EUKARYOTIC DNA POLYMERASES
Hübscher, Ulrich, Maga, Giovanni, Spadari, Silvio
Published in Annual review of biochemistry (01.01.2002)
Published in Annual review of biochemistry (01.01.2002)
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Okazaki Fragment Processing: Modulation of the Strand Displacement Activity of DNA Polymerase δ by the Concerted Action of Replication Protein A, Proliferating Cell Nuclear Antigen, and Flap Endonuclease-1
Maga, Giovanni, Villani, Giuseppe, Tillement, Vanessa, Stucki, Manuel, Locatelli, Giada A., Frouin, Isabelle, Spadari, Silvio, Hübscher, Ulrich
Published in Proceedings of the National Academy of Sciences - PNAS (04.12.2001)
Published in Proceedings of the National Academy of Sciences - PNAS (04.12.2001)
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Specific Targeting of Hepatitis C Virus NS3 RNA Helicase. Discovery of the Potent and Selective Competitive Nucleotide-Mimicking Inhibitor QU663
Maga, Giovanni, Gemma, Sandra, Fattorusso, Caterina, Locatelli, Giada A, Butini, Stefania, Persico, Marco, Kukreja, Gagan, Romano, Maria Pia, Chiasserini, Luisa, Savini, Luisa, Novellino, Ettore, Nacci, Vito, Spadari, Silvio, Campiani, Giuseppe
Published in Biochemistry (Easton) (19.07.2005)
Published in Biochemistry (Easton) (19.07.2005)
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Journal Article
Inhibition of mammalian DNA polymerases by resveratrol: mechanism and structural determinants
Locatelli, Giada A, Savio, Monica, Forti, Luca, Shevelev, Igor, Ramadan, Kristijan, Stivala, Lucia A, Vannini, Vanio, Hübscher, Ulrich, Spadari, Silvio, Maga, Giovanni
Published in Biochemical journal (15.07.2005)
Published in Biochemical journal (15.07.2005)
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Journal Article
Sensitivity of Monkey B Virus (Cercopithecine herpesvirus 1) to Antiviral Drugs: Role of Thymidine Kinase in Antiviral Activities of Substrate Analogs and Acyclonucleosides
FOCHER, Federico, LOSSANI, Andrea, MEDVECZKY, Maria, SHUGAR, David, VERRI, Annalisa, SPADARI, Silvio, MAIOLI, Andrew, GAMBINO, Joseph J, WRIGHT, George E, EBERLE, Richard, BLACK, Darla H, MEDVECZKY, Peter
Published in Antimicrobial Agents and Chemotherapy (01.06.2007)
Published in Antimicrobial Agents and Chemotherapy (01.06.2007)
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Journal Article
Inhibition of Herpes Simplex Virus Thymidine Kinases by 2-Phenylamino-6-oxopurines and Related Compounds: Structure−Activity Relationships and Antiherpetic Activity in Vivo
Manikowski, Andrzej, Verri, Annalisa, Lossani, Andrea, Gebhardt, Bryan M, Gambino, Joseph, Focher, Federico, Spadari, Silvio, Wright, George E
Published in Journal of medicinal chemistry (02.06.2005)
Published in Journal of medicinal chemistry (02.06.2005)
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Journal Article
Selective Interaction of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Nonnucleoside Inhibitor Efavirenz and Its Thio-Substituted Analog with Different Enzyme-Substrate Complexes
MAGA, G, UBIALI, D, SALVETTI, R, PREGNOLATO, M, SPADARI, S
Published in Antimicrobial Agents and Chemotherapy (01.05.2000)
Published in Antimicrobial Agents and Chemotherapy (01.05.2000)
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Journal Article
High Potency of Indolyl Aryl Sulfone Nonnucleoside Inhibitors towards Drug-Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutants Is Due to Selective Targeting of Different Mechanistic Forms of the Enzyme
CANCIO, Reynel, SILVESTRI, Romano, MAGA, Giovanni, RAGNO, Rino, ARTICO, Marino, DE MARTINO, Gabriella, LA REGINA, Giuseppe, CRESPAN, Emmanuele, ZANOLI, Samantha, HÜBSCHER, Ulrich, SPADARI, Silvio
Published in Antimicrobial Agents and Chemotherapy (01.11.2005)
Published in Antimicrobial Agents and Chemotherapy (01.11.2005)
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Journal Article
Gln145Met/Leu Changes in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Resistance to Nucleoside and Nonnucleoside Analogs and Impair Virus Replication
Paolucci, Stefania, Baldanti, Fausto, Maga, Giovanni, Cancio, Reynel, Zazzi, Maurizio, Zavattoni, Maurizio, Chiesa, Antonella, Spadari, Silvio, Gerna, Giuseppe
Published in Antimicrobial Agents and Chemotherapy (01.12.2004)
Published in Antimicrobial Agents and Chemotherapy (01.12.2004)
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Journal Article
Novel Nonsubstrate Inhibitors of Human Thymidine Phosphorylase, a Potential Target for Tumor-Dependent Angiogenesis
Focher, Federico, Ubiali, Daniela, Pregnolato, Massimo, Zhi, Chengxin, Gambino, Joseph, Wright, George E, Spadari, Silvio
Published in Journal of medicinal chemistry (29.06.2000)
Published in Journal of medicinal chemistry (29.06.2000)
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Journal Article
