A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing
Zhang, Wen-Wei, Karmakar, Subir, Gannavaram, Sreenivas, Dey, Ranadhir, Lypaczewski, Patrick, Ismail, Nevien, Siddiqui, Abid, Simonyan, Vahan, Oliveira, Fabiano, Coutinho-Abreu, Iliano V., DeSouza-Vieira, Thiago, Meneses, Claudio, Oristian, James, Serafim, Tiago D., Musa, Abu, Nakamura, Risa, Saljoughian, Noushin, Volpedo, Greta, Satoskar, Monika, Satoskar, Sanika, Dagur, Pradeep K., McCoy, J. Philip, Kamhawi, Shaden, Valenzuela, Jesus G., Hamano, Shinjiro, Satoskar, Abhay R., Matlashewski, Greg, Nakhasi, Hira L.
Published in Nature communications (10.07.2020)
Published in Nature communications (10.07.2020)
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Journal Article
Dual-scRNA-seq analysis reveals rare and uncommon parasitized cell populations in chronic L. donovani infection
Karagiannis, Konstantinos, Gannavaram, Sreenivas, Verma, Chaitenya, Pacheco-Fernandez, Thalia, Bhattacharya, Parna, Nakhasi, Hira L., Satoskar, Abhay R.
Published in Cell reports (Cambridge) (26.09.2023)
Published in Cell reports (Cambridge) (26.09.2023)
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Journal Article
Determinants of Innate Immunity in Visceral Leishmaniasis and Their Implication in Vaccine Development
Volpedo, Greta, Pacheco-Fernandez, Thalia, Bhattacharya, Parna, Oljuskin, Timur, Dey, Ranadhir, Gannavaram, Sreenivas, Satoskar, Abhay R, Nakhasi, Hira L
Published in Frontiers in immunology (12.10.2021)
Published in Frontiers in immunology (12.10.2021)
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Journal Article
Deletion of MIF gene from live attenuated LdCen−/− parasites enhances protective CD4+ T cell immunity
Fiuza, Jacqueline Araújo, Gannavaram, Sreenivas, Gaze, Soraya Torres, de Ornellas, Letícia Gambogi, Alves, Érica Alessandra, Ismail, Nevien, Nakhasi, Hira Lal, Correa-Oliveira, Rodrigo
Published in Scientific reports (05.05.2023)
Published in Scientific reports (05.05.2023)
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Journal Article
Production of leishmanin skin test antigen from Leishmania donovani for future reintroduction in the field
Dey, Ranadhir, Alshaweesh, Jalal, Singh, Kamaleshwar P., Lypaczewski, Patrick, Karmakar, Subir, Klenow, Laura, Paulini, Kayla, Kaviraj, Swarnendu, Kamhawi, Shaden, Valenzuela, Jesus G., Singh, Sanjay, Hamano, Shinjiro, Satoskar, Abhay R., Gannavaram, Sreenivas, Nakhasi, Hira L., Matlashewski, Greg
Published in Nature communications (02.11.2023)
Published in Nature communications (02.11.2023)
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Journal Article
Revival of Leishmanization and Leishmanin
Pacheco-Fernandez, Thalia, Volpedo, Greta, Gannavaram, Sreenivas, Bhattacharya, Parna, Dey, Ranadhir, Satoskar, Abhay, Matlashewski, Greg, Nakhasi, Hira L
Published in Frontiers in cellular and infection microbiology (17.03.2021)
Published in Frontiers in cellular and infection microbiology (17.03.2021)
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Journal Article
Manufacturing and preclinical toxicity of GLP grade gene deleted attenuated Leishmania donovani parasite vaccine
Avishek, Kumar, Beg, Mirza A., Vats, Kavita, Singh, Avinash Kumar, Dey, Ranadhir, Singh, Kamaleshwar P., Singh, Rajesh Kumar, Gannavaram, Sreenivas, Ramesh, V., Mulla, Mohmad Sadik A., Bhatnagar, Upendra, Singh, Sanjay, Nakhasi, Hira L., Salotra, Poonam, Selvapandiyan, Angamuthu
Published in Scientific reports (25.06.2024)
Published in Scientific reports (25.06.2024)
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Journal Article
Preclinical validation of a live attenuated dermotropic Leishmania vaccine against vector transmitted fatal visceral leishmaniasis
Karmakar, Subir, Ismail, Nevien, Oliveira, Fabiano, Oristian, James, Zhang, Wen Wei, Kaviraj, Swarnendu, Singh, Kamaleshwar P., Mondal, Abhishek, Das, Sushmita, Pandey, Krishna, Bhattacharya, Parna, Volpedo, Greta, Gannavaram, Sreenivas, Satoskar, Monika, Satoskar, Sanika, Sastry, Rajiv M., Oljuskin, Timur, Sepahpour, Telly, Meneses, Claudio, Hamano, Shinjiro, Das, Pradeep, Matlashewski, Greg, Singh, Sanjay, Kamhawi, Shaden, Dey, Ranadhir, Valenzuela, Jesus G., Satoskar, Abhay, Nakhasi, Hira L.
