Structure activity relationships of 4-hydroxy-2-pyridones: A novel class of antituberculosis agents
Ng, Pearly Shuyi, Manjunatha, Ujjini H., Rao, Srinivasa P.S., Camacho, Luis R., Ma, Ngai Ling, Herve, Maxime, Noble, Christian G., Goh, Anne, Peukert, Stefan, Diagana, Thierry T., Smith, Paul W., Kondreddi, Ravinder Reddy
Published in European journal of medicinal chemistry (01.12.2015)
Published in European journal of medicinal chemistry (01.12.2015)
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Discovery of NVP-LDE225, a Potent and Selective Smoothened Antagonist
Pan, Shifeng, Wu, Xu, Jiang, Jiqing, Gao, Wenqi, Wan, Yongqin, Cheng, Dai, Han, Dong, Liu, Jun, Englund, Nathan P, Wang, Yan, Peukert, Stefan, Miller-Moslin, Karen, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Jiang, Yun, Tsao, Jeffrey, Sun, Fangxian, Pferdekamper, AnneMarie C, Dodd, Stephanie, Tuntland, Tove, Maniara, Wieslawa, Kelleher, Joseph F, Yao, Yung-mae, Warmuth, Markus, Williams, Juliet, Dorsch, Marion
Published in ACS medicinal chemistry letters (10.06.2010)
Published in ACS medicinal chemistry letters (10.06.2010)
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Design and structure–activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): Tetramic, tetronic acids and dihydropyridin-2-ones
Peukert, Stefan, Sun, Yingchuan, Zhang, Rui, Hurley, Brian, Sabio, Mike, Shen, Xiaoyu, Gray, Christen, Dzink-Fox, JoAnn, Tao, Jianshi, Cebula, Regina, Wattanasin, Sompong
Published in Bioorganic & medicinal chemistry (15.03.2008)
Published in Bioorganic & medicinal chemistry (15.03.2008)
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Biophysical Investigation of the Mode of Inhibition of Tetramic Acids, the Allosteric Inhibitors of Undecaprenyl Pyrophosphate Synthase
Lee, Lac V, Granda, Brian, Dean, Karl, Tao, Jianshi, Liu, Eugene, Zhang, Rui, Peukert, Stefan, Wattanasin, Sompong, Xie, Xiaoling, Ryder, Neil S, Tommasi, Ruben, Deng, Gejing
Published in Biochemistry (Easton) (29.06.2010)
Published in Biochemistry (Easton) (29.06.2010)
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A method for estimating the risk of drug-induced phototoxicity and its application to smoothened inhibitors
Peukert, Stefan, Nunez, Jill, He, Feng, Dai, Miao, Yusuff, Naeem, DiPesa, Alan, Miller-Moslin, Karen, Karki, Rajesh, Lagu, Bharat, Harwell, Chris, Zhang, Yalin, Bauer, Daniel, Kelleher, Joseph F., Egan, William
Published in MedChemComm (01.10.2011)
Published in MedChemComm (01.10.2011)
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Molecular Basis for Kv1.5 Channel Block
Decher, Niels, Pirard, Bernard, Bundis, Florian, Peukert, Stefan, Baringhaus, Karl-Heinz, Busch, Andreas E., Steinmeyer, Klaus, Sanguinetti, Michael C.
Published in The Journal of biological chemistry (02.01.2004)
Published in The Journal of biological chemistry (02.01.2004)
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Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer
Tria, George S, Abrams, Tinya, Baird, Jason, Burks, Heather E, Firestone, Brant, Gaither, L. Alex, Hamann, Lawrence G, He, Guo, Kirby, Christina A, Kim, Sunkyu, Lombardo, Franco, Macchi, Kaitlin J, McDonnell, Donald P, Mishina, Yuji, Norris, John D, Nunez, Jill, Springer, Clayton, Sun, Yingchuan, Thomsen, Noel M, Wang, Chunrong, Wang, Jianling, Yu, Bing, Tiong-Yip, Choi-Lai, Peukert, Stefan
Published in Journal of medicinal chemistry (12.04.2018)
Published in Journal of medicinal chemistry (12.04.2018)
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Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma
Buonamici, Silvia, Williams, Juliet, Morrissey, Michael, Wang, Anlai, Guo, Ribo, Vattay, Anthony, Hsiao, Kathy, Yuan, Jing, Green, John, Ospina, Beatriz, Yu, Qunyan, Ostrom, Lance, Fordjour, Paul, Anderson, Dustin L, Monahan, John E, Kelleher, Joseph F, Peukert, Stefan, Pan, Shifeng, Wu, Xu, Maira, Sauveur-Michel, García-Echeverría, Carlos, Briggs, Kimberly J, Watkins, D Neil, Yao, Yung-mae, Lengauer, Christoph, Warmuth, Markus, Sellers, William R, Dorsch, Marion
Published in Science translational medicine (29.09.2010)
Published in Science translational medicine (29.09.2010)
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Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ERα+ Breast Cancer
Burks, Heather E, Abrams, Tinya, Kirby, Christina A, Baird, Jason, Fekete, Alexander, Hamann, Lawrence G, Kim, Sunkyu, Lombardo, Franco, Loo, Alice, Lubicka, Danuta, Macchi, Kaitlin, McDonnell, Donald P, Mishina, Yuji, Norris, John D, Nunez, Jill, Saran, Chitra, Sun, Yingchuan, Thomsen, Noel M, Wang, Chunrong, Wang, Jianling, Peukert, Stefan
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ER alpha plus Breast Cancer
Burks, Heather E., Abrams, Tinya, Kirby, Christina A., Baird, Jason, Fekete, Alexander, Hamann, Lawrence G., Kim, Sunkyu, Lombardo, Franco, Loo, Alice, Lubicka, Danuta, Macchi, Kaitlin, McDonnell, Donald P., Mishina, Yuji, Norris, John D., Nunez, Jill, Saran, Chitra, Sun, Yingchuan, Thomsen, Noel M., Wang, Chunrong, Wang, Jianling, Peukert, Stefan
Published in Journal of medicinal chemistry (13.04.2017)
Published in Journal of medicinal chemistry (13.04.2017)
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Discovery of a brain-sparing GIRK1/4 inhibitor for pharmacological cardioversion of atrial fibrillation
Peukert, Stefan, Gulgeze Efthymiou, Hatice Belgin, Mo, Ruowei, Peng, Yunshan, Ma, Fupeng, Barbe, Guillaume, Bebernitz, Gregory, Fridrich, Cary, Buono, Chiara, Williams, Eric T., Daniels, Thomas, Li, Lisha, Zhang, Xia, Adachi, Yuichiro, Abe, Mie, Taggart, Andrew K.P.
