BL-8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: the COMBAT trial
Bockorny, Bruno, Semenisty, Valerya, Macarulla, Teresa, Borazanci, Erkut, Wolpin, Brian M, Stemmer, Salomon M, Golan, Talia, Geva, Ravit, Borad, Mitesh J, Pedersen, Katrina S, Park, Joon Oh, Ramirez, Robert A, Abad, David G, Feliu, Jaime, Muñoz, Andres, Ponz-Sarvise, Mariano, Peled, Amnon, Lustig, Tzipora M, Bohana-Kashtan, Osnat, Shaw, Stephen M, Sorani, Ella, Chaney, Marya, Kadosh, Shaul, Vainstein Haras, Abi, Von Hoff, Daniel D, Hidalgo, Manuel
Published in Nature medicine (01.06.2020)
Published in Nature medicine (01.06.2020)
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Motixafortide and Pembrolizumab Combined to Nanoliposomal Irinotecan, Fluorouracil, and Folinic Acid in Metastatic Pancreatic Cancer: The COMBAT/KEYNOTE-202 Trial
Bockorny, Bruno, Macarulla, Teresa, Semenisty, Valerya, Borazanci, Erkut, Feliu, Jaime, Ponz-Sarvise, Mariano, Abad, David Gutierrez, Oberstein, Paul, Alistar, Angela, Muñoz, Andres, Geva, Ravit, Guillén-Ponce, Carmen, Fernandez, Mercedes Salgado, Peled, Amnon, Chaney, Marya, Gliko-Kabir, Irit, Shemesh-Darvish, Liron, Ickowicz, Debby, Sorani, Ella, Kadosh, Shaul, Vainstein-Haras, Abi, Hidalgo, Manuel
Published in Clinical cancer research (15.09.2021)
Published in Clinical cancer research (15.09.2021)
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Laquinimod enhances central nervous system barrier functions
Lühder, Fred, Kebir, Hania, Odoardi, Francesca, Litke, Tanja, Sonneck, Maike, Alvarez, Jorge Ivan, Winchenbach, Jan, Eckert, Nadine, Hayardeny, Liat, Sorani, Ella, Lodygin, Dmitri, Flügel, Alexander, Prat, Alexandre
Published in Neurobiology of disease (01.06.2017)
Published in Neurobiology of disease (01.06.2017)
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Safety and in vivo immune assessment of escalating doses of oral laquinimod in patients with RRMS
Ziemssen, Tjalf, Tumani, Hayrettin, Sehr, Tony, Thomas, Katja, Paul, Friedemann, Richter, Nils, Samara, Emil, Spiegelstein, Ofer, Sorani, Ella, Bar-Ilan, Oren, Mimrod, Dorit, Hayardeny, Liat
Published in Journal of neuroinflammation (31.08.2017)
Published in Journal of neuroinflammation (31.08.2017)
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AGI-134: a fully synthetic α-Gal glycolipid that converts tumors into in situ autologous vaccines, induces anti-tumor immunity and is synergistic with an anti-PD-1 antibody in mouse melanoma models
Shaw, Stephen M, Middleton, Jenny, Wigglesworth, Kim, Charlemagne, Amber, Schulz, Oliver, Glossop, Melanie S, Whalen, Giles F, Old, Robert, Westby, Mike, Pickford, Chris, Tabakman, Rinat, Carmi-Levy, Irit, Vainstein, Abi, Sorani, Ella, Zur, Arik A, Kristian, Sascha A
Published in Cancer cell international (19.12.2019)
Published in Cancer cell international (19.12.2019)
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Prolonged CXCR4 Receptor Occupancy By Motixafortide Following a Single Subcutaneous Injection Is Associated with Extended Mobilization of CD34+ Cells in Peripheral Blood for > 24 Hours
Crees, Zachary David, Stockerl-Goldstein, Keith, Sorani, Ella, Ickowicz, Debby, Darvish, Liron, DiPersio, John F.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
The High Affinity CXCR4 Inhibitor, BL-8040, Impairs the Infiltration, Migration, Viability, and Differentiation of Regulatory T Cells
Abraham, Michal, Mishalian, Inbal, Vainstein, Abi, Shemesh-Darvish, Liron, Sorani, Ella, Eizenberg, Orly, Peled, Amnon
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Use of Combination Premedication Prior to Motixafortide Administration Reduced Severity and Frequency of AEs in the Phase 3 Genesis Trial - a Single Center Analysis
Crees, Zachary David, Stockerl-Goldstein, Keith, Schroeder, Mark A., Vij, Ravi, Sorani, Ella, Gliko Kabir, Irit, Goldstein, Inbal, Lustig, Tzipi, Kadosh, Shaul, DiPersio, John F.
