The Lipid Kinase PIP5K1C Regulates Pain Signaling and Sensitization
Wright, Brittany D., Loo, Lipin, Street, Sarah E., Ma, Anqi, Taylor-Blake, Bonnie, Stashko, Michael A., Jin, Jian, Janzen, William P., Frye, Stephen V., Zylka, Mark J.
Published in Neuron (Cambridge, Mass.) (21.05.2014)
Published in Neuron (Cambridge, Mass.) (21.05.2014)
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Journal Article
The Synthesis and Initial Evaluation of MerTK Targeted PET Agents
Wang, Li, Zhou, Yubai, Wu, Xuedan, Ma, Xinrui, Li, Bing, Ding, Ransheng, Stashko, Michael A, Wu, Zhanhong, Wang, Xiaodong, Li, Zibo
Published in Molecules (Basel, Switzerland) (22.02.2022)
Published in Molecules (Basel, Switzerland) (22.02.2022)
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Journal Article
Pseudo-Cyclization through Intramolecular Hydrogen Bond Enables Discovery of Pyridine Substituted Pyrimidines as New Mer Kinase Inhibitors
Zhang, Weihe, Zhang, Dehui, Stashko, Michael A, DeRyckere, Deborah, Hunter, Debra, Kireev, Dmitri, Miley, Michael J, Cummings, Christopher, Lee, Minjung, Norris-Drouin, Jacqueline, Stewart, Wendy M, Sather, Susan, Zhou, Yingqiu, Kirkpatrick, Gregory, Machius, Mischa, Janzen, William P, Earp, H. Shelton, Graham, Douglas K, Frye, Stephen V, Wang, Xiaodong
Published in Journal of medicinal chemistry (12.12.2013)
Published in Journal of medicinal chemistry (12.12.2013)
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Journal Article
Discovery of Macrocyclic Pyrimidines as MerTK‐Specific Inhibitors
McIver, Andrew L., Zhang, Weihe, Liu, Qingyang, Jiang, Xinpeng, Stashko, Michael A., Nichols, James, Miley, Michael J., Norris‐Drouin, Jacqueline, Machius, Mischa, DeRyckere, Deborah, Wood, Edgar, Graham, Douglas K., Earp, H. Shelton, Kireev, Dmitri, Frye, Stephen V., Wang, Xiaodong
Published in ChemMedChem (03.02.2017)
Published in ChemMedChem (03.02.2017)
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Journal Article
Efficacy of a Mer and Flt3 tyrosine kinase small molecule inhibitor, UNC1666, in acute myeloid leukemia
Lee-Sherick, Alisa B, Zhang, Weihe, Menachof, Kelly K, Hill, Amanda A, Rinella, Sean, Kirkpatrick, Gregory, Page, Lauren S, Stashko, Michael A, Jordan, Craig T, Wei, Qi, Liu, Jing, Zhang, Dehui, DeRyckere, Deborah, Wang, Xiaodong, Frye, Stephen, Earp, H Shelton, Graham, Douglas K
Published in Oncotarget (30.03.2015)
Published in Oncotarget (30.03.2015)
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Journal Article
Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors
Baughman, Brandi M, Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A, Jessen, Henning J, Pearce, Kenneth H, Frye, Stephen V, Shears, Stephen B
Published in PloS one (21.06.2017)
Published in PloS one (21.06.2017)
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Journal Article
A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors
Baughman, Brandi M, Wang, Huanchen, An, Yi, Kireev, Dmitri, Stashko, Michael A, Jessen, Henning J, Pearce, Kenneth H, Frye, Stephen V, Shears, Stephen B
Published in PloS one (13.10.2016)
Published in PloS one (13.10.2016)
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Journal Article
Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy
Szczepankiewicz, Bruce G, Liu, Gang, Hajduk, Philip J, Abad-Zapatero, Cele, Pei, Zhonghua, Xin, Zhili, Lubben, Thomas H, Trevillyan, James M, Stashko, Michael A, Ballaron, Stephen J, Liang, Heng, Huang, Flora, Hutchins, Charles W, Fesik, Stephen W, Jirousek, Michael R
Published in Journal of the American Chemical Society (09.04.2003)
