Genetic instability from a single S phase after whole-genome duplication
Gemble, Simon, Wardenaar, René, Keuper, Kristina, Srivastava, Nishit, Nano, Maddalena, Macé, Anne-Sophie, Tijhuis, Andréa E., Bernhard, Sara Vanessa, Spierings, Diana C. J., Simon, Anthony, Goundiam, Oumou, Hochegger, Helfrid, Piel, Matthieu, Foijer, Floris, Storchová, Zuzana, Basto, Renata
Published in Nature (London) (07.04.2022)
Published in Nature (London) (07.04.2022)
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Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals
Levine, Michelle S., Bakker, Bjorn, Boeckx, Bram, Moyett, Julia, Lu, James, Vitre, Benjamin, Spierings, Diana C., Lansdorp, Peter M., Cleveland, Don W., Lambrechts, Diether, Foijer, Floris, Holland, Andrew J.
Published in Developmental cell (06.02.2017)
Published in Developmental cell (06.02.2017)
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Gene copy-number changes and chromosomal instability induced by aneuploidy confer resistance to chemotherapy
Ippolito, Marica Rosaria, Martis, Valentino, Martin, Sara, Tijhuis, Andréa E., Hong, Christy, Wardenaar, René, Dumont, Marie, Zerbib, Johanna, Spierings, Diana C.J., Fachinetti, Daniele, Ben-David, Uri, Foijer, Floris, Santaguida, Stefano
Published in Developmental cell (13.09.2021)
Published in Developmental cell (13.09.2021)
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cGAS–STING drives the IL-6-dependent survival of chromosomally instable cancers
Hong, Christy, Schubert, Michael, Tijhuis, Andréa E., Requesens, Marta, Roorda, Maurits, van den Brink, Anouk, Ruiz, Lorena Andrade, Bakker, Petra L., van der Sluis, Tineke, Pieters, Wietske, Chen, Mengting, Wardenaar, René, van der Vegt, Bert, Spierings, Diana C. J., de Bruyn, Marco, van Vugt, Marcel A. T. M., Foijer, Floris
Published in Nature (London) (14.07.2022)
Published in Nature (London) (14.07.2022)
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Genome-wide forward genetic screening to identify receptors and proteins mediating nanoparticle uptake and intracellular processing
Montizaan, Daphne, Bartucci, Roberta, Reker-Smit, Catharina, de Weerd, Sander, Åberg, Christoffer, Guryev, Victor, Spierings, Diana C. J., Salvati, Anna
Published in Nature nanotechnology (01.07.2024)
Published in Nature nanotechnology (01.07.2024)
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Improved assembly and variant detection of a haploid human genome using single‐molecule, high‐fidelity long reads
Vollger, Mitchell R., Logsdon, Glennis A., Audano, Peter A., Sulovari, Arvis, Porubsky, David, Peluso, Paul, Wenger, Aaron M., Concepcion, Gregory T., Kronenberg, Zev N., Munson, Katherine M., Baker, Carl, Sanders, Ashley D., Spierings, Diana C.J., Lansdorp, Peter M., Surti, Urvashi, Hunkapiller, Michael W., Eichler, Evan E.
Published in Annals of human genetics (01.03.2020)
Published in Annals of human genetics (01.03.2020)
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Single-cell sequencing reveals karyotype heterogeneity in murine and human malignancies
Bakker, Bjorn, Taudt, Aaron, Belderbos, Mirjam E, Porubsky, David, Spierings, Diana C J, de Jong, Tristan V, Halsema, Nancy, Kazemier, Hinke G, Hoekstra-Wakker, Karina, Bradley, Allan, de Bont, Eveline S J M, van den Berg, Anke, Guryev, Victor, Lansdorp, Peter M, Colomé-Tatché, Maria, Foijer, Floris
Published in Genome Biology (31.05.2016)
Published in Genome Biology (31.05.2016)
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Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses
Shaikh, Nadeem, Mazzagatti, Alice, De Angelis, Simone, Johnson, Sarah C, Bakker, Bjorn, Spierings, Diana C J, Wardenaar, René, Maniati, Eleni, Wang, Jun, Boemo, Michael A, Foijer, Floris, McClelland, Sarah E
Published in Genome Biology (20.10.2022)
Published in Genome Biology (20.10.2022)
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A living biobank of ovarian cancer ex vivo models reveals profound mitotic heterogeneity
Nelson, Louisa, Tighe, Anthony, Golder, Anya, Littler, Samantha, Bakker, Bjorn, Moralli, Daniela, Murtuza Baker, Syed, Donaldson, Ian J., Spierings, Diana C. J., Wardenaar, René, Neale, Bethanie, Burghel, George J., Winter-Roach, Brett, Edmondson, Richard, Clamp, Andrew R., Jayson, Gordon C., Desai, Sudha, Green, Catherine M., Hayes, Andy, Foijer, Floris, Morgan, Robert D., Taylor, Stephen S.
