Thrombopoietin receptor agonist (TPO-RA) treatment raises platelet counts and reduces anti-platelet antibody levels in mice with immune thrombocytopenia (ITP)
Kapur, Rick, Aslam, Rukhsana, Speck, Edwin R., Rebetz, Johan M., Semple, John W.
Published in Platelets (Edinburgh) (02.04.2020)
Published in Platelets (Edinburgh) (02.04.2020)
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Journal Article
Mature murine megakaryocytes present antigen-MHC class I molecules to T cells and transfer them to platelets
Zufferey, Anne, Speck, Edwin R., Machlus, Kellie R., Aslam, Rukhsana, Guo, Li, McVey, Mark J., Kim, Michael, Kapur, Rick, Boilard, Eric, Italiano, Joseph E., Semple, John W.
Published in Blood advances (12.09.2017)
Published in Blood advances (12.09.2017)
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Journal Article
Platelet-bound lipopolysaccharide enhances Fc receptor–mediated phagocytosis of IgG-opsonized platelets
Semple, John W., Aslam, Rukhsana, Kim, Michael, Speck, Edwin R., Freedman, John
Published in Blood (01.06.2007)
Published in Blood (01.06.2007)
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Journal Article
Gastrointestinal microbiota contributes to the development of murine transfusion-related acute lung injury
Kapur, Rick, Kim, Michael, Rebetz, Johan, Hallström, Björn, Björkman, Jonas T., Takabe-French, Alisa, Kim, Noel, Liu, Jonathan, Shanmugabhavananthan, Shanjeevan, Milosevic, Stefan, McVey, Mark J., Speck, Edwin R., Semple, John W.
Published in Blood advances (10.07.2018)
Published in Blood advances (10.07.2018)
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Journal Article
T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10
Kapur, Rick, Kim, Michael, Aslam, Rukhsana, McVey, Mark J., Tabuchi, Arata, Luo, Alice, Liu, Jonathan, Li, Yuan, Shanmugabhavananthan, Shanjeevan, Speck, Edwin R., Zufferey, Anne, Yousef, George, Zhang, Haibo, Rondina, Matthew T., Weyrich, Andrew S., Porcelijn, Leendert, Kuebler, Wolfgang M., Slutsky, Arthur S., Semple, John W.
Published in Blood (04.05.2017)
Published in Blood (04.05.2017)
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Journal Article
CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell–mediated immune thrombocytopenia
Guo, Li, Kapur, Rick, Aslam, Rukshana, Speck, Edwin R., Zufferey, Anne, Zhao, Yajing, Kim, Michael, Lazarus, Alan H., Ni, Heyu, Semple, John W.
Published in Blood (11.02.2016)
Published in Blood (11.02.2016)
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Journal Article
Platelet and red blood cell phagocytosis kinetics are differentially controlled by phosphatase activity within mononuclear cells
Aslam, Rukhsana, Kim, Michael, Speck, Edwin R., Seetanah, Arjuna Contram, Molinski, Steven, Freedman, John, Semple, John W.
Published in Transfusion (Philadelphia, Pa.) (01.11.2007)
Published in Transfusion (Philadelphia, Pa.) (01.11.2007)
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Journal Article
Evaluation of Platelet Gel Characteristics Using Thrombin Produced by the Thrombin Processing Device: A Comparative Study
Semple, Elisabeth, PhD, Speck, Edwin R., BRT, Aslam, Rukhsana, PhD, Kim, Michael, BSc, Kumar, Vijay, PhD, Semple, John W., PhD
Published in Journal of oral and maxillofacial surgery (01.04.2008)
Published in Journal of oral and maxillofacial surgery (01.04.2008)
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Journal Article
A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell–mediated responses that are differentially sensitive to therapy
Chow, Leola, Aslam, Rukhsana, Speck, Edwin R., Kim, Michael, Cridland, Norman, Webster, Michelle Lee, Chen, Pingguo, Sahib, Kim, Ni, Heyu, Lazarus, Alan H., Garvey, M. Bernadette, Freedman, John, Semple, John W.
