Renal Organic Anion Transporters 1 and 3 In Vitro: Gone but Not Forgotten
Caetano-Pinto, Pedro, Stahl, Simone H.
Published in International journal of molecular sciences (01.10.2023)
Published in International journal of molecular sciences (01.10.2023)
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Multiple compound-related adverse properties contribute to liver injury caused by endothelin receptor antagonists
Kenna, J Gerry, Stahl, Simone H, Eakins, Julie A, Foster, Alison J, Andersson, Linda C, Bergare, Jonas, Billger, Martin, Elebring, Marie, Elmore, Charles S, Thompson, Richard A
Published in The Journal of pharmacology and experimental therapeutics (01.02.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.02.2015)
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Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging
Barber, Jane A, Stahl, Simone H, Summers, Claire, Barrett, Gillian, Park, B Kevin, Foster, John R, Kenna, J Gerald
Published in Toxicological sciences (01.11.2015)
Published in Toxicological sciences (01.11.2015)
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Challenges and Opportunities for Improved Drug-Drug Interaction Predictions for Renal OCT2 and MATE1/2-K Transporters
Krishnan, Srinivasan, Ramsden, Diane, Ferguson, Douglas, Stahl, Simone H, Wang, Joanne, McGinnity, Dermot F, Hariparsad, Niresh
Published in Clinical pharmacology and therapeutics (01.09.2022)
Published in Clinical pharmacology and therapeutics (01.09.2022)
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Regulation of Drug Transport Proteins—From Mechanisms to Clinical Impact: A White Paper on Behalf of the International Transporter Consortium
Brouwer, Kim L.R., Evers, Raymond, Hayden, Elizabeth, Hu, Shuiying, Li, Cindy Yanfei, Meyer zu Schwabedissen, Henriette E., Neuhoff, Sibylle, Oswald, Stefan, Piquette‐Miller, Micheline, Saran, Chitra, Sjöstedt, Noora, Sprowl, Jason A., Stahl, Simone H., Yue, Wei
Published in Clinical pharmacology and therapeutics (01.09.2022)
Published in Clinical pharmacology and therapeutics (01.09.2022)
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Journal Article
Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity
Zou, Ling, Stecula, Adrian, Gupta, Anshul, Prasad, Bhagwat, Chien, Huan-Chieh, Yee, Sook Wah, Wang, Li, Unadkat, Jashvant D, Stahl, Simone H, Fenner, Katherine S, Giacomini, Kathleen M
Published in Molecular pharmacology (01.07.2018)
Published in Molecular pharmacology (01.07.2018)
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Utilization of OATP1B Biomarker Coproporphyrin-I to Guide Drug-Drug Interaction Risk Assessment: Evaluation by the Pharmaceutical Industry
Kikuchi, Ryota, Chothe, Paresh P, Chu, Xiaoyan, Huth, Felix, Ishida, Kazuya, Ishiguro, Naoki, Jiang, Rongrong, Shen, Hong, Stahl, Simone H, Varma, Manthena V S, Willemin, Marie-Emilie, Morse, Bridget L
Published in Clinical pharmacology and therapeutics (01.12.2023)
Published in Clinical pharmacology and therapeutics (01.12.2023)
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A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery
Sjögren, Anna-Karin, Breitholtz, Katarina, Ahlberg, Ernst, Milton, Lucas, Forsgard, Malin, Persson, Mikael, Stahl, Simone H., Wilmer, Martijn J., Hornberg, Jorrit J.
