Chemical space docking enables large-scale structure-based virtual screening to discover ROCK1 kinase inhibitors
Beroza, Paul, Crawford, James J., Ganichkin, Oleg, Gendelev, Leo, Harris, Seth F., Klein, Raphael, Miu, Anh, Steinbacher, Stefan, Klingler, Franca-Maria, Lemmen, Christian
Published in Nature communications (28.10.2022)
Published in Nature communications (28.10.2022)
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Journal Article
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers
Gerritz, Samuel W, Cianci, Christopher, Kim, Sean, Pearce, Bradley C, Deminie, Carol, Discotto, Linda, McAuliffe, Brian, Minassian, Beatrice F, Shi, Shuhao, Zhu, Shirong, Zhai, Weixu, Pendri, Annapurna, Li, Guo, Poss, Michael A, Edavettal, Suzanne, McDonnell, Patricia A, Lewis, Hal A, Maskos, Klaus, Mörtl, Mario, Kiefersauer, Reiner, Steinbacher, Stefan, Baldwin, Eric T, Metzler, William, Bryson, James, Healy, Matthew D, Philip, Thomas, Zoeckler, Mary, Schartman, Richard, Sinz, Michael, Leyva-Grado, Victor H, Hoffmann, Hans-Heinrich, Langley, David R, Meanwell, Nicholas A, Krystal, Mark
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2011)
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Journal Article
A combined spectroscopic and crystallographic approach to probing drug–human serum albumin interactions
Buttar, David, Colclough, Nicola, Gerhardt, Stefan, MacFaul, Philip A., Phillips, Scott D., Plowright, Alleyn, Whittamore, Paul, Tam, Kin, Maskos, Klaus, Steinbacher, Stefan, Steuber, Holger
Published in Bioorganic & medicinal chemistry (01.11.2010)
Published in Bioorganic & medicinal chemistry (01.11.2010)
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Journal Article
Structure of the Murine Unglycosylated IgG1 Fc Fragment
Feige, Matthias J., Nath, Susanne, Catharino, Silvia R., Weinfurtner, Daniel, Steinbacher, Stefan, Buchner, Johannes
Published in Journal of molecular biology (21.08.2009)
Published in Journal of molecular biology (21.08.2009)
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Journal Article
Crystal Structure of the Thermosome, the Archaeal Chaperonin and Homolog of CCT
Ditzel, Lars, Löwe, Jan, Stock, Daniela, Stetter, Karl-Otto, Huber, Harald, Huber, Robert, Steinbacher, Stefan
Published in Cell (03.04.1998)
Published in Cell (03.04.1998)
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Journal Article
The Crystal Structures of Zea mays and Arabidopsis 4-Hydroxyphenylpyruvate Dioxygenase
Iris M. Fritze, Lars Linden, Jörg Freigang, Auerbach, Günter, Huber, Robert, Steinbacher, Stefan
Published in Plant physiology (Bethesda) (01.04.2004)
Published in Plant physiology (Bethesda) (01.04.2004)
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Journal Article
Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser422 containing epitope on pathological tau
van Ameijde, Jeroen, Crespo, Rosa, Janson, Roosmarijn, Juraszek, Jarek, Siregar, Berdien, Verveen, Hanneke, Sprengers, Imke, Nahar, Tariq, Hoozemans, Jeroen J, Steinbacher, Stefan, Willems, Roland, Delbroek, Lore, Borgers, Marianne, Dockx, Koen, Van Kolen, Kristof, Mercken, Marc, Pascual, Gabriel, Koudstaal, Wouter, Apetri, Adrian
Published in Acta neuropathologica communications (12.07.2018)
Published in Acta neuropathologica communications (12.07.2018)
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Journal Article
A common antigenic motif recognized by naturally occurring human VH5–51/VL4–1 anti-tau antibodies with distinct functionalities
Apetri, Adrian, Crespo, Rosa, Juraszek, Jarek, Pascual, Gabriel, Janson, Roosmarijn, Zhu, Xueyong, Zhang, Heng, Keogh, Elissa, Holland, Trevin, Wadia, Jay, Verveen, Hanneke, Siregar, Berdien, Mrosek, Michael, Taggenbrock, Renske, Ameijde, Jeroenvan, Inganäs, Hanna, van Winsen, Margot, Koldijk, Martin H., Zuijdgeest, David, Borgers, Marianne, Dockx, Koen, Stoop, Esther J. M., Yu, Wenli, Brinkman-van der Linden, Els C., Ummenthum, Kimberley, van Kolen, Kristof, Mercken, Marc, Steinbacher, Stefan, de Marco, Donata, Hoozemans, Jeroen J., Wilson, Ian A., Koudstaal, Wouter, Goudsmit, Jaap
