Proposal for Pharmacologically Distinct Conformers of PDE4 Cyclic AMP Phosphodiesterases
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Book Review
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An Algorithm-Directed Two-Component Library Synthesized Via Solid-Phase Methodology Yielding Potent and Orally Bioavailable p38 MAP Kinase Inhibitors
McKenna, Jeffrey M, Halley, Frank, Souness, John E, McLay, Iain M, Pickett, Stephen D, Collis, Alan J, Page, Kenneth, Ahmed, Imtiaz
Published in Journal of medicinal chemistry (23.05.2002)
Published in Journal of medicinal chemistry (23.05.2002)
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The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy
MCLAY, Lain M, HALLEY, Frank, FOSTER, Martyn, HELE, David, JAYYOSI, Zaid, KELLEY, Mike, MASLEN, Chris, MILLER, Glen, OULDELHKIM, Marie-Claude, PAGE, Kenneth, PHIPPS, Simon, POLLOCK, Kenneth, SOUNESS, John E, PORTER, Barry, RATCLIFFE, Andrew J, REDFORD, Elisabeth J, WEBBER, Stephen, SLATER, Bryan, THYBAUD, Veronique, WILSHER, Nicola, MCKENNA, Jeffrey, BENNING, Veronique, BIRRELL, Mark, BURTON, Brenda, BELVISI, Maria, COLLIS, Alan, CONSTAN, Alex
Published in Bioorganic & medicinal chemistry (01.02.2001)
Published in Bioorganic & medicinal chemistry (01.02.2001)
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Mapping the kinase domain of janus kinase 3
Adams, Christopher, Aldous, David J., Amendola, Shelley, Bamborough, Paul, Bright, Colin, Crowe, Sarah, Eastwood, Paul, Fenton, Garry, Foster, Martyn, Harrison, Trevor K.P., King, Sue, Lai, Justine, Lawrence, Christopher, Letallec, Jean-Philippe, McCarthy, Clive, Moorcroft, Neil, Page, Kenneth, Rao, Sudha, Redford, Jane, Sadiq, Shazia, Smith, Keith, Souness, John E., Thurairatnam, Sukanthini, Vine, Mark, Wyman, Barry
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
Published in Bioorganic & medicinal chemistry letters (15.09.2003)
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Journal Article
RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency
Collis, Alan J, Foster, Martyn L, Halley, Frank, Maslen, Christopher, McLay, Iain M, Page, Kenneth M, Redford, E.Jane, Souness, John E, Wilsher, Nicola E
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
Published in Bioorganic & medicinal chemistry letters (12.03.2001)
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Journal Article
Selective Type IV Phosphodiesterase Inhibitors as Antiasthmatic Agents. The Syntheses and Biological Activities of 3-(Cyclopentyloxy)-4-methoxybenzamides and Analogs
Ashton, Michael J, Cook, David C, Fenton, Garry, Karlsson, Jan-Anders, Palfreyman, Malcolm N, Raeburn, David, Ratcliffe, Andrew J, Souness, John E, Thurairatnam, Suga, Vicker, Nigel
Published in Journal of medicinal chemistry (01.05.1994)
Published in Journal of medicinal chemistry (01.05.1994)
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Journal Article
Suppression of anti-CD3-induced interleukin-4 and interleukin-5 release from splenocytes of mesocestoides corti-infected BALB/c mice by phosphodiesterase 4 inhibitors
Souness, John E, Houghton, Clare, Sardar, Nughat, Withnall, Michael T
Published in Biochemical pharmacology (15.09.1999)
Published in Biochemical pharmacology (15.09.1999)
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Evidence that cyclic AMP phosphodiesterase inhibitors suppress interleukin‐2 release from murine splenocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer
Souness, John E., Houghton, Clare, Sardar, Nughat, Withnall, Michael T.