Published in Archives of toxicology (01.10.2018)
Published in Archives of toxicology (01.10.2018)
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Journal Article
Amplifying the Impact of Kidney Microphysiological Systems: Predicting Renal Clearance Using Mechanistic Modelling Based on Reconstructed Drug Secretion
Caetano-Pinto, Pedro, Nordell, Par, Nieskens, Tom, Haughan, Katie, Fenner, Katherine S, Stahl, Simone H
Published in ALTEX, alternatives to animal experimentation (22.06.2023)
Published in ALTEX, alternatives to animal experimentation (22.06.2023)
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Journal Article
Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity
Battista, Christina, Yang, Kyunghee, Stahl, Simone H, Mettetal, Jerome T, Watkins, Paul B, Siler, Scott Q, Howell, Brett A
Published in Toxicological sciences (01.11.2018)
Published in Toxicological sciences (01.11.2018)
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A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity
Sison-Young, Rowena L., Lauschke, Volker M., Johann, Esther, Alexandre, Eliane, Antherieu, Sébastien, Aerts, Hélène, Gerets, Helga H. J., Labbe, Gilles, Hoët, Delphine, Dorau, Martina, Schofield, Christopher A., Lovatt, Cerys A., Holder, Julie C., Stahl, Simone H., Richert, Lysiane, Kitteringham, Neil R., Jones, Robert P., Elmasry, Mohamed, Weaver, Richard J., Hewitt, Philip G., Ingelman-Sundberg, Magnus, Goldring, Chris E., Park, B. Kevin
Published in Archives of toxicology (01.03.2017)
Published in Archives of toxicology (01.03.2017)
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Leveraging microphysiological systems to address challenges encountered during development of oligonucleotide therapeutics
Ramsden, Diane, Belair, David G, Agarwal, Saket, Andersson, Patrik, Humphreys, Sara, Dalmas, Deidre A, Stahl, Simone H, Maclauchlin, Chris, Cichocki, Joseph A
Published in ALTEX, alternatives to animal experimentation (2022)
Published in ALTEX, alternatives to animal experimentation (2022)
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The analysis of acetaminophen (paracetamol) and seven metabolites in rat, pig and human plasma by U(H)PLC–MS
Dargue, Rebecca, Grant, Isobelle, Nye, Leanne C, Nicholls, Andy, Dare, Theo, Stahl, Simone H, Plumb, Robert S, Lee, Karla, Jalan, Rajiv, Coen, Muireann, Wilson, Ian D
Published in Bioanalysis (01.04.2020)
Published in Bioanalysis (01.04.2020)
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Journal Article
Molecular Mechanisms for Species Differences in Organic Anion Transporter 1, OAT1: Implications for Renal Drug Toxicity
Zou, Ling, Stecula, Adrian, Gupta, Anshul, Prasad, Bhagwat, Chien, Huan-Chieh, Yee, Sook Wah, Wang, Li, Unadkat, Jashvant D., Stahl, Simone H., Fenner, Katherine S., Giacomini, Kathleen M.
Published in Molecular pharmacology (01.07.2018)
Published in Molecular pharmacology (01.07.2018)
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Journal Article
Systems toxicology: modelling biomarkers of glutathione homeostasis and paracetamol metabolism
Stahl, Simone H., Yates, James W., Nicholls, Andrew W., Kenna, J. Gerry, Coen, Muireann, Ortega, Fernando, Nicholson, Jeremy K., Wilson, Ian D.
Published in Drug discovery today. Technologies (01.08.2015)
Published in Drug discovery today. Technologies (01.08.2015)
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Journal Article
Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity
Battista, Christina, Yang, Kyunghee, Stahl, Simone H., Mettetal, Jerome T., Watkins, Paul B., Siler, Scott Q., Howell, Brett A.
Published in Toxicological sciences (30.07.2018)
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Published in Toxicological sciences (30.07.2018)
Journal Article
Epidermal growth factor receptor mediates the basolateral uptake of phosphorothioate-modified antisense oligonucleotides in the kidney
Caetano-Pinto, Pedro, Haughan, Katie, Kragl, Angelique, Tzvetkov, Mladen V., Fenner, Katherine S., Stahl, Simone H.
Published in Organs-on-a-chip (01.12.2022)
Published in Organs-on-a-chip (01.12.2022)
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