Published in Nature communications (13.02.2020)
Published in Nature communications (13.02.2020)
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Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition
Cohen-Sharir, Yael, McFarland, James M., Abdusamad, Mai, Marquis, Carolyn, Bernhard, Sara V., Kazachkova, Mariya, Tang, Helen, Ippolito, Marica R., Laue, Kathrin, Zerbib, Johanna, Malaby, Heidi L. H., Jones, Andrew, Stautmeister, Lisa-Marie, Bockaj, Irena, Wardenaar, René, Lyons, Nicholas, Nagaraja, Ankur, Bass, Adam J., Spierings, Diana C. J., Foijer, Floris, Beroukhim, Rameen, Santaguida, Stefano, Golub, Todd R., Stumpff, Jason, Storchová, Zuzana, Ben-David, Uri
Published in Nature (London) (18.02.2021)
Published in Nature (London) (18.02.2021)
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Short-term molecular consequences of chromosome mis-segregation for genome stability
Garribba, Lorenza, De Feudis, Giuseppina, Martis, Valentino, Galli, Martina, Dumont, Marie, Eliezer, Yonatan, Wardenaar, René, Ippolito, Marica Rosaria, Iyer, Divya Ramalingam, Tijhuis, Andréa E., Spierings, Diana C. J., Schubert, Michael, Taglietti, Silvia, Soriani, Chiara, Gemble, Simon, Basto, Renata, Rhind, Nick, Foijer, Floris, Ben-David, Uri, Fachinetti, Daniele, Doksani, Ylli, Santaguida, Stefano
Published in Nature communications (11.03.2023)
Published in Nature communications (11.03.2023)
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DNA Replication Vulnerabilities Render Ovarian Cancer Cells Sensitive to Poly(ADP-Ribose) Glycohydrolase Inhibitors
Pillay, Nisha, Tighe, Anthony, Nelson, Louisa, Littler, Samantha, Coulson-Gilmer, Camilla, Bah, Nourdine, Golder, Anya, Bakker, Bjorn, Spierings, Diana C.J., James, Dominic I., Smith, Kate M., Jordan, Allan M., Morgan, Robert D., Ogilvie, Donald J., Foijer, Floris, Jackson, Dean A., Taylor, Stephen S.
Published in Cancer cell (18.03.2019)
Published in Cancer cell (18.03.2019)
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Ongoing chromosomal instability and karyotype evolution in human colorectal cancer organoids
Bolhaqueiro, Ana C. F., Ponsioen, Bas, Bakker, Bjorn, Klaasen, Sjoerd J., Kucukkose, Emre, van Jaarsveld, Richard H., Vivié, Judith, Verlaan-Klink, Ingrid, Hami, Nizar, Spierings, Diana C. J., Sasaki, Nobuo, Dutta, Devanjali, Boj, Sylvia F., Vries, Robert G. J., Lansdorp, Peter M., van de Wetering, Marc, van Oudenaarden, Alexander, Clevers, Hans, Kranenburg, Onno, Foijer, Floris, Snippert, Hugo J. G., Kops, Geert J. P. L.
Published in Nature genetics (01.05.2019)
Published in Nature genetics (01.05.2019)
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Transient genomic instability drives tumorigenesis through accelerated clonal evolution
Shoshani, Ofer, Bakker, Bjorn, de Haan, Lauren, Tijhuis, Andréa E, Wang, Yin, Kim, Dong Hyun, Maldonado, Marcus, Demarest, Matthew A, Artates, Jon, Zhengyu, Ouyang, Mark, Adam, Wardenaar, René, Sasik, Roman, Spierings, Diana C J, Vitre, Benjamin, Fisch, Kathleen, Foijer, Floris, Cleveland, Don W
Published in Genes & development (01.08.2021)
Published in Genes & development (01.08.2021)
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A non-genetic switch triggers alternative telomere lengthening and cellular immortalization in ATRX deficient cells
Turkalo, Timothy K., Maffia, Antonio, Schabort, Johannes J., Regalado, Samuel G., Bhakta, Mital, Blanchette, Marco, Spierings, Diana C. J., Lansdorp, Peter M., Hockemeyer, Dirk
Published in Nature communications (20.02.2023)
Published in Nature communications (20.02.2023)
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Author Correction: Genome-wide forward genetic screening to identify receptors and proteins mediating nanoparticle uptake and intracellular processing
Montizaan, Daphne, Bartucci, Roberta, Reker-Smit, Catharina, de Weerd, Sander, Åberg, Christoffer, Guryev, Victor, Spierings, Diana C. J., Salvati, Anna
Published in Nature nanotechnology (01.09.2024)
Published in Nature nanotechnology (01.09.2024)
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p53 Prohibits Propagation of Chromosome Segregation Errors that Produce Structural Aneuploidies
Soto, Mar, Raaijmakers, Jonne A., Bakker, Bjorn, Spierings, Diana C.J., Lansdorp, Peter M., Foijer, Floris, Medema, René H.
Published in Cell reports (Cambridge) (20.06.2017)
Published in Cell reports (Cambridge) (20.06.2017)
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Premature mitotic entry induced by ATR inhibition potentiates olaparib inhibition‐mediated genomic instability, inflammatory signaling, and cytotoxicity in BRCA2‐deficient cancer cells
Schoonen, Pepijn M., Kok, Yannick P., Wierenga, Elles, Bakker, Bjorn, Foijer, Floris, Spierings, Diana C. J., Vugt, Marcel A. T. M.
Published in Molecular oncology (01.11.2019)
Published in Molecular oncology (01.11.2019)
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