Biphenylsulfonamide endothelin receptor antagonists. 2. Discovery of 4'-oxazolyl biphenylsulfonamides as a new class of potent, highly selective ET(A) antagonists
Murugesan, N, Gu, Z, Stein, P D, Spergel, S, Mathur, A, Leith, L, Liu, E C, Zhang, R, Bird, E, Waldron, T, Marino, A, Morrison, R A, Webb, M L, Moreland, S, Barrish, J C
Published in Journal of medicinal chemistry (10.08.2000)
Published in Journal of medicinal chemistry (10.08.2000)
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Synthesis and antiviral activity of novel isonucleoside analogs
Tino, Joseph A, Clark, Junius M, Field, A. Kirk, Jacobs, Glenn A, Lis, Karen A, Michalik, Teresa L, McGeever-Rubin, Bridgette, Slusarchyk, William A, Spergel, Steven H
Published in Journal of medicinal chemistry (30.04.1993)
Published in Journal of medicinal chemistry (30.04.1993)
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Aminodiol HIV Protease Inhibitors. Synthesis And Structure−Activity Relationships Of P1/P1‘ Compounds: Correlation between Lipophilicity and Cytotoxicity
Chen, Ping, Cheng, Peter T. W, Alam, Masud, Beyer, Barbara D, Bisacchi, Gregory S, Dejneka, Tamara, Evans, Adelaide J, Greytok, Jill A, Hermsmeier, Mark A, Humphreys, W. Griffith, Jacobs, Glenn A, Kocy, Octavian, Lin, Pin-Fang, Lis, Karen A, Marella, Michael A, Ryono, Denis E, Sheaffer, Amy K, Spergel, Steven H, Sun, Chong-qing, Tino, Joseph A, Vite, Gregory, Colonno, Richard J, Zahler, Robert, Barrish, Joel C
Published in Journal of medicinal chemistry (10.05.1996)
Published in Journal of medicinal chemistry (10.05.1996)
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Aminodiol HIV protease inhibitors. 2. 1,1-Dimethyl-2-hydroxyethyl carbamate derivatives with enhanced potency
Bisacchi, G.S., Ahmad, S., Alam, M., Ashfaq, A., Barrish, J., Cheng, P.T.W., Greytok, J., Hermsmeier, M., Lin, P.-F., Merchant, Z., Skoog, M., Spergel, S., Zahler, R.
Published in Bioorganic & medicinal chemistry letters (02.03.1995)
Published in Bioorganic & medicinal chemistry letters (02.03.1995)
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Palladium-Catalyzed α-Heteroarylation Route to 4-, 5-, 6- and 7-Azaindoles
Published in Synfacts
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Rational Design and Synthesis of an Orally Active Indolopyridone as a Novel Conformationally Constrained Cannabinoid Ligand Possessing Antiinflammatory Properties
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Published in Journal of medicinal chemistry (22.05.2003)
Published in Journal of medicinal chemistry (22.05.2003)
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Biphenylsulfonamide Endothelin Receptor Antagonists. 4. Discovery of N-[[2‘-[[(4,5-Dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1‘-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), A Highly Potent and Orally Active ETA Selective Antagonist
Murugesan, Natesan, Gu, Zhengxiang, Spergel, Steven, Young, Marian, Chen, Ping, Mathur, Arvind, Leith, Leslie, Hermsmeier, Mark, Liu, Eddie C.-K, Zhang, Rongan, Bird, Eileen, Waldron, Tom, Marino, Anthony, Koplowitz, Barry, Humphreys, W. Griffith, Chong, Saeho, Morrison, Richard A, Webb, Maria L, Moreland, Suzanne, Trippodo, Nick, Barrish, Joel C
Published in Journal of medicinal chemistry (02.01.2003)
Published in Journal of medicinal chemistry (02.01.2003)
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Biphenylsulfonamide Endothelin Receptor Antagonists. 2. Discovery of 4‘-Oxazolyl Biphenylsulfonamides as a New Class of Potent, Highly Selective ETA Antagonists
Murugesan, Natesan, Gu, Zhengxiang, Stein, Philip D, Spergel, Steven, Mathur, Arvind, Leith, Leslie, Liu, Eddie C.-K, Zhang, Rongan, Bird, Eileen, Waldron, Tom, Marino, Anthony, Morrison, Richard A, Webb, Maria L, Moreland, Suzanne, Barrish, Joel C
Published in Journal of medicinal chemistry (10.08.2000)
Published in Journal of medicinal chemistry (10.08.2000)
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Biphenylsulfonamide Endothelin Antagonists: Structure−Activity Relationships of a Series of Mono- and Disubstituted Analogues and Pharmacology of the Orally Active Endothelin Antagonist 2‘-Amino-N- (3,4-dimethyl-5-isoxazolyl)-4‘-(2-methylpropyl)[1,1‘-biphenyl]-2-sulfonamide (BMS-187308)
Murugesan, Natesan, Gu, Zhengxiang, Stein, Philip D, Bisaha, Sharon, Spergel, Steve, Girotra, Ravi, Lee, Ving G, Lloyd, John, Misra, Raj N, Schmidt, Joan, Mathur, Arvind, Stratton, Leslie, Kelly, Yolanda F, Bird, Eileen, Waldron, Tom, Liu, Eddie C.-K, Zhang, Rongan, Lee, Helen, Serafino, Randy, Abboa-Offei, Benoni, Mathers, Parker, Giancarli, Mary, Seymour, Andrea Ann, Webb, Maria L, Moreland, Suzanne, Barrish, Joel C, Hunt, John T
Published in Journal of medicinal chemistry (17.12.1998)
Published in Journal of medicinal chemistry (17.12.1998)
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Biphenylsulfonamide Endothelin Receptor Antagonists. Part 3: Structure–Activity Relationship of 4′-Heterocyclic Biphenylsulfonamides
Murugesan, Natesan, Gu, Zhengxiang, Stein, Philip D., Spergel, Steven, Bisaha, Sharon, Liu, Eddie C.-K., Zhang, Rongan, Webb, Maria L., Moreland, Suzanne, Barrish, Joel C.
