The imidazo[1,2-a]pyridine ring system as a scaffold for potent dual phosphoinositide-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors
Stec, Markian M., Andrews, Kristin L., Bo, Yunxin, Caenepeel, Sean, Liao, Hongyu, McCarter, John, Mullady, Erin L., San Miguel, Tisha, Subramanian, Raju, Tamayo, Nuria, Whittington, Douglas A., Wang, Ling, Wu, Tian, Zalameda, Leeanne P., Zhang, Nancy, Hughes, Paul E., Norman, Mark H.
Published in Bioorganic & medicinal chemistry letters (01.10.2015)
Published in Bioorganic & medicinal chemistry letters (01.10.2015)
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Structure–Activity Relationships of Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Investigations of Various 6,5-Heterocycles to Improve Metabolic Stability
Stec, Markian M, Andrews, Kristin L, Booker, Shon K, Caenepeel, Sean, Freeman, Daniel J, Jiang, Jian, Liao, Hongyu, McCarter, John, Mullady, Erin L, San Miguel, Tisha, Subramanian, Raju, Tamayo, Nuria, Wang, Ling, Yang, Kevin, Zalameda, Leeanne P, Zhang, Nancy, Hughes, Paul E, Norman, Mark H
Published in Journal of medicinal chemistry (28.07.2011)
Published in Journal of medicinal chemistry (28.07.2011)
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Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 2. Leveraging Structure-Based Drug Design to Identify Analogues with Improved Pharmacokinetic Profiles
St. Jean, David J., Ashton, Kate S., Bartberger, Michael D., Chen, Jie, Chmait, Samer, Cupples, Rod, Galbreath, Elizabeth, Helmering, Joan, Hong, Fang-Tsao, Jordan, Steven R., Liu, Longbin, Kunz, Roxanne K., Michelsen, Klaus, Nishimura, Nobuko, Pennington, Lewis D., Poon, Steve F., Reid, Darren, Sivits, Glenn, Stec, Markian M., Tadesse, Seifu, Tamayo, Nuria, Van, Gwyneth, Yang, Kevin C., Zhang, Jiandong, Norman, Mark H., Fotsch, Christopher, Lloyd, David J., Hale, Clarence
Published in Journal of medicinal chemistry (23.01.2014)
Published in Journal of medicinal chemistry (23.01.2014)
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Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511
Norman, Mark H, Andrews, Kristin L, Bo, Yunxin Y, Booker, Shon K, Caenepeel, Sean, Cee, Victor J, D’Angelo, Noel D, Freeman, Daniel J, Herberich, Bradley J, Hong, Fang-Tsao, Jackson, Claire L. M, Jiang, Jian, Lanman, Brian A, Liu, Longbin, McCarter, John D, Mullady, Erin L, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Miguel, Tisha San, Smith, Adrian L, Stec, Markian M, Tadesse, Seifu, Tasker, Andrew, Aidasani, Divesh, Zhu, Xiaochun, Subramanian, Raju, Tamayo, Nuria A, Wang, Ling, Whittington, Douglas A, Wu, Bin, Wu, Tian, Wurz, Ryan P, Yang, Kevin, Zalameda, Leeanne, Zhang, Nancy, Hughes, Paul E
Published in Journal of medicinal chemistry (13.09.2012)
Published in Journal of medicinal chemistry (13.09.2012)
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P450-mediated O-demethylated metabolite is responsible for rat hepatobiliary toxicity of pyridyltriazine-containing PI3K inhibitors
Subramanian, Raju, Aidasani, Divesh, Bailey, Keith, Branstetter, Dan, Everds, Nancy, Jiang, Jian, Norman, Mark H, Primack, Ronya, Skiles, Gary L, Soto, Irene, Stec, Markian M, Wagner, Mylo, Wu, Tian, Zhu, Xiaochun, Lebrec, Hervé
Published in Toxicological sciences (01.11.2014)
Published in Toxicological sciences (01.11.2014)
