PI3K/mTOR inhibitor omipalisib prolongs cardiac repolarization along with a mild proarrhythmic outcome in the AV block dog model
van Bavel, J. J. A., Pham, C., Beekman, H. D. M., Houtman, M. J. C., Bossu, A., Sparidans, R. W., van der Heyden, M. A. G., Vos, M. A.
Published in Frontiers in cardiovascular medicine (03.08.2022)
Published in Frontiers in cardiovascular medicine (03.08.2022)
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Development and validation of a quantitative assay for the measurement of two HIV-fusion inhibitors, enfuvirtide and tifuvirtide, and one metabolite of enfuvirtide (M-20) in human plasma by liquid chromatography–tandem mass spectrometry
van den Broek, I., Sparidans, R.W., Huitema, A.D.R., Schellens, J.H.M., Beijnen, J.H.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (06.06.2006)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (06.06.2006)
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Phase I and pharmacological study of the farnesyltransferase inhibitor tipifarnib (Zarnestra , R115777) in combination with gemcitabine and cisplatin in patients with advanced solid tumours
SIEGEL-LAKHAI, W. S, CRUL, M, ZHANG, S, SPARIDANS, R. W, PLUIM, D, HOWES, A, SOLANKI, B, BEIJNEN, J. H, SCHELLENS, J. H. M
Published in British journal of cancer (28.11.2005)
Published in British journal of cancer (28.11.2005)
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Bioanalysis of ibrutinib, and its dihydrodiol- and glutathione cycle metabolites by liquid chromatography-tandem mass spectrometry
Rood, J.J.M., Dormans, P.J.A., van Haren, M.J., Schellens, J.H.M., Beijnen, J.H., Sparidans, R.W.
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.07.2018)
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15.07.2018)
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Bioanalysis of EGFRm inhibitor osimertinib, and its glutathione cycle- and desmethyl metabolites by liquid chromatography-tandem mass spectrometry
Rood, J.J.M., van Haren, M.J., Beijnen, J.H., Sparidans, R.W.
Published in Journal of pharmaceutical and biomedical analysis (05.01.2020)
Published in Journal of pharmaceutical and biomedical analysis (05.01.2020)
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Isolated lung perfusion with melphalan: Pharmacokinetics and toxicity in a pig model
van der Elst, A., Oosterling, S.J., Paul, M.A., Vonk, A.M.A., Sparidans, R.W., van der Sijp, J.R.M.
Published in Journal of surgical oncology (01.04.2006)
Published in Journal of surgical oncology (01.04.2006)
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High-performance ion-exchange chromatography with in-line complexation of bisphosphonates and their quality control in pharmaceutical preparations
Sparidans, Rolf W., den Hartigh, Jan, Vermeij, Pieter
Published in Journal of pharmaceutical and biomedical analysis (01.11.1995)
Published in Journal of pharmaceutical and biomedical analysis (01.11.1995)
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The determination of pamidronate in pharmaceutical preparations by ion-pair liquid chromatography after derivatization with phenylisothiocyanate
Sparidans, Rolf W, den Hartigh, Jan, Ramp-Koopmanschap, Willy M, Langebroek, Ria H, Vermeij, Pieter
Published in Journal of pharmaceutical and biomedical analysis (01.11.1997)
Published in Journal of pharmaceutical and biomedical analysis (01.11.1997)
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Hepatic artery infusion of high-dose melphalan at reduced flow during isolated hepatic perfusion for the treatment of colorectal metastases confined to the liver: A clinical and pharmacologic evaluation
van Iersel, L.B.J, Verlaan, M.R, Vahrmeijer, A.L, van Persijn van Meerten, E.L, Tijl, F.G.J, Sparidans, R.W, Gelderblom, H, Kuppen, P.J.K, Tollenaar, R.A.E.M, van de Velde, C.J.H
Published in European journal of surgical oncology (01.09.2007)
Published in European journal of surgical oncology (01.09.2007)
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Drug-Drug Interaction between Itraconazole and the Antiretroviral Drug Lopinavir/Ritonavir in an HIV-1-Infected Patient with Disseminated Histoplasmosis
Crommentuyn, Kristel M. L., Mulder, Jan W., Sparidans, Rolf W., Huitema, Alwin D. R., Schellens, Jan H. M., Beijnen, Jos H.
Published in Clinical infectious diseases (15.04.2004)
Published in Clinical infectious diseases (15.04.2004)
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In-vitro cytotoxicity of ET-743 (Trabectedin, Yondelis), a marine anti-cancer drug, in the Hep G2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction
Brandon, Esther F A, Meijerman, Irma, Klijn, Joyce S, den Arend, Dineke, Sparidans, Rolf W, Lázaro, Louis López, Beijnen, Jos H, Schellens, Jan H M
Published in Anti-cancer drugs (01.10.2005)
Published in Anti-cancer drugs (01.10.2005)
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Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man
Sparidans, R W, Rosing, H, Hillebrand, M J, López-Lázaro, L, Jimeno, J M, Manzanares, I, van Kesteren, C, Cvitkovic, E, van Oosterom, A T, Schellens, J H, Beijnen, J H
Published in Anti-cancer drugs (01.09.2001)
Published in Anti-cancer drugs (01.09.2001)
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Journal Article
Sensitive liquid chromatographic assay for amprenavir, a human immunodeficiency virus protease inhibitor, in human plasma, cerebrospinal fluid and semen
Sparidans, Rolf W, Hoetelmans, Richard M.W, Beijnen, Jos H
Published in Journal of chromatography. B, Biomedical sciences and applications (26.05.2000)
Published in Journal of chromatography. B, Biomedical sciences and applications (26.05.2000)
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Journal Article
Chromatographic analysis of bisphosphonates
Sparidans, Rolf W, den Hartigh, Jan, Cremers, Serge, Vermeij, Pieter
Published in Journal of Chromatography A (28.01.2000)
Published in Journal of Chromatography A (28.01.2000)
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Journal Article
Quantitative determination of abacavir (1592U89), a novel nucleoside reverse transcriptase inhibitor, in human plasma using isocratic reversed-phase high-performance liquid chromatography with ultraviolet detection
Veldkamp, Agnes I, Sparidans, Rolf W, Hoetelmans, Richard M.W, Beijnen, Jos H
Published in Journal of chromatography. B, Biomedical sciences and applications (24.12.1999)
Published in Journal of chromatography. B, Biomedical sciences and applications (24.12.1999)
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Journal Article
Improved and simplified liquid chromatographic assay for adefovir, a novel antiviral drug, in human plasma using derivatization with chloroacetaldehyde
Sparidans, Rolf W, Veldkamp, Agnes, Hoetelmans, Richard M.W, Beijnen, Jos H
Published in Journal of chromatography. B, Biomedical sciences and applications (24.12.1999)
Published in Journal of chromatography. B, Biomedical sciences and applications (24.12.1999)
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Journal Article
Semi-automatic liquid chromatographic analysis of olpadronate in urine and serum using derivatization with (9-fluorenylmethyl)chloroformate
Sparidans, Rolf W, den Hartigh, Jan, Cremers, Serge, Beijnen, Jos H, Vermeij, Pieter
Published in Journal of chromatography. B, Biomedical sciences and applications (11.02.2000)
Published in Journal of chromatography. B, Biomedical sciences and applications (11.02.2000)
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