HIV-1 Protease Mutations and Inhibitor Modifications Monitored on a Series of Complexes. Structural Basis for the Effect of the A71V Mutation on the Active Site
Skálová, Tereza, Dohnálek, Jan, Dušková, Jarmila, Petroková, Hana, Hradílek, Martin, Souček, Milan, Konvalinka, Jan, Hašek, Jindřich
Published in Journal of medicinal chemistry (21.09.2006)
Published in Journal of medicinal chemistry (21.09.2006)
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Simple Method for Screening Candida Species Isolates for the Presence of Secreted Proteinases: a Tool for the Prediction of Successful Inhibitory Treatment
DOSTAL, Jiri, HAMAL, Petr, PAVLICKOVA, Libuse, SOUCEK, Milan, RUML, Tomas, PICHOVA, Iva, HRUSKOVA-HEIDINGSFELDOVA, Olga
Published in Journal of Clinical Microbiology (01.02.2003)
Published in Journal of Clinical Microbiology (01.02.2003)
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Hydroxyethylamine Isostere of an HIV-1 Protease Inhibitor Prefers Its Amine to the Hydroxy Group in Binding to Catalytic Aspartates. A Synchrotron Study of HIV-1 Protease in Complex with a Peptidomimetic Inhibitor
Dohnálek, Jan, Hašek, Jindřich, Dušková, Jarmila, Petroková, Hana, Hradilek, Martin, Souček, Milan, Konvalinka, Jan, Brynda, Jiří, Sedláček, Juraj, Fábry, Milan
Published in Journal of medicinal chemistry (28.03.2002)
Published in Journal of medicinal chemistry (28.03.2002)
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An Ethylenamine Inhibitor Binds Tightly to Both Wild Type and Mutant HIV-1 Proteases. Structure and Energy Study
Skálová, Tereza, Hašek, Jindřich, Dohnálek, Jan, Petroková, Hana, Buchtelová, Eva, Dušková, Jarmila, Souček, Milan, Majer, Pavel, Uhlíková, Táňa, Konvalinka, Jan
Published in Journal of medicinal chemistry (24.04.2003)
Published in Journal of medicinal chemistry (24.04.2003)
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Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex
Brynda, Jiří, Řezáčová, Pavlína, Fábry, Milan, Hořejší, Magdalena, Štouračová, Renata, Souček, Milan, Hradílek, Martin, Konvalinka, Jan, Sedláček, Juraj
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2004)
Published in Acta crystallographica. Section D, Biological crystallography. (01.11.2004)
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On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 Å resolution
Dušková, Jarmila, Dohnálek, Jan, Skálová, Tereza, Petroková, Hana, Vondráčková, Eva, Hradílek, Martin, Konvalinka, Jan, Souček, Milan, Brynda, Jiří, Fábry, Milan, Sedláček, Juraj, Hašek, Jindřich
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2006)
Published in Acta crystallographica. Section D, Biological crystallography. (01.05.2006)
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Unusual Binding Mode of an HIV-1 Protease Inhibitor Explains its Potency against Multi-drug-resistant Virus Strains
Weber, Jan, Mesters, Jeroen R, Lepšı́k, Martin, Prejdová, Jana, Švec, Martin, Šponarová, Jana, Mlčochová, Petra, Skalická, Kristina, Střı́šovský, Kvido, Uhlı́ková, Táňa, Souček, Milan, Machala, Ladislav, Staňková, Marie, Vondrášek, Jiřı́, Klimkait, Thomas, Kraeusslich, Hans-Georg, Hilgenfeld, Rolf, Konvalinka, Jan
Published in Journal of molecular biology (06.12.2002)
Published in Journal of molecular biology (06.12.2002)
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Determining and overcoming resistance to HIV protease inhibitors
Prejdová, Jana, Soucek, Milan, Konvalinka, Jan
Published in Current drug targets. Infectious disorders (01.06.2004)