Published in British journal of pharmacology (01.06.1997)
Published in British journal of pharmacology (01.06.1997)
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Immunosuppressive and anti-inflammatory effects of cyclic AMP phosphodiesterase (PDE) type 4 inhibitors
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Book Review
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Anti‐inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor
Raeburn, David, Underwood, Stephen L., Lewis, Susan A., Woodman, Valerie R., Battram, Cliff H., Tomkinson, Adrian, Sharma, Steven, Jordan, Roy, Souness, John E., Webber, Stephen E., Karlsson, Jan‐Anders
Published in British journal of pharmacology (01.12.1994)
Published in British journal of pharmacology (01.12.1994)
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Journal Article
Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone
Souness, John E., Villamil, Maria E., Scott, Lisa C., Tomkinson, Adrian, Giembycz, Mark A., Raeburn, David
Published in British journal of pharmacology (01.04.1994)
Published in British journal of pharmacology (01.04.1994)
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Journal Article
Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNFα generation from human monocytes by interacting with a ‘low‐affinity’ phosphodiesterase 4 conformer
Souness, John E., Griffin, Miriam, Maslen, Christopher, Ebsworth, Karen, Scott, Lisa C., Pollock, Kenneth, Palfreyman, Malcolm N., Karlsson, Jan‐Anders
Published in British journal of pharmacology (01.06.1996)
Published in British journal of pharmacology (01.06.1996)
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Journal Article
Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY‐5445, vinpocetine and 1‐methyl‐3‐isobutyl‐8‐(methylamino)xanthine
Souness, John E., Brazdil, Roman, Diocee, Baljeet K., Jordan, Roy
Published in British journal of pharmacology (01.11.1989)
Published in British journal of pharmacology (01.11.1989)
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Journal Article
Novel Cyclic Compounds as Potent Phosphodiesterase 4 Inhibitors
He, Wei, Huang, Fu-Chih, Hanney, Barbara, Souness, John, Miller, Bruce, Liang, Guyan, Mason, Jon, Djuric, Stevan
Published in Journal of medicinal chemistry (22.10.1998)
Published in Journal of medicinal chemistry (22.10.1998)
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Characterization of guinea-pig eosinophil phosphodiesterase activity. Assessment of its involvement in regulating superoxide generation
Souness, J E, Carter, C M, Diocee, B K, Hassall, G A, Wood, L J, Turner, N C
Published in Biochemical pharmacology (25.07.1991)
Published in Biochemical pharmacology (25.07.1991)
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Journal Article
Mapping the kinase domain of Janus Kinase 3: Recent advances in the design of kinase inhibitors as novel therapeutic agents
ADAMS, Christopher, ALDOUS, David J, KING, Sue, LAI, Justine, LAWRENCE, Christopher, LETALLEC, Jean-Philippe, MCCARTHY, Clive, MOORCROFT, Neil, PAGE, Kenneth, RAO, Sudha, REDFORD, Jane, SADIQ, Shazia, AMENDOLA, Shelley, SMITH, Keith, SOUNESS, John E, THURAIRATNAM, Sukanthini, VINE, Mark, WYMAN, Barry, BAMBOROUGH, Paul, BRIGHT, Colin, CROWE, Sarah, EASTWOOD, Paul, FENTON, Garry, FOSTER, Martyn, HARRISON, Trevor K. P
Published in Bioorganic & medicinal chemistry letters (2003)
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Published in Bioorganic & medicinal chemistry letters (2003)
Journal Article
The synthesis and biological evaluation of a novel series of indole PDE4 inhibitors I
Hulme, Christopher, Moriarty, Kevin, Miller, Bruce, Mathew, Rose, Ramanjulu, Mercy, Cox, Paul, Souness, John, Page, Ken M., Uhl, Joanne, Travis, Jeffrey, Huang, Fu-chih, Labaudiniere, Richard, Djuric, Stevan W.
Published in Bioorganic & medicinal chemistry letters (21.07.1998)
Published in Bioorganic & medicinal chemistry letters (21.07.1998)
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