Family-wide Structural Analysis of Human Numb-Associated Protein Kinases
Sorrell, Fiona J., Szklarz, Marta, Abdul Azeez, Kamal R., Elkins, Jon M., Knapp, Stefan
Published in Structure (London) (01.03.2016)
Published in Structure (London) (01.03.2016)
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Journal Article
Structural complexity in the KCTD family of Cullin3-dependent E3 ubiquitin ligases
Pinkas, Daniel M, Sanvitale, Caroline E, Bufton, Joshua C, Sorrell, Fiona J, Solcan, Nicolae, Chalk, Rod, Doutch, James, Bullock, Alex N
Published in Biochemical journal (01.11.2017)
Published in Biochemical journal (01.11.2017)
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Journal Article
Structural basis of Keap1 interactions with Nrf2
Canning, Peter, Sorrell, Fiona J., Bullock, Alex N.
Published in Free radical biology & medicine (01.11.2015)
Published in Free radical biology & medicine (01.11.2015)
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Journal Article
Identification and Characterization of a Small-Molecule Inhibitor of Death-Associated Protein Kinase 1
Wilbek, Theis S., Skovgaard, Tine, Sorrell, Fiona J., Knapp, Stefan, Berthelsen, Jens, Strømgaard, Kristian
Published in Chembiochem : a European journal of chemical biology (02.01.2015)
Published in Chembiochem : a European journal of chemical biology (02.01.2015)
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Journal Article
Development of a differential scanning fluorimetry based high throughput screening assay for the discovery of affinity binders against an anthrax protein
Sorrell, Fiona J., Greenwood, Gemma K., Birchall, Kristian, Chen, Beining
Published in Journal of pharmaceutical and biomedical analysis (05.09.2010)
Published in Journal of pharmaceutical and biomedical analysis (05.09.2010)
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Journal Article
Improved 2,4-Diarylthiazole-Based Antiprion Agents: Switching the Sense of the Amide Group at C5 Leads to an Increase in Potency
Thompson, Mark J., Louth, Jennifer C., Greenwood, Gemma K., Sorrell, Fiona J., Knight, Sandra G., Adams, Nathan B. P., Chen, Beining
Published in ChemMedChem (03.09.2010)
Published in ChemMedChem (03.09.2010)
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Journal Article
Synthesis and Structure–Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3‑b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity
Verdonck, Sven, Pu, Szu-Yuan, Sorrell, Fiona J, Elkins, Jon M, Froeyen, Mathy, Gao, Ling-Jie, Prugar, Laura I, Dorosky, Danielle E, Brannan, Jennifer M, Barouch-Bentov, Rina, Knapp, Stefan, Dye, John M, Herdewijn, Piet, Einav, Shirit, De Jonghe, Steven
Published in Journal of medicinal chemistry (27.06.2019)
Published in Journal of medicinal chemistry (27.06.2019)
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Journal Article
Systematic Potency and Property Assessment of VHL Ligands and Implications on PROTAC Design
Krieger, Johannes, Sorrell, Fiona J., Wegener, Ansgar A., Leuthner, Birgitta, Machrouhi‐Porcher, Fouzia, Hecht, Martin, Leibrock, Eva M., Müller, Juliane E., Eisert, Jonathan, Hartung, Ingo V., Schlesiger, Sarah
Published in ChemMedChem (17.04.2023)
Published in ChemMedChem (17.04.2023)
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Journal Article
Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases
Henderson, Scott H., Sorrell, Fiona J., Bennett, James M., Fedorov, Oleg, Hanley, Marcus T., Godoi, Paulo H., Ruela de Sousa, Roberta, Robinson, Sean, Navratilova, Iva Hopkins, Elkins, Jonathan M., Ward, Simon E.