Published in Communications biology (30.07.2021)
Published in Communications biology (30.07.2021)
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Journal Article
Neutrophil-dendritic cell interaction plays an important role in live attenuated Leishmania vaccine induced immunity
Bhattacharya, Parna, Ismail, Nevien, Saxena, Ankit, Gannavaram, Sreenivas, Dey, Ranadhir, Oljuskin, Timur, Akue, Adovi, Takeda, Kazuyo, Yu, James, Karmakar, Subir, Dagur, Pradeep K, McCoy, Jr, John Philip, Nakhasi, Hira L
Published in PLoS neglected tropical diseases (01.02.2022)
Published in PLoS neglected tropical diseases (01.02.2022)
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Journal Article
Intradermal Immunization of Leishmania donovani Centrin Knock-Out Parasites in Combination with Salivary Protein LJM19 from Sand Fly Vector Induces a Durable Protective Immune Response in Hamsters
Fiuza, Jacqueline Araújo, Dey, Ranadhir, Davenport, Dwann, Abdeladhim, Maha, Meneses, Claudio, Oliveira, Fabiano, Kamhawi, Shaden, Valenzuela, Jesus G, Gannavaram, Sreenivas, Nakhasi, Hira L
Published in PLoS neglected tropical diseases (01.01.2016)
Published in PLoS neglected tropical diseases (01.01.2016)
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Journal Article
Leishmania Major Centrin Gene-Deleted Parasites Generate Skin Resident Memory T-Cell Immune Response Analogous to Leishmanization
Ismail, Nevien, Karmakar, Subir, Bhattacharya, Parna, Sepahpour, Telly, Takeda, Kazuyo, Hamano, Shinjiro, Matlashewski, Greg, Satoskar, Abhay R, Gannavaram, Sreenivas, Dey, Ranadhir, Nakhasi, Hira L
Published in Frontiers in immunology (28.03.2022)
Published in Frontiers in immunology (28.03.2022)
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Journal Article
Centrin-deficient Leishmania mexicana confers protection against New World cutaneous leishmaniasis
Volpedo, Greta, Pacheco-Fernandez, Thalia, Holcomb, Erin A., Zhang, Wen-Wei, Lypaczewski, Patrick, Cox, Blake, Fultz, Rebecca, Mishan, Chelsea, Verma, Chaitenya, Huston, Ryan H., Wharton, Abigail R., Dey, Ranadhir, Karmakar, Subir, Oghumu, Steve, Hamano, Shinjiro, Gannavaram, Sreenivas, Nakhasi, Hira L., Matlashewski, Greg, Satoskar, Abhay R.
Published in npj vaccines (02.03.2022)
Published in npj vaccines (02.03.2022)
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Journal Article
A Leishmania-specific gene upregulated at the amastigote stage is crucial for parasite survival
Avishek, Kumar, Ahuja, Kavita, Pradhan, Dibyabhaba, Gannavaram, Sreenivas, Selvapandiyan, Angamuthu, Nakhasi, Hira L., Salotra, Poonam
Published in Parasitology research (1987) (01.10.2018)
Published in Parasitology research (1987) (01.10.2018)
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Journal Article
Whole genome sequencing of live attenuated Leishmania donovani parasites reveals novel biomarkers of attenuation and enables product characterization
Gannavaram, Sreenivas, Torcivia, John, Gasparyan, Lusine, Kaul, Amit, Ismail, Nevien, Simonyan, Vahan, Nakhasi, Hira L.
Published in Scientific reports (05.07.2017)
Published in Scientific reports (05.07.2017)
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Journal Article
The History of Live Attenuated Centrin Gene-Deleted Leishmania Vaccine Candidates
Volpedo, Greta, Bhattacharya, Parna, Gannavaram, Sreenivas, Pacheco-Fernandez, Thalia, Oljuskin, Timur, Dey, Ranadhir, Satoskar, Abhay R, Nakhasi, Hira L
Published in Pathogens (Basel) (02.04.2022)
Published in Pathogens (Basel) (02.04.2022)
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Journal Article
Centrin-Deleted Leishmania donovani Parasites Help CD4 + T Cells to Acquire Th1 Phenotype and Multi-Functionality Through Downregulation of CD200-CD200R Immune Inhibitory Axis
Singh, Rakesh K, Gannavaram, Sreenivas, Ismail, Nevien, Kaul, Amit, Gedda, Mallikarjuna Rao, Nakhasi, Hira L
Published in Frontiers in immunology (04.06.2018)
Published in Frontiers in immunology (04.06.2018)
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Journal Article
The Preclinical Validation of 405 nm Light Parasiticidal Efficacy on Leishmania donovani in Ex Vivo Platelets in a Rag2 -/- Mouse Model
Kaldhone, Pravin R, Azodi, Nazli, Markle, Hannah L, Dahiya, Neetu, Stewart, Caitlin, Anderson, John, MacGregor, Scott, Maclean, Michelle, Nakhasi, Hira L, Gannavaram, Sreenivas, Atreya, Chintamani
Published in Microorganisms (Basel) (29.01.2024)
Published in Microorganisms (Basel) (29.01.2024)
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