Helminth Cysteine Proteases Inhibit TRIF-dependent Activation of Macrophages via Degradation of TLR3
Donnelly, Sheila, O’Neill, Sandra M., Stack, Colin M., Robinson, Mark W., Turnbull, Lynne, Whitchurch, Cynthia, Dalton, John P.
Published in The Journal of biological chemistry (29.01.2010)
Published in The Journal of biological chemistry (29.01.2010)
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Journal Article
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidase
McGowan, Sheena, Porter, Corrine J, Lowther, Jonathan, Stack, Colin M, Golding, Sarah J, Skinner-Adams, Tina S, Trenholme, Katharine R, Teuscher, Franka, Donnelly, Sheila M, Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, DeGori, Ross, Buckle, Ashley M, Gardiner, Donald L, Whisstock, James C, Dalton, John P
Published in Proceedings of the National Academy of Sciences - PNAS (24.02.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (24.02.2009)
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Journal Article
Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases
McGowan, Sheena, Oellig, Christine A, Birru, Woldeamanuel A, Caradoc-Davies, Tom T, Stack, Colin M, Lowther, Jonathan, Skinner-Adams, Tina, Mucha, Artur, Kafarski, Pawel, Grembecka, Jolanta, Trenholme, Katharine R, Buckle, Ashley M, Gardiner, Donald L, Dalton, John P, Whisstock, James C
Published in Proceedings of the National Academy of Sciences - PNAS (09.02.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (09.02.2010)
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Journal Article
Structural and Functional Relationships in the Virulence-associated Cathepsin L Proteases of the Parasitic Liver Fluke, Fasciola hepatica
Stack, Colin M., Caffrey, Conor R., Donnelly, Sheila M., Seshaadri, Amritha, Lowther, Jonathan, Tort, Jose F., Collins, Peter R., Robinson, Mark W., Xu, Weibo, McKerrow, James H., Craik, Charles S., Geiger, Sebastian R., Marion, Rachel, Brinen, Linda S., Dalton, John P.
Published in The Journal of biological chemistry (11.04.2008)
Published in The Journal of biological chemistry (11.04.2008)
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Journal Article
Identification of Phosphinate Dipeptide Analog Inhibitors Directed against the Plasmodium falciparum M17 Leucine Aminopeptidase as Lead Antimalarial Compounds
Skinner-Adams, Tina S, Lowther, Jonathan, Teuscher, Franka, Stack, Colin M, Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, Trenholme, Katharine R, Dalton, John P, Gardiner, Donald L
Published in Journal of medicinal chemistry (29.11.2007)
Published in Journal of medicinal chemistry (29.11.2007)
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Journal Article
The in vitro effects of interferon-gamma, alone or in combination with amphotericin B, tested against the pathogenic fungi Candida albicans and Aspergillus fumigatus
El-Khoury, Moufid, Ligot, Rogine, Mahoney, Simon, Stack, Colin M, Perrone, Gabriel G, Morton, C Oliver
Published in BMC research notes (01.08.2017)
Published in BMC research notes (01.08.2017)
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Journal Article
The importance of pH in regulating the function of the Fasciola hepatica cathepsin L1 cysteine protease
Lowther, Jonathan, Robinson, Mark W, Donnelly, Sheila M, Xu, Weibo, Stack, Colin M, Matthews, Jacqueline M, Dalton, John P
Published in PLoS neglected tropical diseases (01.01.2009)
Published in PLoS neglected tropical diseases (01.01.2009)
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Journal Article
The polyene antifungals, amphotericin B and nystatin, cause cell death in Saccharomyces cerevisiae by a distinct mechanism to amphibian-derived antimicrobial peptides
Serhan, George, Stack, Colin M, Perrone, Gabriel G, Morton, Charles Oliver
Published in Annals of clinical microbiology and antimicrobials (12.05.2014)
Published in Annals of clinical microbiology and antimicrobials (12.05.2014)
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Journal Article
The M18 Aspartyl Aminopeptidase of the Human Malaria Parasite Plasmodium falciparum
Teuscher, Franka, Lowther, Jonathan, Skinner-Adams, Tina S., Spielmann, Tobias, Dixon, Matthew W.A., Stack, Colin M., Donnelly, Sheila, Mucha, Artur, Kafarski, Paweł, Vassiliou, Stamatia, Gardiner, Donald L., Dalton, John P., Trenholme, Katharine R.
