Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas
Aslan, Katrin, Turco, Verena, Blobner, Jens, Sonner, Jana K., Liuzzi, Anna Rita, Núñez, Nicolás Gonzalo, De Feo, Donatella, Kickingereder, Philipp, Fischer, Manuel, Green, Ed, Sadik, Ahmed, Friedrich, Mirco, Sanghvi, Khwab, Kilian, Michael, Cichon, Frederik, Wolf, Lara, Jähne, Kristine, von Landenberg, Anna, Bunse, Lukas, Sahm, Felix, Schrimpf, Daniel, Meyer, Jochen, Alexander, Allen, Brugnara, Gianluca, Röth, Ralph, Pfleiderer, Kira, Niesler, Beate, von Deimling, Andreas, Opitz, Christiane, Breckwoldt, Michael O., Heiland, Sabine, Bendszus, Martin, Wick, Wolfgang, Becher, Burkhard, Platten, Michael
Published in Nature communications (18.02.2020)
Published in Nature communications (18.02.2020)
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Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate
Bunse, Lukas, Pusch, Stefan, Bunse, Theresa, Sahm, Felix, Sanghvi, Khwab, Friedrich, Mirco, Alansary, Dalia, Sonner, Jana K., Green, Edward, Deumelandt, Katrin, Kilian, Michael, Neftel, Cyril, Uhlig, Stefanie, Kessler, Tobias, von Landenberg, Anna, Berghoff, Anna S., Marsh, Kelly, Steadman, Mya, Zhu, Dongwei, Nicolay, Brandon, Wiestler, Benedikt, Breckwoldt, Michael O., Al-Ali, Ruslan, Karcher-Bausch, Simone, Bozza, Matthias, Oezen, Iris, Kramer, Magdalena, Meyer, Jochen, Habel, Antje, Eisel, Jessica, Poschet, Gernot, Weller, Michael, Preusser, Matthias, Nadji-Ohl, Minou, Thon, Niklas, Burger, Michael C., Harter, Patrick N., Ratliff, Miriam, Harbottle, Richard, Benner, Axel, Schrimpf, Daniel, Okun, Jürgen, Herold-Mende, Christel, Turcan, Sevin, Kaulfuss, Stefan, Hess‐Stumpp, Holger, Bieback, Karen, Cahill, Daniel P., Plate, Karl H., Hänggi, Daniel, Dorsch, Marion, Suvà, Mario L., Niemeyer, Barbara A., von Deimling, Andreas, Wick, Wolfgang, Platten, Michael
Published in Nature medicine (01.08.2018)
Published in Nature medicine (01.08.2018)
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Dietary tryptophan links encephalogenicity of autoreactive T cells with gut microbial ecology
Sonner, Jana K., Keil, Melanie, Falk-Paulsen, Maren, Mishra, Neha, Rehman, Ateequr, Kramer, Magdalena, Deumelandt, Katrin, Röwe, Julian, Sanghvi, Khwab, Wolf, Lara, von Landenberg, Anna, Wolff, Hendrik, Bharti, Richa, Oezen, Iris, Lanz, Tobias V., Wanke, Florian, Tang, Yilang, Brandao, Ines, Mohapatra, Soumya R., Epping, Lisa, Grill, Alexandra, Röth, Ralph, Niesler, Beate, Meuth, Sven G., Opitz, Christiane A., Okun, Jürgen G., Reinhardt, Christoph, Kurschus, Florian C., Wick, Wolfgang, Bode, Helge B., Rosenstiel, Philip, Platten, Michael
Published in Nature communications (25.10.2019)
Published in Nature communications (25.10.2019)
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Identification of early neurodegenerative pathways in progressive multiple sclerosis
Kaufmann, Max, Schaupp, Anna-Lena, Sun, Rosa, Coscia, Fabian, Dendrou, Calliope A., Cortes, Adrian, Kaur, Gurman, Evans, Hayley G., Mollbrink, Annelie, Navarro, José Fernández, Sonner, Jana K., Mayer, Christina, DeLuca, Gabriele C., Lundeberg, Joakim, Matthews, Paul M., Attfield, Kathrine E., Friese, Manuel A., Mann, Matthias, Fugger, Lars
Published in Nature neuroscience (01.07.2022)
Published in Nature neuroscience (01.07.2022)
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In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis
Kirschbaum, Klara, Sonner, Jana K., Zeller, Matthias W., Deumelandt, Katrin, Bode, Julia, Sharma, Rakesh, Krüwel, Thomas, Fischer, Manuel, Hoffmann, Angelika, da Silva, Milene Costa, Muckenthaler, Martina U., Wick, Wolfgang, Tews, Björn, Chen, John W., Heiland, Sabine, Bendszus, Martin, Platten, Michael, Breckwoldt, Michael O.
