Direct Involvement of Retinoblastoma Family Proteins in DNA Repair by Non-homologous End-Joining
Cook, Rebecca, Zoumpoulidou, Georgia, Luczynski, Maciej T., Rieger, Simone, Moquet, Jayne, Spanswick, Victoria J., Hartley, John A., Rothkamm, Kai, Huang, Paul H., Mittnacht, Sibylle
Published in Cell reports (Cambridge) (31.03.2015)
Published in Cell reports (Cambridge) (31.03.2015)
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Repair of DNA interstrand crosslinks: molecular mechanisms and clinical relevance
McHugh, Peter J, Spanswick, Victoria J, Hartley, John A
Published in The lancet oncology (01.08.2001)
Published in The lancet oncology (01.08.2001)
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Phase I Study of Sequence-Selective Minor Groove DNA Binding Agent SJG-136 in Patients with Advanced Solid Tumors
HOCHHAUSER, Daniel, MEYER, Timothy, JODRELL, Duncan, SPANSWICK, VictoriaJ, WU, Jenny, CLINGEN, Peter H, LOADMAN, Paul, COBB, Margaret, GUMBRELL, Lindsey, BEGENT, Richard H, HARTLEY, John A
Published in Clinical cancer research (15.03.2009)
Published in Clinical cancer research (15.03.2009)
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Evidence for different mechanisms of 'unhooking' for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples
Spanswick, Victoria J, Lowe, Helen L, Newton, Claire, Bingham, John P, Bagnobianchi, Alessia, Kiakos, Konstantinos, Craddock, Charles, Ledermann, Jonathan A, Hochhauser, Daniel, Hartley, John A
Published in BMC cancer (28.09.2012)
Published in BMC cancer (28.09.2012)
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Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma
Spanswick, Victoria J., Craddock, Charles, Sekhar, Mallika, Mahendra, Prem, Shankaranarayana, Paneesha, Hughes, R. George, Hochhauser, Daniel, Hartley, John A.
Published in Blood (01.07.2002)
Published in Blood (01.07.2002)
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PANTHER: AZD8931, inhibitor of EGFR, ERBB2 and ERBB3 signalling, combined with FOLFIRI: a Phase I/II study to determine the importance of schedule and activity in colorectal cancer
Propper, David J., Gao, Fangfei, Saunders, Mark P., Sarker, Debashis, Hartley, John A., Spanswick, Victoria J., Lowe, Helen L., Hackett, Louise D., Ng, Tony T., Barber, Paul R., Weitsman, Gregory E., Pearce, Sarah, White, Laura, Lopes, Andre, Forsyth, Sharon, Hochhauser, Daniel
Published in British journal of cancer (19.01.2023)
Published in British journal of cancer (19.01.2023)
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γ-H2AX Foci Formation as a Pharmacodynamic Marker of DNA Damage Produced by DNA Cross-Linking Agents: Results from 2 Phase I Clinical Trials of SJG-136 (SG2000)
WU, Jenny, CLINGEN, Peter H, SPANSWICK, Victoria J, MELLINAS-GOMEZ, Maria, MEYER, Tim, PUZANOV, Igor, JODRELL, Duncan, HOCHHAUSER, Daniel, HARTLEY, John A
Published in Clinical cancer research (01.02.2013)
Published in Clinical cancer research (01.02.2013)
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Time-dependent cytotoxicity induced by SJG-136 (NSC 694501): influence of the rate of interstrand cross-link formation on DNA damage signaling
Arnould, Stéphanie, Spanswick, Victoria J, Macpherson, Janet S, Hartley, John A, Thurston, David E, Jodrell, Duncan I, Guichard, Sylvie M
Published in Molecular cancer therapeutics (01.06.2006)
Published in Molecular cancer therapeutics (01.06.2006)
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Phase I Pharmacokinetic and Pharmacodynamic Study of SJG-136, a Novel DNA Sequence Selective Minor Groove Cross-linking Agent, in Advanced Solid Tumors
PUZANOV, Igor, LEE, Wooin, ROTHENBERG, Mace L, CHEN, Alice P, WADE CALCUTT, M, HACHEY, David L, VERMEULEN, Wendy L, SPANSWICK, Victoria J, LIAO, Chih-Yi, HARTLEY, John A, BERLIN, Jordan D
Published in Clinical cancer research (01.06.2011)
