Type IIA topoisomerase inhibition by a new class of antibacterial agents
Giordano, Ilaria, Spitzfaden, Claus E, Jones, Emma, Theobald, Andrew J, Gorrec, Fabrice, Jones, Jo, Hann, Michael M, May, Earl W, Saunders, Martin R, Fosberry, Andrew, Chan, Pan F, Eggleston, Drake S, Hibbs, Martin, Brown, Kristin Koretke, Lewis, Ceri J, Bax, Benjamin D, Singh, Onkar, Pearson, Neil D, Wohlkonig, Alexandre, Hennessy, Alan, Gentry, Daniel R, Huang, Jianzhong, Shen, Carol, Gwynn, Michael N, Shillings, Anthony
Published in Nature (London) (19.08.2010)
Published in Nature (London) (19.08.2010)
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Journal Article
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin
Chan, Pan F, Srikannathasan, Velupillai, Huang, Jianzhong, Cui, Haifeng, Fosberry, Andrew P, Gu, Minghua, Hann, Michael M, Hibbs, Martin, Homes, Paul, Ingraham, Karen, Pizzollo, Jason, Shen, Carol, Shillings, Anthony J, Spitzfaden, Claus E, Tanner, Robert, Theobald, Andrew J, Stavenger, Robert A, Bax, Benjamin D, Gwynn, Michael N
Published in Nature communications (07.12.2015)
Published in Nature communications (07.12.2015)
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Discovery of functionally distinct anti-C7 monoclonal antibodies and stratification of anti-nicotinic AChR positive Myasthenia Gravis patients
Lekova, Eleonora, Zelek, Wioleta M., Gower, David, Spitzfaden, Claus, Osuch, Isabelle H., John-Morris, Elen, Stach, Lasse, Gormley, Darren, Sanderson, Andrew, Bridges, Angela, Wear, Elizabeth R., Petit-Frere, Sebastien, Burden, Michael N., Priest, Richard, Wattam, Trevor, Kitchen, Semra J., Feeney, Maria, Davis, Susannah, Morgan, B. Paul, Nichols, Eva-Maria
Published in Frontiers in immunology (05.09.2022)
Published in Frontiers in immunology (05.09.2022)
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The structure of ribonuclease P protein from Staphylococcus aureus reveals a unique binding site for single-stranded RNA
Spitzfaden, Claus, Nicholson, Neville, Jones, Jo J, Guth, Sabine, Lehr, Ruth, Prescott, Cathy D, Hegg, Lisa A, Eggleston, Drake S
Published in Journal of molecular biology (07.01.2000)
Published in Journal of molecular biology (07.01.2000)
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Journal Article
Destabilization of the complete protein secondary structure on binding to the chaperone GroEL
Zahn, Ralph, Spitzfaden, Claus, Ottiger, Marcel, Wüthrich, Kurt, Plückthun, Andreas
Published in Nature (London) (17.03.1994)
Published in Nature (London) (17.03.1994)
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Journal Article
Structure of human cyclophilin and its binding site for cyclosporin A determined by X-ray crystallography and NMR spectroscopy
Kallen, Jörg, Spitzfaden, Claus, Zurini, Mauro G. M, Wider, Gerhard, Widmer, Hans, Wüthrich, Kurt, Walkinshaw, Malcolm D
Published in Nature (London) (19.09.1991)
Published in Nature (London) (19.09.1991)
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Journal Article
Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion
Agrawal, Alka, Roué, Mélanie, Spitzfaden, Claus, Petrella, Stéphanie, Aubry, Alexandra, Hann, Michael, Bax, Benjamin, Mayer, Claudine
Published in Biochemical journal (01.12.2013)
Published in Biochemical journal (01.12.2013)
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Journal Article
Cyclosporin A—cyclophilin complex formation A model based on X-ray and NMR data
Spitzfaden, Claus, Weber, Hans-Peter, Braun, Werner, Kallen, Joerg, Wider, Gerhard, Widmer, Hans, Walkinshaw, Malcolm D., Wüthrich, Kurt
