, András
Published in Naunyn-Schmiedeberg's archives of pharmacology (01.03.2020)

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A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors

A molecular mechanism to diversify Ca2+ signaling downstream of Gs protein-coupled receptors

by Brands, Julian, Bravo, Sergi, Jürgenliemke, Lars, Grätz, Lukas, Schihada, Hannes, Frechen, Fabian, Alenfelder, Judith, Pfeil, Cy, Ohse, Paul Georg, Hiratsuka, Suzune, Kawakami, Kouki, Schmacke, Luna C., Heycke, Nina, Inoue, Asuka, König, Gabriele, Pfeifer, Alexander, Wachten, Dagmar, Schulte, Gunnar, Steinmetzer, Torsten, Watts, Val J., Gomeza, Jesús, Simon, Katharina, Kostenis, Evi
Published in Nature communications (03.09.2024)

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In vitro characterization of the furin inhibitor MI-1851: Albumin binding, interaction with cytochrome P450 enzymes and cytotoxicity

In vitro characterization of the furin inhibitor MI-1851: Albumin binding, interaction with cytochrome P450 enzymes and cytotoxicity

by Pászti-Gere, Erzsébet, Szentkirályi-Tóth, Anna, Szabó, Pál, Steinmetzer, Torsten, Fliszár-Nyúl, Eszter, Poór, Miklós
Published in Biomedicine & pharmacotherapy (01.07.2022)

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Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics

Influenza virus activating host proteases: Identification, localization and inhibitors as potential therapeutics

by Garten, Wolfgang, Braden, Carolin, Arendt, Annika, Peitsch, Catharina, Baron, Joanna, Lu, Yinghui, Pawletko, Kerstin, Hardes, Kornelia, Steinmetzer, Torsten, Böttcher-Friebertshäuser, Eva
Published in European journal of cell biology (01.07.2015)

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Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

Effects of NS2B-NS3 protease and furin inhibition on West Nile and Dengue virus replication

by Kouretova, Jenny, Hammamy, M. Zouhir, Epp, Anton, Hardes, Kornelia, Kallis, Stephanie, Zhang, Linlin, Hilgenfeld, Rolf, Bartenschlager, Ralf, Steinmetzer, Torsten
Published in Journal of enzyme inhibition and medicinal chemistry (01.01.2017)

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In vitro interaction of potential antiviral TMPRSS2 inhibitors with human serum albumin and cytochrome P 450 isoenzymes

In vitro interaction of potential antiviral TMPRSS2 inhibitors with human serum albumin and cytochrome P 450 isoenzymes

by Pászti-Gere, Erzsébet, Szentkirályi, Anna, Fedor, Zsófia, Nagy, Gábor, Szimrók, Zoltán, Pászti, Zoltán, Pászti, Anna, Pilgram, Oliver, Steinmetzer, Torsten, Bodnárová, Slávka, Fliszár-Nyúl, Eszter, Poór, Miklós
Published in Biomedicine & pharmacotherapy (01.02.2022)

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NMR-Based Structural Characterization of a Two-Disulfide-Bonded Analogue of the FXIIIa Inhibitor Tridegin: New Insights into Structure-Activity Relationships

NMR-Based Structural Characterization of a Two-Disulfide-Bonded Analogue of the FXIIIa Inhibitor Tridegin: New Insights into Structure-Activity Relationships

by Schmitz, Thomas, Paul George, Ajay Abisheck, Nubbemeyer, Britta, Bäuml, Charlotte A, Steinmetzer, Torsten, Ohlenschläger, Oliver, Biswas, Arijit, Imhof, Diana
Published in International journal of molecular sciences (17.01.2021)

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Surface glycoprotein of Borna disease virus mediates virus spread from cell to cell

Surface glycoprotein of Borna disease virus mediates virus spread from cell to cell

by Lennartz, Frank, Bayer, Karen, Czerwonka, Nadine, Lu, Yinghui, Kehr, Kristine, Hirz, Manuela, Steinmetzer, Torsten, Garten, Wolfgang, Herden, Christiane
Published in Cellular microbiology (01.03.2016)

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