Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19
Park, Min Ju, Shen, Hailian, Spaeth, Jason M., Tolvanen, Jaana H., Failor, Courtney, Knudtson, Jennifer F., McLaughlin, Jessica, Halder, Sunil K., Yang, Qiwei, Bulun, Serdar E., Al-Hendy, Ayman, Schenken, Robert S., Aaltonen, Lauri A., Boyer, Thomas G.
Published in The Journal of biological chemistry (30.03.2018)
Published in The Journal of biological chemistry (30.03.2018)
Get full text
Journal Article
Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity
Turunen, Mikko, Spaeth, Jason M., Keskitalo, Salla, Park, Min Ju, Kivioja, Teemu, Clark, Alison D., Mäkinen, Netta, Gao, Fangjian, Palin, Kimmo, Nurkkala, Helka, Vähärautio, Anna, Aavikko, Mervi, Kämpjärvi, Kati, Vahteristo, Pia, Kim, Chongwoo A., Aaltonen, Lauri A., Varjosalo, Markku, Taipale, Jussi, Boyer, Thomas G.
Published in Cell reports (Cambridge) (08.05.2014)
Published in Cell reports (Cambridge) (08.05.2014)
Get full text
Journal Article
MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling
Zhou, Haiying, Spaeth, Jason M, Kim, Nam Hee, Xu, Xuan, Friez, Michael J, Schwartz, Charles E, Boyer, Thomas G
Published in Proceedings of the National Academy of Sciences - PNAS (27.11.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (27.11.2012)
Get full text
Journal Article
Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet
Krebs, Philippe, Fan, Weiwei, Chen, Yen-Hui, Tobita, Kimimasa, Downes, Michael R, Wood, Malcolm R, Sun, Lei, Li, Xiaohong, Xia, Yu, Ding, Ning, Spaeth, Jason M, Moresco, Eva Marie Y, Boyer, Thomas G, Lo, Cecilia Wen Ya, Yen, Jeffrey, Evans, Ronald M, Beutler, Bruce
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (06.12.2011)
Get full text
Journal Article
The Contribution of Transcriptional Coregulators in the Maintenance of β-cell Function and Identity
Davidson, Rebecca K, Kanojia, Sukrati, Spaeth, Jason M
Published in Endocrinology (Philadelphia) (01.02.2021)
Published in Endocrinology (Philadelphia) (01.02.2021)
Get full text
Journal Article
Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning
Spaeth, Jason M, Gupte, Manisha, Perelis, Mark, Yang, Yu-Ping, Cyphert, Holly, Guo, Shuangli, Liu, Jin-Hua, Guo, Min, Bass, Joseph, Magnuson, Mark A, Wright, Christopher, Stein, Roland
Published in Diabetes (New York, N.Y.) (01.11.2017)
Published in Diabetes (New York, N.Y.) (01.11.2017)
Get full text
Journal Article
The SWI/SNF chromatin remodelling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo
Davidson, Rebecca K., Wu, Wenting, Kanojia, Sukrati, George, Rajani M., Huter, Kayla, Sandoval, Kassandra, Osmulski, Meredith, Casey, Nolan, Spaeth, Jason M.
Published in Diabetologia (01.10.2024)
Published in Diabetologia (01.10.2024)
Get full text
Journal Article
HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes
Russell, Mark A, Redick, Sambra D, Blodgett, David M, Richardson, Sarah J, Leete, Pia, Krogvold, Lars, Dahl-Jørgensen, Knut, Bottino, Rita, Brissova, Marcela, Spaeth, Jason M, Babon, Jenny Aurielle B, Haliyur, Rachana, Powers, Alvin C, Yang, Chaoxing, Kent, Sally C, Derr, Alan G, Kucukural, Alper, Garber, Manuel G, Morgan, Noel G, Harlan, David M
Published in Diabetes (New York, N.Y.) (01.05.2019)
Published in Diabetes (New York, N.Y.) (01.05.2019)
Get full text
Journal Article
The Chd4 Helicase Regulates Chromatin Accessibility and Gene Expression Critical for β-Cell Function In Vivo
Davidson, Rebecca K, Kanojia, Sukrati, Wu, Wenting, Kono, Tatsuyoshi, Xu, Jerry, Osmulski, Meredith, Bone, Robert N, Casey, Nolan, Evans-Molina, Carmella, Sims, Emily K, Spaeth, Jason M
Published in Diabetes (New York, N.Y.) (01.06.2023)
Published in Diabetes (New York, N.Y.) (01.06.2023)
Get full text
Journal Article
Mediator and human disease
Spaeth, Jason M., Kim, Nam Hee, Boyer, Thomas G.
Published in Seminars in cell & developmental biology (01.09.2011)
Published in Seminars in cell & developmental biology (01.09.2011)
Get full text
Journal Article
The Pdx1-Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β-Cell Function
Spaeth, Jason M, Liu, Jin-Hua, Peters, Daniel, Guo, Min, Osipovich, Anna B, Mohammadi, Fardin, Roy, Nilotpal, Bhushan, Anil, Magnuson, Mark A, Hebrok, Matthias, Wright, Christopher V E, Stein, Roland
Published in Diabetes (New York, N.Y.) (01.09.2019)
Published in Diabetes (New York, N.Y.) (01.09.2019)
Get full text
Journal Article
The Chd4 subunit of the NuRD complex regulates Pdx1-controlled genes involved in β-cell function
Davidson, Rebecca K, Weaver, Staci A, Casey, Nolan, Kanojia, Sukrati, Hogarth, Elise, Schneider Aguirre, Rebecca, Sims, Emily K, Evans-Molina, Carmella, Spaeth, Jason M
Published in Journal of molecular endocrinology (01.08.2022)
Published in Journal of molecular endocrinology (01.08.2022)
Get full text
Journal Article
The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice
Spaeth, Jason M., Hunter, Chad S., Bonatakis, Lauren, Guo, Min, French, Catherine A., Slack, Ian, Hara, Manami, Fisher, Simon E., Ferrer, Jorge, Morrisey, Edward E., Stanger, Ben Z., Stein, Roland
Published in Diabetologia (01.08.2015)
Published in Diabetologia (01.08.2015)
Get full text
Journal Article
B lymphocytes protect islet β cells in diabetes prone NOD mice treated with imatinib
Wilson, Christopher S, Spaeth, Jason M, Karp, Jay, Stocks, Blair T, Hoopes, Emilee M, Stein, Roland W, Moore, Daniel J
Published in JCI insight (02.05.2019)
Published in JCI insight (02.05.2019)
Get full text
Journal Article