Published in Journal of the American Chemical Society (09.04.2003)
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Journal Article
Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions
Zhou, Yubai, Mukherjee, Sandip, Huang, Daowei, Chakraborty, Molee, Gu, Chunfang, Zong, Guangning, Stashko, Michael A., Pearce, Kenneth H., Shears, Stephen B., Chakraborty, Anutosh, Wang, Huanchen, Wang, Xiaodong
Published in Journal of medicinal chemistry (12.05.2022)
Published in Journal of medicinal chemistry (12.05.2022)
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Journal Article
Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors
Kong, Deyu, Tian, Qiang, Chen, Zhilong, Zheng, Hongchao, Stashko, Michael A., Yan, Dan, Earp, H. Shelton, Frye, Stephen V., DeRyckere, Deborah, Kireev, Dmitri, Graham, Douglas K., Wang, Xiaodong
Published in Journal of medicinal chemistry (11.04.2024)
Published in Journal of medicinal chemistry (11.04.2024)
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Journal Article
Discovery, Structure−Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors
Pei, Zhonghua, Li, Xiaofeng, Longenecker, Kenton, von Geldern, Thomas W, Wiedeman, Paul E, Lubben, Thomas H, Zinker, Bradley A, Stewart, Kent, Ballaron, Stephen J, Stashko, Michael A, Mika, Amanda K, Beno, David W. A, Long, Michelle, Wells, Heidi, Kempf-Grote, Anita J, Madar, David J, McDermott, Todd S, Bhagavatula, Lakshmi, Fickes, Michael G, Pireh, Daisy, Solomon, Larry R, Lake, Marc R, Edalji, Rohinton, Fry, Elizabeth H, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (15.06.2006)
Published in Journal of medicinal chemistry (15.06.2006)
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Journal Article
Nonsteroidal Selective Glucocorticoid Modulators: The Effect of C-10 Substitution on Receptor Selectivity and Functional Potency of 5-Allyl-2,5-dihydro-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines
Kym, Philip R, Kort, Michael E, Coghlan, Michael J, Moore, Jimmie L, Tang, Rui, Ratajczyk, James D, Larson, Daniel P, Elmore, Steven W, Pratt, John K, Stashko, Michael A, Falls, H. Douglass, Lin, Chun W, Nakane, Masake, Miller, Loan, Tyree, Curtis M, Miner, Jeffery N, Jacobson, Peer B, Wilcox, Denise M, Nguyen, Phong, Lane, Benjamin C
Published in Journal of medicinal chemistry (13.03.2003)
Published in Journal of medicinal chemistry (13.03.2003)
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Journal Article
UNC2025, a Potent and Orally Bioavailable MER/FLT3 Dual Inhibitor
Zhang, Weihe, DeRyckere, Deborah, Hunter, Debra, Liu, Jing, Stashko, Michael A, Minson, Katherine A, Cummings, Christopher T, Lee, Minjung, Glaros, Trevor G, Newton, Dianne L, Sather, Susan, Zhang, Dehui, Kireev, Dmitri, Janzen, William P, Earp, H. Shelton, Graham, Douglas K, Frye, Stephen V, Wang, Xiaodong
Published in Journal of medicinal chemistry (28.08.2014)
Published in Journal of medicinal chemistry (28.08.2014)
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Journal Article
Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure–Activity Analysis
Gu, Chunfang, Stashko, Michael A, Puhl-Rubio, Ana C, Chakraborty, Molee, Chakraborty, Anutosh, Frye, Stephen V, Pearce, Kenneth H, Wang, Xiaodong, Shears, Stephen B, Wang, Huanchen
Published in Journal of medicinal chemistry (14.02.2019)
Published in Journal of medicinal chemistry (14.02.2019)
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Journal Article
