CAR T-cell-mediated delivery of bispecific innate immune cell engagers for neuroblastoma
Pascual-Pasto, Guillem, McIntyre, Brendan, Hines, Margaret G, Giudice, Anna M, Garcia-Gerique, Laura, Hoffmann, Jennifer, Mishra, Pamela, Matlaga, Stephanie, Lombardi, Simona, Shraim, Rawan, Schürch, Patrick M, Yarmarkovich, Mark, Hofmann, Ted J, Alikarami, Fatemeh, Martinez, Daniel, Tsang, Matthew, Gil-de-Gómez, Luis, Spear, Timothy T, Bernt, Kathrin M, Wolpaw, Adam J, Dimitrov, Dimiter S, Li, Wei, Bosse, Kristopher R
Published in Nature communications (21.08.2024)
Published in Nature communications (21.08.2024)
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Journal Article
How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire
Blevins, Sydney J., Pierce, Brian G., Singh, Nishant K., Riley, Timothy P., Wang, Yuan, Spear, Timothy T., Nishimura, Michael I., Weng, Zhiping, Baker, Brian M.
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
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Journal Article
HCV T Cell Receptor Chain Modifications to Enhance Expression, Pairing, and Antigen Recognition in T Cells for Adoptive Transfer
Foley, Kendra C., Spear, Timothy T., Murray, David C., Nagato, Kaoru, Garrett-Mayer, Elizabeth, Nishimura, Michael I.
Published in Molecular therapy. Oncolytics (16.06.2017)
Published in Molecular therapy. Oncolytics (16.06.2017)
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Journal Article
Strategies to genetically engineer T cells for cancer immunotherapy
Spear, Timothy T., Nagato, Kaoru, Nishimura, Michael I.
Published in Cancer Immunology, Immunotherapy (01.06.2016)
Published in Cancer Immunology, Immunotherapy (01.06.2016)
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Journal Article
Book Review
How an alloreactive T-cell receptor achieves peptide and MHC specificity
Wang, Yuan, Singh, Nishant K., Spear, Timothy T., Hellman, Lance M., Piepenbrink, Kurt H., McMahan, Rachel H., Rosen, Hugo R., Vander Kooi, Craig W., Nishimura, Michael I., Baker, Brian M.
Published in Proceedings of the National Academy of Sciences - PNAS (13.06.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (13.06.2017)
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Journal Article
Differential scanning fluorimetry based assessments of the thermal and kinetic stability of peptide–MHC complexes
Hellman, Lance M., Yin, Liusong, Wang, Yuan, Blevins, Sydney J., Riley, Timothy P., Belden, Orrin S., Spear, Timothy T., Nishimura, Michael I., Stern, Lawrence J., Baker, Brian M.
Published in Journal of immunological methods (01.05.2016)
Published in Journal of immunological methods (01.05.2016)
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Journal Article
TCR gene-modified T cells can efficiently treat established hepatitis C-associated hepatocellular carcinoma tumors
Spear, Timothy T., Callender, Glenda G., Roszkowski, Jeffrey J., Moxley, Kelly M., Simms, Patricia E., Foley, Kendra C., Murray, David C., Scurti, Gina M., Li, Mingli, Thomas, Justin T., Langerman, Alexander, Garrett-Mayer, Elizabeth, Zhang, Yi, Nishimura, Michael I.
Published in Cancer Immunology, Immunotherapy (01.03.2016)
Published in Cancer Immunology, Immunotherapy (01.03.2016)
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Journal Article
Altered Peptide Ligands Impact the Diversity of Polyfunctional Phenotypes in T Cell Receptor Gene-Modified T Cells
Spear, Timothy T., Wang, Yuan, Smith, Thomas W., Simms, Patricia E., Garrett-Mayer, Elizabeth, Hellman, Lance M., Baker, Brian M., Nishimura, Michael I.
Published in Molecular therapy (04.04.2018)
Published in Molecular therapy (04.04.2018)
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Journal Article
Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells
Spear, Timothy T., Wang, Yuan, Foley, Kendra C., Murray, David C., Scurti, Gina M., Simms, Patricia E., Garrett-Mayer, Elizabeth, Hellman, Lance M., Baker, Brian M., Nishimura, Michael I.
