Potential of ileal bile acid transporter inhibition as a therapeutic target in Alagille syndrome and progressive familial intrahepatic cholestasis
Kamath, Binita M., Stein, Philip, Houwen, Roderick H. J., Verkade, Henkjan J.
Published in Liver international (01.08.2020)
Published in Liver international (01.08.2020)
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Journal Article
Treatment of Clostridium difficile Infection with a Small-Molecule Inhibitor of Toxin UDP-Glucose Hydrolysis Activity
Stroke, Ilana L, Letourneau, Jeffrey J, Miller, Teresa E, Xu, Yan, Pechik, Igor, Savoly, Diana R, Ma, Linh, Sturzenbecker, Laurie J, Sabalski, Joan, Stein, Philip D, Webb, Maria L, Hilbert, David W
Published in Antimicrobial agents and chemotherapy (01.05.2018)
Published in Antimicrobial agents and chemotherapy (01.05.2018)
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Journal Article
Synthesis and SAR studies of novel benzodiazepinedione-based inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB)
Letourneau, Jeffrey J., Stroke, Ilana L., Hilbert, David W., Cole, Andrew G., Sturzenbecker, Laurie J., Marinelli, Brett A., Quintero, Jorge G., Sabalski, Joan, Li, Yanfang, Ma, Linh, Pechik, Igor, Stein, Philip D., Webb, Maria L.
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
Published in Bioorganic & medicinal chemistry letters (15.12.2018)
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Journal Article
Identification and initial optimization of inhibitors of Clostridium difficile (C. difficile) toxin B (TcdB)
Letourneau, Jeffrey J., Stroke, Ilana L., Hilbert, David W., Sturzenbecker, Laurie J., Marinelli, Brett A., Quintero, Jorge G., Sabalski, Joan, Ma, Linh, Diller, David J., Stein, Philip D., Webb, Maria L.
Published in Bioorganic & medicinal chemistry letters (15.02.2018)
Published in Bioorganic & medicinal chemistry letters (15.02.2018)
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Journal Article
Differences in efficacy of monepantel, derquantel and abamectin against multi-resistant nematodes of sheep
Kaminsky, Ronald, Bapst, Beatrice, Stein, Philip A., Strehlau, Guenther A., Allan, Brooke A., Hosking, Barry C., Rolfe, Peter F., Sager, Heinz
Published in Parasitology research (1987) (01.07.2011)
Published in Parasitology research (1987) (01.07.2011)
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Journal Article
Genome-wide association study of N370S homozygous Gaucher disease reveals the candidacy of CLN8 gene as a genetic modifier contributing to extreme phenotypic variation
Zhang, Clarence K., Stein, Philip B., Liu, Jun, Wang, Zuoheng, Yang, Ruhua, Cho, Judy H., Gregersen, Peter K., Aerts, Johannes M.F.G., Zhao, Hongyu, Pastores, Gregory M., Mistry, Pramod K.
Published in American journal of hematology (01.04.2012)
Published in American journal of hematology (01.04.2012)
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Journal Article
Synthesis and SAR of potent and selective tetrahydropyrazinoisoquinolinone 5-HT2C receptor agonists
Zhao, Guohua, Kwon, Chet, Bisaha, Sharon N., Stein, Philip D., Rossi, Karen A., Cao, Xueying, Ung, Thao, Wu, Ginger, Hung, Chen-Pin, Malmstrom, Sarah E., Zhang, Ge, Qu, Qinling, Gan, Jinping, Keim, William J., Cullen, Mary Jane, Rohrbach, Kenneth W., Devenny, James, Pelleymounter, Mary Ann, Miller, Keith J., Robl, Jeffrey A.
