Adaptive response to inflammation contributes to sustained myelopoiesis and confers a competitive advantage in myelodysplastic syndrome HSCs
Muto, Tomoya, Walker, Callum S., Choi, Kwangmin, Hueneman, Kathleen, Smith, Molly A., Gul, Zartash, Garcia-Manero, Guillermo, Ma, Averil, Zheng, Yi, Starczynowski, Daniel T.
Published in Nature immunology (01.05.2020)
Published in Nature immunology (01.05.2020)
Get full text
Journal Article
U2AF1 mutations induce oncogenic IRAK4 isoforms and activate innate immune pathways in myeloid malignancies
Smith, Molly A., Choudhary, Gaurav S., Pellagatti, Andrea, Choi, Kwangmin, Bolanos, Lyndsey C., Bhagat, Tushar D., Gordon-Mitchell, Shanisha, Von Ahrens, Dagny, Pradhan, Kith, Steeples, Violetta, Kim, Sanghyun, Steidl, Ulrich, Walter, Matthew, Fraser, Iain D. C., Kulkarni, Aishwarya, Salomonis, Nathan, Komurov, Kakajan, Boultwood, Jacqueline, Verma, Amit, Starczynowski, Daniel T.
Published in Nature cell biology (01.05.2019)
Published in Nature cell biology (01.05.2019)
Get full text
Journal Article
Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia
Chlon, Timothy M., Stepanchick, Emily, Hershberger, Courtney E., Daniels, Noah J., Hueneman, Kathleen M., Kuenzi Davis, Ashley, Choi, Kwangmin, Zheng, Yi, Gurnari, Carmelo, Haferlach, Torsten, Padgett, Richard A., Maciejewski, Jaroslaw P., Starczynowski, Daniel T.
Published in Cell stem cell (04.11.2021)
Published in Cell stem cell (04.11.2021)
Get full text
Journal Article
Sequential CRISPR gene editing in human iPSCs charts the clonal evolution of myeloid leukemia and identifies early disease targets
Wang, Tiansu, Pine, Allison R., Kotini, Andriana G., Yuan, Han, Zamparo, Lee, Starczynowski, Daniel T., Leslie, Christina, Papapetrou, Eirini P.
Published in Cell stem cell (03.06.2021)
Published in Cell stem cell (03.06.2021)
Get full text
Journal Article
Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype
Kuchenbauer, Florian, Lam, Wan, Hogge, Donna, Humphries, R Keith, Marra, Marco, Morin, Ryan, Wells, Richard A, Buckstein, Rena, Hirst, Martin, Starczynowski, Daniel T, Sung, Sandy, Muranyi, Andrew, Karsan, Aly, Argiropoulos, Bob
Published in Nature medicine (01.01.2010)
Published in Nature medicine (01.01.2010)
Get full text
Journal Article
Targeting IRAK1 as a Therapeutic Approach for Myelodysplastic Syndrome
Rhyasen, Garrett W., Bolanos, Lyndsey, Fang, Jing, Jerez, Andres, Wunderlich, Mark, Rigolino, Carmela, Mathews, Lesley, Ferrer, Marc, Southall, Noel, Guha, Rajarshi, Keller, Jonathan, Thomas, Craig, Beverly, Levi J., Cortelezzi, Agostino, Oliva, Esther N., Cuzzola, Maria, Maciejewski, Jaroslaw P., Mulloy, James C., Starczynowski, Daniel T.
Published in Cancer cell (08.07.2013)
Published in Cancer cell (08.07.2013)
Get full text
Journal Article
Chemotherapy resistance in acute myeloid leukemia is mediated by A20 suppression of spontaneous necroptosis
Culver-Cochran, Ashley E., Hassan, Aishlin, Hueneman, Kathleen, Choi, Kwangmin, Ma, Averil, VanCauwenbergh, Brett, O’Brien, Eric, Wunderlich, Mark, Perentesis, John P., Starczynowski, Daniel T.