Published in Proceedings of the National Academy of Sciences - PNAS (15.11.2016)
Published in Proceedings of the National Academy of Sciences - PNAS (15.11.2016)
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Tryptophan metabolism drives dynamic immunosuppressive myeloid states in IDH-mutant gliomas
Friedrich, Mirco, Sankowski, Roman, Bunse, Lukas, Kilian, Michael, Green, Edward, Ramallo Guevara, Carina, Pusch, Stefan, Poschet, Gernot, Sanghvi, Khwab, Hahn, Markus, Bunse, Theresa, Münch, Philipp, Gegner, Hagen M, Sonner, Jana K, von Landenberg, Anna, Cichon, Frederik, Aslan, Katrin, Trobisch, Tim, Schirmer, Lucas, Abu-Sammour, Denis, Kessler, Tobias, Ratliff, Miriam, Schrimpf, Daniel, Sahm, Felix, Hopf, Carsten, Heiland, Dieter H, Schnell, Oliver, Beck, Jürgen, Böttcher, Chotima, Fernandez-Zapata, Camila, Priller, Josef, Heiland, Sabine, Gutcher, Ilona, Quintana, Francisco J, von Deimling, Andreas, Wick, Wolfgang, Prinz, Marco, Platten, Michael
Published in Nature cancer (01.07.2021)
Published in Nature cancer (01.07.2021)
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Protective effect of TCR-mediated MAIT cell activation during experimental autoimmune encephalomyelitis
Walkenhorst, Mark, Sonner, Jana K., Meurs, Nina, Engler, Jan Broder, Bauer, Simone, Winschel, Ingo, Woo, Marcel S., Raich, Lukas, Winkler, Iris, Vieira, Vanessa, Unger, Lisa, Salinas, Gabriela, Lantz, Olivier, Friese, Manuel A., Willing, Anne
Published in Nature communications (28.10.2024)
Published in Nature communications (28.10.2024)
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K27M-mutant histone-3 as a novel target for glioma immunotherapy
Ochs, Katharina, Ott, Martina, Bunse, Theresa, Sahm, Felix, Bunse, Lukas, Deumelandt, Katrin, Sonner, Jana K., Keil, Melanie, von Deimling, Andreas, Wick, Wolfgang, Platten, Michael
Published in Oncoimmunology (12.05.2017)
Published in Oncoimmunology (12.05.2017)
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Neuronal metabotropic glutamate receptor 8 protects against neurodegeneration in CNS inflammation
Woo, Marcel S, Ufer, Friederike, Rothammer, Nicola, Di Liberto, Giovanni, Binkle, Lars, Haferkamp, Undine, Sonner, Jana K, Engler, Jan Broder, Hornig, Sönke, Bauer, Simone, Wagner, Ingrid, Egervari, Kristof, Raber, Jacob, Duvoisin, Robert M, Pless, Ole, Merkler, Doron, Friese, Manuel A
Published in The Journal of experimental medicine (03.05.2021)
Published in The Journal of experimental medicine (03.05.2021)
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Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination
Kapell, Hannah, Fazio, Luca, Dyckow, Julia, Schwarz, Sophia, Cruz-Herranz, Andrés, Mayer, Christina, Campos, Joaquin, D'Este, Elisa, Möbius, Wiebke, Cordano, Christian, Pröbstel, Anne-Katrin, Gharagozloo, Marjan, Zulji, Amel, Narayanan Naik, Venu, Delank, Anna, Cerina, Manuela, Müntefering, Thomas, Lerma-Martin, Celia, Sonner, Jana K, Sin, Jung Hyung, Disse, Paul, Rychlik, Nicole, Sabeur, Khalida, Chavali, Manideep, Srivastava, Rajneesh, Heidenreich, Matthias, Fitzgerald, Kathryn C, Seebohm, Guiscard, Stadelmann, Christine, Hemmer, Bernhard, Platten, Michael, Jentsch, Thomas J, Engelhardt, Maren, Budde, Thomas, Nave, Klaus-Armin, Calabresi, Peter A, Friese, Manuel A, Green, Ari J, Acuna, Claudio, Rowitch, David H, Meuth, Sven G, Schirmer, Lucas
Published in The Journal of clinical investigation (01.04.2023)
Published in The Journal of clinical investigation (01.04.2023)
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STING orchestrates the neuronal inflammatory stress response in multiple sclerosis
Woo, Marcel S., Mayer, Christina, Binkle-Ladisch, Lars, Sonner, Jana K., Rosenkranz, Sina C., Shaposhnykov, Artem, Rothammer, Nicola, Tsvilovskyy, Volodymyr, Lorenz, Svenja M., Raich, Lukas, Bal, Lukas C., Vieira, Vanessa, Wagner, Ingrid, Bauer, Simone, Glatzel, Markus, Conrad, Marcus, Merkler, Doron, Freichel, Marc, Friese, Manuel A.
