Successful Transfer of Umbilical Cord Blood CD34 + Hematopoietic Stem and Progenitor-derived NK Cells in Older Acute Myeloid Leukemia Patients
Dolstra, Harry, Roeven, Mieke W H, Spanholtz, Jan, Hangalapura, Basav N, Tordoir, Marleen, Maas, Frans, Leenders, Marij, Bohme, Fenna, Kok, Nina, Trilsbeek, Carel, Paardekooper, Jos, van der Waart, Anniek B, Westerweel, Peter E, Snijders, Tjeerd J F, Cornelissen, Jan, Bos, Gerard, Pruijt, Hans F M, de Graaf, Aniek O, van der Reijden, Bert A, Jansen, Joop H, van der Meer, Arnold, Huls, Gerwin, Cany, Jeannette, Preijers, Frank, Blijlevens, Nicole M A, Schaap, Nicolaas M
Published in Clinical cancer research (01.08.2017)
Published in Clinical cancer research (01.08.2017)
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Natural killer cells in clinical development as non-engineered, engineered, and combination therapies
Lamers-Kok, Nina, Panella, Denise, Georgoudaki, Anna-Maria, Liu, Haiping, Özkazanc, Didem, Kučerová, Lucia, Duru, Adil Doganay, Spanholtz, Jan, Raimo, Monica
Published in Journal of hematology and oncology (08.11.2022)
Published in Journal of hematology and oncology (08.11.2022)
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Clinical-grade generation of active NK cells from cord blood hematopoietic progenitor cells for immunotherapy using a closed-system culture process
Spanholtz, Jan, Preijers, Frank, Tordoir, Marleen, Trilsbeek, Carel, Paardekooper, Jos, de Witte, Theo, Schaap, Nicolaas, Dolstra, Harry
Published in PloS one (16.06.2011)
Published in PloS one (16.06.2011)
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The Rise of Allogeneic Natural Killer Cells As a Platform for Cancer Immunotherapy: Recent Innovations and Future Developments
Veluchamy, John P, Kok, Nina, van der Vliet, Hans J, Verheul, Henk M W, de Gruijl, Tanja D, Spanholtz, Jan
Published in Frontiers in immunology (31.05.2017)
Published in Frontiers in immunology (31.05.2017)
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Genetic Engineering of Natural Killer Cells for Enhanced Antitumor Function
Mantesso, Simone, Geerts, Dirk, Spanholtz, Jan, Kučerová, Lucia
Published in Frontiers in immunology (16.12.2020)
Published in Frontiers in immunology (16.12.2020)
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Journal Article
Combination of NK Cells and Cetuximab to Enhance Anti-Tumor Responses in RAS Mutant Metastatic Colorectal Cancer
Veluchamy, John Pradeep, Spanholtz, Jan, Tordoir, Marleen, Thijssen, Victor L, Heideman, Daniëlle A M, Verheul, Henk M W, de Gruijl, Tanja D, van der Vliet, Hans J
Published in PloS one (17.06.2016)
Published in PloS one (17.06.2016)
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Journal Article
High log-scale expansion of functional human natural killer cells from umbilical cord blood CD34-positive cells for adoptive cancer immunotherapy
Spanholtz, Jan, Tordoir, Marleen, Eissens, Diana, Preijers, Frank, van der Meer, Arnold, Joosten, Irma, Schaap, Nicolaas, de Witte, Theo M, Dolstra, Harry
Published in PloS one (15.02.2010)
Published in PloS one (15.02.2010)
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Journal Article
Natural Killer Cells Generated from Cord Blood Hematopoietic Progenitor Cells Efficiently Target Bone Marrow-Residing Human Leukemia Cells in NOD/SCID/IL2Rgnull Mice
Cany, Jeannette, van der Waart, Anniek B., Tordoir, Marleen, Franssen, Gerben M., Hangalapura, Basav N., de Vries, Jolanda, Boerman, Otto, Schaap, Nicolaas, van der Voort, Robbert, Spanholtz, Jan, Dolstra, Harry
Published in PloS one (05.06.2013)
Published in PloS one (05.06.2013)
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Journal Article
Natural killer cells generated from cord blood hematopoietic progenitor cells efficiently target bone marrow-residing human leukemia cells in NOD/SCID/IL2Rg(null) mice
