Enabling, Decagram-Scale Synthesis of Macrocyclic MCL‑1 Inhibitor ABBV-467
Brady, Patrick B., Sorensen, Bryan K., Risi, Roberto M., Curtin, Michael L., Mantei, Robert A., Florjancic, Alan S., Mastracchio, Anthony, Ji, Cheng, Kunzer, Aaron R., Lai, Chunqiu, Storer, Gregory E., Chan, Vincent S., Henry, Rodger F., Souers, Andrew J., Michaelides, Michael R., Judd, Andrew S., Hansen, T. Matthew
Published in Journal of organic chemistry (17.11.2023)
Published in Journal of organic chemistry (17.11.2023)
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SAR and characterization of non-substrate isoindoline urea inhibitors of nicotinamide phosphoribosyltransferase (NAMPT)
Curtin, Michael L., Heyman, H. Robin, Clark, Richard F., Sorensen, Bryan K., Doherty, George A., Hansen, T. Matthew, Frey, Robin R., Sarris, Kathy A., Aguirre, Ana L., Shrestha, Anurupa, Tu, Noah, Woller, Kevin, Pliushchev, Marina A., Sweis, Ramzi F., Cheng, Min, Wilsbacher, Julie L., Kovar, Peter J., Guo, Jun, Cheng, Dong, Longenecker, Kenton L., Raich, Diana, Korepanova, Alla V., Soni, Nirupama B., Algire, Mikkel A., Richardson, Paul L., Marin, Violeta L., Badagnani, Ilaria, Vasudevan, Anil, Buchanan, F. Greg, Maag, David, Chiang, Gary G., Tse, Chris, Michaelides, Michael R.
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
Published in Bioorganic & medicinal chemistry letters (01.08.2017)
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Imidazo[2,1- b]thiazoles: Multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases
Fidanze, Steve D., Erickson, Scott A., Wang, Gary T., Mantei, Robert, Clark, Richard F., Sorensen, Bryan K., Bamaung, Nwe Y., Kovar, Peter, Johnson, Eric F., Swinger, Kerren K., Stewart, Kent D., Zhang, Qian, Tucker, Lora A., Pappano, William N., Wilsbacher, Julie L., Wang, Jieyi, Sheppard, George S., Bell, Randy L., Davidsen, Steven K., Hubbard, Robert D.
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
Published in Bioorganic & medicinal chemistry letters (15.04.2010)
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Discovery and Metabolic Stabilization of Potent and Selective 2-Amino-N-(adamant-2-yl) Acetamide 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors
Rohde, Jeffrey J, Pliushchev, Marina A, Sorensen, Bryan K, Wodka, Dariusz, Shuai, Qi, Wang, Jiahong, Fung, Steven, Monzon, Katina M, Chiou, William J, Pan, Liping, Deng, Xiaoqing, Chovan, Linda E, Ramaiya, Atul, Mullally, Mark, Henry, Rodger F, Stolarik, DeAnne F, Imade, Hovis M, Marsh, Kennan C, Beno, David W. A, Fey, Thomas A, Droz, Brian A, Brune, Michael E, Camp, Heidi S, Sham, Hing L, Frevert, Ernst Uli, Jacobson, Peer B, Link, J. T
Published in Journal of medicinal chemistry (11.01.2007)
Published in Journal of medicinal chemistry (11.01.2007)
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Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 4. Side Chain Conformational Restriction Leads to ETB Selectivity
von Geldern, Thomas W, Tasker, Andrew S, Sorensen, Bryan K, Winn, Martin, Szczepankiewicz, Bruce G, Dixon, Douglas B, Chiou, William J, Wang, Liming, Wessale, Jerry L, Adler, Andy, Marsh, Kennan C, Nguyen, Bach, Opgenorth, Terry J
Published in Journal of medicinal chemistry (09.09.1999)
Published in Journal of medicinal chemistry (09.09.1999)
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Biaryl amide glucagon receptor antagonists
KURUKULASURIYA, Ravi, SORENSEN, Bryan K, ADLER, Andrew L, COLLINS, Christine A, LINK, James T, PATEL, Jyoti R, JAE, Hwan-Soo, WINN, Marty X, ROHDE, Jeffrey R, GRIHALDE, Nelson D, LIN, Chun W, OGIELA, Christopher A
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
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Discovery of novel nonsteroidal glucocorticoid receptor modulators
LINK, J. T, SORENSEN, Bryan K, PATEL, Jyoti, EMERY, Maurice, GRYNFARB, Marlena, GOOS-NILSSON, Annika
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
Published in Bioorganic & medicinal chemistry letters (03.05.2004)
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Pyrrolidine-3-carboxylic Acids as Endothelin Antagonists. 5. Highly Selective, Potent, and Orally Active ETA Antagonists
Jae, Hwan-Soo, Winn, Martin, von Geldern, Thomas W, Sorensen, Bryan K, Chiou, William J, Nguyen, Bach, Marsh, Kennan C, Opgenorth, Terry J
Published in Journal of medicinal chemistry (08.11.2001)
Published in Journal of medicinal chemistry (08.11.2001)
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Optimization and metabolic stabilization of a class of nonsteroidal glucocorticoid modulators
Link, J.T, Sorensen, Bryan K, Patel, Jyoti, Arendsen, David, Li, Gaoquan, Swanson, Susan, Nguyen, Bach, Emery, Maurice, Grynfarb, Marlena, Goos-Nilsson, Annika
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
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Bile acid conjugates of a nonsteroidal glucocorticoid receptor modulator
Tu, Noah, Link, J.T, Sorensen, Bryan K, Emery, Maurice, Grynfarb, Marlena, Goos-Nilsson, Annika, Nguyen, Bach
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
Published in Bioorganic & medicinal chemistry letters (16.08.2004)
