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Phase I Safety, Pharmacokinetics, and Clinical Activity Study of Lapatinib (GW572016), a Reversible Dual Inhibitor of Epidermal Growth Factor Receptor Tyrosine Kinases, in Heavily Pretreated Patients With Metastatic Carcinomas
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Phase II Study of Predictive Biomarker Profiles for Response Targeting Human Epidermal Growth Factor Receptor 2 (HER-2) in Advanced Inflammatory Breast Cancer With Lapatinib Monotherapy
JOHNSTON, Stephen, TRUDEAU, Maureen, HARRIS, Jennifer, WESTLUND, Ron E, SALAZAR, Vanessa, ZAKS, Tal Z, SPECTOR, Neil L, KAUFMAN, Bella, BOUSSEN, Hamouda, BLACKWELL, Kimberley, LORUSSO, Patricia, LOMBARDI, Donald P, AHMED, Slim Ben, CITRIN, Dennis L, DESILVIO, Michelle L
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Photo-activated psoralen binds the ErbB2 catalytic kinase domain, blocking ErbB2 signaling and triggering tumor cell apoptosis
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Published in PloS one (14.02.2014)
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X-Ray Psoralen Activated Cancer Therapy (X-PACT)
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Published in PloS one (01.09.2016)
Published in PloS one (01.09.2016)
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Lapatinib Plasma and Tumor Concentrations and Effects on HER Receptor Phosphorylation in Tumor
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Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways
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Published in Oncogene (12.09.2002)
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Study of the Biologic Effects of Lapatinib, a Reversible Inhibitor of ErbB1 and ErbB2 Tyrosine Kinases, on Tumor Growth and Survival Pathways in Patients With Advanced Malignancies
Spector, Neil L, Xia, Wenle, Burris, 3rd, Howard, Hurwitz, Herbert, Dees, E Claire, Dowlati, Afshin, O'Neil, Bert, Overmoyer, Beth, Marcom, Paul K, Blackwell, Kimberly L, Smith, Deborah A, Koch, Kevin M, Stead, Andrew, Mangum, Steven, Ellis, Matthew J, Liu, Leihua, Man, Albert K, Bremer, Troy M, Harris, Jennifer, Bacus, Sarah
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Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells
Spector, Neil L, Yarden, Yosef, Smith, Bradley, Lyass, Ljuba, Trusk, Patricia, Pry, Karen, Hill, Jason E, Xia, Wenle, Seger, Rony, Bacus, Sarah S
Published in Proceedings of the National Academy of Sciences - PNAS (19.06.2007)
Published in Proceedings of the National Academy of Sciences - PNAS (19.06.2007)
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A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53
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Published in Science signaling (07.05.2013)
Published in Science signaling (07.05.2013)
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Regulation of survivin by ErbB2 signaling : Therapeutic implications for ErbB2-overexpressing breast cancers
WENLE XIA, BISI, John, WESTLUND, Ron E, SUMIN ZHAO, BACUS, Sarah, SPECTOR, Neil L, STRUM, Jay, LEIHUA LIU, CARRICK, Kevin, GRAHAM, Katherine M, TREECE, Amanda L, HARDWICKE, Mary Ann, DUSH, Michael, QIAOYIN LIAO
Published in Cancer research (Chicago, Ill.) (01.02.2006)
Published in Cancer research (Chicago, Ill.) (01.02.2006)
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Resistance to ErbB2 tyrosine kinase inhibitors in breast cancer is mediated by calcium-dependent activation of RelA
Xia, Wenle, Bacus, Sarah, Husain, Intisar, Liu, Leihua, Zhao, Sumin, Liu, Zuguo, Moseley, 3rd, M Arthur, Thompson, J Will, Chen, Franklin L, Koch, Kevin M, Spector, Neil L
Published in Molecular cancer therapeutics (01.02.2010)
Published in Molecular cancer therapeutics (01.02.2010)
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Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer
Cheng, Qing, Chang, Jeffrey T, Geradts, Joseph, Neckers, Leonard M, Haystead, Timothy, Spector, Neil L, Lyerly, H Kim
Published in Breast cancer research : BCR (17.04.2012)
Published in Breast cancer research : BCR (17.04.2012)
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Phase I pharmacokinetic studies evaluating single and multiple doses of oral GW572016, a dual EGFR-ErbB2 inhibitor, in healthy subjects
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Published in Investigational new drugs (01.01.2005)
Published in Investigational new drugs (01.01.2005)
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Delivery of a Healthy Baby After First-Trimester Maternal Exposure to Lapatinib
Kelly, Hanna, Graham, Mark, Humes, Elizabeth, Dorflinger, Laneta J., Boggess, Kim A., O'Neil, Bert H., Harris, Jennifer, Spector, Neil L., Dees, E. Claire
Published in Clinical breast cancer (01.10.2006)
Published in Clinical breast cancer (01.10.2006)
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