Ad5/3 is able to avoid neutralization by binding to erythrocytes and lymphocytes
Zafar, Sadia, Quixabeira, Dafne Carolina Alves, Kudling, Tatiana Viktorovna, Cervera-Carrascon, Victor, Santos, Joao Manuel, Grönberg-Vähä-Koskela, Susanna, Zhao, Fang, Aronen, Pasi, Heiniö, Camilla, Havunen, Riikka, Sorsa, Suvi, Kanerva, Anna, Hemminki, Akseli
Published in Cancer gene therapy (01.05.2021)
Published in Cancer gene therapy (01.05.2021)
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Adenovirus Encoding Tumor Necrosis Factor Alpha and Interleukin 2 Induces a Tertiary Lymphoid Structure Signature in Immune Checkpoint Inhibitor Refractory Head and Neck Cancer
Clubb, James H A, Kudling, Tatiana V, Heiniö, Camilla, Basnet, Saru, Pakola, Santeri, Cervera Carrascón, Víctor, Santos, João Manuel, Quixabeira, Dafne C A, Havunen, Riikka, Sorsa, Suvi, Zheng, Vincent, Salo, Tuula, Bäck, Leif, Aro, Katri, Tulokas, Sanni, Loimu, Venla, Hemminki, Akseli
Published in Frontiers in immunology (07.03.2022)
Published in Frontiers in immunology (07.03.2022)
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Oncolytic Adenoviruses Armed with Tumor Necrosis Factor Alpha and Interleukin-2 Enable Successful Adoptive Cell Therapy
Havunen, Riikka, Siurala, Mikko, Sorsa, Suvi, Grönberg-Vähä-Koskela, Susanna, Behr, Michael, Tähtinen, Siri, Santos, João Manuel, Karell, Pauliina, Rusanen, Juuso, Nettelbeck, Dirk M., Ehrhardt, Anja, Kanerva, Anna, Hemminki, Akseli
Published in Molecular therapy. Oncolytics (17.03.2017)
Published in Molecular therapy. Oncolytics (17.03.2017)
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Journal Article
Adenovirus Armed With TNFa and IL2 Added to aPD-1 Regimen Mediates Antitumor Efficacy in Tumors Refractory to aPD-1
Cervera-Carrascon, Victor, Quixabeira, Dafne C A, Santos, Joao M, Havunen, Riikka, Milenova, Ioanna, Verhoeff, Jan, Heiniö, Camilla, Zafar, Sadia, Garcia-Vallejo, Juan J, van Beusechem, Victor W, de Gruijl, Tanja D, Kalervo, Aino, Sorsa, Suvi, Kanerva, Anna, Hemminki, Akseli
Published in Frontiers in immunology (23.07.2021)
Published in Frontiers in immunology (23.07.2021)
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Journal Article
Abscopal Effect in Non-injected Tumors Achieved with Cytokine-Armed Oncolytic Adenovirus
Havunen, Riikka, Santos, João M., Sorsa, Suvi, Rantapero, Tommi, Lumen, Dave, Siurala, Mikko, Airaksinen, Anu J., Cervera-Carrascon, Victor, Tähtinen, Siri, Kanerva, Anna, Hemminki, Akseli
Published in Molecular therapy. Oncolytics (21.12.2018)
Published in Molecular therapy. Oncolytics (21.12.2018)
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Journal Article
Cytokine-Coding Oncolytic Adenovirus TILT-123 Is Safe, Selective, and Effective as a Single Agent and in Combination with Immune Checkpoint Inhibitor Anti-PD-1
Havunen, Riikka, Kalliokoski, Riikka, Siurala, Mikko, Sorsa, Suvi, Santos, João M, Cervera-Carrascon, Victor, Anttila, Marjukka, Hemminki, Akseli
Published in Cells (Basel, Switzerland) (27.01.2021)
Published in Cells (Basel, Switzerland) (27.01.2021)
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CD40L coding oncolytic adenovirus allows long-term survival of humanized mice receiving dendritic cell therapy
Zafar, Sadia, Sorsa, Suvi, Siurala, Mikko, Hemminki, Otto, Havunen, Riikka, Cervera-Carrascon, Victor, Santos, João Manuel, Wang, Hongjie, Lieber, Andre, De Gruijl, Tanja, Kanerva, Anna, Hemminki, Akseli
Published in Oncoimmunology (03.10.2018)
Published in Oncoimmunology (03.10.2018)
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Journal Article
Effective intravenous delivery of adenovirus armed with TNFα and IL-2 improves anti-PD-1 checkpoint blockade in non-small cell lung cancer
