Synthesis and Structure−Activity Relationship of Acrylamides as KCNQ2 Potassium Channel Openers
Wu, Yong-Jin, He, Huan, Sun, Li-Qiang, L'Heureux, Alexandre, Chen, Jie, Dextraze, Pierre, Starrett, John E, Boissard, Christopher G, Gribkoff, Valentin K, Natale, Joanne, Dworetzky, Steven I
Published in Journal of medicinal chemistry (20.05.2004)
Published in Journal of medicinal chemistry (20.05.2004)
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Synthesis, Oral Bioavailability Determination, and in vitro Evaluation of Prodrugs of the Antiviral Agent 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA)
Starrett, John E. Jr, Tortolani, David R, Russell, John, Hitchcock, Michael J. M, Whiterock, Valerie, Martin, John C, Mansuri, Muzammil M
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Published in Journal of medicinal chemistry (01.06.1994)
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1-(2,3-DIDEOXY-BETA-D-GLYCERO-PENT-2-ENOFURANOSYL)THYMINE - A HIGHLY POTENT AND SELECTIVE ANTI-HIV AGENT
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Published in Journal of medicinal chemistry (01.02.1989)
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Serine 232 and Methionine 272 Define the Ligand Binding Pocket in Retinoic Acid Receptor Subtypes
Ostrowski, J, Roalsvig, T, Hammer, L, Marinier, A, Starrett, Jr, J E, Yu, K L, Reczek, P R
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Radiochemical synthesis and biodistribution of a novel maxi-K potassium channel opener
Kiesewetter, Dale O, Jagoda, Elaine M, Starrett, John E, Gribkoff, Valentin K, Hewawasam, Piyasena, Srinivas, Nugahally, Salazar, Daniel, Eckelman, William C
Published in Nuclear medicine and biology (2002)
Published in Nuclear medicine and biology (2002)
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Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels
Gribkoff, Valentin K, Starrett, John E, Dworetzky, Steven I, Hewawasam, Piyasena, Boissard, Christopher G, Cook, Deborah A, Frantz, Stephen W, Heman, Karen, Hibbard, Jeffrey R, Huston, Kevin, Johnson, Graham, Krishnan, Bala S, Kinney, Gene G, Lombardo, Lynn A, Meanwell, Nicholas A, Molinoff, Perry B, Myers, Robert A, Moon, Sandra L, Ortiz, Astrid, Pajor, Lorraine, Pieschl, Rick L, Post-Munson, Debra J, Signor, Laura J, Srinivas, Nugehally, Taber, Matthew T, Thalody, George, Trojnacki, Joanne T, Wiener, Harvey, Yeleswaram, Krishnaswamy, Yeola, Sarita W
Published in Nature medicine (01.04.2001)
Published in Nature medicine (01.04.2001)
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The synthesis and structure–activity relationships of 4-aryl-3-aminoquinolin-2-ones: a new class of calcium-Dependent, large conductance, potassium (maxi-K) channel openers targeted for post-stroke neuroprotection
Hewawasam, Piyasena, Fan, Wenhong, Knipe, Jay, Moon, Sandra L, Boissard, Christopher G, Gribkoff, Valentin K, Starrett, John E
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
Published in Bioorganic & medicinal chemistry letters (08.07.2002)
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The synthesis and characterization of BMS-204352 (MaxiPost) and related 3-fluorooxindoles as openers of maxi-K potassium channels
HEWAWASAM, Piyasena, GRIBKOFF, Valentin K, PAJOR, Lorraine M, KNIPE, Jay, QI GAO, PERRONE, Robert, STARRETT, John E, PENDRI, Yadagiri, DWORETZKY, Steven I, MEANWELL, Nicholas A, MARTINEZ, Eduardo, BOISSARD, Christopher G, POST-MUNSON, Debra J, TROJNACKI, Joanne T, YELESWARAM, Krishnaswamy
Published in Bioorganic & medicinal chemistry letters (08.04.2002)
Published in Bioorganic & medicinal chemistry letters (08.04.2002)
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4-Aryl-3-(hydroxyalkyl)quinolin-2-ones: Novel Maxi-K Channel Opening Relaxants of Corporal Smooth Muscle Targeted for Erectile Dysfunction
Hewawasam, Piyasena, Fan, Wenhong, Ding, Min, Flint, Kim, Cook, Deborah, Goggins, Gregory D, Myers, Robert A, Gribkoff, Valentin K, Boissard, Christopher G, Dworetzky, Steven I, Starrett, John E, Lodge, Nicholas J