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Design and Synthesis of Peripherally Restricted Transient Receptor Potential Vanilloid 1 (TRPV1) Antagonists
Tamayo, Nuria, Liao, Hongyu, Stec, Markian M, Wang, Xianghong, Chakrabarti, Partha, Retz, Dan, Doherty, Elizabeth M, Surapaneni, Sekhar, Tamir, Rami, Bannon, Anthony W, Gavva, Narender R, Norman, Mark H
Published in Journal of medicinal chemistry (08.05.2008)
Published in Journal of medicinal chemistry (08.05.2008)
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Journal Article
Correction to Selective Class I Phosphoinositide 3‑Kinase Inhibitors: Optimization of a Series of Pyridyltriazines Leading to the Identification of a Clinical Candidate, AMG 511
Norman, Mark H, Andrews, Kristin L, Bo, Yunxin Y, Booker, Shon K, Caenepeel, Sean, Cee, Victor J, D’Angelo, Noel D, Freeman, Daniel J, Herberich, Bradley J, Hong, Fang-Tsao, Jackson, Claire L. M, Jiang, Jian, Lanman, Brian A, Liu, Longbin, McCarter, John D, Mullady, Erin L, Nishimura, Nobuko, Pettus, Liping H, Reed, Anthony B, Miguel, Tisha San, Smith, Adrian L, Stec, Markian M, Tadesse, Seifu, Tasker, Andrew, Aidasani, Divesh, Zhu, Xiaochun, Subramanian, Raju, Tamayo, Nuria A, Wang, Ling, Whittington, Douglas A, Wu, Bin, Wu, Tian, Wurz, Ryan P, Yang, Kevin, Zalameda, Leeanne, Zhang, Nancy, Hughes, Paul E
Published in Journal of medicinal chemistry (25.10.2012)
Published in Journal of medicinal chemistry (25.10.2012)
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Journal Article
Substituted aryl pyrimidines as potent and soluble TRPV1 antagonists
Stec, Markian M., Bo, Yunxin, Chakrabarti, Partha P., Liao, Lillian, Ncube, Mqhele, Tamayo, Nuria, Tamir, Rami, Gavva, Narender R., Treanor, James J.S., Norman, Mark H.
Published in Bioorganic & medicinal chemistry (15.09.2008)
Published in Bioorganic & medicinal chemistry (15.09.2008)
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MCL-1 단백질을 억제하는 화합물
LOW JONATHAN D, HARRINGTON PAUL E, BROWN SEAN P, LANMAN BRIAN ALAN, LI KEXUE, LI YUNXIAO, TAYGERLY JOSHUA, STEC MARKIAN M, KOHN TODD J, ASHTON KATE, PICKRELL ALEXANDER J, KALLER MATTHEW R, MINATTI ANA ELENA
Year of Publication 26.12.2019
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Year of Publication 26.12.2019
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MCL-1 INHIBITOR FORMULATIONS
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Year of Publication 29.12.2023
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FORBINDELSER, DER HÆMMER MCL-1-PROTEIN
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Year of Publication 24.11.2023
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COMPOUNDS THAT INHIBIT MCL-1 PROTEIN
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Year of Publication 28.04.2023
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Year of Publication 28.04.2023
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COMPOUNDS THAT INHIBIT MCL-1 PROTEIN
ASHTON, KATE, HARRINGTON, PAUL, E, LI, KEXUE, LANMAN, BRIAN, ALAN, LOW, JONATHAN, D, MINATTI, ANA, ELENA, TAYGERLY, JOSHUA, KALLER, MATTHEW, R, LI, YUNXIAO, KOHN, TODD, J, STEC, MARKIAN, M, BROWN, SEAN, P, PICKRELL, ALEXANDER, J
Year of Publication 28.04.2023
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Year of Publication 28.04.2023
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