Published in Bioorganic & medicinal chemistry letters (01.04.2023)
Published in Bioorganic & medicinal chemistry letters (01.04.2023)
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Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders
Bonazzi, Simone, Goold, Carleton P, Gray, Audrey, Thomsen, Noel M, Nunez, Jill, Karki, Rajeshri G, Gorde, Aakruti, Biag, Jonathan D, Malik, Hasnain A, Sun, Yingchuan, Liang, Guiqing, Lubicka, Danuta, Salas, Sarah, Labbe-Giguere, Nancy, Keaney, Erin P, McTighe, Stephanie, Liu, Shanming, Deng, Lin, Piizzi, Grazia, Lombardo, Franco, Burdette, Doug, Dodart, Jean-Cosme, Wilson, Christopher J, Peukert, Stefan, Curtis, Daniel, Hamann, Lawrence G, Murphy, Leon O
Published in Journal of medicinal chemistry (13.02.2020)
Published in Journal of medicinal chemistry (13.02.2020)
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Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes
Bonazzi, Simone, Gray, Audrey, Thomsen, Noel M., Biag, Jonathan, Labbe-Giguere, Nancy, Keaney, Erin P., Malik, Hasnain A., Sun, Yingchuan, Nunez, Jill, Karki, Rajeshri G., Knapp, Mark, Elling, Robert, Fuller, John, Pardee, Gwynn, Craig, Lucas, Capre, Ketthsy, Salas, Sarah, Gorde, Aakruti, Liang, Guiqing, Lubicka, Danuta, McTighe, Stephanie M., Goold, Carleton, Liu, Shanming, Deng, Lin, Hong, Jin, Fekete, Alexander, Stadelmann, Pascal, Frieauff, Wilfried, Elhajouji, Azeddine, Bauer, Daniel, Lerchner, Andreas, Radetich, Branko, Furet, Pascal, Piizzi, Grazia, Burdette, Doug, Wilson, Christopher J., Peukert, Stefan, Hamann, Lawrence G., Murphy, Leon O., Curtis, Daniel
Published in Journal of medicinal chemistry (13.07.2023)
Published in Journal of medicinal chemistry (13.07.2023)
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Abstract 922: Preclinical anticancer activity of LSZ102, a novel oral selective estrogen receptor degrader targeting wild-type and mutant ER
Gaither, L. Alex, Yip, Choi Lai Tiong, Wang, Chunrong, Toy, Weiyi, Sheng, Qing, Chen, Jinyun, Mishina, Yuji, Das, Rita, Peukert, Stefan, Loo, Alice, Chandarlapaty, Sarat, Crystal, Adam, Abrams, Tinya J.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Discovery of NVP-LEQ506, a Second-Generation Inhibitor of Smoothened
Peukert, Stefan, He, Feng, Dai, Miao, Zhang, Rui, Sun, Yingchuan, Miller-Moslin, Karen, McEwan, Michael, Lagu, Bharat, Wang, Kate, Yusuff, Naeem, Bourret, Aaron, Ramamurthy, Arun, Maniara, Wieslawa, Amaral, Adam, Vattay, Anthony, Wang, Anlai, Guo, Ribo, Yuan, Jing, Green, John, Williams, Juliet, Buonamici, Silvia, Kelleher III, Joseph F., Dorsch, Marion
Published in ChemMedChem (01.08.2013)
Published in ChemMedChem (01.08.2013)
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A NEW PLATFORM FOR DESIGNING LIGANDS FOR ASYMMETRIC INDUCTION IN ALLYLIC ALKYLATIONS
TROST, BM, BREIT, B, PEUKERT, S, ZAMBRANO, J, ZILLER, JW
Published in Angewandte Chemie International Edition (17.11.1995)
Published in Angewandte Chemie International Edition (17.11.1995)
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1-Amino-4-benzylphthalazines as Orally Bioavailable Smoothened Antagonists with Antitumor Activity
Miller-Moslin, Karen, Peukert, Stefan, Jain, Rishi K, McEwan, Michael A, Karki, Rajesh, Llamas, Luis, Yusuff, Naeem, He, Feng, Li, Yanhong, Sun, Yingchuan, Dai, Miao, Perez, Lawrence, Michael, Walter, Sheng, Tao, Lei, Huangshu, Zhang, Rui, Williams, Juliet, Bourret, Aaron, Ramamurthy, Arun, Yuan, Jing, Guo, Ribo, Matsumoto, Melissa, Vattay, Anthony, Maniara, Wieslawa, Amaral, Adam, Dorsch, Marion, Kelleher, Joseph F
Published in Journal of medicinal chemistry (09.07.2009)
Published in Journal of medicinal chemistry (09.07.2009)
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