Structure-Based Optimization of ML300-Derived, Noncovalent Inhibitors Targeting the Severe Acute Respiratory Syndrome Coronavirus 3CL Protease (SARS-CoV‑2 3CLpro)
Han, Sang Hoon, Goins, Christopher M, Arya, Tarun, Shin, Woo-Jin, Maw, Joshua, Hooper, Alice, Sonawane, Dhiraj P, Porter, Matthew R, Bannister, Breyanne E, Crouch, Rachel D, Lindsey, A. Abigail, Lakatos, Gabriella, Martinez, Steven R, Alvarado, Joseph, Akers, Wendell S, Wang, Nancy S, Jung, Jae U, Macdonald, Jonathan D, Stauffer, Shaun R
Published in Journal of medicinal chemistry (24.02.2022)
Published in Journal of medicinal chemistry (24.02.2022)
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A TOX-ic axis of epigenetic stem cell maintenance and chemoresistance in colon cancer
Hubert, Christopher G., Stauffer, Shaun R., Lathia, Justin D.
Published in PLoS biology (15.09.2023)
Published in PLoS biology (15.09.2023)
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Discovery, Synthesis, And Structure-Based Optimization of a Series of N‑(tert-Butyl)-2‑(N‑arylamido)-2-(pyridin-3-yl) Acetamides (ML188) as Potent Noncovalent Small Molecule Inhibitors of the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) 3CL Protease
Jacobs, Jon, Grum-Tokars, Valerie, Zhou, Ya, Turlington, Mark, Saldanha, S. Adrian, Chase, Peter, Eggler, Aimee, Dawson, Eric S, Baez-Santos, Yahira M, Tomar, Sakshi, Mielech, Anna M, Baker, Susan C, Lindsley, Craig W, Hodder, Peter, Mesecar, Andrew, Stauffer, Shaun R
Published in Journal of medicinal chemistry (24.01.2013)
Published in Journal of medicinal chemistry (24.01.2013)
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Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity
Aho, Erin R., Wang, Jing, Gogliotti, Rocco D., Howard, Gregory C., Phan, Jason, Acharya, Pankaj, Macdonald, Jonathan D., Cheng, Ken, Lorey, Shelly L., Lu, Bin, Wenzel, Sabine, Foshage, Audra M., Alvarado, Joseph, Wang, Feng, Shaw, J. Grace, Zhao, Bin, Weissmiller, April M., Thomas, Lance R., Vakoc, Christopher R., Hall, Matthew D., Hiebert, Scott W., Liu, Qi, Stauffer, Shaun R., Fesik, Stephen W., Tansey, William P.
Published in Cell reports (Cambridge) (12.03.2019)
Published in Cell reports (Cambridge) (12.03.2019)
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Chemical inhibition of fatty acid absorption and cellular uptake limits lipotoxic cell death
Ahowesso, Constance, Black, Paul N., Saini, Nipun, Montefusco, David, Chekal, Jessica, Malosh, Chrysa, Lindsley, Craig W., Stauffer, Shaun R., DiRusso, Concetta C.
Published in Biochemical pharmacology (01.11.2015)
Published in Biochemical pharmacology (01.11.2015)
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A PAM of the α1A-Adrenergic receptor rescues biomarker, long-term potentiation, and cognitive deficits in Alzheimer’s disease mouse models without effects on blood pressure
Papay, Robert S., Stauffer, Shaun R., Perez, Dianne M.
Published in Current research in pharmacology and drug discovery (01.01.2023)
Published in Current research in pharmacology and drug discovery (01.01.2023)
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Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354
Wen, Wandong, Young, Summer E., Duvernay, Matthew T., Schulte, Michael L., Nance, Kellie D., Melancon, Bruce J., Engers, Julie, Locuson, Charles W., Wood, Michael R., Daniels, J. Scott, Wu, Wenjun, Lindsley, Craig W., Hamm, Heidi E., Stauffer, Shaun R.
Published in Bioorganic & medicinal chemistry letters (01.10.2014)
Published in Bioorganic & medicinal chemistry letters (01.10.2014)
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361 WDR5 represents a therapeutically exploitable target for cancer stem cells in glioblastoma
Hubert, Christopher, Mitchell, Kelly, Sprowls, Samuel, Shakya, Sajina, Arora, Sonali, Silver, Daniel J., Goins, Christopher M., Wallace, Lisa, Roversi, Gustavo, Schafer, Rachel, Kay, Kristen, Miller, Tyler E., Lauko, Adam, Bassett, John, Kashyap, Anjali, Kass, J. D’Amato, Mulkearns-Hubert, Erin E., Johnson, Sadie, Alvarado, Joseph, Rich, Jeremy N., Paddison, Patrick J., Patel, Anoop P., Stauffer, Shaun R., Hubert, Christopher G., Lathia, Justin D.
Published in Journal of clinical and translational science (01.04.2023)
Published in Journal of clinical and translational science (01.04.2023)
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Journal Article
Screening of Homogeneous Catalysts by Fluorescence Resonance Energy Transfer. Identification of Catalysts for Room-Temperature Heck Reactions
Stambuli, James P, Stauffer, Shaun R, Shaughnessy, Kevin H, Hartwig, John F
Published in Journal of the American Chemical Society (21.03.2001)
Published in Journal of the American Chemical Society (21.03.2001)
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Journal Article
CDK9 Inhibition by Dinaciclib Is a Therapeutic Vulnerability in Epithelioid Hemangioendothelioma
Pobbati, Ajaybabu V, Burtscher, Ashley, Rajaram Siva, Nandini, Hallett, Andrea, Romigh, Todd, Che, Kepeng, Zhao, Bin, Coker, Jesse A, Wang, Nancy, Stauffer, Shaun R, Rubin, Brian P
Published in Clinical cancer research (13.09.2024)
Published in Clinical cancer research (13.09.2024)
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Journal Article
Discovery of WD Repeat-Containing Protein 5 (WDR5)–MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design
Chacón Simon, Selena, Wang, Feng, Thomas, Lance R, Phan, Jason, Zhao, Bin, Olejniczak, Edward T, Macdonald, Jonathan D, Shaw, J. Grace, Schlund, Caden, Payne, William, Creighton, Joy, Stauffer, Shaun R, Waterson, Alex G, Tansey, William P, Fesik, Stephen W
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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Targeting zoonotic viruses: Structure-based inhibition of the 3C-like protease from bat coronavirus HKU4—The likely reservoir host to the human coronavirus that causes Middle East Respiratory Syndrome (MERS)
St. John, Sarah E., Tomar, Sakshi, Stauffer, Shaun R., Mesecar, Andrew D.
Published in Bioorganic & medicinal chemistry (01.09.2015)
Published in Bioorganic & medicinal chemistry (01.09.2015)
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