Published in Blood (11.02.2010)
Published in Blood (11.02.2010)
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Journal Article
DJ-1/PARK7 Impairs Bacterial Clearance in Sepsis
Amatullah, Hajera, Shan, Yuexin, Beauchamp, Brittany L, Gali, Patricia L, Gupta, Sahil, Maron-Gutierrez, Tatiana, Speck, Edwin R, Fox-Robichaud, Alison E, Tsang, Jennifer L Y, Mei, Shirley H J, Mak, Tak W, Rocco, Patricia R M, Semple, John W, Zhang, Haibo, Hu, Pingzhao, Marshall, John C, Stewart, Duncan J, Harper, Mary-Ellen, Liaw, Patricia C, Liles, W Conrad, Dos Santos, Claudia C
Published in American journal of respiratory and critical care medicine (01.04.2017)
Published in American journal of respiratory and critical care medicine (01.04.2017)
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Journal Article
Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia
Aslam, Rukhsana, Hu, Yu, Gebremeskel, Simon, Segel, George B., Speck, Edwin R., Guo, Li, Kim, Michael, Ni, Heyu, Freedman, John, Semple, John W.
Published in Blood (06.09.2012)
Published in Blood (06.09.2012)
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Journal Article
Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-α production in vivo
Aslam, Rukhsana, Speck, Edwin R., Kim, Michael, Crow, Andrew R., Bang, K. W. Annie, Nestel, Frederick P., Ni, Heyu, Lazarus, Alan H., Freedman, John, Semple, John W.
Published in Blood (15.01.2006)
Published in Blood (15.01.2006)
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Journal Article
Transfusion-related immunomodulation by platelets is dependent on their expression of MHC Class I molecules and is independent of white cells
Aslam, Rukhsana, Speck, Edwin R., Kim, Michael, Freedman, John, Semple, John W.
Published in Transfusion (Philadelphia, Pa.) (01.09.2008)
Published in Transfusion (Philadelphia, Pa.) (01.09.2008)
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Journal Article
Allogeneic platelet transfusions prevent murine T-cell–mediated immune thrombocytopenia
Guo, Li, Yang, Lei, Speck, Edwin R., Aslam, Rukhsana, Kim, Michael, McKenzie, Christopher G.J., Lazarus, Alan H., Ni, Heyu, Hou, Ming, Freedman, John, Semple, John W.
Published in Blood (16.01.2014)
Published in Blood (16.01.2014)
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Journal Article
Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury
Fung, Yoke Lin, Kim, Michael, Tabuchi, Arata, Aslam, Rukhsana, Speck, Edwin R., Chow, Leola, Kuebler, Wolfgang M., Freedman, John, Semple, John W.
Published in Blood (21.10.2010)
Published in Blood (21.10.2010)
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Journal Article
Epitope specificity and isotype of monoclonal anti-D antibodies dictate their ability to inhibit phagocytosis of opsonized platelets
Kjaersgaard, Mimi, Aslam, Rukhsana, Kim, Michael, Speck, Edwin R., Freedman, John, Stewart, Donald I.H., Wiersma, Erik J., Semple, John W.
Published in Blood (15.08.2007)
Published in Blood (15.08.2007)
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Journal Article
A novel immunosuppressive pathway involving peroxynitrate-mediated nitration of platelet antigens within antigen-presenting cells
Semple, John W., Speck, Edwin R., Fabron Jr, Antonio, Kim, Rukhsana Aslam Michael, Freedman, John
Published in Transfusion (Philadelphia, Pa.) (01.09.2008)
Published in Transfusion (Philadelphia, Pa.) (01.09.2008)
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Journal Article
Immune responsiveness against allogeneic platelet transfusions is determined by the recipient's major histocompatibility complex class II phenotype
Sayeh, Ebrahim, Aslam, Rukshana, Speck, Edwin R., Le-Tien, Hoang, Lazarus, Alan H., Freedman, John, Semple, John W.
Published in Transfusion (Philadelphia, Pa.) (01.11.2004)
Published in Transfusion (Philadelphia, Pa.) (01.11.2004)
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