Published in Nature communications (24.10.2024)
Published in Nature communications (24.10.2024)
Get full text
Journal Article
A calcium- and calpain-dependent pathway determines the response to lenalidomide in myelodysplastic syndromes
Fang, Jing, Liu, Xiaona, Bolanos, Lyndsey, Barker, Brenden, Rigolino, Carmela, Cortelezzi, Agostino, Oliva, Esther N, Cuzzola, Maria, Grimes, H Leighton, Fontanillo, Celia, Komurov, Kakajan, MacBeth, Kyle, Starczynowski, Daniel T
Published in Nature medicine (01.07.2016)
Published in Nature medicine (01.07.2016)
Get full text
Journal Article
Loss of Tifab, a del(5q) MDS gene, alters hematopoiesis through derepression of Toll-like receptor-TRAF6 signaling
Varney, Melinda E, Niederkorn, Madeline, Konno, Hiroyasu, Matsumura, Takayuki, Gohda, Jin, Yoshida, Nobuaki, Akiyama, Taishin, Christie, Susanne, Fang, Jing, Miller, David, Jerez, Andres, Karsan, Aly, Maciejewski, Jaroslaw P, Meetei, Ruhikanta A, Inoue, Jun-ichiro, Starczynowski, Daniel T
Published in The Journal of experimental medicine (19.10.2015)
Published in The Journal of experimental medicine (19.10.2015)
Get full text
Journal Article
Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation
Muto, Tomoya, Walker, Callum S, Agarwal, Puneet, Vick, Eric, Sampson, Avery, Choi, Kwangmin, Niederkorn, Madeline, Ishikawa, Chiharu, Hueneman, Kathleen, Varney, Melinda, Starczynowski, Daniel T
Published in Haematologica (Roma) (01.10.2023)
Published in Haematologica (Roma) (01.10.2023)
Get full text
Journal Article
Mitochondrial Fragmentation Triggers Ineffective Hematopoiesis in Myelodysplastic Syndromes
Aoyagi, Yasushige, Hayashi, Yoshihiro, Harada, Yuka, Choi, Kwangmin, Matsunuma, Natsumi, Sadato, Daichi, Maemoto, Yuki, Ito, Akihiro, Yanagi, Shigeru, Starczynowski, Daniel T, Harada, Hironori
Published in Cancer discovery (01.01.2022)
Published in Cancer discovery (01.01.2022)
Get full text
Journal Article
Overcoming adaptive therapy resistance in AML by targeting immune response pathways
Melgar, Katelyn, Walker, Morgan M, Jones, LaQuita M, Bolanos, Lyndsey C, Hueneman, Kathleen, Wunderlich, Mark, Jiang, Jian-Kang, Wilson, Kelli M, Zhang, Xiaohu, Sutter, Patrick, Wang, Amy, Xu, Xin, Choi, Kwangmin, Tawa, Gregory, Lorimer, Donald, Abendroth, Jan, O'Brien, Eric, Hoyt, Scott B, Berman, Ellin, Famulare, Christopher A, Mulloy, James C, Levine, Ross L, Perentesis, John P, Thomas, Craig J, Starczynowski, Daniel T
Published in Science translational medicine (04.09.2019)
Published in Science translational medicine (04.09.2019)
Get more information
Journal Article
TNF-α-induced alterations in stromal progenitors enhance leukemic stem cell growth via CXCR2 signaling
Agarwal, Puneet, Li, Hui, Choi, Kwangmin, Hueneman, Kathleen, He, Jianbo, Welner, Robert S., Starczynowski, Daniel T., Bhatia, Ravi
Published in Cell reports (Cambridge) (13.07.2021)
Published in Cell reports (Cambridge) (13.07.2021)
Get full text
Journal Article
TIFAB Regulates USP15-Mediated p53 Signaling during Stressed and Malignant Hematopoiesis
Niederkorn, Madeline, Hueneman, Kathleen, Choi, Kwangmin, Varney, Melinda E., Romano, Laurel, Pujato, Mario A., Greis, Kenneth D., Inoue, Jun-ichiro, Meetei, Ruhikanta, Starczynowski, Daniel T.
Published in Cell reports (Cambridge) (25.02.2020)
Published in Cell reports (Cambridge) (25.02.2020)
Get full text
Journal Article
TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis
Fang, Jing, Muto, Tomoya, Kleppe, Maria, Bolanos, Lyndsey C., Hueneman, Kathleen M., Walker, Callum S., Sampson, Leesa, Wellendorf, Ashley M., Chetal, Kashish, Choi, Kwangmin, Salomonis, Nathan, Choi, Yongwon, Zheng, Yi, Cancelas, Jose A., Levine, Ross L., Starczynowski, Daniel T.
Published in Cell reports (Cambridge) (30.01.2018)
Published in Cell reports (Cambridge) (30.01.2018)
Get full text
Journal Article
ASXL1 mutations are associated with a response to alvocidib and 5-azacytidine combination in myelodysplastic neoplasms
Riabov, Vladimir, Xu, Qingyu, Schmitt, Nanni, Streuer, Alexander, Ge, Guo, Bolanos, Lyndsey, Wunderlich, Mark, Jann, Johann-Christoph, Wein, Alina, Altrock, Eva, Demmerle, Marie, Mukherjee, Sanjay, Ali, Abdullah Mahmood, Rapp, Felicitas, Nowak, Verena, Weimer, Nadine, Obländer, Julia, Palme, Iris, Göl, Melda, Jawhar, Ahmed, Darwich, Ali, Wuchter, Patrick, Weiss, Christel, Raza, Azra, Foulks, Jason M, Starczynowski, Daniel T, Yang, Feng-Chun, Metzgeroth, Georgia, Steiner, Laurenz, Jawhar, Mohamad, Hofmann, Wolf-Karsten, Nowak, Daniel
Published in Haematologica (Roma) (01.05.2024)
Published in Haematologica (Roma) (01.05.2024)
Get full text
Journal Article
Cytotoxic effects of bortezomib in myelodysplastic syndrome/acute myeloid leukemia depend on autophagy-mediated lysosomal degradation of TRAF6 and repression of PSMA1
Fang, Jing, Rhyasen, Garrett, Bolanos, Lyndsey, Rasch, Christopher, Varney, Melinda, Wunderlich, Mark, Goyama, Susumu, Jansen, Gerrit, Cloos, Jacqueline, Rigolino, Carmela, Cortelezzi, Agostino, Mulloy, James C., Oliva, Esther N., Cuzzola, Maria, Starczynowski, Daniel T.
Published in Blood (26.07.2012)
Published in Blood (26.07.2012)
Get full text
Journal Article