NPC1 enables cholesterol mobilization during long‐term potentiation that can be restored in Niemann–Pick disease type C by CYP46A1 activation
Mitroi, Daniel N, Pereyra‐Gómez, Guadalupe, Soto‐Huelin, Beatriz, Senovilla, Fernando, Kobayashi, Toshihide, Esteban, Jose A, Ledesma, María Dolores
Published in EMBO reports (05.11.2019)
Published in EMBO reports (05.11.2019)
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Lipid‐induced lysosomal damage after demyelination corrupts microglia protective function in lysosomal storage disorders
Gabandé‐Rodríguez, Enrique, Pérez‐Cañamás, Azucena, Soto‐Huelin, Beatriz, Mitroi, Daniel N, Sánchez‐Redondo, Sara, Martínez‐Sáez, Elena, Venero, César, Peinado, Héctor, Ledesma, María Dolores
Published in The EMBO journal (15.01.2019)
Published in The EMBO journal (15.01.2019)
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Journal Article
Ellagic acid and its metabolites urolithins A/B ameliorate most common disease phenotypes in cellular and mouse models for lysosomal storage disorders by enhancing extracellular vesicle secretion
Soto-Huelin, Beatriz, Babiy, Bohdan, Pastor, Oscar, Díaz-García, Mario, Toledano-Zaragoza, Ana, Frutos, María Dolores, Espín, Juan Carlos, Tomás-Barberán, Francisco A., Busto, Rebeca, Ledesma, María Dolores
Published in Neurobiology of disease (15.06.2023)
Published in Neurobiology of disease (15.06.2023)
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Adeno-associated viral vector serotype 9-based gene therapy for Niemann-Pick disease type A
Samaranch, Lluis, Pérez-Cañamás, Azucena, Soto-Huelin, Beatriz, Sudhakar, Vivek, Jurado-Arjona, Jerónimo, Hadaczek, Piotr, Ávila, Jesús, Bringas, John R, Casas, Josefina, Chen, Haifeng, He, Xingxuan, Schuchman, Edward H, Cheng, Seng H, Forsayeth, John, Bankiewicz, Krystof S, Ledesma, María Dolores
Published in Science translational medicine (21.08.2019)
Published in Science translational medicine (21.08.2019)
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NASAL DELIVERY OF GLUCOCORTICOIDS ENCAPSULATED IN CHITOSAN NANOPARTICLES FOR THE TREATMENT OF BRAIN PATHOLOGY IN THE ACID SPHINGOMYELINASE DEFICIENCY
Naya, Sara, Alleva, María, Soto-Huelin, Beatriz, De La Fuente, Jesús M, Ledesma, Maria Dolores
Published in IBRO neuroscience reports (01.10.2023)
Published in IBRO neuroscience reports (01.10.2023)
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Journal Article
NPC 1 enables cholesterol mobilization during long‐term potentiation that can be restored in Niemann–Pick disease type C by CYP 46A1 activation
Mitroi, Daniel N, Pereyra‐Gómez, Guadalupe, Soto‐Huelin, Beatriz, Senovilla, Fernando, Kobayashi, Toshihide, Esteban, Jose A, Ledesma, María Dolores
Published in EMBO reports (05.11.2019)
Published in EMBO reports (05.11.2019)
Get full text
Journal Article