Published in FEBS letters (06.04.1992)
Published in FEBS letters (06.04.1992)
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The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits
Bertrand, Sophie M, Ancellin, Nicolas, Beaufils, Benjamin, Bingham, Ryan P, Borthwick, Jennifer A, Boullay, Anne-Bénédicte, Boursier, Eric, Carter, Paul S, Chung, Chun-wa, Churcher, Ian, Dodic, Nerina, Fouchet, Marie-Hélène, Fournier, Charlène, Francis, Peter L, Gummer, Laura A, Herry, Kenny, Hobbs, Andrew, Hobbs, Clare I, Homes, Paul, Jamieson, Craig, Nicodeme, Edwige, Pickett, Stephen D, Reid, Iain H, Simpson, Graham L, Sloan, Lisa A, Smith, Sarah E, Somers, Donald O’N, Spitzfaden, Claus, Suckling, Colin J, Valko, Klara, Washio, Yoshiaki, Young, Robert J
Published in Journal of medicinal chemistry (24.09.2015)
Published in Journal of medicinal chemistry (24.09.2015)
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Journal Article
Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening
Borthwick, Jennifer A, Ancellin, Nicolas, Bertrand, Sophie M, Bingham, Ryan P, Carter, Paul S, Chung, Chun-wa, Churcher, Ian, Dodic, Nerina, Fournier, Charlène, Francis, Peter L, Hobbs, Andrew, Jamieson, Craig, Pickett, Stephen D, Smith, Sarah E, Somers, Donald O’N, Spitzfaden, Claus, Suckling, Colin J, Young, Robert J
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
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Journal Article
Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases
Miles, Timothy J., Hennessy, Alan J., Bax, Ben, Brooks, Gerald, Brown, Barry S., Brown, Pamela, Cailleau, Nathalie, Chen, Dongzhao, Dabbs, Steven, Davies, David T., Esken, Joel M., Giordano, Ilaria, Hoover, Jennifer L., Huang, Jianzhong, Jones, Graham E., Kusalakumari Sukmar, Senthill K., Spitzfaden, Claus, Markwell, Roger E., Minthorn, Elisabeth A., Rittenhouse, Steve, Gwynn, Michael N., Pearson, Neil D.
Published in Bioorganic & medicinal chemistry letters (01.10.2013)
Published in Bioorganic & medicinal chemistry letters (01.10.2013)
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Journal Article
Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide
Srikannathasan, Velupillai, Wohlkonig, Alexandre, Shillings, Anthony, Singh, Onkar, Chan, Pan F., Huang, Jianzhong, Gwynn, Michael N., Fosberry, Andrew P., Homes, Paul, Hibbs, Martin, Theobald, Andrew J., Spitzfaden, Claus, Bax, Benjamin D.
Published in Acta crystallographica. Section F, Structural biology communications (01.10.2015)
Published in Acta crystallographica. Section F, Structural biology communications (01.10.2015)
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Journal Article
Inhibition of fibril formation in beta-amyloid peptide by a novel series of benzofurans
Howlett, D R, Perry, A E, Godfrey, F, Swatton, J E, Jennings, K H, Spitzfaden, C, Wadsworth, H, Wood, S J, Markwell, R E
Published in Biochemical journal (15.05.1999)
Published in Biochemical journal (15.05.1999)
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Journal Article
Structural studies on bacterial type IIA topoisomerases - targets for quinolone and coumarin antibiotics
Bax, Ben, Hibbs, Martin, Jones, Emma, Theobald, Andrew, Fosberry, Andrew, Spitzfaden, Claus, Shillings, Anthony, Wohlkonig, Alexandre, Koretke, Kristin K., Huang, Jianzhong, Pearson, Neil, Gwynn, Michael N.
Published in Acta crystallographica. Section A, Foundations of crystallography (16.08.2009)
Published in Acta crystallographica. Section A, Foundations of crystallography (16.08.2009)
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