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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A Phase I Safety and Feasibility Study to Evaluate Motixafortide (CXCR4/SDF-1 Inhibition) and Natalizumab (VLA-4/VCAM-1 Inhibition) As a Novel Regimen to Mobilize CD34+ Hematopoietic Stem Cells for Gene Therapy in Sickle Cell Disease
Crees, Zachary D., Rettig, Michael P., Jayasinghe, Reyka G., Ruminski, Peter, Vainstein, Abi, Sorani, Ella, King, Allison A., DiPersio, John F.
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Motixafortide and G-CSF to mobilize hematopoietic stem cells for autologous transplantation in multiple myeloma: a randomized phase 3 trial
Crees, Zachary D, Rettig, Michael P, Jayasinghe, Reyka G, Stockerl-Goldstein, Keith, Larson, Sarah M, Arpad, Illes, Milone, Giulio A, Martino, Massimo, Stiff, Patrick, Sborov, Douglas, Pereira, Denise, Micallef, Ivana, Moreno-Jiménez, Gemma, Mikala, Gabor, Coronel, Maria Liz Paciello, Holtick, Udo, Hiemenz, John, Qazilbash, Muzaffar H, Hardy, Nancy, Latif, Tahir, García-Cadenas, Irene, Vainstein-Haras, Abi, Sorani, Ella, Gliko-Kabir, Irit, Goldstein, Inbal, Ickowicz, Debby, Shemesh-Darvish, Liron, Kadosh, Shaul, Gao, Feng, Schroeder, Mark A, Vij, Ravi, DiPersio, John F
Published in Nature medicine (01.04.2023)
Published in Nature medicine (01.04.2023)
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Immunophenotypic and Single-Cell Transcriptional Profiling of CD34+ Hematopoietic Stem and Progenitor Cells Mobilized with Motixafortide (BL-8040) and G-CSF Versus Plerixafor and G-CSF Versus Placebo and G-CSF: A Correlative Study of the Genesis Trial
Crees, Zachary D., Retting, Michael, Jayasinghe, Reyka G, Stockerl-Goldstein, Keith E., Vainstein, Abi, Sorani, Ella, Ickowicz, Debby, Shemesh-Darvish, Liron, Kadosh, Shaul, DiPersio, John F.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Combined Inhibition of CXCR4 Signaling and System xc- Transporter Activity Induces Synthetic Lethality in T-ALL Cells By Suppressing Gsh and Inducing Ferroptosis
Xia, Jun, Sun, Stephanie, Jotte, Matthew RM, Uy, Geoffrey L, Sorani, Ella, Vainstein, Abi, Davish, Liron Shemesh, Caldwell, Katherine E, Hawkins, William G, Link, Daniel C.
Published in Blood (05.11.2020)
Published in Blood (05.11.2020)
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Journal Article
Prolonged CXCR4 Receptor Occupancy By Motixafortide Following a Single Subcutaneous Injection Is Associated with Extended Mobilization of CD34+ Cells in Peripheral Blood for > 24 Hours
Crees, Zachary D, Stockerl-Goldstein, Keith, Sorani, Ella, Ickowicz, Debby, Darvish, Liron, DiPersio, John F.
