4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors
Churcher, Ian, Beher, Dirk, Best, Jonathan D., Castro, José L., Clarke, Earl E., Gentry, Amy, Harrison, Timothy, Hitzel, Laure, Kay, Euan, Kerrad, Sonia, Lewis, Huw D., Morentin-Gutierrez, Pablo, Mortishire-Smith, Russell, Oakley, Paul J., Reilly, Michael, Shaw, Duncan E., Shearman, Mark S., Teall, Martin R., Williams, Susie, Wrigley, Jonathan D.J.
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
Published in Bioorganic & medicinal chemistry letters (15.01.2006)
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Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2S,3R)-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy-N-((3S)-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1H-benzo[e][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement
Churcher, Ian, Williams, Susie, Kerrad, Sonia, Harrison, Timothy, Castro, José L, Shearman, Mark S, Lewis, Huw D, Clarke, Earl E, Wrigley, Jonathan D. J, Beher, Dirk, Tang, Yui S, Liu, Wensheng
Published in Journal of medicinal chemistry (05.06.2003)
Published in Journal of medicinal chemistry (05.06.2003)
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Journal Article
Design and Synthesis of Highly Potent Benzodiazepine γ-Secretase Inhibitors: Preparation of (2 S ,3 R )-3-(3,4- Difluorophenyl)-2-(4-fluorophenyl)-4- hydroxy- N -((3 S )-1-methyl-2-oxo-5- phenyl-2,3-dihydro-1 H -benzo[ e ][1,4]- diazepin-3-yl)butyramide by Use of an Asymmetric Ireland−Claisen Rearrangement
Churcher, Ian, Williams, Susie, Kerrad, Sonia, Harrison, Timothy, Castro, José L., Shearman, Mark S., Lewis, Huw D., Clarke, Earl E., Wrigley, Jonathan D. J., Beher, Dirk, Tang, Yui S., Liu, Wensheng
Published in Journal of medicinal chemistry (01.06.2003)
Published in Journal of medicinal chemistry (01.06.2003)
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Journal Article
Design and synthesis of highly potent benzodiazepine γ-secretase inhibitors: Preparation of (2S, 3R)-3-(3,4-difluorophenyl)-2-(4-fluorophenyl)-4-hydroxy-N-((3S)-1-methyl-2-o xo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]-diazepin-3-yl)butyramide by use of an asymmetric Ireland-Claisen rearrangement
CHURCHER, Ian, WILLIAMS, Susie, TANG, Yui S, WENSHENG LIU, KERRAD, Sonia, HARRISON, Timothy, CASTRO, José L, SHEARMAN, Mark S, LEWIS, Huw D, CLARKE, Earl E, WRIGLEY, Jonathan D. J, BEHER, Dirk
Published in Journal of medicinal chemistry (2003)
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Published in Journal of medicinal chemistry (2003)
Journal Article
composto ciclo-hexil-sulfona, uso do mesmo, e, composição farmacêutica
Martin Richard Teall, Kevin Dinnell, Paul Joseph Oakley, Duncan Edward Shaw, Ian Churcher, Timothy Harrison, Alan John Nadin, Brian John Williams, Susannah Williams, Sonia Kerrad
Year of Publication 24.07.2018
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Year of Publication 24.07.2018
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CYCLOHEXYL SULPHONE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS
CHURCHER, IAN, HARRISON, TIMOTHY, TEALL, MARTIN RICHARD, KERRAD, SONIA, OAKLEY, PAUL JOSEPH, SHAW, DUNCAN EDWARD, WILLIAMS, SUSANNAH
Year of Publication 18.01.2011
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Year of Publication 18.01.2011
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CYCLOHEXYL-SULPHONE ALS GAMMA-SEKRETASE- INHIBITOREN
CHURCHER, IAN, HARRISON, TIMOTHY, KERRAD, SONIA, NADIN, ALAN JOHN, THOMSON, JOANNE, SHAW, DUNCAN EDWARD, OWENS, ANDREW, WILLIAMS, SUSANNAH
Year of Publication 15.04.2010
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Year of Publication 15.04.2010
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CYCLOHEXYL SULPHONES AS GAMMA-SECRETASE INHIBITORS
CHURCHER, IAN, HARRISON, TIMOTHY, KERRAD, SONIA, NADIN, ALAN JOHN, THOMSON, JOANNE, SHAW, DUNCAN EDWARD, WILLIAMS, SUSANNAH, OWENS, ANDREW, PATE
Year of Publication 14.04.2010
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Year of Publication 14.04.2010
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NOVEL CYCLOHEXYL SULPHONES
