LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis
Reed, Alex, Ichu, Taka-Aki, Milosevich, Natalia, Melillo, Bruno, Schafroth, Michael A., Otsuka, Yuka, Scampavia, Louis, Spicer, Timothy P., Cravatt, Benjamin F.
Published in ACS chemical biology (17.06.2022)
Published in ACS chemical biology (17.06.2022)
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Journal Article
Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming
Grandjean, Julia M D, Madhavan, Aparajita, Cech, Lauren, Seguinot, Bryan O, Paxman, Ryan J, Smith, Emery, Scampavia, Louis, Powers, Evan T, Cooley, Christina B, Plate, Lars, Spicer, Timothy P, Kelly, Jeffery W, Wiseman, R Luke
Published in Nature chemical biology (01.10.2020)
Published in Nature chemical biology (01.10.2020)
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Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
Plate, Lars, Cooley, Christina B, Chen, John J, Paxman, Ryan J, Gallagher, Ciara M, Madoux, Franck, Genereux, Joseph C, Dobbs, Wesley, Garza, Dan, Spicer, Timothy P, Scampavia, Louis, Brown, Steven J, Rosen, Hugh, Powers, Evan T, Walter, Peter, Hodder, Peter, Wiseman, R Luke, Kelly, Jeffery W
Published in eLife (20.07.2016)
Published in eLife (20.07.2016)
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SYNGAP1 Controls the Maturation of Dendrites, Synaptic Function, and Network Activity in Developing Human Neurons
Llamosas, Nerea, Arora, Vineet, Vij, Ridhima, Kilinc, Murat, Bijoch, Lukasz, Rojas, Camilo, Reich, Adrian, Sridharan, BanuPriya, Willems, Erik, Piper, David R, Scampavia, Louis, Spicer, Timothy P, Miller, Courtney A, Holder, J Lloyd, Rumbaugh, Gavin
Published in The Journal of neuroscience (07.10.2020)
Published in The Journal of neuroscience (07.10.2020)
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Journal Article
Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins
Aziz, Faisal, Reddy, Kanamata, Fernandez Vega, Virneliz, Dey, Raja, Hicks, Katherine A., Rao, Sumitha, Jordan, Luis Ortiz, Smith, Emery, Shumate, Justin, Scampavia, Louis, Carpino, Nicholas, Spicer, Timothy P., French, Jarrod B.
Published in Journal of medicinal chemistry (08.02.2024)
Published in Journal of medicinal chemistry (08.02.2024)
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Journal Article
Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening
Hou, Shurong, Tiriac, Hervé, Sridharan, Banu Priya, Scampavia, Louis, Madoux, Franck, Seldin, Jan, Souza, Glauco R., Watson, Donald, Tuveson, David, Spicer, Timothy P.
Published in SLAS discovery (01.07.2018)
Published in SLAS discovery (01.07.2018)
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Journal Article
Stabilization of amyloidogenic immunoglobulin light chains by small molecules
Morgan, Gareth J., Yan, Nicholas L., Mortenson, David E., Rennella, Enrico, Blundon, Joshua M., Gwin, Ryan M., Lin, Chung-Yon, Stanfield, Robyn L., Brown, Steven J., Rosen, Hugh, Spicer, Timothy P., Fernandez-Vega, Virneliz, Merlini, Giampaolo, Kay, Lewis E., Wilson, Ian A., Kelly, Jeffery W.