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
Published in Bioorganic & medicinal chemistry letters (01.07.2013)
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Journal Article
(3R,5S,E)-7-(4-(4-Fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1H-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic Acid (BMS-644950): A Rationally Designed Orally Efficacious 3-Hydroxy-3-methylglutaryl Coenzyme-A Reductase Inhibitor with Reduced Myotoxicity Potential
Ahmad, Saleem, Madsen, Cort S, Stein, Philip D, Janovitz, Evan, Huang, Christine, Ngu, Khehyong, Bisaha, Sharon, Kennedy, Lawrence J, Chen, Bang-Chi, Zhao, Rulin, Sitkoff, Doree, Monshizadegan, Hossain, Yin, Xiaohong, Ryan, Carol S, Zhang, Rongan, Giancarli, Mary, Bird, Eileen, Chang, Ming, Chen, Xing, Setters, Robert, Search, Debra, Zhuang, Shaobin, Nguyen-Tran, Van, Cuff, Carolyn A, Harrity, Thomas, Darienzo, Celia J, Li, Tong, Reeves, Richard A, Blanar, Michael A, Barrish, Joel C, Zahler, Robert, Robl, Jeffrey A
Published in Journal of medicinal chemistry (08.05.2008)
Published in Journal of medicinal chemistry (08.05.2008)
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Journal Article
The Guinea Pig as a Preclinical Model for Demonstrating the Efficacy and Safety of Statins
Madsen, Cort S, Janovitz, Evan, Zhang, Rongan, Nguyen-Tran, Van, Ryan, Carol S, Yin, Xiaohong, Monshizadegan, Hossain, Chang, Ming, D'Arienzo, Celia, Scheer, Susan, Setters, Robert, Search, Debra, Chen, Xing, Zhuang, Shaobin, Kunselman, Lori, Peters, Andrew, Harrity, Thomas, Apedo, Atsu, Huang, Christine, Cuff, Carolyn A, Kowala, Mark C, Blanar, Michael A, Sun, Chong-Qing, Robl, Jeffrey A, Stein, Philip D
Published in The Journal of pharmacology and experimental therapeutics (01.02.2008)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2008)
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Journal Article
Design, Structure−Activity Relationships, X-ray Crystal Structure, and Energetic Contributions of a Critical P1 Pharmacophore: 3-Chloroindole-7-yl-Based Factor Xa Inhibitors
Shi, Yan, Sitkoff, Doree, Zhang, Jing, Klei, Herbert E, Kish, Kevin, Liu, Eddie C.-K, Hartl, Karen S, Seiler, Steve M, Chang, Ming, Huang, Christine, Youssef, Sonia, Steinbacher, Thomas E, Schumacher, William A, Grazier, Nyeemah, Pudzianowski, Andrew, Apedo, Atsu, Discenza, Lorell, Yanchunas, Joseph, Stein, Philip D, Atwal, Karnail S
Published in Journal of medicinal chemistry (11.12.2008)
Published in Journal of medicinal chemistry (11.12.2008)
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Journal Article
Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors
Shi, Yan, O’Connor, Stephen P., Sitkoff, Doree, Zhang, Jing, Shi, Mengxiao, Bisaha, Sharon N., Wang, Ying, Li, Chi, Ruan, Zheming, Michael Lawrence, R., Klei, Herbert E., Kish, Kevin, Liu, Eddie C.-K., Seiler, Steve M., Schweizer, Liang, Steinbacher, Thomas E., Schumacher, William A., Robl, Jeffrey A., Macor, John E., Atwal, Karnail S., Stein, Philip D.
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
Published in Bioorganic & medicinal chemistry letters (15.12.2011)
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Journal Article
Aroylguanidine-based factor Xa inhibitors: The discovery of BMS-344577
Shi, Yan, Li, Chi, O’Connor, Stephen P., Zhang, Jing, Shi, Mengxiao, Bisaha, Sharon N., Wang, Ying, Sitkoff, Doree, Pudzianowski, Andrew T., Huang, Christine, Klei, Herbert E., Kish, Kevin, Yanchunas, Joseph, Liu, Eddie C.-K., Hartl, Karen S., Seiler, Steve M., Steinbacher, Thomas E., Schumacher, William A., Atwal, Karnail S., Stein, Philip D.