Kudling, Tatiana V., Clubb, James H.A., Pakola, Santeri, Quixabeira, Dafne C.A., Lähdeniemi, Iris A.K., Heiniö, Camilla, Arias, Victor, Havunen, Riikka, Cervera-Carrascon, Victor, Santos, Joao M., Sutinen, Eva, Räsänen, Jari, Borenius, Kristian, Mäyränpää, Mikko I., Aaltonen, Eero, Sorsa, Suvi, Hemminki, Otto, Kanerva, Anna, Verschuren, Emmy W., Ilonen, Ilkka, Hemminki, Akseli
Published in Oncoimmunology (31.12.2023)
Published in Oncoimmunology (31.12.2023)
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Development of a Syrian hamster anti-PD-L1 monoclonal antibody enables oncolytic adenoviral immunotherapy modelling in an immunocompetent virus replication permissive setting
Clubb, James H A, Kudling, Tatiana V, Girych, Mykhailo, Haybout, Lyna, Pakola, Santeri, Hamdan, Firas, Cervera-Carrascon, Víctor, Hemmes, Annabrita, Grönberg-Vähä-Koskela, Susanna, Santos, João Manuel, Quixabeira, Dafne C A, Basnet, Saru, Heiniö, Camilla, Arias, Victor, Jirovec, Elise, Kaptan, Shreyas, Havunen, Riikka, Sorsa, Suvi, Erikat, Abdullah, Schwartz, Joel, Anttila, Marjukka, Aro, Katri, Viitala, Tapani, Vattulainen, Ilpo, Cerullo, Vincenzo, Kanerva, Anna, Hemminki, Akseli
Published in Frontiers in immunology (03.02.2023)
Published in Frontiers in immunology (03.02.2023)
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Journal Article
Tumor microenvironment remodeling by an engineered oncolytic adenovirus results in improved outcome from PD-L1 inhibition
Cervera-Carrascon, Victor, Quixabeira, Dafne C.A., Santos, Joao Manuel, Havunen, Riikka, Zafar, Sadia, Hemminki, Otto, Heiniö, Camilla, Munaro, Eleonora, Siurala, Mikko, Sorsa, Suvi, Mirtti, Tuomas, Järvinen, Petrus, Mildh, Markus, Nisen, Harry, Rannikko, Antti, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli
Published in Oncoimmunology (01.01.2020)
Published in Oncoimmunology (01.01.2020)
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Journal Article
Comparison of Clinically Relevant Oncolytic Virus Platforms for Enhancing T Cell Therapy of Solid Tumors
Cervera-Carrascon, Victor, Quixabeira, Dafne C.A., Havunen, Riikka, Santos, Joao M., Kutvonen, Emma, Clubb, James H.A., Siurala, Mikko, Heiniö, Camilla, Zafar, Sadia, Koivula, Teija, Lumen, Dave, Vaha, Marjo, Garcia-Horsman, Arturo, Airaksinen, Anu J., Sorsa, Suvi, Anttila, Marjukka, Hukkanen, Veijo, Kanerva, Anna, Hemminki, Akseli
Published in Molecular therapy. Oncolytics (26.06.2020)
Published in Molecular therapy. Oncolytics (26.06.2020)
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Journal Article
Oncolytic adenovirus coding for bispecific T cell engager against human MUC-1 potentiates T cell response against solid tumors
Basnet, Saru, Santos, Joao M., Quixabeira, Dafne C.A., Clubb, James H.A., Grönberg-Vähä-Koskela, Susanna A.M., Arias, Victor, Pakola, Santeri, Kudling, Tatiana V., Heiniö, Camilla, Havunen, Riikka, Cervera-Carrascon, Victor, Sorsa, Suvi, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli
Published in Molecular therapy. Oncolytics (16.03.2023)
Published in Molecular therapy. Oncolytics (16.03.2023)
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Journal Article
739 Emerging proteomic and safety analysis of blood from solid tumor patients receiving TILT-123 (Ad5/3-E2F-d24-hTNFa-IRES-hIL2) monotherapy in TUNIMO phase 1 clinical trial
Pakola, Santeri A, Cervera-Carrascon, Victor, Peltola, Katriina, Alanko, Tuomo, Korpisaari, Riitta, Jaakkola, Marjut, Sormunen, Jorma, Kononen, Juha, Clubb, James, Jirovec, Elise, Kudling, Tatiana, Haybout, Lyna, Quixabeira, Dafne CA, Kistler, Claudia, Santos, Joao, Sorsa, Suvi, Havunen, Riikka, Hemminki, Akseli
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