Discovery of ((4R,5S)-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a Highly Potent, Selective, Orally Efficacious, and Safe Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
Pei, Zhonghua, Li, Xiaofeng, von Geldern, Thomas W, Madar, David J, Longenecker, Kenton, Yong, Hong, Lubben, Thomas H, Stewart, Kent D, Zinker, Bradley A, Backes, Bradley J, Judd, Andrew S, Mulhern, Mathew, Ballaron, Stephen J, Stashko, Michael A, Mika, Amanda K, Beno, David W. A, Reinhart, Glenn A, Fryer, Ryan M, Preusser, Lee C, Kempf-Grote, Anita J, Sham, Hing L, Trevillyan, James M
Published in Journal of medicinal chemistry (02.11.2006)
Published in Journal of medicinal chemistry (02.11.2006)
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Journal Article
Crystal Structures of DPP-IV (CD26) from Rat Kidney Exhibit Flexible Accommodation of Peptidase-Selective Inhibitors
Longenecker, Kenton L, Stewart, Kent D, Madar, David J, Jakob, Clarissa G, Fry, Elizabeth H, Wilk, Sherwin, Lin, Chun W, Ballaron, Stephen J, Stashko, Michael A, Lubben, Thomas H, Yong, Hong, Pireh, Daisy, Pei, Zhonghua, Basha, Fatima, Wiedeman, Paul E, von Geldern, Thomas W, Trevillyan, James M, Stoll, Vincent S
Published in Biochemistry (Easton) (20.06.2006)
Published in Biochemistry (Easton) (20.06.2006)
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Journal Article
MerTK activity is not necessary for the proliferation of glioblastoma stem cells
Hoque, Monira, Wai Wong, Siu, Recasens, Ariadna, Abbassi, Ramzi, Nguyen, Nghi, Zhang, Dehui, Stashko, Michael A., Wang, Xiaodong, Frye, Stephen, Day, Bryan W., Baell, Jonathan, Munoz, Lenka
Published in Biochemical pharmacology (01.04.2021)
Published in Biochemical pharmacology (01.04.2021)
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Journal Article
Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group
Zhao, Jichen, Zhang, Dehui, Zhang, Weihe, Stashko, Michael A, DeRyckere, Deborah, Vasileiadi, Eleana, Parker, Rebecca E, Hunter, Debra, Liu, Qingyang, Zhang, Yuewei, Norris-Drouin, Jacqueline, Li, Bing, Drewry, David H, Kireev, Dmitri, Graham, Douglas K, Earp, Henry Shelton, Frye, Stephen V, Wang, Xiaodong
Published in Journal of medicinal chemistry (21.11.2018)
Published in Journal of medicinal chemistry (21.11.2018)
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Journal Article
SETDB1 Triple Tudor Domain Ligand, (R,R)‑59, Promotes Methylation of Akt1 in Cells
Uguen, Mélanie, Deng, Yu, Li, Fengling, Shell, Devan J., Norris-Drouin, Jacqueline L., Stashko, Michael A., Ackloo, Suzanne, Arrowsmith, Cheryl H., James, Lindsey I., Liu, Pengda, Pearce, Kenneth H., Frye, Stephen V.
Published in ACS chemical biology (18.08.2023)
Published in ACS chemical biology (18.08.2023)
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Journal Article
Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach
Merten, Eric M, Sears, John D, Leisner, Tina M, Hardy, P Brian, Ghoshal, Anirban, Hossain, Mohammad Anwar, Asressu, Kesatebrhan Haile, Brown, Peter J, Tse, Edwin G, Stashko, Michael A, Li, Kelin, Norris-Drouin, Jacqueline L, Herring, Laura E, Mordant, Angie L, Webb, Thomas S, Mills, Christine A, Barker, Natalie K, Streblow, Zachary J, Perveen, Sumera, Arrowsmith, Cheryl H, Couñago, Rafael Miguez, Arnold, Jamie J, Cameron, Craig E, Streblow, Daniel N, Moorman, Nathaniel J, Heise, Mark T, Willson, Timothy M, Popov, Konstantin I, Pearce, Kenneth H
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2024)
Published in Proceedings of the National Academy of Sciences - PNAS (15.10.2024)
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