Cysteine protecting groups: applications in peptide and protein science
Spears, Richard J, McMahon, Clíona, Chudasama, Vijay
Published in Chemical Society reviews (04.10.2021)
Published in Chemical Society reviews (04.10.2021)
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Journal Article
Tyrosine bioconjugation - an emergent alternative
Szijj, Peter A, Kostadinova, Kristina A, Spears, Richard J, Chudasama, Vijay
Published in Organic & biomolecular chemistry (28.11.2020)
Published in Organic & biomolecular chemistry (28.11.2020)
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Journal Article
Site-selective C-C modification of proteins at neutral pH using organocatalyst-mediated cross aldol ligations
Spears, Richard J., Brabham, Robin L., Budhadev, Darshita, Keenan, Tessa, McKenna, Sophie, Walton, Julia, Brannigan, James. A., Brzozowski, A. Marek, Wilkinson, Anthony J., Plevin, Michael, Fascione, Martin A.
Published in Chemical science (Cambridge) (2018)
Published in Chemical science (Cambridge) (2018)
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Journal Article
Correction: Tyrosine bioconjugation - an emergent alternative
Szijj, Peter A, Kostadinova, Kristina A, Spears, Richard J, Chudasama, Vijay
Published in Organic & biomolecular chemistry (09.11.2022)
Published in Organic & biomolecular chemistry (09.11.2022)
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Journal Article
Reperfusion Injury in Patients With Acute Myocardial Infarction: JACC Scientific Statement
Welt, Frederick G P, Batchelor, Wayne, Spears, J Richard, Penna, Claudia, Pagliaro, Pasquale, Ibanez, Borja, Drakos, Stavros G, Dangas, George, Kapur, Navin K
Published in Journal of the American College of Cardiology (04.06.2024)
Published in Journal of the American College of Cardiology (04.06.2024)
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Journal Article
Disulfide Modified IgG1: An Investigation of Biophysical Profile and Clinically Relevant Fc Interactions
Bahou, Calise, Love, Elizabeth A, Leonard, Siobhán, Spears, Richard J, Maruani, Antoine, Armour, Kathryn, Baker, James R, Chudasama, Vijay
Published in Bioconjugate chemistry (17.04.2019)
Published in Bioconjugate chemistry (17.04.2019)
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Journal Article
Unearthing the unique stability of thiophosphonium-C-terminal cysteine adducts on peptides and proteins
Spears, Richard J, Chrzastek, Alina, Yap, Steven Y, Karu, Kersti, Aliev, Abil E, Baker, James R, Chudasama, Vijay
Published in Chemical communications (Cambridge, England) (28.04.2022)
Published in Chemical communications (Cambridge, England) (28.04.2022)
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Journal Article
Chemo- and regio-selective differential modification of native cysteines on an antibody via the use of dehydroalanine forming reagents
Yap, Steven Y., Butcher, Tobias, Spears, Richard J., McMahon, Clíona, Thanasi, Ioanna A., Baker, James R., Chudasama, Vijay
Published in Chemical science (Cambridge) (2024)
Published in Chemical science (Cambridge) (2024)
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Journal Article
A Plug-and-Play Platform for the Formation of Trifunctional Cysteine Bioconjugates that also Offers Control over Thiol Cleavability
Bahou, Calise, Szijj, Peter A, Spears, Richard J, Wall, Archie, Javaid, Faiza, Sattikar, Afrah, Love, Elizabeth A, Baker, James R, Chudasama, Vijay
Published in Bioconjugate chemistry (21.04.2021)
Published in Bioconjugate chemistry (21.04.2021)
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Journal Article
Correction: Use of pyridazinediones as extracellular cleavable linkers through reversible cysteine conjugation
Bahou, Calise, Spears, Richard J, Aliev, Abil E, Maruani, Antoine, Fernandez, Marcos, Javaid, Faiza, Szijj, Peter A, Baker, James R, Chudasama, Vijay
Published in Chemical communications (Cambridge, England) (15.11.2022)
Published in Chemical communications (Cambridge, England) (15.11.2022)
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Journal Article
Use of pyridazinediones as extracellular cleavable linkers through reversible cysteine conjugation
Bahou, Calise, Spears, Richard J, Aliev, Abil E, Maruani, Antoine, Fernandez, Marcos, Javaid, Faiza, Szijj, Peter A, Baker, James R, Chudasama, Vijay
Published in Chemical communications (Cambridge, England) (05.12.2019)
Published in Chemical communications (Cambridge, England) (05.12.2019)
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Journal Article
Cross aldol OPAL bioconjugation outcompetes intramolecular hemiaminal cyclisation of proline adjacent N-terminal α-oxo aldehydes at acidic pH
Tufail, Afzaal, Akkad, Saeed, Hatton, Natasha E, Yates, Nicholas D. J, Spears, Richard J, Keenan, Tessa, Parkin, Alison, Signoret, Nathalie, Fascione, Martin A
Published in RSC advances (23.01.2024)
Published in RSC advances (23.01.2024)
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Journal Article
A novel thiol-labile cysteine protecting group for peptide synthesis based on a pyridazinedione (PD) scaffold
Spears, Richard J, McMahon, Clíona, Shamsabadi, Monika, Bahou, Calise, Thanasi, Ioanna A, Rochet, Léa N. C, Forte, Nafsika, Thoreau, Fabien, Baker, James R, Chudasama, Vijay
Published in Chemical communications (Cambridge, England) (13.01.2022)
Published in Chemical communications (Cambridge, England) (13.01.2022)
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Journal Article
Hydrogel Cross-Linking via Thiol-Reactive Pyridazinediones
Bahou, Calise, Spears, Richard J., Ramírez Rosales, Angela M., Rochet, Léa N. C., Barber, Lydia J., Stankevich, Ksenia S., Miranda, Juliana F., Butcher, Tobias C., Kerrigan, Adam M., Lazarov, Vlado K., Grey, William, Chudasama, Vijay, Spicer, Christopher D.
Published in Biomacromolecules (13.11.2023)
Published in Biomacromolecules (13.11.2023)
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Journal Article
A Tale of Two Bioconjugations: pH Controlled Divergent Reactivity of Protein α-oxo-Aldehydes in Competing α-oxo-Mannich and Catalyst-Free Aldol Ligations
Keenan, Tessa, Spears, Richard J, Akkad, Saeed, Mahon, Clare S, Hatton, Natasha E, Walton, Julia, Noble, Amanda, Yates, Nicholas D, Baumann, Christoph G, Parkin, Alison, Signoret, Nathalie, Fascione, Martin A
Published in ACS chemical biology (19.11.2021)
Published in ACS chemical biology (19.11.2021)
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Journal Article
Evidence for a Boat Conformation at the Transition State of GH76 α-1,6-Mannanases-Key Enzymes in Bacterial and Fungal Mannoprotein Metabolism
Thompson, Andrew J., Speciale, Gaetano, Iglesias-Fernández, Javier, Hakki, Zalihe, Belz, Tyson, Cartmell, Alan, Spears, Richard J., Chandler, Emily, Temple, Max J., Stepper, Judith, Gilbert, Harry J., Rovira, Carme, Williams, Spencer J., Davies, Gideon J.
Published in Angewandte Chemie (International ed.) (27.04.2015)
Published in Angewandte Chemie (International ed.) (27.04.2015)
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Journal Article