Published in Cell (25.07.2024)
Published in Cell (25.07.2024)
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T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas
Kilian, Michael, Friedrich, Mirco, Sanghvi, Khwab, Green, Edward, Pusch, Stefan, Kawauchi, Daisuke, Löwer, Martin, Sonner, Jana K, Krämer, Christopher, Zaman, Julia, Jung, Stefanie, Breckwoldt, Michael O, Willimsky, Gerald, Eichmüller, Stefan B, von Deimling, Andreas, Wick, Wolfgang, Sahm, Felix, Platten, Michael, Bunse, Lukas
Published in Clinical cancer research (15.01.2022)
Published in Clinical cancer research (15.01.2022)
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Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation
Adam, Isabell, Dewi, Dyah L., Mooiweer, Joram, Sadik, Ahmed, Mohapatra, Soumya R., Berdel, Bianca, Keil, Melanie, Sonner, Jana K., Thedieck, Kathrin, Rose, Adam J., Platten, Michael, Heiland, Ines, Trump, Saskia, Opitz, Christiane A.
Published in Oncoimmunology (02.12.2018)
Published in Oncoimmunology (02.12.2018)
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The NR4A2/VGF pathway fuels inflammation-induced neurodegeneration via promoting neuronal glycolysis
Woo, Marcel S, Bal, Lukas C, Winschel, Ingo, Manca, Elias, Walkenhorst, Mark, Sevgili, Bachar, Sonner, Jana K, Di Liberto, Giovanni, Mayer, Christina, Binkle-Ladisch, Lars, Rothammer, Nicola, Unger, Lisa, Raich, Lukas, Hadjilaou, Alexandros, Noli, Barbara, Manai, Antonio L, Vieira, Vanessa, Meurs, Nina, Wagner, Ingrid, Pless, Ole, Cocco, Cristina, Stephens, Samuel B, Glatzel, Markus, Merkler, Doron, Friese, Manuel A
Published in The Journal of clinical investigation (15.08.2024)
Published in The Journal of clinical investigation (15.08.2024)
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Upregulation of Phosphodiesterase 2A Augments T Cell Activation by Changing cGMP/cAMP Cross-Talk
Kurelic, Roberta, Krieg, Paula F., Sonner, Jana K., Bhaiyan, Gloria, Ramos, Gustavo C., Frantz, Stefan, Friese, Manuel A., Nikolaev, Viacheslav O.
Published in Frontiers in pharmacology (05.10.2021)
Published in Frontiers in pharmacology (05.10.2021)
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GPR52 regulates cAMP in T cells but is dispensable for encephalitogenic responses
Krieg, Paula F, Sonner, Jana K, Kurelic, Roberta, Engler, Jan Broder, Scharenberg, Marlena F, Bauer, Simone, Nikolaev, Viacheslav O, Friese, Manuel A
Published in Frontiers in immunology (24.01.2023)
Published in Frontiers in immunology (24.01.2023)
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Tryptophan-2,3-Dioxygenase (TDO) deficiency is associated with subclinical neuroprotection in a mouse model of multiple sclerosis
Lanz, Tobias V., Williams, Sarah K., Stojic, Aleksandar, Iwantscheff, Simeon, Sonner, Jana K., Grabitz, Carl, Becker, Simon, Böhler, Laura-Inés, Mohapatra, Soumya R., Sahm, Felix, Küblbeck, Günter, Nakamura, Toshikazu, Funakoshi, Hiroshi, Opitz, Christiane A., Wick, Wolfgang, Diem, Ricarda, Platten, Michael
Published in Scientific reports (24.01.2017)
Published in Scientific reports (24.01.2017)
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General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation
Keil, Melanie, Sonner, Jana K, Lanz, Tobias V, Oezen, Iris, Bunse, Theresa, Bittner, Stefan, Meyer, Hannah V, Meuth, Sven G, Wick, Wolfgang, Platten, Michael
Published in Journal of neuroimmunology (15.08.2016)
Published in Journal of neuroimmunology (15.08.2016)
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Sex- and species-specific contribution of CD99 to T cell costimulation during multiple sclerosis
Winschel, Ingo, Willing, Anne, Engler, Jan Broder, Walkenhorst, Mark, Meurs, Nina, Binkle-Ladisch, Lars, Woo, Marcel S, Pfeffer, Lena Kristina, Sonner, Jana K, Borgmeyer, Uwe, Hagen, Sven Hendrik, Grünhagel, Benjamin, Claussen, Janna M, Altfeld, Marcus, Friese, Manuel A
Published in Biology of sex differences (15.05.2024)
Published in Biology of sex differences (15.05.2024)
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