Published in European journal of medicinal chemistry (05.04.2024)
Published in European journal of medicinal chemistry (05.04.2024)
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Journal Article
Discovery of a Potent Dual SLK/STK10 Inhibitor Based on a Maleimide Scaffold
Serafim, Ricardo A. M, Sorrell, Fiona J, Berger, Benedict-Tilman, Collins, Ross J, Vasconcelos, Stanley N. S, Massirer, Katlin B, Knapp, Stefan, Bennett, James, Fedorov, Oleg, Patel, Hitesh, Zuercher, William J, Elkins, Jonathan M
Published in Journal of medicinal chemistry (23.09.2021)
Published in Journal of medicinal chemistry (23.09.2021)
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Journal Article
Sequence and structural variations determining the recruitment of WNK kinases to the KLHL3 E3 ligase
Chen, Zhuoyao, Zhang, Jinwei, Murillo-de-Ozores, Adrián R, Castañeda-Bueno, María, D'Amico, Francesca, Heilig, Raphael, Manning, Charlotte E, Sorrell, Fiona J, D'Angiolella, Vincenzo, Fischer, Roman, Mulder, Monique P C, Gamba, Gerardo, Alessi, Dario R, Bullock, Alex N
Published in Biochemical journal (18.03.2022)
Published in Biochemical journal (18.03.2022)
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Journal Article
Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model
Fromont, Christophe, Atzori, Alessio, Kaur, Divneet, Hashmi, Lubna, Greco, Graziella, Cabanillas, Alejandro, Nguyen, Huy Van, Jones, D. Heulyn, Garzón, Miguel, Varela, Ana, Stevenson, Brett, Iacobini, Greg P, Lenoir, Marc, Rajesh, Sundaresan, Box, Clare, Kumar, Jitendra, Grant, Paige, Novitskaya, Vera, Morgan, Juliet, Sorrell, Fiona J, Redondo, Clara, Kramer, Andreas, Harris, C. John, Leighton, Brendan, Vickers, Steven P, Cheetham, Sharon C, Kenyon, Colin, Grabowska, Anna M, Overduin, Michael, Berditchevski, Fedor, Weston, Chris J, Knapp, Stefan, Fischer, Peter M, Butterworth, Sam
Published in Journal of medicinal chemistry (09.07.2020)
Published in Journal of medicinal chemistry (09.07.2020)
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Journal Article
WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop
Agajanian, Megan J., Walker, Matthew P., Axtman, Alison D., Ruela-de-Sousa, Roberta R., Serafin, D. Stephen, Rabinowitz, Alex D., Graham, David M., Ryan, Meagan B., Tamir, Tigist, Nakamichi, Yuko, Gammons, Melissa V., Bennett, James M., Couñago, Rafael M., Drewry, David H., Elkins, Jonathan M., Gileadi, Carina, Gileadi, Opher, Godoi, Paulo H., Kapadia, Nirav, Müller, Susanne, Santiago, André S., Sorrell, Fiona J., Wells, Carrow I., Fedorov, Oleg, Willson, Timothy M., Zuercher, William J., Major, Michael B.
Published in Cell reports (Cambridge) (02.01.2019)
Published in Cell reports (Cambridge) (02.01.2019)
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Journal Article
Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity
Thompson, Mark J., Louth, Jennifer C., Ferrara, Steven, Jackson, Matthew P., Sorrell, Fiona J., Cochrane, Edward J., Gever, Joel, Baxendale, Sarah, Silber, B. Michael, Roehl, Henry H., Chen, Beining
Published in European journal of medicinal chemistry (01.09.2011)
Published in European journal of medicinal chemistry (01.09.2011)
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Journal Article
Structure-Activity Relationship Refinement and Further Assessment of Indole-3-glyoxylamides as a Lead Series against Prion Disease
Thompson, Mark J., Louth, Jennifer C., Ferrara, Steven, Sorrell, Fiona J., Irving, Benjamin J., Cochrane, Edward J., Meijer, Anthony J. H. M., Chen, Beining
Published in ChemMedChem (03.01.2011)
Published in ChemMedChem (03.01.2011)
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Journal Article
Synthesis and Structure-Activity Relationships of 3,5-Disubstituted-pyrrolo2,3- bpyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity
Verdonck, Sven, Pu, Szu-Yuan, Sorrell, Fiona J, Elkins, Jon M, Froeyen, Mathy, Gao, Ling-Jie, Prugar, Laura I, Dorosky, Danielle E, Brannan, Jennifer M, Barouch-Bentov, Rina, Knapp, Stefan, Dye, John M, Herdewijn, Piet, Einav, Shirit, De Jonghe, Steven
Published in Journal of medicinal chemistry (27.06.2019)
Published in Journal of medicinal chemistry (27.06.2019)
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Journal Article
Inside Cover: Improved 2,4-Diarylthiazole-Based Antiprion Agents: Switching the Sense of the Amide Group at C5 Leads to an Increase in Potency (ChemMedChem 9/2010)
Thompson, Mark J., Louth, Jennifer C., Greenwood, Gemma K., Sorrell, Fiona J., Knight, Sandra G., Adams, Nathan B. P., Chen, Beining
Published in ChemMedChem (03.09.2010)
Published in ChemMedChem (03.09.2010)
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Journal Article