An integrated QSAR-PBK/D modelling approach for predicting detoxification and DNA adduct formation of 18 acyclic food-borne α,β-unsaturated aldehydes
Kiwamoto, R., Spenkelink, A., Rietjens, I.M.C.M., Punt, A.
Published in Toxicology and applied pharmacology (01.01.2015)
Published in Toxicology and applied pharmacology (01.01.2015)
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Physiologically Based Biokinetic (PBBK) Model for Safrole Bioactivation and Detoxification in Rats
Martati, E, Boersma, M. G, Spenkelink, A, Khadka, D. B, Punt, A, Vervoort, J, van Bladeren, P. J, Rietjens, I. M. C. M
Published in Chemical research in toxicology (20.06.2011)
Published in Chemical research in toxicology (20.06.2011)
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A physiologically based in silico model for trans-2-hexenal detoxification and DNA adduct formation in human including interindividual variation indicates efficient detoxification and a negligible genotoxicity risk
Kiwamoto, R., Spenkelink, A., Rietjens, I. M. C. M., Punt, A.
Published in Archives of toxicology (01.09.2013)
Published in Archives of toxicology (01.09.2013)
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Journal Article
Identification of nevadensin as an important herb-based constituent inhibiting estragole bioactivation and physiology-based biokinetic modeling of its possible in vivo effect
Alhusainy, W., Paini, A., Punt, A., Louisse, J., Spenkelink, A., Vervoort, J., Delatour, T., Scholz, G., Schilter, B., Adams, T., van Bladeren, P.J., Rietjens, I.M.C.M.
Published in Toxicology and applied pharmacology (01.06.2010)
Published in Toxicology and applied pharmacology (01.06.2010)
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Genotoxic effects in the Eastern mudminnow (Umbra pygmaea) after prolonged exposure to River Rhine water, as assessed by use of the in vivo SCE and Comet assays
Penders, E.J.M., Spenkelink, A., Hoogenboezem, W., Rotteveel, S.G.P., Maas, J.L., Alink, G.M.
Published in Environmental and molecular mutagenesis (01.05.2012)
Published in Environmental and molecular mutagenesis (01.05.2012)
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Matrix modulation of the bioactivation of estragole by different alkenylbenzenes-containing herbs and spices and physiologically-based biokinetic modeling of possible in vivo effects
Alhusainy, W, van den Berg, S, Campana, A, Paini, A, Spenkelink, A, Punt, A, Scholz, G, Schilter, B, Adams, T, van Bladeren, P.J, Rietjens, I.M.C.M
Published in Toxicology (Amsterdam) (2011)
Published in Toxicology (Amsterdam) (2011)
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Genotoxic effects in the Eastern mudminnow ( Umbra pygmaea L.) after exposure to Rhine water, as assessed by use of the SCE and Comet assays: A comparison between 1978 and 2005
Alink, G.M., Quik, J.T.K., Penders, E.J.M., Spenkelink, A., Rotteveel, S.G.P., Maas, J.L., Hoogenboezem, W.
Published in Mutation research (28.07.2007)
Published in Mutation research (28.07.2007)
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Delayed effects of pre- and early-life time exposure to polychlorinated biphenyls on tadpoles of two amphibian species ( Xenopus laevis and Rana temporaria)
Gutleb, A.C, Appelman, J, Bronkhorst, M.C, van den Berg, J.H.J, Spenkelink, A, Brouwer, A, Murk, A.J
Published in Environmental toxicology and pharmacology (01.12.1999)
Published in Environmental toxicology and pharmacology (01.12.1999)
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Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose–response curves for developmental toxicity of phenol in rat and human
Strikwold, Marije, Spenkelink, Bert, Woutersen, Ruud A., Rietjens, Ivonne M. C. M., Punt, Ans
Published in Archives of toxicology (01.09.2013)
Published in Archives of toxicology (01.09.2013)
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Journal Article
Genotoxicity testing of samples generated during UV/H2O2 treatment of surface water for the production of drinking water using the Ames test in vitro and the Comet assay and the SCE test in vivo
Penders, E J M, Martijn, A J, Spenkelink, A, Alink, G M, I M C M Rietjens, Hoogenboezem, W
Published in Journal of water supply : research and technology - AQUA (01.01.2012)
Published in Journal of water supply : research and technology - AQUA (01.01.2012)
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Use of physiologically based kinetic (PBK) modeling to study interindividual human variation and species differences in plasma concentrations of quercetin and its metabolites
Boonpawa, Rungnapa, Moradi, Nooshin, Spenkelink, Albertus, Rietjens, Ivonne M.C.M., Punt, Ans
Published in Biochemical pharmacology (15.12.2015)
Published in Biochemical pharmacology (15.12.2015)
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Journal Article
Physiologically based biokinetic (PBBK) modeling of safrole bioactivation and detoxification in humans as compared with rats
Martati, Erryana, Boersma, Marelle G, Spenkelink, Albertus, Khadka, Dambar B, van Bladeren, Peter J, Rietjens, Ivonne M C M, Punt, Ans
Published in Toxicological sciences (01.08.2012)
Published in Toxicological sciences (01.08.2012)
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Relative embryotoxic potency of p-substituted phenols in the embryonic stem cell test (EST) and comparison to their toxic potency in vivo and in the whole embryo culture (WEC) assay
Strikwold, Marije, Woutersen, Ruud A., Spenkelink, Bert, Punt, Ans, Rietjens, Ivonne M.C.M.
Published in Toxicology letters (03.09.2012)
Published in Toxicology letters (03.09.2012)
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Journal Article
Physiologically based kinetic modeling of bioactivation and detoxification of the alkenylbenzene methyleugenol in human as compared with rat
Al-Subeihi, Ala' A.A., Spenkelink, Bert, Punt, Ans, Boersma, Marelle G., van Bladeren, Peter J., Rietjens, Ivonne M.C.M.
Published in Toxicology and applied pharmacology (01.05.2012)
Published in Toxicology and applied pharmacology (01.05.2012)
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Journal Article
Evaluation of the interindividual human variation in bioactivation of methyleugenol using physiologically based kinetic modeling and Monte Carlo simulations
Al-Subeihi, Ala′ A.A., Alhusainy, Wasma, Kiwamoto, Reiko, Spenkelink, Bert, van Bladeren, Peter J., Rietjens, Ivonne M.C.M., Punt, Ans
Published in Toxicology and applied pharmacology (01.03.2015)
Published in Toxicology and applied pharmacology (01.03.2015)
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