Structural Requirements of Transmembrane Domain 3 for Activation by the M1 Muscarinic Receptor Agonists AC-42, AC-260584, Clozapine, and N-Desmethylclozapine: Evidence for Three Distinct Modes of Receptor Activation
Spalding, Tracy A, Ma, Jian-Nong, Ott, Thomas R, Friberg, Mikael, Bajpai, Abhishek, Bradley, Stefania Risso, Davis, Robert E, Brann, Mark R, Burstein, Ethan S
Published in Molecular pharmacology (01.12.2006)
Published in Molecular pharmacology (01.12.2006)
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Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson’s Disease
McFarland, Krista, Spalding, Tracy A, Hubbard, David, Ma, Jian-Nong, Olsson, Roger, Burstein, Ethan S
Published in ACS chemical neuroscience (20.11.2013)
Published in ACS chemical neuroscience (20.11.2013)
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Pharmacological Characterization of AC-90179 [2-(4-Methoxyphenyl)-N-(4-methyl-benzyl)-N-(1-methyl-piperidin-4-yl)-acetamide Hydrochloride]: A Selective Serotonin 2A Receptor Inverse Agonist
Vanover, Kimberly E, Harvey, Scott C, Son, Thomas, Bradley, Stefania Risso, Kold, Henriette, Makhay, Malath, Veinbergs, Isaac, Spalding, Tracy A, Weiner, David M, Andersson, Carl Magnus, Tolf, Bo-Ragnar, Brann, Mark R, Hacksell, Uli, Davis, Robert E
Published in The Journal of pharmacology and experimental therapeutics (01.09.2004)
Published in The Journal of pharmacology and experimental therapeutics (01.09.2004)
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Homologous Mutations Near the Junction of the Sixth Transmembrane Domain and the Third Extracellular Loop Lead to Constitutive Activity and Enhanced Agonist Affinity at all Muscarinic Receptor Subtypes
Ford, Diane J, Essex, Anthony, Spalding, Tracy A, Burstein, Ethan S, Ellis, John
Published in The Journal of pharmacology and experimental therapeutics (01.03.2002)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2002)
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Allosteric modulation of G-protein coupled receptors
Jensen, Anders A, Spalding, Tracy A
Published in European Journal of Pharmaceutical Sciences (01.03.2004)
Published in European Journal of Pharmaceutical Sciences (01.03.2004)
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Book Review
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N-Acylthiadiazolines, a New Class of Liver X Receptor Agonists with Selectivity for LXRβ
Molteni, Valentina, Li, Xiaolin, Nabakka, Juliet, Liang, Fang, Wityak, John, Koder, Alan, Vargas, Leo, Romeo, Russell, Mitro, Nico, Mak, Puiying A, Seidel, H. Martin, Haslam, Jennifer A, Chow, Donald, Tuntland, Tove, Spalding, Tracy A, Brock, Ansgar, Bradley, Michelle, Castrillo, Antonio, Tontonoz, Peter, Saez, Enrique
Published in Journal of medicinal chemistry (23.08.2007)
Published in Journal of medicinal chemistry (23.08.2007)
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Discovery of pyrimidine benzimidazoles as Lck inhibitors: Part I
Zhang, Guobao, Ren, Pingda, Gray, Nathanael S., Sim, Taebo, Liu, Yi, Wang, Xia, Che, Jianwei, Tian, Shin-Shay, Sandberg, Mark L., Spalding, Tracy A., Romeo, Russell, Iskandar, Maya, Chow, Donald, Martin Seidel, H., Karanewsky, Donald S., He, Yun
Published in Bioorganic & medicinal chemistry (15.10.2008)
Published in Bioorganic & medicinal chemistry (15.10.2008)
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Journal Article
Discovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II
Zhang, Guobao, Ren, Pingda, Gray, Nathanael S., Sim, Taebo, Wang, Xia, Liu, Yi, Che, Jianwei, Dong, Weitong, Tian, Shin-Shay, Sandberg, Mark L., Spalding, Tracy A., Romeo, Russell, Iskandar, Maya, Wang, Zhiliang, Seidel, H. Martin, Karanewsky, Donald S., He, Yun
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
Published in Bioorganic & medicinal chemistry letters (01.12.2009)