Published in Proceedings of the National Academy of Sciences - PNAS (23.04.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (23.04.2019)
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A novel three-dimensional high-throughput screening approach identifies inducers of a mutant KRAS selective lethal phenotype
Kota, Smitha, Hou, Shurong, Guerrant, William, Madoux, Franck, Troutman, Scott, Fernandez-Vega, Virneliz, Alekseeva, Nina, Madala, Neeharika, Scampavia, Louis, Kissil, Joseph, Spicer, Timothy P
Published in Oncogene (01.08.2018)
Published in Oncogene (01.08.2018)
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Journal Article
Target-based discovery of a broad-spectrum flukicide
Sprague, Daniel J, Park, Sang-Kyu, Gramberg, Svenja, Bauer, Lisa, Rohr, Claudia M, Chulkov, Evgeny G, Smith, Emery, Scampavia, Louis, Spicer, Timothy P, Haeberlein, Simone, Marchant, Jonathan S
Published in Nature structural & molecular biology (07.05.2024)
Published in Nature structural & molecular biology (07.05.2024)
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Journal Article
Applications for Open Source Microplate-Compatible Illumination Panels
Baillargeon, Pierre, Spicer, Timothy P, Scampavia, Louis
Published in Journal of visualized experiments (03.10.2019)
Published in Journal of visualized experiments (03.10.2019)
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Journal Article
Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication
Thenin-Houssier, Suzie, de Vera, Ian Mitchelle S, Pedro-Rosa, Laura, Brady, Angela, Richard, Audrey, Konnick, Briana, Opp, Silvana, Buffone, Cindy, Fuhrmann, Jakob, Kota, Smitha, Billack, Blase, Pietka-Ottlik, Magdalena, Tellinghuisen, Timothy, Choe, Hyeryun, Spicer, Timothy, Scampavia, Louis, Diaz-Griffero, Felipe, Kojetin, Douglas J, Valente, Susana T
Published in Antimicrobial agents and chemotherapy (01.04.2016)
Published in Antimicrobial agents and chemotherapy (01.04.2016)
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Journal Article
A Simple Procedure for Creating Scalable Phenotypic Screening Assays in Human Neurons
Sridharan, BanuPriya, Hubbs, Christopher, Llamosas, Nerea, Kilinc, Murat, Singhera, Fakhar U, Willems, Erik, Piper, David R, Scampavia, Louis, Rumbaugh, Gavin, Spicer, Timothy P
Published in Scientific reports (21.06.2019)
Published in Scientific reports (21.06.2019)
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Journal Article
A new vulnerability to BET inhibition due to enhanced autophagy in BRCA2 deficient pancreatic cancer
Lee, EunJung, Archasappawat, Suyakarn, Ji, Keely, Pena, Jocelyn, Fernandez-Vega, Virneliz, Gangaraju, Ritika, Beesabathuni, Nitin Sai, Kim, Martin Jean, Tian, Qi, Shah, Priya S, Scampavia, Louis, Spicer, Timothy P, Hwang, Chang-Il
Published in Cell death & disease (21.09.2023)
Published in Cell death & disease (21.09.2023)
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Journal Article
Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity
Smith, Emery, Janovick, Jo Ann, Bannister, Thomas D, Shumate, Justin, Ganapathy, Vadivel, Scampavia, Louis, Spicer, Timothy P
Published in Scientific reports (29.06.2020)
Published in Scientific reports (29.06.2020)
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Journal Article
A unique hyperdynamic dimer interface permits small molecule perturbation of the melanoma oncoprotein MITF for melanoma therapy
Liu, Zaizhou, Chen, Kaige, Dai, Jun, Xu, Peng, Sun, Wei, Liu, Wanlin, Zhao, Zhixin, Bennett, Steven P, Li, Peifeng, Ma, Tiancheng, Lin, Yuqi, Kawakami, Akinori, Yu, Jing, Wang, Fei, Wang, Chunxi, Li, Miao, Chase, Peter, Hodder, Peter, Spicer, Timothy P, Scampavia, Louis, Cao, Chunyang, Pan, Lifeng, Dong, Jiajia, Chen, Yong, Yu, Biao, Guo, Min, Fang, Pengfei, Fisher, David E, Wang, Jing
Published in Cell research (01.01.2023)
Published in Cell research (01.01.2023)
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Journal Article
A 1536-Well 3D Viability Assay to Assess the Cytotoxic Effect of Drugs on Spheroids
Madoux, Franck, Tanner, Allison, Vessels, Michelle, Willetts, Lynsey, Hou, Shurong, Scampavia, Louis, Spicer, Timothy P.
Published in SLAS discovery (01.06.2017)
Published in SLAS discovery (01.06.2017)
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Journal Article
Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate
Madoux, Franck, Dreymuller, Daniela, Pettiloud, Jean-Phillipe, Santos, Radleigh, Becker-Pauly, Christoph, Ludwig, Andreas, Fields, Gregg B, Bannister, Thomas, Spicer, Timothy P, Cudic, Mare, Scampavia, Louis D, Minond, Dmitriy
Published in Scientific reports (05.12.2016)
Published in Scientific reports (05.12.2016)
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