Published in Transplantation and cellular therapy (01.02.2024)
Published in Transplantation and cellular therapy (01.02.2024)
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CXCR4 Inhibition with BL-8040 in Combination with Nelarabine in Patients with Relapsed or Refractory T-Cell Acute Lymphoblastic Leukemia / Lymphoblastic Lymphoma
Uy, Geoffrey L., Kadia, Tapan M., Stock, Wendy, Brammer, Jonathan E, Bohana-Kashtan, Osnat, Vainstein, Abi, Sorani, Ella, Chen, Hemda, DiPersio, John F., Link, Daniel C.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
CXCR4 Blockade By BL-8040 in T Cell Acute Lymphoblastic Leukemia Decreases Mitochondrial Mass and Induces Non-Apoptotic Cell Death
Xia, Jun, Sun, Stephanie, Jotte, Matthew RM, Uy, Geoffrey L., Bohana-Kashtan, Osnat, Sorani, Ella, Vainstein, Abi, Peled, Amnon, Link, Daniel C.
Published in Blood (13.11.2019)
Published in Blood (13.11.2019)
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Journal Article
BL‐8040 CXCR4 antagonist is safe and demonstrates antileukemic activity in combination with cytarabine for the treatment of relapsed/refractory acute myelogenous leukemia: An open‐label safety and efficacy phase 2a study
Borthakur, Gautam, Ofran, Yishai, Tallman, Martin S., Foran, James, Uy, Geoffrey L., DiPersio, John F., Showel, Margaret M., Shimoni, Avichai, Nagler, Arnon, Rowe, Jacob M., Altman, Jessica K., Abraham, Michal, Peled, Amnon, Shaw, Stephen, Bohana‐Kashtan, Osnat, Sorani, Ella, Pereg, Yaron, Foley‐Comer, Adam, Oberkovitz, Galia, Lustig, Tzipi M., Glicko‐Kabir, Irit, Aharon, Arnon, Vainstein‐Haras, Abi, Kadosh, Shaul E., Samara, Emil, Al‐Rawi, Ahmed N., Pemmaraju, Naveen, Bueso‐Ramos, Carlos, Cortes, Jorge E., Andreeff, Michael
Published in Cancer (15.04.2021)
Published in Cancer (15.04.2021)
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CXCR4 antagonist (BL-8040) to enhance antitumor effects by increasing tumor infiltration of antigen-specific effector T-cells
Gaur, Pankaj, Verma, Vivek, Gupta, Seema, Sorani, Ella, Vainstein Haras, Abi, Oberkovitz, Galia, Peled, Amnon, Khleif, Samir
Published in Journal of clinical oncology (10.02.2018)
Published in Journal of clinical oncology (10.02.2018)
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Journal Article
Intratumoral administration of the alpha-Gal glycolipid AGI-134 to induce tumor regression in a mouse model of melanoma
Shaw, Stephen M., Wigglesworth, Kim, Middleton, Jenny, Vainstein Haras, Abi, Sorani, Ella, Tabakman, Rinat, Carmi Levy, Irit, Kristian, Sascha A.
Published in Journal of clinical oncology (10.02.2018)
Published in Journal of clinical oncology (10.02.2018)
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Journal Article
Motixafortide (BL-8040) and G-CSF Versus Placebo and G-CSF to Mobilize Hematopoietic Stem Cells for Autologous Stem Cell Transplantation in Patients with Multiple Myeloma: The Genesis Trial
Crees, Zachary D., Stockerl-Goldstein, Keith E., Larson, Sarah, Illés, Árpád, Milone, Giuseppe, Martino, Massimo, Stiff, Patrick, Sborov, Douglas W., Pereira, Denise L., Micallef, Ivana N., Moreno Jiménez, Gemma, Mikala, Gábor, paciello Coronel, Maria liz, Holtick, Udo, Hiemenz, John W., Qazilbash, Muzaffar H., Hardy, Nancy M., Latif, Tahir, García-Cadenas, Irene, Vainstein, Abi, Sorani, Ella, Gliko-Kabir, Irit, Goldstein, Inbal, Kadosh, Shaul, DiPersio, John F.
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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