New limits proposed for the management of non-mutagenic impurities
Slikkerveer, Anja, Doehr, Olaf, Claude, Nancy, Hutchinson, Richard, Harvey, James, Spanhaak, Steven
Published in Regulatory toxicology and pharmacology (01.06.2024)
Published in Regulatory toxicology and pharmacology (01.06.2024)
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Journal Article
Management of organic impurities in small molecule medicinal products: Deriving safe limits for use in early development
Harvey, James, Fleetwood, Andrew, Ogilvie, Ron, Teasdale, Andrew, Wilcox, Phil, Spanhaak, Steven
Published in Regulatory toxicology and pharmacology (01.03.2017)
Published in Regulatory toxicology and pharmacology (01.03.2017)
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Journal Article
The ICH S8 immunotoxicity guidance. Immune function assessment and toxicological pathology: Autonomous or synergistic methods to predict immunotoxicity?
Spanhaak, Steven
Published in Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie (01.07.2006)
Published in Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie (01.07.2006)
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Journal Article
Food allergen (peanut)–specific T H2 clones generated from the peripheral blood of a patient with peanut allergy
de Jong, Esther C., Spanhaak, Steven, Martens, Ben P.M., Kapsenberg, Martien L., Penninks, André H., Wierenga, Eddy A.
Published in Journal of allergy and clinical immunology (01.07.1996)
Published in Journal of allergy and clinical immunology (01.07.1996)
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Journal Article
Development of the ICH Guidelines for Immunotoxicology Evaluation of Pharmaceuticals Using a Survey of Industry Practices
Weaver, James L., Tsutsui, Naohisa, Hisada, Shigeru, Vidal, Jean-Marc, Spanhaak, Steven, Sawada, Jun-ichi, Hastings, Kenneth L., van der Laan, Jan Willem, van Loveren, Henk, Kawabata, Thomas T., Sims, Jennifer, Durham, Stephen K., Fueki, Osamu, Matula, Tibor I., Kusunoki, Hirofumi, Ulrich, Peter, Nakamura, Kazuichi
Published in Journal of immunotoxicology (01.07.2005)
Published in Journal of immunotoxicology (01.07.2005)
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Journal Article
Food allergen (peanut)-specific TH2 clones generated from the peripheral blood of a patient with peanut allergy
DE JONG, E. C, SPANHAAK, S, MARTENS, B. P. M, KAPSENBERG, M. L, PENNINKS, A. H, WIERENGA, E. A
Published in Journal of allergy and clinical immunology (01.07.1996)
Published in Journal of allergy and clinical immunology (01.07.1996)
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Journal Article
Local lymph node activation and IgE responses in Brown Norway and Wistar rats after dermal application of sensitizing and non-sensitizing chemicals
Arts, Josje H.E., Dröge, Sonja C.M., Spanhaak, Steven, Bloksma, Nanne, Penninks, AndréH., Kuper, C.Frieke
Published in Toxicology (Amsterdam) (28.02.1997)
Published in Toxicology (Amsterdam) (28.02.1997)
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Journal Article
Effect of β-carotene on immunological indexes in healthy male smokers
van Poppel, G, Spanhaak, S, Ockhuizen, T
Published in The American journal of clinical nutrition (01.03.1993)
Published in The American journal of clinical nutrition (01.03.1993)
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Journal Article
Effect of (Beta)-carotene on immunological indexes in healthy male smokers
van Poppel, Geert, Spanhaak, Steven, Ockhuizen, Theodore
Published in The American journal of clinical nutrition (01.03.1993)
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Published in The American journal of clinical nutrition (01.03.1993)
Journal Article
Intestinal T lymphocytes of different rat strains in immunotoxicity
Bruder, M C, Spanhaak, S, Bruijntjes, J P, Michielsen, C P, Vos, J G, Kuper, C F
Published in Toxicologic pathology (01.03.1999)
Published in Toxicologic pathology (01.03.1999)
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Journal Article
A new method to measure iron absorption from the enrichment of 57Fe and 58Fe in young erythroid cells
van den Heuvel, Ellen G. H. M, Muys, Theo, Pellegrom, Hillie, Bruyntjes, Joost P, van Dokkum, Wim, Spanhaak, Steven, Schaafsma, Gertjan
Published in Clinical chemistry (Baltimore, Md.) (01.03.1998)
Published in Clinical chemistry (Baltimore, Md.) (01.03.1998)
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Journal Article
Development of the ICH Guidelines for Immunotoxicology Evaluation of Pharmaceuticals Using a Survey of Industry Practices
Weaver, James L., Tsutsui, Naohisa, Hisada, Shigeru, Vidal, Jean-Marc, Spanhaak, Steven, Sawada, Jun-ichi, Hastings, Kenneth L., van der Laan, Jan Willem, van Loveren, Henk, Kawabata, Thomas T., Sims, Jennifer, Durham, Stephen K., Fueki, Osamu, Matula, Tibor I., Kusunoki, Hirofumi, Ulrich, Peter, Nakamura, Kazuichi
Published in Journal of Immunotoxicology (01.01.2005)
Published in Journal of Immunotoxicology (01.01.2005)
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