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2,4-Diarylpyrrolidine-3-carboxylic AcidsPotent ETA Selective Endothelin Receptor Antagonists. 1. Discovery of A-127722
Winn, Martin, von Geldern, Thomas W, Opgenorth, Terry J, Jae, Hwan-Soo, Tasker, Andrew S, Boyd, Steven A, Kester, Jeffrey A, Mantei, Robert A, Bal, Radhika, Sorensen, Bryan K, Wu-Wong, Jinshyun R, Chiou, William J, Dixon, Douglas B, Novosad, Eugene I, Hernandez, Lisa, Marsh, Kennan C
Published in Journal of medicinal chemistry (01.03.1996)
Published in Journal of medicinal chemistry (01.03.1996)
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An Evaluation of a C-Glucuronide as a liver targeting group: conjugate of a glucocorticoid antagonist
Sorensen, Bryan K., Link, J.T., von Geldern, Thomas, Emery, Maurice, Wang, Jiahong, Hickman, Bach, Grynfarb, Marlena, Goos-Nilsson, Annika, Carroll, Sherry
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
Published in Bioorganic & medicinal chemistry letters (21.07.2003)
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Stereoselective Synthesis of ABBV-992 Enabled by a Flow Diazotization and a Partial Reduction of a Pyridone
Brady, Patrick B., Harper, Kaid C., Sorensen, Bryan K., Greszler, Stephen N., Lai, Chunqiu, Florjancic, Alan S., Zhao, Gang, Shelat, Bhadra H., Storer, Gregory E., Henry, Rodger F., Hansen, T. Matthew
Published in Organic process research & development (16.08.2024)
Published in Organic process research & development (16.08.2024)
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Potent and Selective Non-Benzodioxole-Containing Endothelin-A Receptor Antagonists
Tasker, Andrew S, Sorensen, Bryan K, Jae, Hwan-Soo, Winn, Martin, von Geldern, Thomas W, Dixon, Douglas B, Chiou, William J, Dayton, Brian D, Calzadila, Samuel, Hernandez, Lisa, Marsh, Kennan C, WuWong, J. Ruth, Opgenorth, Terry J
Published in Journal of medicinal chemistry (31.01.1997)
Published in Journal of medicinal chemistry (31.01.1997)
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Discovery of a series of pyrrolidine-based endothelin receptor antagonists with enhanced ET A receptor selectivity
Boyd, Steven A, Mantei, Robert A, Tasker, Andrew S, Liu, Gang, Sorensen, Bryan K, Henry Jr, Kenneth J, von Geldern, Thomas W, Winn, Martin, Wu-Wong, Jinshyun R, Chiou, William J, Dixon, Douglas B, Hutchins, Charles W, Marsh, Kennan C, Nguyen, Bach, Opgenorth, Terry J
Published in Bioorganic & medicinal chemistry (01.06.1999)
Published in Bioorganic & medicinal chemistry (01.06.1999)
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Adamantane sulfone and sulfonamide 11-β-HSD1 Inhibitors
Sorensen, Bryan, Winn, Martin, Rohde, Jeff, Shuai, Qi, Wang, Jiahong, Fung, Steven, Monzon, Katina, Chiou, William, Stolarik, DeAnne, Imade, Hovis, Pan, Liping, Deng, Xiaoqing, Chovan, Linda, Longenecker, Kenton, Judge, Russell, Qin, Wenying, Brune, Michael, Camp, Heidi, Frevert, Ernst U., Jacobson, Peer, Link, J.T.
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
Published in Bioorganic & medicinal chemistry letters (15.01.2007)
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Potent and selective inhibitors of an aspartyl protease-like endothelin converting enzyme identified in rat lung
Shiosaki, Kazumi, Tasker, Andrew S, Sullivan, Gerard M, Sorensen, Bryan K, von Geldern, Thomas W, Wu-Wong, Jinshyun R, Marselle, Carol A, Opgenorth, Terry J
Published in Journal of medicinal chemistry (19.02.1993)
Published in Journal of medicinal chemistry (19.02.1993)
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Adamantane 11-β-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction
Sorensen, Bryan, Rohde, Jeff, Wang, Jiahong, Fung, Steven, Monzon, Katina, Chiou, William, Pan, Liping, Deng, Xiaoqing, Stolarik, DeAnne, Frevert, Ernst U., Jacobson, Peer, Link, J.T.
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
Published in Bioorganic & medicinal chemistry letters (01.12.2006)
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Discovery of potent and selective inhibitors of 11β-HSD1 for the treatment of metabolic syndrome
Richards, Steven, Sorensen, Bryan, Jae, Hwan-soo, Winn, Marty, Chen, Yixian, Wang, Jiahong, Fung, Steven, Monzon, Katina, Frevert, Ernst U., Jacobson, Peer, Sham, Hing, Link, J.T.
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
Published in Bioorganic & medicinal chemistry letters (15.12.2006)
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Abstract A245: Imidazo[2,1-b]thiazole and imidazo[1,2-a]pyridine amides as novel inhibitors of the insulin-like growth factor (IGF1R) and members of the epidermal growth factor family of tyrosine kinases
Fidanze, Steve D., Erickson, Scott A., Hubbard, Robert D., Wang, Gary T., Mantei, Robert A., BaMaung, Nwe Y., Clark, Richard F., Sorensen, Bryan K., Kovar, Peter, Pappano, William, Zhang, Qian, Wilsbacher, Julie L., Hu, Xiaoming, Tucker, Lora A., Cheng, Min, Swinger, Kerren K., Stewart, Kent D., Wang, Jieyi, Bell, Randy L., Davidsen, Steven K., Sheppard, George S.
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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