Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking
Kennedy, Kit, Cobbold, Simon A, Hanssen, Eric, Birnbaum, Jakob, Spillman, Natalie J, McHugh, Emma, Brown, Hannah, Tilley, Leann, Spielmann, Tobias, McConville, Malcolm J, Ralph, Stuart A
Published in PLoS biology (18.07.2019)
Published in PLoS biology (18.07.2019)
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Journal Article
Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
Bridgford, Jessica L., Xie, Stanley C., Cobbold, Simon A., Pasaje, Charisse Flerida A., Herrmann, Susann, Yang, Tuo, Gillett, David L., Dick, Lawrence R., Ralph, Stuart A., Dogovski, Con, Spillman, Natalie J., Tilley, Leann
Published in Nature communications (18.09.2018)
Published in Nature communications (18.09.2018)
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Journal Article
Na+ Regulation in the Malaria Parasite Plasmodium falciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials
Spillman, Natalie J., Allen, Richard J.W., McNamara, Case W., Yeung, Bryan K.S., Winzeler, Elizabeth A., Diagana, Thierry T., Kirk, Kiaran
Published in Cell host & microbe (13.02.2013)
Published in Cell host & microbe (13.02.2013)
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Journal Article
Protein Export into Malaria Parasite-Infected Erythrocytes: Mechanisms and Functional Consequences
Spillman, Natalie J, Beck, Josh R, Goldberg, Daniel E
Published in Annual review of biochemistry (01.01.2015)
Published in Annual review of biochemistry (01.01.2015)
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Journal Article
Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome
Xie, Stanley C, Gillett, David L, Spillman, Natalie J, Tsu, Christopher, Luth, Madeline R, Ottilie, Sabine, Duffy, Sandra, Gould, Alexandra E, Hales, Paul, Seager, Benjamin A, Charron, Carlie L, Bruzzese, Frank, Yang, Xiaofeng, Zhao, Xiansi, Huang, Shih-Chung, Hutton, Craig A, Burrows, Jeremy N, Winzeler, Elizabeth A, Avery, Vicky M, Dick, Lawrence R, Tilley, Leann
Published in Journal of medicinal chemistry (21.11.2018)
Published in Journal of medicinal chemistry (21.11.2018)
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Journal Article
The chaperonin TRiC forms an oligomeric complex in the malaria parasite cytosol
Spillman, Natalie J., Beck, Josh R., Ganesan, Suresh M., Niles, Jacquin C., Goldberg, Daniel E.
Published in Cellular microbiology (01.06.2017)
Published in Cellular microbiology (01.06.2017)
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Journal Article
Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum
Vaidya, Akhil B., Morrisey, Joanne M., Zhang, Zhongsheng, Das, Sudipta, Daly, Thomas M., Otto, Thomas D., Spillman, Natalie J., Wyvratt, Matthew, Siegl, Peter, Marfurt, Jutta, Wirjanata, Grennady, Sebayang, Boni F., Price, Ric N., Chatterjee, Arnab, Nagle, Advait, Stasiak, Marcin, Charman, Susan A., Angulo-Barturen, Iñigo, Ferrer, Santiago, Belén Jiménez-Díaz, María, Martínez, María Santos, Gamo, Francisco Javier, Avery, Vicky M., Ruecker, Andrea, Delves, Michael, Kirk, Kiaran, Berriman, Matthew, Kortagere, Sandhya, Burrows, Jeremy, Fan, Erkang, Bergman, Lawrence W.
