Acyl glucuronide reactivity in perspective
Bradshaw, Peter R., Athersuch, Toby J., Stachulski, Andrew V., Wilson, Ian D.
Published in Drug discovery today (01.09.2020)
Published in Drug discovery today (01.09.2020)
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Synthesis of MeBmt and related derivatives via syn-selective ATH-DKR
Rolt, Adam, O'Neill, Paul M, Liang, T Jake, Stachulski, Andrew V
Published in RSC advances (08.12.2019)
Published in RSC advances (08.12.2019)
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Systemic efficacy on Cryptosporidium parvum infection of aminoxanide (RM-5061), a new amino-acid ester thiazolide prodrug of tizoxanide
Diawara, El Hadji, François, Arnaud, Stachulski, Andrew V, Razakandrainibe, Romy, Costa, Damien, Favennec, Loïc, Rossignol, Jean-François, Gargala, Gilles
Published in Parasitology (01.07.2021)
Published in Parasitology (01.07.2021)
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Discovery and Optimization of a 4‑Aminopiperidine Scaffold for Inhibition of Hepatitis C Virus Assembly
Rolt, Adam, Talley, Daniel C, Park, Seung Bum, Hu, Zongyi, Dulcey, Andrés, Ma, Christopher, Irvin, Parker, Leek, Madeleine, Wang, Amy Q, Stachulski, Andrew V, Xu, Xin, Southall, Noel, Ferrer, Marc, Liang, T. Jake, Marugan, Juan J
Published in Journal of medicinal chemistry (08.07.2021)
Published in Journal of medicinal chemistry (08.07.2021)
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Therapeutic Potential of Nitazoxanide: An Appropriate Choice for Repurposing versus SARS-CoV-2?
Stachulski, Andrew V, Taujanskas, Joshua, Pate, Sophie L, Rajoli, Rajith K. R, Aljayyoussi, Ghaith, Pennington, Shaun H, Ward, Stephen A, Hong, Weiqian David, Biagini, Giancarlo A, Owen, Andrew, Nixon, Gemma L, Leung, Suet C, O’Neill, Paul M
Published in ACS infectious diseases (11.06.2021)
Published in ACS infectious diseases (11.06.2021)
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Transacylation and hydrolysis of the acyl glucuronides of ibuprofen and its α-methyl-substituted analogues investigated by 1H NMR spectroscopy and computational chemistry: Implications for drug design
Richards, Selena E., Bradshaw, Peter R., Johnson, Caroline H., Stachulski, Andrew V., Athersuch, Toby J., Nicholson, Jeremy K., Lindon, John C., Wilson, Ian D.
Published in Journal of pharmaceutical and biomedical analysis (15.08.2024)
Published in Journal of pharmaceutical and biomedical analysis (15.08.2024)
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Journal Article
Transacylation and hydrolysis of the acyl glucuronides of ibuprofen and its α-methyl-substituted analogues investigated by 1 H NMR spectroscopy and computational chemistry: Implications for drug design
Richards, Selena E, Bradshaw, Peter R, Johnson, Caroline H, Stachulski, Andrew V, Athersuch, Toby J, Nicholson, Jeremy K, Lindon, John C, Wilson, Ian D
Published in Journal of pharmaceutical and biomedical analysis (15.08.2024)
Published in Journal of pharmaceutical and biomedical analysis (15.08.2024)
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Convenient syntheses of trans-resveratrol 3-O and 4′-O-β-d-glucuronides and a study of their aqueous stability
Fraser, Megan K., Gorecka, Aleksandra, Yates, Edwin A., Iggo, Jonathan A., Baj, Krzysztof, Stachulski, Andrew V.