745 Immune cell profiling of advanced-stage solid tumors patients treated with an oncolytic adenovirus encoding for TNF-a and IL-2 (TILT-123)
Quixabeira, Dafne CA, Pakola, Santeri A, Clubb, James, Haybout, Lyna, Jirovec, Elise, Kudling, Tatiana, Santos, Joao, Cervera-Carrascon, Victor, Peltola, Katriina, Alanko, Tuomo, Sormunen, Jorma, Korpisaari, Riitta, Jaakkola, Marjut, Kononen, Juha, Juteau, Susanna, Kistler, Claudia, Sorsa, Suvi, Havunen, Riikka, Hemminki, Akseli
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
711 Development of oncolytic adenovirus Ad5/3-E2F-D24-hTNFa-IRES-hIL2 (TILT-123) for the treatment of solid tumours – from preclinical testing to phase I clinical trials
Clubb, James, Cervera-Carrascon, Victor, Peltola, Katriina, Alanko, Tuomo, Korpisaari, Riitta, Jaakkola, Marjut, Sormunen, Jorma, Kononen, Juha, Santos, Joao Manuel, Pakola, Santeri A, Jirovec, Elise, Kudling, Tatiana, Haybout, Lyna, Quixabeira, Dafne CA, Kistler, Claudia, Havunen, Riikka, Sorsa, Suvi, Hemminki, Akseli
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
749 Early phase oncology experience on the use of an oncolytic adenovirus encoding for TNFa and IL-2 for the treatment of solid tumors – Interim results
Santos, Joao, Svane, Inge, Peltola, Katriina, Alanko, Tuomo, Korpisaari, Riitta, Juteau, Susanna, Jaakkola, Marjut, Sormunen, Jorma, Kononen, Juha, Ellebaek, Eva, Monberg, Tine, Donia, Marco, Khammari, Amir, Dreno, Brigitte, Pakola, Santeri A, Clubb, James, Jirovec, Elise, Quixabeira, Dafne CA, Kudling, Tatiana, Haybout, Lyna, Cervera-Carrascon, Victor, Kistler, Claudia, Sorsa, Suvi, Havunen, Riikka, Hemminki, Akseli
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
814 Enhancing anti-tumor response in ICI-refractory non-small cell lung cancer through intravenous administration of oncolytic adenovirus armed with hTNFα and hIL-2 in combination with aPD-1 blockade
Kudling, Tatiana V, Clubb, James, Pakola, Santeri A, Quixabeira, Dafne Alves, Lähdeniemi, Iris, Heiniö, Camilla, Arias, Victor, Grönberg-Vähä-Koskela, Susanna AM, Havunen, Riikka, Cervera-Carrascon, Victor, Santos, Joao Manuel, Sutinen, Eva, Räsänen, Jari, Borenius, Kristian, Mäyränpää, Mikko, Altonen, Eero, Sorsa, Suvi, Hemminki, Otto, Kanerva, Anna, Verschuren, Emmy W, Ilonen, Ilkka, Hemminki, Akseli
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
1518 T-cell inducing oncolytic virus (igrelimogene litadenorepvec; TILT-123) shows safety, anti-tumor activity and induction of immune responses in advanced solid tumor patients (full report on TUNIMO)
Santos, Joao, Peltola, Katriina, Alanko, Tuomo, Pakola, Santeri A, Clubb, James, Jirovec, Elise, Haybout, Lyna, Kudling, Tatiana V, Korpisaari, Riitta, Juteau, Susanna, Jaakkola, Marjut, Sormunen, Jorma, Kononen, Juha, Quixabeira, Dafne CA, Kistler, Claudia, Sorsa, Suvi, Havunen, Riikka, Cervera-Carrascon, Victor, Hemminki, Akseli
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
Adenovirus Coding for Interleukin-2 and Tumor Necrosis Factor Alpha Replaces Lymphodepleting Chemotherapy in Adoptive T Cell Therapy
Santos, João Manuel, Cervera-Carrascon, Víctor, Havunen, Riikka, Zafar, Sadia, Siurala, Mikko, Sorsa, Suvi, Anttila, Marjukka, Kanerva, Anna, Hemminki, Akseli
Published in Molecular therapy (05.09.2018)
Published in Molecular therapy (05.09.2018)
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Journal Article
Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses
Watanabe, Keisuke, Luo, Yanping, Da, Tong, Guedan, Sonia, Ruella, Marco, Scholler, John, Keith, Brian, Young, Regina M, Engels, Boris, Sorsa, Suvi, Siurala, Mikko, Havunen, Riikka, Tähtinen, Siri, Hemminki, Akseli, June, Carl H
Published in JCI insight (05.04.2018)
Published in JCI insight (05.04.2018)
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