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
Published in Bioorganic & medicinal chemistry letters (15.12.2009)
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Journal Article
Synthesis and evaluation of acylguanidine FXa inhibitors
O’Connor, Stephen P., Atwal, Karnail, Li, Chi, Liu, Eddie C.-K., Seiler, Steven M., Shi, Mengxiao, Shi, Yan, Stein, Philip D., Wang, Ying
Published in Bioorganic & medicinal chemistry (15.08.2008)
Published in Bioorganic & medicinal chemistry (15.08.2008)
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Journal Article
Cyanoguanidine-based lactam derivatives as a novel class of orally bioavailable factor Xa inhibitors
Shi, Yan, Zhang, Jing, Shi, Mengxiao, O’Connor, Stephen P., Bisaha, Sharon N., Li, Chi, Sitkoff, Doree, Pudzianowski, Andrew T., Chong, Saeho, Klei, Herbert E., Kish, Kevin, Yanchunas, Joseph, Liu, Eddie C.-K., Hartl, Karen S., Seiler, Steve M., Steinbacher, Thomas E., Schumacher, William A., Atwal, Karnail S., Stein, Philip D.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Amino(methyl) pyrrolidines as novel scaffolds for factor Xa inhibitors
Shi, Yan, Sitkoff, Doree, Zhang, Jing, Han, Wei, Hu, Zilun, Stein, Philip D., Wang, Ying, Kennedy, Lawrence J., O’Connor, Stephen P., Ahmad, Saleem, Liu, Eddie C.-K., Seiler, Steve M., Lam, Patrick Y.S., Robl, Jeffrey A., Macor, John E., Atwal, Karnail S., Zahler, Robert
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
Published in Bioorganic & medicinal chemistry letters (01.11.2007)
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Journal Article
The Discovery of Sulfonamide Endothelin Antagonists and the Development of the Orally Active ETA Antagonist 5-(Dimethylamino)-N-(3,4-dimethyl-5- isoxazolyl)-1-naphthalenesulfonamide
Stein, Philip D, Hunt, John T, Floyd, David M, Moreland, Suzanne, Dickinson, Kenneth E. J, Mitchell, Caroline, Liu, Eddie C.-K, Webb, Maria L, Murugesan, Natesan
Published in Journal of medicinal chemistry (01.02.1994)
Published in Journal of medicinal chemistry (01.02.1994)
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Journal Article
One-Pot Synthesis and Conformational Features of N,N ‘-Disubstituted Ketene Aminals
Shi, Yan, Zhang, Jing, Grazier, Nyeemah, Stein, Philip D, Atwal, Karnail S, Traeger, Sarah C, Callahan, Sharon P, Malley, Mary F, Galella, Michael A, Gougoutas, Jack Z
Published in Journal of organic chemistry (09.01.2004)
Published in Journal of organic chemistry (09.01.2004)
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Journal Article
Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors
Shi, Yan, Zhang, Jing, Stein, Philip D., Shi, Mengxiao, O’Connor, Stephen P., Bisaha, Sharon N., Li, Chi, Atwal, Karnail S., Bisacchi, Gregory S., Sitkoff, Doree, Pudzianowski, Andrew T., Liu, Eddie C., Hartl, Karen S., Seiler, Steven M., Youssef, Sonia, Steinbacher, Thomas E., Schumacher, William A., Rendina, Alan R., Bozarth, Jeffrey M., Peterson, Tara L., Zhang, Ge, Zahler, Robert
Published in Bioorganic & medicinal chemistry letters (15.12.2005)
Published in Bioorganic & medicinal chemistry letters (15.12.2005)
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Journal Article
A switch in enantiomer preference between mitochondrial F1F0-ATPase chemotypes
BISAHA, Sharon N, MALLEY, Mary F, PUDZIANOWSKI, Andrew, MONSHIZADEGAN, Hossain, PAULINA WANG, MADSEN, Cort S, GOUGOUTAS, Jack Z, STEIN, Philip D
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
Published in Bioorganic & medicinal chemistry letters (02.06.2005)
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Journal Article