Published in The Journal of biological chemistry (19.10.2007)
Published in The Journal of biological chemistry (19.10.2007)
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Journal Article
Comparative analysis of Tritrichomonas foetus (Riedmüller, 1928) cat genotype, T. foetus (Riedmüller, 1928) cattle genotype and Tritrichomonas suis (Davaine, 1875) at 10 DNA loci
Šlapeta, Jan, Müller, Norbert, Stack, Colin M., Walker, Giselle, Lew-Tabor, Ala, Tachezy, Jan, Frey, Caroline F.
Published in International journal for parasitology (01.12.2012)
Published in International journal for parasitology (01.12.2012)
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Journal Article
Plasmodium falciparum neutral aminopeptidases: new targets for anti-malarials
Skinner-Adams, Tina S., Stack, Colin M., Trenholme, Katharine R., Brown, Chris L., Grembecka, Jolanta, Lowther, Jonathan, Mucha, Artur, Drag, Marcin, Kafarski, Pawel, McGowan, Sheena, Whisstock, James C., Gardiner, Donald L., Dalton, John P.
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (2010)
Published in Trends in biochemical sciences (Amsterdam. Regular ed.) (2010)
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Journal Article
Proteomics and phylogenetic analysis of the cathepsin L protease family of the helminth pathogen Fasciola hepatica: expansion of a repertoire of virulence-associated factors
Robinson, Mark W, Tort, Jose F, Lowther, Jonathan, Donnelly, Sheila M, Wong, Emily, Xu, Weibo, Stack, Colin M, Padula, Matthew, Herbert, Ben, Dalton, John P
Published in Molecular & cellular proteomics (01.06.2008)
Published in Molecular & cellular proteomics (01.06.2008)
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Journal Article
Comparative proteomic analysis of two pathogenic Tritrichomonas foetus genotypes: there is more to the proteome than meets the eye
Stroud, Leah J., Šlapeta, Jan, Padula, Matthew P., Druery, Dylan, Tsiotsioras, George, Coorssen, Jens R., Stack, Colin M.
Published in International journal for parasitology (01.03.2017)
Published in International journal for parasitology (01.03.2017)
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Journal Article
Proteomics and Phylogenetic Analysis of the Cathepsin L Protease Family of the Helminth Pathogen Fasciola hepatica
Robinson, Mark W., Tort, Jose F., Lowther, Jonathan, Donnelly, Sheila M., Wong, Emily, Xu, Weibo, Stack, Colin M., Padula, Matthew, Herbert, Ben, Dalton, John P.
Published in Molecular & cellular proteomics (01.06.2008)
Published in Molecular & cellular proteomics (01.06.2008)
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Journal Article
Characterization of the Plasmodium falciparum M17 Leucyl Aminopeptidase: A PROTEASE INVOLVED IN AMINO ACID REGULATION WITH POTENTIAL FOR ANTIMALARIAL DRUG DEVELOPMENT
Stack, Colin M, Lowther, Jonathan, Cunningham, Eithne, Donnelly, Sheila, Gardiner, Donald L, Trenholme, Katharine R, Skinner-Adams, Tina S, Teuscher, Franka, Grembecka, Jolanta, Mucha, Artur, Kafarski, Pawel, Lua, Linda, Bell, Angus, Dalton, John P
Published in The Journal of biological chemistry (19.01.2007)
Published in The Journal of biological chemistry (19.01.2007)
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Journal Article
A Plasmodium falciparum S33 proline aminopeptidase is associated with changes in erythrocyte deformability
da Silva, Fabio L., Dixon, Matthew W.A., Stack, Colin M., Teuscher, Franka, Taran, Elena, Jones, Malcolm K., Lovas, Erica, Tilley, Leann, Brown, Christopher L., Trenholme, Katharine R., Dalton, John P., Gardiner, Donald L., Skinner-Adams, Tina S.
Published in Experimental parasitology (01.10.2016)
Published in Experimental parasitology (01.10.2016)
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Journal Article
The M17 Leucine Aminopeptidase of the Malaria Parasite Plasmodium falciparum: Importance of Active Site Metal Ions in the Binding of Substrates and Inhibitors
Maric, Selma, Donnelly, Sheila M, Robinson, Mark W, Skinner-Adams, Tina, Trenholme, Katharine R, Gardiner, Donald L, Dalton, John P, Stack, Colin M, Lowther, Jonathan
Published in Biochemistry (Easton) (16.06.2009)
Published in Biochemistry (Easton) (16.06.2009)
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