Published in Cancer Immunology, Immunotherapy (01.11.2017)
Published in Cancer Immunology, Immunotherapy (01.11.2017)
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Journal Article
Regression of renal cell carcinoma by T cell receptor-engineered T cells targeting a human endogenous retrovirus
Barisic, Stefan, Brahmbhatt, Elizabeth M, Cherkasova, Elena, Spear, Timothy T, Savani, Ujjawal, Pierre, Stephanie, Scurti, Gina M, Chen, Long, Igboko, Muna, Nadal, Rosa, Zeng, Gang, Parry, Gordon, Stroncek, David F, Highfill, Steven, Dalheim, Annika V, Reger, Robert, Nishimura, Michael I, Childs, Richard W
Published in Journal for immunotherapy of cancer (01.09.2024)
Published in Journal for immunotherapy of cancer (01.09.2024)
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Journal Article
Hepatitis C virus‐cross‐reactive TCR gene‐modified T cells: a model for immunotherapy against diseases with genomic instability
Spear, Timothy T., Riley, Timothy P., Lyons, Gretchen E., Callender, Glenda G., Roszkowski, Jeffrey J., Wang, Yuan, Simms, Patricia E., Scurti, Gina M., Foley, Kendra C., Murray, David C., Hellman, Lance M., McMahan, Rachel H., Iwashima, Makio, Garrett‐Mayer, Elizabeth, Rosen, Hugo R., Baker, Brian M., Nishimura, Michael I.
Published in Journal of leukocyte biology (01.09.2016)
Published in Journal of leukocyte biology (01.09.2016)
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Journal Article
A Real-World, Single Institution, Post-Market Comparison of Pegaspargase and Calasparagase Pegol-Mknl Therapeutic Drug Monitoring and Toxicity
Spear, Timothy T, Oranges, Katelyn, McDonough, Sara, Ma, Yiming, Gerace, Carolyn, Phillips, Charles A, Rheingold, Susan R
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
T cell receptor-engineered T cells targeting a human endogenous retrovirus in kidney cancer
Barisic, Stefan, Brahmbhatt, Elizabeth M., Cherkasova, Elena, Nadal, Rosa, Savani, Ujjawal, Pierre, Stephanie, Chen, Long, Spear, Timothy T., Scurti, Gina M., Zeng, Gang, Parry, Gordon, Stroncek, David F., Highfill, Steven L., Dalheim, Annika V., Reger, Robert N., Nishimura, Michael I., Childs, Richard W.
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Journal Article
Abstract 5121: Next-generation immunocompetent and humanized neuroblastoma murine models for the discovery and validation of novel immunotherapies
Spear, Timothy T., Posthill, Elisabeth, Groff, David, Giudice, Anna M., Bosse, Kristopher R., Ma, Leyuan, Schoenberger, Stephen P., Maris, John M.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
How structural adaptability exists alongside HLA-A2 bias in the human a beta TCR repertoire
Blevins, Sydney J, Pierce, Brian G, Singh, Nishant K, Riley, Timothy P, Wang, Yuan, Spear, Timothy T, Nishimura, Michael I, Weng, Zhiping, Baker, Brian M
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
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Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
Journal Article
How structural adaptability exists alongside HLA-A2 bias in the human a[Beta] TCR repertoire
Blevins, Sydney J, Pierce, Brian G, Singh, Nishant K, Riley, Timothy P, Wang, Yuan, Spear, Timothy T, Nishimura, Michael I, Weng, Zhiping, Baker, Brian M
Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
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Published in Proceedings of the National Academy of Sciences - PNAS (01.03.2016)
Journal Article
Hepatitis C virus-cross-reactive TCR gene-modified T cells: A model for immunotherapy against diseases with genomic instability
Spear, Timothy T, Riley, Timothy, Foley, Kendra C, Murray, David C, Simms, Patricia E, Scurti, Gina M, Wang, Yuan, Hellman, Lance M, McMahan, Rachel H, Rosen, Hugo R, Baker, Brian M, Nishimura, Michael I
Published in The Journal of immunology (1950) (01.05.2016)
Published in The Journal of immunology (1950) (01.05.2016)
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Journal Article