First demonstration of cerebrospinal fluid and plasma A beta lowering with oral administration of a beta-site amyloid precursor protein-cleaving enzyme 1 inhibitor in nonhuman primates
Sankaranarayanan, Sethu, Holahan, Marie A, Colussi, Dennis, Crouthamel, Ming-Chih, Devanarayan, Viswanath, Ellis, Joan, Espeseth, Amy, Gates, Adam T, Graham, Samuel L, Gregro, Allison R, Hazuda, Daria, Hochman, Jerome H, Holloway, Katharine, Jin, Lixia, Kahana, Jason, Lai, Ming-tain, Lineberger, Janet, McGaughey, Georgia, Moore, Keith P, Nantermet, Philippe, Pietrak, Beth, Price, Eric A, Rajapakse, Hemaka, Stauffer, Shaun, Steinbeiser, Melissa A, Seabrook, Guy, Selnick, Harold G, Shi, Xiao-Ping, Stanton, Matthew G, Swestock, John, Tugusheva, Katherine, Tyler, Keala X, Vacca, Joseph P, Wong, Jacky, Wu, Guoxin, Xu, Min, Cook, Jacquelynn J, Simon, Adam J
Published in The Journal of pharmacology and experimental therapeutics (01.01.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2009)
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Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation
Stauffer, Shaun R., Stanton, Matthew G., Gregro, Alison R., Steinbeiser, Melissa A., Shaffer, Jennifer R., Nantermet, Philippe G., Barrow, James C., Rittle, Kenneth E., Collusi, Dennis, Espeseth, Amy S., Lai, Ming-Tain, Pietrak, Beth L., Holloway, M. Katharine, McGaughey, Georgia B., Munshi, Sanjeev K., Hochman, Jerome H., Simon, Adam J., Selnick, Harold G., Graham, Samuel L., Vacca, Joseph P.
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
Published in Bioorganic & medicinal chemistry letters (15.03.2007)
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Evolution of Tertiary Carbinamine BACE‐1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing
Nantermet, Philippe G., Rajapakse, Hemaka A., Stanton, Mathew G., Stauffer, Shaun R., Barrow, James C., Gregro, Allison R., Moore, Keith P., Steinbeiser, Melissa A., Swestock, John, Selnick, Harold G., Graham, Samuel L., McGaughey, Georgia B., Colussi, Dennis, Lai, Ming‐Tain, Sankaranarayanan, Sethu, Simon, Adam J., Munshi, Sanjeev, Cook, Jacquelynn J., Holahan, Marie A., Michener, Maria S., Vacca, Joseph P.
Published in ChemMedChem (12.01.2009)
Published in ChemMedChem (12.01.2009)
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Synthesis and Evaluation of Imidazole Acetic Acid Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor as Novel Antithrombotics
Barrow, James C, Nantermet, Philippe G, Stauffer, Shaun R, Ngo, Phung L, Steinbeiser, Melissa A, Mao, Shi-Shan, Carroll, Steven S, Bailey, Carolyn, Colussi, Dennis, Bosserman, Michelle, Burlein, Christine, Cook, Jacquelynn J, Sitko, Gary, Tiller, Philip R, Miller-Stein, Cynthia M, Rose, Mark, McMasters, Daniel R, Vacca, Joseph P, Selnick, Harold G
Published in Journal of medicinal chemistry (04.12.2003)
Published in Journal of medicinal chemistry (04.12.2003)
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First Demonstration of Cerebrospinal Fluid and Plasma Aβ Lowering with Oral Administration of a β-Site Amyloid Precursor Protein-Cleaving Enzyme 1 Inhibitor in Nonhuman Primates
Sethu Sankaranarayanan, Marie A. Holahan, Dennis Colussi, Ming-Chih Crouthamel, Viswanath Devanarayan, Joan Ellis, Amy Espeseth, Adam T. Gates, Samuel L. Graham, Allison R. Gregro, Daria Hazuda, Jerome H. Hochman, Katharine Holloway, Lixia Jin, Jason Kahana, Ming-tain Lai, Janet Lineberger, Georgia McGaughey, Keith P. Moore, Philippe Nantermet, Beth Pietrak, Eric A. Price, Hemaka Rajapakse, Shaun Stauffer, Melissa A. Steinbeiser, Guy Seabrook, Harold G. Selnick, Xiao-Ping Shi, Matthew G. Stanton, John Swestock, Katherine Tugusheva, Keala X. Tyler, Joseph P. Vacca, Jacky Wong, Guoxin Wu, Min Xu, Jacquelynn J. Cook, Adam J. Simon
Published in The Journal of pharmacology and experimental therapeutics (01.01.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.01.2009)
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Journal Article
Evolution of tertiary carbinamine BACE-1 inhibitors: Abeta reduction in rhesus CSF upon oral dosing
Nantermet, Philippe G, Rajapakse, Hemaka A, Stanton, Mathew G, Stauffer, Shaun R, Barrow, James C, Gregro, Allison R, Moore, Keith P, Steinbeiser, Melissa A, Swestock, John, Selnick, Harold G, Graham, Samuel L, McGaughey, Georgia B, Colussi, Dennis, Lai, Ming-Tain, Sankaranarayanan, Sethu, Simon, Adam J, Munshi, Sanjeev, Cook, Jacquelynn J, Holahan, Marie A, Michener, Maria S, Vacca, Joseph P
Published in ChemMedChem (01.01.2009)
Published in ChemMedChem (01.01.2009)
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