Published in Nature communications (25.11.2014)
Published in Nature communications (25.11.2014)
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Journal Article
A single point mutation in the Plasmodium falciparum FtsH1 metalloprotease confers actinonin resistance
Goodman, Christopher D, Uddin, Taher, Spillman, Natalie J, McFadden, Geoffrey I
Published in eLife (17.07.2020)
Published in eLife (17.07.2020)
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Journal Article
Na+ extrusion imposes an acid load on the intraerythrocytic malaria parasite
Spillman, Natalie J., Allen, Richard J.W., Kirk, Kiaran
Published in Molecular and biochemical parasitology (01.05.2013)
Published in Molecular and biochemical parasitology (01.05.2013)
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Journal Article
The structure of the PA28–20S proteasome complex from Plasmodium falciparum and implications for proteostasis
Xie, Stanley C., Metcalfe, Riley D., Hanssen, Eric, Yang, Tuo, Gillett, David L., Leis, Andrew P., Morton, Craig J., Kuiper, Michael J., Parker, Michael W., Spillman, Natalie J., Wong, Wilson, Tsu, Christopher, Dick, Lawrence R., Griffin, Michael D. W., Tilley, Leann
Published in Nature microbiology (01.11.2019)
Published in Nature microbiology (01.11.2019)
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Journal Article
Acid extrusion from the intraerythrocytic malaria parasite is not via a Na +/H + exchanger
Spillman, Natalie J., Allen, Richard J.W., Kirk, Kiaran
Published in Molecular and biochemical parasitology (01.11.2008)
Published in Molecular and biochemical parasitology (01.11.2008)
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Journal Article
Na+ Regulation in the Malaria Parasite Plasmodiumfalciparum Involves the Cation ATPase PfATP4 and Is a Target of the Spiroindolone Antimalarials
Spillman, Natalie J, Allen, Richard JW, McNamara, Case W, Yeung, Bryan KS, Winzeler, Elizabeth A, Diagana, Thierry T, Kirk, Kiaran
Published in Cell host & microbe (13.02.2013)
Published in Cell host & microbe (13.02.2013)
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Journal Article
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
Reader, Janette, van der Watt, Mariëtte E., Taylor, Dale, Le Manach, Claire, Mittal, Nimisha, Ottilie, Sabine, Theron, Anjo, Moyo, Phanankosi, Erlank, Erica, Nardini, Luisa, Venter, Nelius, Lauterbach, Sonja, Bezuidenhout, Belinda, Horatscheck, Andre, van Heerden, Ashleigh, Spillman, Natalie J., Cowell, Anne N., Connacher, Jessica, Opperman, Daniel, Orchard, Lindsey M., Llinás, Manuel, Istvan, Eva S., Goldberg, Daniel E., Boyle, Grant A., Calvo, David, Mancama, Dalu, Coetzer, Theresa L., Winzeler, Elizabeth A., Duffy, James, Koekemoer, Lizette L., Basarab, Gregory, Chibale, Kelly, Birkholtz, Lyn-Marié
Published in Nature communications (11.01.2021)
Published in Nature communications (11.01.2021)
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Journal Article
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium
Jiménez-Díaz, María Belén, Ebert, Daniel, Salinas, Yandira, Pradhan, Anupam, Lehane, Adele M, Myrand-Lapierre, Marie-Eve, O'Loughlin, Kathleen G, Shackleford, David M, Justino de Almeida, Mariana, Carrillo, Angela K, Clark, Julie A, Dennis, Adelaide S M, Diep, Jonathon, Deng, Xiaoyan, Duffy, Sandra, Endsley, Aaron N, Fedewa, Greg, Guiguemde, W Armand, Gómez, María G, Holbrook, Gloria, Horst, Jeremy, Kim, Charles C, Liu, Jian, Lee, Marcus C S, Matheny, Amy, Martínez, María Santos, Miller, Gregory, Rodríguez-Alejandre, Ane, Sanz, Laura, Sigal, Martina, Spillman, Natalie J, Stein, Philip D, Wang, Zheng, Zhu, Fangyi, Waterson, David, Knapp, Spencer, Shelat, Anang, Avery, Vicky M, Fidock, David A, Gamo, Francisco-Javier, Charman, Susan A, Mirsalis, Jon C, Ma, Hongshen, Ferrer, Santiago, Kirk, Kiaran, Angulo-Barturen, Iñigo, Kyle, Dennis E, DeRisi, Joseph L, Floyd, David M, Guy, R Kiplin
Published in Proceedings of the National Academy of Sciences - PNAS (16.12.2014)
Published in Proceedings of the National Academy of Sciences - PNAS (16.12.2014)
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Journal Article
The structure of the Plasmodium falciparum 20S proteasome in complex with the PA28 activator
Metcalfe, Riley D., Xie, Stanley C., Hanssen, Eric, Yang, Tuo, Gillett, David L., Leis, Andrew, Morton, Craig J., Kuiper, Michael J., Parker, Michael W., Spillman, Natalie J., Wong, Wilson, Tsu, Christopher, Dick, Lawrence R., Griffin, Michael D. W., Tilley, Leann
Published in Acta crystallographica. Section A, Foundations and advances (20.07.2019)
Published in Acta crystallographica. Section A, Foundations and advances (20.07.2019)
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Journal Article
Na super(+) extrusion imposes an acid load on the intraerythrocytic malaria parasite
Spillman, Natalie J, Allen, Richard JW, Kirk, Kiaran
Published in Molecular and biochemical parasitology (01.05.2013)
Published in Molecular and biochemical parasitology (01.05.2013)
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Journal Article
Na +-dependent acid efflux from P. falciparum: PfNHE or residual nigericin?
Spillman, Natalie J., Allen, Richard J.W., Kirk, Kiaran
Published in Molecular and biochemical parasitology (01.07.2009)
Published in Molecular and biochemical parasitology (01.07.2009)
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