Published in Acta neuropathologica communications (31.05.2018)
Published in Acta neuropathologica communications (31.05.2018)
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Journal Article
Sequence Statistics Reliably Predict Stabilizing Mutations in a Protein Domain
Steipe, Boris, Schiller, Britta, Plückthun, Andreas, Steinbacher, Stefan
Published in Journal of molecular biology (15.07.1994)
Published in Journal of molecular biology (15.07.1994)
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Journal Article
Crystal Structure of P22 Tailspike Protein: Interdigitated Subunits in a Thermostable Trimer
Steinbacher, Stefan, Seckler, Robert, Miller, Stefan, Steipe, Boris, Huber, Robert, Reinemer, Peter
Published in Science (American Association for the Advancement of Science) (15.07.1994)
Published in Science (American Association for the Advancement of Science) (15.07.1994)
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Journal Article
Crystal Structure of the Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase from Bacillus subtilis
Steinbacher, Stefan, Kaiser, Johannes, Gerhardt, Stefan, Eisenreich, Wolfgang, Huber, Robert, Bacher, Adelbert, Rohdich, Felix
Published in Journal of molecular biology (20.06.2003)
Published in Journal of molecular biology (20.06.2003)
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Journal Article
The Structural Basis of Riboflavin Binding to Schizosaccharomyces pombe 6,7-Dimethyl-8-ribityllumazine Synthase
Gerhardt, Stefan, Haase, Ilka, Steinbacher, Stefan, Kaiser, Jens T., Cushman, Mark, Bacher, Adelbert, Huber, Robert, Fischer, Markus
Published in Journal of molecular biology (17.05.2002)
Published in Journal of molecular biology (17.05.2002)
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Journal Article
Molecular Characterization of Lantibiotic-synthesizing Enzyme EpiD Reveals a Function for Bacterial Dfp Proteins in Coenzyme A Biosynthesis
Kupke, Thomas, Uebele, Michael, Schmid, Dietmar, Jung, Günther, Blaesse, Michael, Steinbacher, Stefan
Published in The Journal of biological chemistry (13.10.2000)
Published in The Journal of biological chemistry (13.10.2000)
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Journal Article
Arabidopsis thaliana Flavoprotein AtHAL3a Catalyzes the Decarboxylation of 4′-Phosphopantothenoylcysteine to 4′-Phosphopantetheine, a Key Step in Coenzyme A Biosynthesis
Kupke, Thomas, Hernández-Acosta, Pilar, Steinbacher, Stefan, Culiáñez-Macià, Francisco A.
Published in The Journal of biological chemistry (01.06.2001)
Published in The Journal of biological chemistry (01.06.2001)
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Journal Article
Biosynthesis of Riboflavin in Archaea Studies on the Mechanism of 3,4-Dihydroxy-2-butanone-4-phosphate Synthase of Methanococcus jannaschii
Fischer, Markus, Romisch, Werner, Schiffmann, Susanne, Kelly, Mark, Oschkinat, Hartmut, Steinbacher, Stefan, Huber, Robert, Eisenreich, Wolfgang, Richter, Gerald, Bacher, Adelbert
Published in The Journal of biological chemistry (01.11.2002)
Published in The Journal of biological chemistry (01.11.2002)
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Journal Article
Structure of 3,4-Dihydroxy-2-butanone 4-Phosphate Synthase from Methanococcus jannaschii in Complex with Divalent Metal Ions and the Substrate Ribulose 5-Phosphate
Steinbacher, Stefan, Schiffmann, Susanne, Richter, Gerald, Huber, Robert, Bacher, Adelbert, Fischer, Markus
Published in The Journal of biological chemistry (24.10.2003)
Published in The Journal of biological chemistry (24.10.2003)
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Journal Article
Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways
Laupitz, Ralf, Hecht, Stefan, Amslinger, Sabine, Zepeck, Ferdinand, Kaiser, Johannes, Richter, Gerald, Schramek, Nicholas, Steinbacher, Stefan, Huber, Robert, Arigoni, Duilio, Bacher, Adelbert, Eisenreich, Wolfgang, Rohdich, Felix
Published in European journal of biochemistry (01.07.2004)
Published in European journal of biochemistry (01.07.2004)
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