Published in Clinical cancer research (01.06.2011)
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Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment
Ip, Laura R H, Poulogiannis, George, Viciano, Felipe Cia, Sasaki, Junko, Kofuji, Satoshi, Spanswick, Victoria J, Hochhauser, Daniel, Hartley, John A, Sasaki, Takehiko, Gewinner, Christina A
Published in Oncotarget (30.04.2015)
Published in Oncotarget (30.04.2015)
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Inhibition of Carboplatin-Induced DNA Interstrand Cross-link Repair by Gemcitabine in Patients Receiving these Drugs for Platinum-Resistant Ovarian Cancer
LEDERMANN, Jonathan A, GABRA, Hani, JAYSON, Gordon C, SPANSWICK, Victoria J, RUSTIN, Gordon J. S, JITLAL, Mark, JAMES, Lindsay E, HARTLEY, John A
Published in Clinical cancer research (01.10.2010)
Published in Clinical cancer research (01.10.2010)
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SJG-136 (NSC 694501), a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity. Part 1: Cellular pharmacology, in vitro and initial in vivo antitumor activity
HARTLEY, John A, SPANSWICK, Victoria J, HOLLINGSHEAD, Melinda G, SCHWEIKART, Karen M, TOMASZEWSKI, Joseph E, SAUSVILLE, Edward A, GREGSON, Stephen J, HOWARD, Philip W, THURSTON, David E, BROOKS, Natalie, CLINGEN, Peter H, MCHUGH, Peter J, HOCHHAUSER, Daniel, PEDLEY, R. Barbara, KELLAND, Lloyd R, ALLEY, Michael C, SCHULTZ, Robert
Published in Cancer research (Chicago, Ill.) (15.09.2004)
Published in Cancer research (Chicago, Ill.) (15.09.2004)
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Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours
Mellinas-Gomez, Maria, Spanswick, Victoria J, Paredes-Moscosso, Solange R, Robson, Matthew, Pedley, R Barbara, Thurston, David E, Baines, Stephen J, Stell, Anneliese, Hartley, John A
Published in BMC veterinary research (19.08.2015)
Published in BMC veterinary research (19.08.2015)
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Pharmacokinetics, pharmacodynamics and metabolism of the dimeric pyrrolobenzodiazepine SJG-136 in rats
Reid, Joel M., Buhrow, Sarah A., Kuffel, Mary J., Jia, Lee, Spanswick, Victoria J., Hartley, John A., Thurston, David E., Tomaszewski, Joseph E., Ames, Matthew M.
Published in Cancer chemotherapy and pharmacology (01.09.2011)
Published in Cancer chemotherapy and pharmacology (01.09.2011)
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Quinone oxidoreductase-2-mediated prodrug cancer therapy
Middleton, Mark R, Knox, Richard, Cattell, Emma, Oppermann, Udo, Midgley, Rachel, Ali, Raghib, Auton, Tim, Agarwal, Roshan, Anderson, David, Sarker, Debashis, Judson, Ian, Osawa, Tsuyoshi, Spanswick, Victoria J, Davies, Scot, Hartley, John A, Kerr, David J
Published in Science translational medicine (14.07.2010)
Published in Science translational medicine (14.07.2010)
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Synthesis and biological evaluation of novel pyrrolo[2,1- c][1,4]benzodiazepine prodrugs for use in antibody-directed enzyme prodrug therapy
Masterson, Luke A., Spanswick, Victoria J., Hartley, John A., Begent, Richard H., Howard, Philip W., Thurston, David E.
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
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Autologous plasma activates Akt/protein kinase B and enhances basal survival and resistance to DNA damage‐induced apoptosis in B‐chronic lymphocytic leukaemia cells
Wickremasinghe, R. Gitendra, Ganeshaguru, Kanagasabai, Jones, Dylan T., Lindsay, Caroline, Spanswick, Victoria J., Hartley, John A., Wadhwa, Meenu, Thorpe, Robin, Hoffbrand, A. Victor, Prentice, H. Grant, Mehta, Atul B.
Published in British journal of haematology (01.09.2001)
Published in British journal of haematology (01.09.2001)
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