Maraviroc (UK-427,857), a Potent, Orally Bioavailable, and Selective Small-Molecule Inhibitor of Chemokine Receptor CCR5 with Broad-Spectrum Anti-Human Immunodeficiency Virus Type 1 Activity
DORR, Patrick, WESTBY, Mike, WEBSTER, Rob, ARMOUR, Duncan, PRICE, David, STAMMEN, Blanda, WOOD, Anthony, PERROS, Manos, DOBBS, Susan, GRIFFIN, Paul, IRVINE, Becky, MACARTNEY, Malcolm, MORI, Julie, RICKETT, Graham, SMITH-BURCHNELL, Caroline, NAPIER, Carolyn
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Small Molecules Targeting Hepatitis C Virus-Encoded NS5A Cause Subcellular Redistribution of Their Target: Insights into Compound Modes of Action
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Published in Journal of Virology (01.07.2011)
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Overcoming HERG affinity in the discovery of the CCR5 antagonist maraviroc
Price, David A., Armour, Duncan, de Groot, Marcel, Leishman, Derek, Napier, Carolyn, Perros, Manos, Stammen, Blanda L., Wood, Anthony
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
Published in Bioorganic & medicinal chemistry letters (01.09.2006)
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Overcoming hERG affinity in the discovery of maraviroc; a CCR5 antagonist for the treatment of HIV
Price, David A, Armour, Duncan, de Groot, Marcel, Leishman, Derek, Napier, Carolyn, Perros, Manos, Stammen, Blanda L, Wood, Anthony
Published in Current topics in medicinal chemistry (01.09.2008)
Published in Current topics in medicinal chemistry (01.09.2008)
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Discovery and Optimization of Selective Nav1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain
Bagal, Sharan K., Bungay, Peter J., Denton, Stephen M., Gibson, Karl R., Glossop, Melanie S., Hay, Tanya L., Kemp, Mark I., Lane, Charlotte A. L., Lewis, Mark L., Maw, Graham N., Million, William A., Payne, C. Elizabeth, Poinsard, Cedric, Rawson, David J., Stammen, Blanda L., Stevens, Edward B., Thompson, Lisa R.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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2,4-Diaminopyridine delta-opioid receptor agonists and their associated hERG pharmacology
Owen, Dafydd R, Rodriguez-Lens, Margarita, Corless, Martin D, Gaulier, Steven M, Horne, Valerie A, Kinloch, Ross A, Maw, Graham N, Pearce, David W, Rees, Huw, Ringer, Tracy J, Ryckmans, Thomas, Stammen, Blanda L C
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Published in Bioorganic & medicinal chemistry letters (15.03.2009)
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The design and discovery of novel amide CCR5 antagonists
Pryde, David C., Corless, Martin, Fenwick, David R., Mason, Helen J., Stammen, Blanda C., Stephenson, Peter T., Ellis, David, Bachelor, David, Gordon, David, Barber, Christopher G., Wood, Anthony, Middleton, Donald S., Blakemore, David C., Parsons, Gemma C., Eastwood, Rachel, Platts, Michelle Y., Statham, Keith, Paradowski, Kerry A., Burt, Catherine, Klute, Wolfgang
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
Published in Bioorganic & medicinal chemistry letters (15.02.2009)
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The Discovery of Tropane-derived CCR5 Receptor Antagonists
Armour, Duncan R., De Groot, Marcel J., Price, David A., Stammen, Blanda L. C., Wood, Anthony, Perros, Manos, Burt, Catherine
Published in Chemical biology & drug design (01.04.2006)
Published in Chemical biology & drug design (01.04.2006)
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Preparation of cyclic ethers for polyether synthesis by catalytic ring-closing enyne metathesis of alkynyl ethers
Stephen Clark, J, Elustondo, Frédéric, Trevitt, Graham P, Boyall, Dean, Robertson, Jerod, Blake, Alexander J, Wilson, Claire, Stammen, Blanda
Published in Tetrahedron (04.03.2002)
Published in Tetrahedron (04.03.2002)
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Discovery and Optimization of Selective Na(v)1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain
Bagal, Sharan K., Bungay, Peter J., Denton, Stephen M., Gibson, Karl R., Glossop, Melanie S., Hay, Tanya L., Kemp, Mark I., Lane, Charlotte A. L., Lewis, Mark L., Maw, Graham N., Million, William A., Payne, C. Elizabeth, Poinsard, Cedric, Rawson, David J., Stammen, Blanda L., Stevens, Edward B., Thompson, Lisa R.
Published in ACS medicinal chemistry letters (01.06.2015)
Published in ACS medicinal chemistry letters (01.06.2015)
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Initial synthesis of UK-427,857 (Maraviroc)
Price, David A., Gayton, Simon, Selby, Matthew D., Ahman, Jens, Haycock-Lewandowski, Sarah, Stammen, Blanda L., Warren, Andrew
Published in Tetrahedron letters (25.07.2005)
Published in Tetrahedron letters (25.07.2005)
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Discovery and Optimization of Selective Na v 1.8 Modulator Series That Demonstrate Efficacy in Preclinical Models of Pain
Bagal, Sharan K., Bungay, Peter J., Denton, Stephen M., Gibson, Karl R., Glossop, Melanie S., Hay, Tanya L., Kemp, Mark I., Lane, Charlotte A. L., Lewis, Mark L., Maw, Graham N., Million, William A., Payne, C. Elizabeth, Poinsard, Cedric, Rawson, David J., Stammen, Blanda L., Stevens, Edward B., Thompson, Lisa R.
Published in ACS medicinal chemistry letters (11.06.2015)
Published in ACS medicinal chemistry letters (11.06.2015)
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2,4-Diaminopyridine 6-opioid receptor agonists and their associated hERG pharmacology
OWEN, Dafydd R, RODRIGUEZ-LENS, Margarita, RYCKMANS, Thomas, STAMMEN, Blanda L. C, CORLESS, Martin D, GAULIER, Steven M, HOME, Valerie A, KINLOCH, Ross A, MAW, Graham N, PEARCE, David W, REES, Huw, RINGER, Tracy J
Published in Bioorganic & medicinal chemistry letters (2009)
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Published in Bioorganic & medicinal chemistry letters (2009)
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AZABICYCLOALKANES AS CCR5 MODULATORS
Price, David Anthony, Wood, Anthony, Edwards, Martin Paul, Armour, Duncan Robert, Perros, Manoussos, Stammen, Blanda Luzia Christa
Year of Publication 26.01.2018
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Year of Publication 26.01.2018
Patent
AZABICYCLOALKANES AS CCR5 MODULATORS
Price, David Anthony, Wood, Anthony, Edwards, Martin Paul, Armour, Duncan Robert, Perros, Manoussos, Stammen, Blanda Luzia Christa
Year of Publication 03.11.2017
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Year of Publication 03.11.2017
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