Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses
Gorby, Claire, Sotolongo Bellón, Junel, Wilmes, Stephan, Warda, Walid, Pohler, Elizabeth, Fyfe, Paul K, Cozzani, Adeline, Ferrand, Christophe, Walter, Mark R, Mitra, Suman, Piehler, Jacob, Moraga, Ignacio
Published in Science signaling (15.09.2020)
Published in Science signaling (15.09.2020)
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Journal Article
Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency
Gardner, Scott, Jin, Yibo, Fyfe, Paul K, Voisin, Tomas B, Bellón, Junel Sotolongo, Pohler, Elizabeth, Piehler, Jacob, Moraga, Ignacio, Bubeck, Doryen
Published in Nature communications (07.03.2024)
Published in Nature communications (07.03.2024)
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Journal Article
Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response
Shih, Han-Po, Ding, Jing-Ya, Sotolongo Bellón, Junel, Lo, Yu-Fang, Chung, Pei-Han, Ting, He-Ting, Peng, Jhan-Jie, Wu, Tsai-Yi, Lin, Chia-Hao, Lo, Chia-Chi, Lin, You-Ning, Yeh, Chun-Fu, Chen, Jiun-Bo, Wu, Ting-Shu, Liu, Yuag-Meng, Kuo, Chen-Yen, Wang, Shang-Yu, Tu, Kun-Hua, Ng, Chau Yee, Lei, Wei-Te, Tsai, Yu-Huan, Chen, Jou-Han, Chuang, Ya-Ting, Huang, Jing-Yi, Rey, Félix A, Chen, Hung-Kai, Chang, Tse-Wen, Piehler, Jacob, Chi, Chih-Yu, Ku, Cheng-Lung
Published in The Journal of experimental medicine (05.09.2022)
Published in The Journal of experimental medicine (05.09.2022)
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Journal Article
Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization
Stüber, Jakob C., Richter, Christian P., Bellón, Junel Sotolongo, Schwill, Martin, König, Iwo, Schuler, Benjamin, Piehler, Jacob, Plückthun, Andreas
Published in Communications biology (21.06.2021)
Published in Communications biology (21.06.2021)
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Journal Article
Four-color single-molecule imaging with engineered tags resolves the molecular architecture of signaling complexes in the plasma membrane
Sotolongo Bellón, Junel, Birkholz, Oliver, Richter, Christian P., Eull, Florian, Kenneweg, Hella, Wilmes, Stephan, Rothbauer, Ulrich, You, Changjiang, Walter, Mark R., Kurre, Rainer, Piehler, Jacob
Published in Cell reports methods (28.02.2022)
Published in Cell reports methods (28.02.2022)
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Journal Article
Structure of the IFNγ receptor complex guides design of biased agonists
Mendoza, Juan L, Escalante, Nichole K, Jude, Kevin M, Sotolongo Bellon, Junel, Su, Leon, Horton, Tim M, Tsutsumi, Naotaka, Berardinelli, Steven J, Haltiwanger, Robert S, Piehler, Jacob, Engleman, Edgar G, Garcia, K Christopher
Published in Nature (London) (07.03.2019)
Published in Nature (London) (07.03.2019)
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Journal Article
Structure of the IFN[gamma] receptor complex guides design of biased agonists
Mendoza, Juan L, Escalante, Nichole K, Jude, Kevin M, Sotolongo Bellon, Junel, Su, Leon, Horton, Tim M, Tsutsumi, Naotaka
Published in Nature (London) (01.03.2019)
Published in Nature (London) (01.03.2019)
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Journal Article
Engineered IL-10 variants elicit potent immuno-modulatory activities at therapeutic low ligand doses
Gorby, Claire, Junel Sotolongo Bellon, Wilmes, Stephan, Warda, Walid, Pohler, Elizabeth, Fyfe, Paul, Cozzani, Adeline, Ferrand, Christophe, Walter, Mark, Mitra, Suman, Piehler, Jacob, Moraga, Ignacio
Published in bioRxiv (11.03.2020)
Published in bioRxiv (11.03.2020)
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