CHURCHER IAN, SHAW DUNCAN EDWARD, WILLIAMS BRIAN JOHN, NADIN ALAN JOHN, TEALL MARTIN RICHARD, WILLIAMS SUSANNAH, DINNELL KEVIN, OAKLEY PAUL JOSEPH, KERRAD SONIA, HARRISON TIMOTHY
Year of Publication 29.07.2011
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Year of Publication 29.07.2011
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Cyclohexyl sulphone derivatives as gamma-secretase inhibitors
SUSANNAH WILLIAMS, PAUL JOSEPH OAKLEY, IAN CHURCHER, DUNCAN EDWARD SHAW, MARTIN RICHARD TEALL, TIMOTHY HARRISON, SONIA KERRAD
Year of Publication 18.02.2010
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Year of Publication 18.02.2010
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Cyclohexyl sulphones as gamma-secretase inhibitors
SUSANNAH WILLIAMS, JOANNE THOMSON, ANDREW PATE OWENS, ALAN JOHN NADIN, DUNCAN EDWARD SHAW, IAN CHURCHER, TIMOTHY HARRISON, SONIA KERRAD
Year of Publication 15.10.2009
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Year of Publication 15.10.2009
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Cyclohexyl sulphones as gamma-secretase inhibitors
SUSANNAH WILLIAMS, JOANNE THOMSON, ANDREW PATE OWENS, ALAN JOHN NADIN, DUNCAN EDWARD SHAW, IAN CHURCHER, TIMOTHY HARRISON, SONIA KERRAD
Year of Publication 28.05.2009
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Year of Publication 28.05.2009
Patent
SULFONE, DIE DIE AKTIVITÄT VON GAMMA-SECRETASE MODULIEREN
CHURCHER, IAN, HARRISON, TIMOTHY, TEALL, MARTIN RICHARD, KERRAD, SONIA, NADIN, ALAN JOHN, OAKLEY, PAUL JOSEPH, OWENS, ANDREW PATE, DINNELL, KEVIN, SHAW, DUNCAN EDWARD, WILLIAMS, BRIAN JOHN, WILLIAMS, SUSANNAH, CASTRO PINEIRO, JOSE LUIS
Year of Publication 15.03.2011
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Year of Publication 15.03.2011
Patent
NOVEL CYCLOHEXYL SULPHONES
SUSANNAH WILLIAMS, KEVIN DINNELL, PAUL JOSEPH OAKLEY, IAN CHURCHER, BRIAN JOHN WILLIAMS, ALAN JOHN NADIN, DUNCAN EDWARD SHAW, TIMOTHY HARRISON, MARTIN RICHARD TEALL, SONIA KERRAD
Year of Publication 30.09.2009
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Year of Publication 30.09.2009
Patent
SULPHONES WHICH MODULATE THE ACTION OF GAMMA SECRETASE
CHURCHER, IAN, HARRISON, TIMOTHY, TEALL, MARTIN RICHARD, KERRAD, SONIA, NADIN, ALAN JOHN, OAKLEY, PAUL JOSEPH, OWENS, ANDREW PATE, DINNELL, KEVIN, SHAW, DUNCAN EDWARD, WILLIAMS, BRIAN JOHN, WILLIAMS, SUSANNAH, CASTRO PINEIRO, JOSE LUIS
Year of Publication 16.02.2011
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Year of Publication 16.02.2011
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CYCLOHEXYLSULFON-DERIVATE ALS GAMMA-SECRETASE-INHIBITOREN
CHURCHER, IAN, HARRISON, TIMOTHY, TEALL, MARTIN RICHARD, KERRAD, SONIA, OAKLEY, PAUL JOSEPH, SHAW, DUNCAN EDWARD, WILLIAMS, SUSANNAH
Year of Publication 31.10.2007
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Year of Publication 31.10.2007
Patent
Ný sýklóhexýl súlfon
SUSANNAH WILLIAMS, KEVIN DINNELL, PAUL JOSEPH OAKLEY, IAN CHURCHER, ALAN JOHN NADIN, DUNCAN EDWARD SHAW, BRIAN JOHN WILLIAMS, TIMOTHY HARRISON, MARTIN RICHARD TEALL, SONIA KERRAD
Year of Publication 15.02.2009
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Year of Publication 15.02.2009
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CYCLOHEXYL-SULPHONE
CHURCHER, IAN, HARRISON, TIMOTHY, TEALL, MARTIN RICHARD, KERRAD, SONIA, NADIN, ALAN JOHN, OAKLEY, PAUL JOSEPH, DINNELL, KEVIN, SHAW, DUNCAN EDWARD, WILLIAMS, BRIAN JOHN, WILLIAMS, SUSANNAH
Year of Publication 30.10.2008
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Year of Publication 30.10.2008
Patent
CYCLOHEXYLSULFON-DERIVATE ALS GAMMA-SECRETASE- INHIBITOREN
CHURCHER, IAN, HARRISON, TIMOTHY, TEALL, MARTIN RICHARD, KERRAD, SONIA, OAKLEY, PAUL JOSEPH, SHAW, DUNCAN EDWARD, WILLIAMS, SUSANNAH
Year of Publication 15.03.2007
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Year of Publication 15.03.2007
Patent
CYCLOHEXYL SULPHONE DERIVATIVES AS GAMMA-SECRETASE INHIBITORS
CHURCHER, IAN, HARRISON, TIMOTHY, TEALL, MARTIN RICHARD, KERRAD, SONIA, OAKLEY, PAUL JOSEPH, SHAW, DUNCAN EDWARD, WILLIAMS, SUSANNAH
Year of Publication 21.02.2007
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Year of Publication 21.02.2007
Patent