Published in Journal of medicinal chemistry (03.07.2003)
Published in Journal of medicinal chemistry (03.07.2003)
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An Assessment of the Effects of Serotonin 6 (5-HT6) Receptor Antagonists in Rodent Models of Learning
Lindner, Mark D, Hodges, Jr, Donald B, Hogan, John B, Orie, Anitra F, Corsa, Jason A, Barten, Donna M, Polson, Craig, Robertson, Barbara J, Guss, Valerie L, Gillman, Kevin W, Starrett, Jr, John E, Gribkoff, Valentin K
Published in The Journal of pharmacology and experimental therapeutics (01.11.2003)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2003)
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(S)-N-[1-(3-Morpholin-4-ylphenyl)ethyl]-3phenylacrylamide: An orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine
Wu, YJ, Boissard, CG, Greco, C, Gribkoff, VK, Harden, DG, He, H, L'Heureux, A, Kang, SH, Kinney, GG, Knox, RJ, Natale, J, Newton, AE, Lehtinen-Oboma, S, Sinz, MW, Sivarao, DV, Starrett, JE, Sun, LQ, Tertyshnikova, S, Thompson, MW, Weaver, D, Wong, HS, Zhang, L, Dworetzky, SL
Published in Journal of medicinal chemistry (17.07.2003)
Published in Journal of medicinal chemistry (17.07.2003)
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RAR‐specific agonist/antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage‐independent cell proliferation
Chen, J.Y., Penco, S., Ostrowski, J., Balaguer, P., Pons, M., Starrett, J.E., Reczek, P., Chambon, P., Gronemeyer, H.
Published in The EMBO journal (15.03.1995)
Published in The EMBO journal (15.03.1995)
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3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction
BOY, Kenneth M, GUERNON, Jason M, STARRETT, John E, SIT, Sing-Yuen, XIE, Kai, HEWAWASAM, Piyasena, BOISSARD, Christopher G, DWORETZKY, Steven I, NATALE, Joanne, GRIBKOFF, Valentin K, LODGE, Nicholas
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
Published in Bioorganic & medicinal chemistry letters (18.10.2004)
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Effects of channel modulators on cloned large-conductance calcium-activated potassium channels
V K Gribkoff, J T Lum-Ragan, C G Boissard, D J Post-Munson, N A Meanwell, J E Starrett, Jr, E S Kozlowski, J L Romine, J T Trojnacki, M C Mckay, J Zhong, S I Dworetzky
Published in Molecular pharmacology (01.07.1996)
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Published in Molecular pharmacology (01.07.1996)
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Cognition-enhancing drugs increase stimulated hippocampal theta rhythm amplitude in the urethane-anesthetized rat
Kinney, G G, Patino, P, Mermet-Bouvier, Y, Starrett, Jr, J E, Gribkoff, V K
Published in The Journal of pharmacology and experimental therapeutics (01.10.1999)
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Published in The Journal of pharmacology and experimental therapeutics (01.10.1999)
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( S)- N-[1-(4-Cyclopropylmethyl-3,4-dihydro-2 H-benzo [1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons
Wu, Yong-Jin, Boissard, Christopher G, Chen, Jie, Fitzpatrick, William, Gao, Qi, Gribkoff, Valentin K, Harden, David G, He, Huan, Knox, Ronald J, Natale, Joanne, Pieschl, Rick L, Starrett, John E, Sun, Li-Qiang, Thompson, Mark, Weaver, David, Wu, Dedong, Dworetzky, Steven I
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
Published in Bioorganic & medicinal chemistry letters (19.04.2004)
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The synthesis and structure-activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: A new class of calcium-dependent, large conductance, potassium (maxi-K) channel opener targeted for urge urinary incontinence
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Published in Bioorganic & medicinal chemistry letters (08.04.2002)
Published in Bioorganic & medicinal chemistry letters (08.04.2002)
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