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
Published in Bioorganic & medicinal chemistry letters (25.02.2002)
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Selective Itk Inhibitors Block T-Cell Activation and Murine Lung Inflammation
Lin, Tai-An, McIntyre, Kim W, Das, Jagabandhu, Liu, Chunjian, O'Day, Kathleen D, Penhallow, Becky, Hung, Chen-Yi, Whitney, Gena S, Shuster, David J, Yang, XiaoXia, Townsend, Robert, Postelnek, Jennifer, Spergel, Steven H, Lin, James, Moquin, Robert V, Furch, Joseph A, Kamath, Amrita V, Zhang, Hongjian, Marathe, Punit H, Perez-Villar, Juan J, Doweyko, Arthur, Killar, Loran, Dodd, John H, Barrish, Joel C, Wityak, John, Kanner, Steven B
Published in Biochemistry (Easton) (31.08.2004)
Published in Biochemistry (Easton) (31.08.2004)
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Discovery and SAR of 2-amino-5-(thioaryl)thiazoles as potent and selective Itk inhibitors
Das, Jagabandhu, Furch, Joseph A., Liu, Chunjian, Moquin, Robert V., Lin, James, Spergel, Steven H., McIntyre, Kim W., Shuster, David J., O’Day, Kathleen D., Penhallow, Becky, Hung, Chen-Yi, Doweyko, Arthur M., Kamath, Amrita, Zhang, Hongjian, Marathe, Punit, Kanner, Steven B., Lin, Tai-An, Dodd, John H., Barrish, Joel C., Wityak, John
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
Published in Bioorganic & medicinal chemistry letters (15.07.2006)
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Imidazoquinoxaline Src-family kinase p56(Lck) inhibitors: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo[1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activity
Chen, P, Doweyko, AM, Norris, D, Gu, HH, Spergel, SH, Das, J, Moquin, RV, Lin, J, Wityak, J, Iwanowicz, EJ, McIntyre, KW, Shuster, DJ, Behnia, K, Chong, S, de Fex, H, Pang, SH, Pitt, S, Shen, DR, Thrall, S, Stanley, P, Kocy, OR, Witmer, MR, Kanner, SB, Schieven, GL, Barrish, JC
Published in Journal of medicinal chemistry (26.08.2004)
Published in Journal of medicinal chemistry (26.08.2004)
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Molecular design, synthesis, and structure-Activity relationships leading to the potent and selective p56(lck) inhibitor BMS-243117
Das, Jagabandhu, Lin, James, Moquin, Robert V, Shen, Zhongqi, Spergel, Steven H, Wityak, John, Doweyko, Arthur M, DeFex, Henry F, Fang, Qiong, Pang, Suhong, Pitt, Sidney, Shen, Ding Ren, Schieven, Gary L, Barrish, Joel C
Published in Bioorganic & medicinal chemistry letters (07.07.2003)
Published in Bioorganic & medicinal chemistry letters (07.07.2003)
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Discovery and SAR of 2-amino-5-[(thiomethyl)aryl]thiazoles as potent and selective Itk inhibitors
Das, Jagabandhu, Liu, Chunjian, Moquin, Robert V., Lin, James, Furch, Joseph A., Spergel, Steven H., McIntyre, Kim W., Shuster, David J., O’Day, Kathleen D., Penhallow, Becky, Hung, Chen-Yi, Kanner, Steven B., Lin, Tai-An, Dodd, John H., Barrish, Joel C., Wityak, John
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
Published in Bioorganic & medicinal chemistry letters (01.05.2006)
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Discovery of novel 2-(aminoheteroaryl)-thiazole-5-carboxamides as potent and orally active Src-family kinase p56(Lck) inhibitors
Chen, Ping, Norris, Derek, Das, Jagabandhu, Spergel, Steven H, Wityak, John, Leith, Leslie, Zhao, Rulin, Chen, Bang-Chi, Pitt, Sidney, Pang, Suhong, Shen, Ding Ren, Zhang, Rosemary, De Fex, Henry F, Doweyko, Arthur M, McIntyre, Kim W, Shuster, David J, Behnia, Kamelia, Schieven, Gary L, Barrish, Joel C
Published in Bioorganic & medicinal chemistry letters (20.12.2004)
Published in Bioorganic & medicinal chemistry letters (20.12.2004)
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Journal Article
Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56(Lck)
Chen, Ping, Norris, Derek, Iwanowicz, Edwin J, Spergel, Steven H, Lin, James, Gu, Henry H, Shen, Zhongqi, Wityak, John, Lin, Tai-An, Pang, Suhong, De Fex, Henry F, Pitt, Sidney, Shen, Ding Ren, Doweyko, Arthur M, Bassolino, Donna A, Roberge, Jacques Y, Poss, Michael A, Chen, Bang-Chi, Schieven, Gary L, Barrish, Joel C
Published in Bioorganic & medicinal chemistry letters (20.05.2002)
Published in Bioorganic & medicinal chemistry letters (20.05.2002)
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