Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms
Spangler, Jamie B., Tomala, Jakub, Luca, Vincent C., Jude, Kevin M., Dong, Shen, Ring, Aaron M., Votavova, Petra, Pepper, Marion, Kovar, Marek, Garcia, K. Christopher
Published in Immunity (Cambridge, Mass.) (19.05.2015)
Published in Immunity (Cambridge, Mass.) (19.05.2015)
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Journal Article
Engineering the IL-4/IL-13 axis for targeted immune modulation
Bernstein, Zachary J, Shenoy, Anjali, Chen, Amy, Heller, Nicola M, Spangler, Jamie B
Published in Immunological reviews (01.11.2023)
Published in Immunological reviews (01.11.2023)
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Journal Article
Interleukin-2 Activity Can Be Fine Tuned with Engineered Receptor Signaling Clamps
Mitra, Suman, Ring, Aaron M., Amarnath, Shoba, Spangler, Jamie B., Li, Peng, Ju, Wei, Fischer, Suzanne, Oh, Jangsuk, Spolski, Rosanne, Weiskopf, Kipp, Kohrt, Holbrook, Foley, Jason E., Rajagopalan, Sumati, Long, Eric O., Fowler, Daniel H., Waldmann, Thomas A., Garcia, K. Christopher, Leonard, Warren J.
Published in Immunity (Cambridge, Mass.) (19.05.2015)
Published in Immunity (Cambridge, Mass.) (19.05.2015)
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Journal Article
Combination antibody treatment down-regulates epidermal growth factor receptor by inhibiting endosomal recycling
Spangler, Jamie B., Neil, Jason R., Abramovitch, Sivan, Yarden, Yosef, White, Forest M., Lauffenburger, Douglas A., Wittrup, K. Dane, Kuriyan, John
Published in Proceedings of the National Academy of Sciences - PNAS (27.07.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (27.07.2010)
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Journal Article
Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy
Isser, Ariel, Silver, Aliyah B., Pruitt, Hawley C., Mass, Michal, Elias, Emma H., Aihara, Gohta, Kang, Si-Sim, Bachmann, Niklas, Chen, Ying-Yu, Leonard, Elissa K., Bieler, Joan G., Chaisawangwong, Worarat, Choy, Joseph, Shannon, Sydney R., Gerecht, Sharon, Weber, Jeffrey S., Spangler, Jamie B., Schneck, Jonathan P.
Published in Nature communications (14.10.2022)
Published in Nature communications (14.10.2022)
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Journal Article
IL-2 can signal via chemokine receptors to promote regulatory T cells’ suppressive function
Sun, Hao, Lee, Ho-Sup, Kim, Sarah Hyun-Ji, Fernandes de Lima, Mikhael, Gingras, Alexandre R., Du, Qinyi, McLaughlin, Wilma, Ablack, Jailail, Lopez-Ramirez, Miguel A., Lagarrigue, Frederic, Fan, Zhichao, Chang, John T., VanDyke, Derek, Spangler, Jamie B., Ginsberg, Mark H.
Published in Cell reports (Cambridge) (29.08.2023)
Published in Cell reports (Cambridge) (29.08.2023)
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Journal Article
Strategies for Glycoengineering Therapeutic Proteins
Dammen-Brower, Kris, Epler, Paige, Zhu, Stanley, Bernstein, Zachary J, Stabach, Paul R, Braddock, Demetrios T, Spangler, Jamie B, Yarema, Kevin J
Published in Frontiers in chemistry (13.04.2022)
Published in Frontiers in chemistry (13.04.2022)
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Journal Article
Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers
Moraga, Ignacio, Spangler, Jamie B, Mendoza, Juan L, Gakovic, Milica, Wehrman, Tom S, Krutzik, Peter, Garcia, K Christopher
Published in eLife (12.05.2017)
Published in eLife (12.05.2017)
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Journal Article
A versatile design platform for glycoengineering therapeutic antibodies
Ludwig, Seth D, Bernstein, Zachary J, Agatemor, Christian, Dammen-Brower, Kris, Ruffolo, Jeffrey, Rosas, Jonah M, Post, Jeremy D, Cole, Robert N, Yarema, Kevin J, Spangler, Jamie B
Published in mAbs (2022)
Published in mAbs (2022)
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Journal Article
Insights into Cytokine-Receptor Interactions from Cytokine Engineering
Spangler, Jamie B, Moraga, Ignacio, Mendoza, Juan L, Garcia, K. Christopher
Published in Annual review of immunology (01.01.2015)
Published in Annual review of immunology (01.01.2015)
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Journal Article
Empowering gene delivery with protein engineering platforms
Kizerwetter, Monika, Pietz, Kevin, Tomasovic, Luke M., Spangler, Jamie B.
Published in Gene therapy (01.12.2023)
Published in Gene therapy (01.12.2023)
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Journal Article
Engineering Anticytokine Antibodies for Immune Modulation
Tomala, Jakub, Cao, Shanelle D, Spangler, Jamie B
Published in The Journal of immunology (1950) (15.01.2024)
Published in The Journal of immunology (1950) (15.01.2024)
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Journal Article
Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells
Glassman, Caleb R., Mathiharan, Yamuna Kalyani, Jude, Kevin M., Su, Leon, Panova, Ouliana, Lupardus, Patrick J., Spangler, Jamie B., Ely, Lauren K., Thomas, Christoph, Skiniotis, Georgios, Garcia, K. Christopher
Published in Cell (18.02.2021)
Published in Cell (18.02.2021)
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Journal Article
Insights into the anticancer mechanisms of interleukin-15 from engineered cytokine therapies
Bernstein, Zachary J, Spangler, Jamie B
Published in The Journal of clinical investigation (01.10.2021)
Published in The Journal of clinical investigation (01.10.2021)
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Journal Article
Engineered antibody fusion proteins for targeted disease therapy
Silver, Aliyah B., Leonard, Elissa K., Gould, Joseph R., Spangler, Jamie B.
Published in Trends in pharmacological sciences (Regular ed.) (01.12.2021)
Published in Trends in pharmacological sciences (Regular ed.) (01.12.2021)
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Journal Article
De novo design of potent and selective mimics of IL-2 and IL-15
Silva, Daniel-Adriano, Yu, Shawn, Ulge, Umut Y., Spangler, Jamie B., Jude, Kevin M., Labão-Almeida, Carlos, Ali, Lestat R., Quijano-Rubio, Alfredo, Ruterbusch, Mikel, Leung, Isabel, Biary, Tamara, Crowley, Stephanie J., Marcos, Enrique, Walkey, Carl D., Weitzner, Brian D., Pardo-Avila, Fátima, Castellanos, Javier, Carter, Lauren, Stewart, Lance, Riddell, Stanley R., Pepper, Marion, Bernardes, Gonçalo, Dougan, Michael, Garcia, K. Christopher, Baker, David
Published in Nature (London) (2019)
Published in Nature (London) (2019)
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Journal Article