Published in ORGANIC CHEMISTRY FRONTIERS (14.05.2024)
Published in ORGANIC CHEMISTRY FRONTIERS (14.05.2024)
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Synthesis, antiviral activity, preliminary pharmacokinetics and structural parameters of thiazolide amine salts
Stachulski, Andrew V, Rossignol, Jean-Francois, Pate, Sophie, Taujanskas, Joshua, Robertson, Craig M, Aerts, Rudi, Pascal, Etienne, Piacentini, Sara, Frazia, Simone La, Santoro, M Gabriella, O'Neill, Paul M
Published in Future medicinal chemistry (01.10.2021)
Published in Future medicinal chemistry (01.10.2021)
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Journal Article
Synthesis and toxicity profile in 293 human embryonic kidney cells of the β D-glucuronide derivatives of ortho-, meta- and para-cresol
London, James A., Wang, Emily C.S., Barsukov, Igor L., Yates, Edwin A., Stachulski, Andrew V.
Published in Carbohydrate research (01.01.2021)
Published in Carbohydrate research (01.01.2021)
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Journal Article
Kinetic modelling of acyl glucuronide and glucoside reactivity and development of structure-property relationships
Bradshaw, Peter R, Richards, Selena E, Wilson, Ian D, Stachulski, Andrew V, Lindon, John C, Athersuch, Toby J
Published in Organic & biomolecular chemistry (19.02.2020)
Published in Organic & biomolecular chemistry (19.02.2020)
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Journal Article
Synthesis and pre-clinical studies of new amino-acid ester thiazolide prodrugs
Stachulski, Andrew V., Swift, Karl, Cooper, Mark, Reynolds, Stephen, Norton, Daniel, Slonecker, Steven D., Rossignol, Jean-François
Published in European journal of medicinal chemistry (27.01.2017)
Published in European journal of medicinal chemistry (27.01.2017)
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Direct evidence for the formation of diastereoisomeric benzylpenicilloyl haptens from benzylpenicillin and benzylpenicillenic acid in patients
Meng, Xiaoli, Jenkins, Rosalind E, Berry, Neil G, Maggs, James L, Farrell, John, Lane, Catherine S, Stachulski, Andrew V, French, Neil S, Naisbitt, Dean J, Pirmohamed, Munir, Park, B Kevin
Published in The Journal of pharmacology and experimental therapeutics (01.09.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2011)
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Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients
Hammond, Thomas G, Meng, Xiaoli, Jenkins, Rosalind E, Maggs, James L, Castelazo, Anahi Santoyo, Regan, Sophie L, Bennett, Stuart N L, Earnshaw, Caroline J, Aithal, Guruprasad P, Pande, Ira, Kenna, J Gerry, Stachulski, Andrew V, Park, B Kevin, Williams, Dominic P
Published in The Journal of pharmacology and experimental therapeutics (01.08.2014)
Published in The Journal of pharmacology and experimental therapeutics (01.08.2014)
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Journal Article
The Generation, Detection, and Effects of Reactive Drug Metabolites
Stachulski, Andrew V., Baillie, Thomas A., Kevin Park, B., Scott Obach, R., Dalvie, Deepak K., Williams, Dominic P., Srivastava, Abhishek, Regan, Sophie L., Antoine, Daniel J., Goldring, Christopher E. P., Chia, Alvin J. L., Kitteringham, Neil R., Randle, Laura E., Callan, Hayley, Castrejon, J. Luis, Farrell, John, Naisbitt, Dean J., Lennard, Martin S.
Published in Medicinal research reviews (01.09.2013)
Published in Medicinal research reviews (01.09.2013)
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Journal Article
Thiazolides as Novel Antiviral Agents. 1. Inhibition of Hepatitis B Virus Replication
Stachulski, Andrew V, Pidathala, Chandrakala, Row, Eleanor C, Sharma, Raman, Berry, Neil G, Iqbal, Mazhar, Bentley, Joanne, Allman, Sarah A, Edwards, Geoffrey, Helm, Alison, Hellier, Jennifer, Korba, Brent E, Semple, J. Edward, Rossignol, Jean-Francois
Published in Journal of medicinal chemistry (23.06.2011)
Published in Journal of medicinal chemistry (23.06.2011)
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