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Integrative Functional Assays, Chemical Genomics and High Throughput Screening: Harnessing Signal Transduction Pathways to a Common HTS Readout
Burstein, Ethan S, Piu, Fabrice, Ma, Jian-Nong, Weissman, Jacques T, Currier, Erika A, Nash, Norman R, Weiner, David M, Spalding, Tracy A, Schiffer, Hans H, Del Tredici, Andria L, Brann, Mark R
Published in Current pharmaceutical design (01.05.2006)
Published in Current pharmaceutical design (01.05.2006)
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Journal Article
Discovery of 2-amino-6-carboxamidobenzothiazoles as potent Lck inhibitors
Huang, Shenlin, Liu, Zuosheng, Tian, Shin-Shay, Sandberg, Mark, Spalding, Tracy A., Romeo, Russell, Iskandar, Maya, Wang, Zhiliang, Karanewsky, Donald, He, Yun
Published in Bioorganic & medicinal chemistry (01.04.2008)
Published in Bioorganic & medicinal chemistry (01.04.2008)
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Constitutive activity of muscarinic acetylcholine receptors
Spalding, Tracy A, Burstein, Ethan S
Published in Journal of receptors and signal transduction (01.01.2006)
Published in Journal of receptors and signal transduction (01.01.2006)
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Journal Article
Identification of a Ligand-dependent Switch within a Muscarinic Receptor
Spalding, Tracy A., Burstein, Ethan S., Henderson, Shaw C., Ducote, Karin R., Brann, Mark R.
Published in The Journal of biological chemistry (21.08.1998)
Published in The Journal of biological chemistry (21.08.1998)
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Just-in-time purification: an effective solution for cherry-picking and purifying active compounds from large legacy libraries
Guintu, Christina, Kwok, Michael, Hanlon, James J, Spalding, Tracy A, Wolff, Karen, Yin, Hong, Kuhen, Kelli, Sasher, Kimberly, Calvin, Paul, Jiang, Shumei, Zhou, Yingyao, Isbell, John J
Published in Journal of biomolecular screening (01.12.2006)
Published in Journal of biomolecular screening (01.12.2006)
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Discovery of novel peptide/receptor interactions: identification of PHM-27 as a potent agonist of the human calcitonin receptor
Ma, Jian-Nong, Currier, Erika A, Essex, Anthony, Feddock, Michele, Spalding, Tracy A, Nash, Norman R, Brann, Mark R, Burstein, Ethan S
Published in Biochemical pharmacology (01.04.2004)
Published in Biochemical pharmacology (01.04.2004)
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Journal Article
Structure of a G-protein-coupling Domain of a Muscarinic Receptor Predicted by Random Saturation Mutagenesis (∗)
Hill-Eubanks, David, Burstein, Ethan S., Spalding, Tracy A., Bräuner-Osborne, Hans, Brann, Mark R.
Published in The Journal of biological chemistry (09.02.1996)
Published in The Journal of biological chemistry (09.02.1996)
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Journal Article
Functional Importance of the Ala116–Pro136 Region in the Calcium-sensing Receptor
Jensen, Anders A., Spalding, Tracy A., Burstein, Ethan S., Sheppard, Paul O., O'Hara, Patrick J., Brann, Mark R., Krogsgaard-Larsen, Povl, Bräuner-Osborne, Hans
Published in The Journal of biological chemistry (01.09.2000)
Published in The Journal of biological chemistry (01.09.2000)
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AC-260584, an orally bioavailable M 1 muscarinic receptor allosteric agonist, improves cognitive performance in an animal model
Bradley, Stefania Risso, Lameh, Jelveh, Ohrmund, Linda, Son, Thomas, Bajpai, Abhishek, Nguyen, Derek, Friberg, Mikael, Burstein, Ethan S., Spalding, Tracy A., Ott, Thomas R., Schiffer, Hans H., Tabatabaei, Ali, McFarland, Krista, Davis, Robert E., Bonhaus, Douglas W.
Published in Neuropharmacology (01.02.2010)
Published in Neuropharmacology (01.02.2010)
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