Cany, Jeannette, van der Waart, Anniek B, Tordoir, Marleen, Franssen, Gerben M, Hangalapura, Basav N, de Vries, Jolanda, Boerman, Otto, Schaap, Nicolaas, van der Voort, Robbert, Spanholtz, Jan, Dolstra, Harry
Published in PloS one (2013)
Published in PloS one (2013)
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Journal Article
384 Single-cell transcriptomics, proteomics and in vitro cytotoxicity of allogeneic cryopreserved natural killer cell therapy GTA002 identify potent effector signatures
Raimo, Monica, Vliet, Amanda van, Vodegel, Denise, Steenmans, Daniëlle, Duru, Adil, Georgoudaki, Anna-Maria, Spanholtz, Jan
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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The Transcription Factor ZNF683/HOBIT Regulates Human NK-Cell Development
Post, Mirte, Cuapio, Angelica, Osl, Markus, Lehmann, Dorit, Resch, Ulrike, Davies, David M, Bilban, Martin, Schlechta, Bernhard, Eppel, Wolfgang, Nathwani, Amit, Stoiber, Dagmar, Spanholtz, Jan, Casanova, Emilio, Hofer, Erhard
Published in Frontiers in immunology (15.05.2017)
Published in Frontiers in immunology (15.05.2017)
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Allogeneic NK cells induce monocyte-to-dendritic cell conversion, control tumor growth, and trigger a pro-inflammatory shift in patient-derived cultures of primary and metastatic colorectal cancer
Toffoli, Elisa C, van Vliet, Amanda A, Verheul, Henk W M, van der Vliet, Hans J, Tuynman, Jurriaan, Spanholtz, Jan, de Gruijl, Tanja D
Published in Journal for immunotherapy of cancer (06.12.2023)
Published in Journal for immunotherapy of cancer (06.12.2023)
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Journal Article
Defining early human NK cell developmental stages in primary and secondary lymphoid tissues
Eissens, Diana N, Spanholtz, Jan, van der Meer, Arnold, van Cranenbroek, Bram, Dolstra, Harry, Kwekkeboom, Jaap, Preijers, Frank W M B, Joosten, Irma
Published in PloS one (03.02.2012)
Published in PloS one (03.02.2012)
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330 Combination therapy with stem cell derived natural killer cells and monoclonal antibodies leads to potent ADCC through engagement of endogenouse CD16
Georgoudaki, Anna-Maria, Lamers-Kok, Nina, Vliet, Amanda van, Özkazanc, Didem, Vodegel, Denise, Steenmans, Daniëlle, Raimo, Monica, Duru, Adil, Spanholtz, Jan
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Early TRAIL-engagement elicits potent multimodal targeting of melanoma by CD34+ progenitor cell-derived NK cells
van Vliet, Amanda A., Peters, Ella, Vodegel, Denise, Steenmans, Daniëlle, Raimo, Monica, Gibbs, Susan, de Gruijl, Tanja D., Duru, Adil D., Spanholtz, Jan, Georgoudaki, Anna-Maria
Published in iScience (21.07.2023)
Published in iScience (21.07.2023)
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Boosting Natural Killer Cell Therapies in Glioblastoma Multiforme Using Supramolecular Cationic Inhibitors of Heat Shock Protein 90
Saha, Tanmoy, van Vliet, Amanda A, Cui, Chunxiao, Macias, Jorge Jimenez, Kulkarni, Arpita, Pham, Luu Nhat, Lawler, Sean, Spanholtz, Jan, Georgoudaki, Anna-Maria, Duru, Adil Doganay, Goldman, Aaron
Published in Frontiers in molecular biosciences (01.12.2021)
Published in Frontiers in molecular biosciences (01.12.2021)
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Wnt3a protein reduces growth factor-driven expansion of human hematopoietic stem and progenitor cells in serum-free cultures
Duinhouwer, Lucia E, Tüysüz, Nesrin, Rombouts, Elwin W J C, Ter Borg, Mariette N D, Mastrobattista, Enrico, Spanholtz, Jan, Cornelissen, Jan J, Ten Berge, Derk, Braakman, Eric
Published in PloS one (25.03.2015)
Published in PloS one (25.03.2015)
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