Published in Current drug targets. Infectious disorders (01.06.2004)
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Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis and Candida lusitaniae
Pichová, Iva, Pavlíčková, Libuše, Dostál, Jiří, Dolejší, Elena, Hrušková‐Heidingsfeldová, Olga, Weber, Jan, Ruml, Tomáš, Souček, Milan
Published in European journal of biochemistry (01.05.2001)
Published in European journal of biochemistry (01.05.2001)
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Journal Article
Role of hydroxyl group and R/S configuration of isostere in binding properties of HIV‐1 protease inhibitors
Petroková, Hana, Dušková, Jarmila, Dohnálek, Jan, Skálová, Tereza, Vondráčková‐Buchtelová, Eva, Souček, Milan, Konvalinka, Jan, Brynda, Jiří, Fábry, Milan, Sedláček, Juraj, Hašek, Jindřich
Published in European journal of biochemistry (01.11.2004)
Published in European journal of biochemistry (01.11.2004)
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Journal Article
Secreted aspartic proteases of Candida albicans, Candida tropicalis, Candida parapsilosis and Candida lusitaniae. Inhibition with peptidomimetic inhibitors
Pichová, I, Pavlícková, L, Dostál, J, Dolejsí, E, Hrusková-Heidingsfeldová, O, Weber, J, Ruml, T, Soucek, M
Published in European journal of biochemistry (01.05.2001)
Published in European journal of biochemistry (01.05.2001)
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A Picomolar Inhibitor of Resistant Strains of Human Immunodeficiency Virus Protease Identified by a Combinatorial Approach
Rinnová, Markéta, Hradilek, Martin, Bařinka, Cyril, Weber, Jan, Souček, Milan, Vondrášek, Jiřı́, Klimkait, Thomas, Konvalinka, Jan
Published in Archives of biochemistry and biophysics (01.10.2000)
Published in Archives of biochemistry and biophysics (01.10.2000)
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Potency Comparison of Peptidomimetic Inhibitors against HIV-1 and HIV-2 Proteinases: Design of Equipotent Lead Compounds
Weber, Jan, Majer, Pavel, Litera, Jaroslav, Urban, Jan, Souček, Milan, Vondrášek, Jiřı́, Konvalinka, Jan, Novek, Petr, Sedláček, Juraj, Štrop, Petr, Kräusslich, Hans-Georg, Pichová, Iva
Published in Archives of biochemistry and biophysics (01.05.1997)
Published in Archives of biochemistry and biophysics (01.05.1997)
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A Modular Approach to HIV-1 Proteinase Inhibitor Design
Uhlı́ková, Tat'ána, Konvalinka, Jan, Pichová, Iva, Souček, Milan, Kräusslich, Hans-Georg, Vondrášek, Jiřı́
Published in Biochemical and biophysical research communications (06.05.1996)
Published in Biochemical and biophysical research communications (06.05.1996)
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Reduced-bond tight-binding inhibitors of HIV-1 protease Fine tuning of the enzyme subsite specificity
Urban, Jan, Konvalinka, Jan, Stehliková, Jana, Gregorová, Eva, Majer, Pavel, Souček, Milan, Andreánsky, Martin, Fábrys, Milan, Štrop, Petr
Published in FEBS letters (17.02.1992)
Published in FEBS letters (17.02.1992)
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A Phenylnorstatine Inhibitor Binding to HIV-1 Protease: Geometry, Protonation, and Subsite−Pocket Interactions Analyzed at Atomic Resolution
Brynda, Jiri, Rezacova, Pavlina, Fabry, Milan, Horejsi, Magdalena, Stouracova, Renata, Sedlacek, Juraj, Soucek, Milan, Hradilek, Martin, Lepsik, Martin, Konvalinka, Jan
Published in Journal of medicinal chemistry (08.04.2004)
Published in Journal of medicinal chemistry (08.04.2004)
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