Nevirapine Resistance Mutation at Codon 181 of the HIV-1 Reverse Transcriptase Confers Stavudine Resistance by Increasing Nucleotide Substrate Discrimination and Phosphorolytic Activity
Blanca, Giuseppina, Baldanti, Fausto, Paolucci, Stefania, Skoblov, Alexander Yu, Victorova, Lyubov, Hübscher, Ulrich, Gerna, Giuseppe, Spadari, Silvio, Maga, Giovanni
Published in The Journal of biological chemistry (02.05.2003)
Published in The Journal of biological chemistry (02.05.2003)
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Journal Article
Drug Resistance Mutations in the Nucleotide Binding Pocket of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Differentially Affect the Phosphorolysis-Dependent Primer Unblocking Activity in the Presence of Stavudine and Zidovudine and Its Inhibition by Efavirenz
Crespan, Emmanuele, Locatelli, Giada A, Cancio, Reynel, Hübscher, Ulrich, Spadari, Silvio, Maga, Giovanni
Published in Antimicrobial Agents and Chemotherapy (01.01.2005)
Published in Antimicrobial Agents and Chemotherapy (01.01.2005)
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Journal Article
Diketo Hexenoic Acid Derivatives Are Novel Selective Non-Nucleoside Inhibitors of Mammalian Terminal Deoxynucleotidyl Transferases, with Potent Cytotoxic Effect against Leukemic Cells
Locatelli, Giada A, Di Santo, Roberto, Crespan, Emmanuele, Costi, Roberta, Roux, Alessandra, Hübscher, Ulrich, Shevelev, Igor, Blanca, Giuseppina, Villani, Giuseppe, Spadari, Silvio, Maga, Giovanni
Published in Molecular pharmacology (01.08.2005)
Published in Molecular pharmacology (01.08.2005)
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Journal Article
Effects of Drug Resistance Mutations L100I and V106A on the Binding of Pyrrolobenzoxazepinone Nonnucleoside Inhibitors to the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Catalytic Complex
LOCATELLI, Giada A, CAMPIANI, Giuseppe, CANCIO, Reynel, MORELLI, Elena, RAMUNNO, Anna, GEMMA, Sandra, HÜBSCHER, Ulrich, SPADARI, Silvio, MAGA, Giovanni
Published in Antimicrobial Agents and Chemotherapy (01.05.2004)
Published in Antimicrobial Agents and Chemotherapy (01.05.2004)
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Journal Article
Human Proliferating Cell Nuclear Antigen, Poly(ADP-ribose) Polymerase-1, and p21
Frouin, Isabelle, Maga, Giovanni, Denegri, Marco, Riva, Federica, Savio, Monica, Spadari, Silvio, Prosperi, Ennio, Scovassi, A.Ivana
Published in The Journal of biological chemistry (01.10.2003)
Published in The Journal of biological chemistry (01.10.2003)
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Journal Article
Potentiation of Inhibition of Wild-Type and Mutant Human Immunodeficiency Virus Type 1 Reverse Transcriptases by Combinations of Nonnucleoside Inhibitors and d- and l-(β)-Dideoxynucleoside Triphosphate Analogs
MAGA, Giovanni, HÜBSCHER, Ulrich, PREGNOLATO, Massimo, UBIALI, Daniela, GOSSELIN, Gilles, SPADARI, Silvio
Published in Antimicrobial Agents and Chemotherapy (01.04.2001)
Published in Antimicrobial Agents and Chemotherapy (01.04.2001)
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Journal Article
Design and Synthesis of Phosphonoacetic Acid (PPA) Ester and Amide Bioisosters of Ribofuranosylnucleoside Diphosphates as Potential Ribonucleotide Reductase Inhibitors and Evaluation of Their Enzyme Inhibitory, Cytostatic and Antiviral Activity
Manfredini, Stefano, Solaroli, Nicola, Angusti, Angela, Nalin, Federico, Durini, Elisa, Vertuani, Silvia, Pricl, Sabrina, Ferrone, Marco, Spadari, Silvio, Focher, Federico, Verri, Annalisa, De Clercq, Erik, Balzarini, Jan
Published in Antiviral chemistry & chemotherapy (01.08.2003)
Published in Antiviral chemistry & chemotherapy (01.08.2003)
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Journal Article
Anti-(herpes simplex virus) activity of 4'-thio-2'-deoxyuridines: a biochemical investigation for viral and cellular target enzymes
Verri, A, Focher, F, Duncombe, R J, Basnak, I, Walker, R T, Coe, P L, de Clercq, E, Andrei, G, Snoeck, R, Balzarini, J, Spadari, S
Published in Biochemical journal (15.10.2000)
Published in Biochemical journal (15.10.2000)
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Journal Article
The Stereoselective Targeting of a Specific Enzyme-Substrate Complex Is the Molecular Mechanism for the Synergic Inhibition of HIV-1 Reverse Transcriptase by (R)-(â)-PPO464
Maga, Giovanni, Ramunno, Anna, Nacci, Vito, Locatelli, Giada A., Spadari, Silvio, Fiorini, Isabella, Baldanti, Fausto, Paolucci, Stefania, Zavattoni, Maurizio, Bergamini, Alberto, Galletti, Bruno, Muck, Sandra, Hubscher, Ulrich, Giorgi, Gianluca, Guiso, Giovanna, Caccia, Silvio, Campiani, Giuseppe
Published in The Journal of biological chemistry (30.11.2001)
Published in The Journal of biological chemistry (30.11.2001)
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