Functional Label-Free Assays for Characterizing the in Vitro Mechanism of Action of Small Molecule Modulators of Capsid Assembly
Lad, Latesh, Clancy, Sheila, Koditek, David, Wong, Melanie H, Jin, Debi, Niedziela-Majka, Anita, Papalia, Giuseppe A, Hung, Magdeleine, Yant, Stephen, Somoza, John R, Hu, Eric, Chou, Chienhung, Tse, Winston, Halcomb, Randall, Sakowicz, Roman, Pagratis, Nikos
Published in Biochemistry (Easton) (07.04.2015)
Published in Biochemistry (Easton) (07.04.2015)
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Journal Article
Structural Basis for Unique Mechanisms of Folding and Hemoglobin Binding by a Malarial Protease
Wang, Stephanie X., Pandey, Kailash C., Somoza, John R., Sijwali, Puran S., Kortemme, Tanja, Brinen, Linda S., Fletterick, Robert J., Rosenthal, Philip J., McKerrow, James H.
Published in Proceedings of the National Academy of Sciences - PNAS (01.08.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (01.08.2006)
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Journal Article
Structural, Biochemical, and Biophysical Characterization of Idelalisib Binding to Phosphoinositide 3-Kinase δ
Somoza, John R., Koditek, David, Villaseñor, Armando G., Novikov, Nikolai, Wong, Melanie H., Liclican, Albert, Xing, Weimei, Lagpacan, Leanna, Wang, Ruth, Schultz, Brian E., Papalia, Giuseppe A., Samuel, Dharmaraj, Lad, Latesh, McGrath, Mary E.
Published in The Journal of biological chemistry (27.03.2015)
Published in The Journal of biological chemistry (27.03.2015)
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Journal Article
Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3‑Kinase (PI3K) β Inhibitor
Chandrasekhar, Jayaraman, Dick, Ryan, Van Veldhuizen, Joshua, Koditek, David, Lepist, Eve-Irene, McGrath, Mary E, Patel, Leena, Phillips, Gary, Sedillo, Kassandra, Somoza, John R, Therrien, Joseph, Till, Nicholas A, Treiberg, Jennifer, Villaseñor, Armando G, Zherebina, Yelena, Perreault, Stephane
Published in Journal of medicinal chemistry (09.08.2018)
Published in Journal of medicinal chemistry (09.08.2018)
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Journal Article
The Structure of the Extracellular Region of Human Hepsin Reveals a Serine Protease Domain and a Novel Scavenger Receptor Cysteine-Rich (SRCR) Domain
Somoza, John R, Ho, Joseph D, Luong, Christine, Ghate, Manjiri, Sprengeler, Paul A, Mortara, Kyle, Shrader, William D, Sperandio, David, Chan, Hedy, McGrath, Mary E, Katz, Bradley A
Published in Structure (London) (01.09.2003)
Published in Structure (London) (01.09.2003)
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Journal Article
Visualizing ATP-Dependent RNA Translocation by the NS3 Helicase from HCV
Appleby, Todd C., Anderson, Robert, Fedorova, Olga, Pyle, Anna M., Wang, Ruth, Liu, Xiaohong, Brendza, Katherine M., Somoza, John R.
Published in Journal of molecular biology (04.02.2011)
Published in Journal of molecular biology (04.02.2011)
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Journal Article
Discovery of Orally Efficacious Phosphoinositide 3‑Kinase δ Inhibitors with Improved Metabolic Stability
Patel, Leena, Chandrasekhar, Jayaraman, Evarts, Jerry, Forseth, Kristen, Haran, Aaron C, Ip, Carmen, Kashishian, Adam, Kim, Musong, Koditek, David, Koppenol, Sandy, Lad, Latesh, Lepist, Eve-Irene, McGrath, Mary E, Perreault, Stephane, Puri, Kamal D, Villaseñor, Armando G, Somoza, John R, Steiner, Bart H, Therrien, Joseph, Treiberg, Jennifer, Phillips, Gary
Published in Journal of medicinal chemistry (13.10.2016)
Published in Journal of medicinal chemistry (13.10.2016)
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Journal Article
2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors
Patel, Leena, Chandrasekhar, Jayaraman, Evarts, Jerry, Haran, Aaron C, Ip, Carmen, Kaplan, Joshua A, Kim, Musong, Koditek, David, Lad, Latesh, Lepist, Eve-Irene, McGrath, Mary E, Novikov, Nikolai, Perreault, Stephane, Puri, Kamal D, Somoza, John R, Steiner, Bart H, Stevens, Kirk L, Therrien, Joseph, Treiberg, Jennifer, Villaseñor, Armando G, Yeung, Arthur, Phillips, Gary
Published in Journal of medicinal chemistry (14.04.2016)
Published in Journal of medicinal chemistry (14.04.2016)
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Journal Article
Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
Somoza, John R, Skene, Robert J, Katz, Bradley A, Mol, Clifford, Ho, Joseph D, Jennings, Andy J, Luong, Christine, Arvai, Andrew, Buggy, Joseph J, Chi, Ellen, Tang, Jie, Sang, Bi-Ching, Verner, Erik, Wynands, Robert, Leahy, Ellen M, Dougan, Douglas R, Snell, Gyorgy, Navre, Marc, Knuth, Mark W, Swanson, Ronald V, McRee, Duncan E, Tari, Leslie W
Published in Structure (London) (01.07.2004)
Published in Structure (London) (01.07.2004)
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Journal Article
Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII)
Koltun, Dmitry O., Parkhill, Eric Q., Kalla, Rao, Perry, Thao D., Elzein, Elfatih, Li, Xiaofen, Simonovich, Scott P., Ziebenhaus, Christopher, Hansen, Timothy R., Marchand, Bruno, Hung, WaiLok K., Lagpacan, Leanna, Hung, Magdeleine, Aoyama, Ron G., Murray, Bernard P., Perry, Jason K., Somoza, John R., Villaseñor, Armando G., Pagratis, Nikos, Zablocki, Jeff A.
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
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Journal Article
Quinolones as HCV NS5B polymerase inhibitors
Kumar, Dange V., Rai, Roopa, Brameld, Ken A., Somoza, John R., Rajagopalan, Ravi, Janc, James W., Xia, Yu M., Ton, Tony L., Shaghafi, Michael B., Hu, Huiyong, Lehoux, Isabelle, To, Nhat, Young, Wendy B., Green, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
Published in Bioorganic & medicinal chemistry letters (01.01.2011)
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Journal Article
3-Heterocyclyl quinolone inhibitors of the HCV NS5B polymerase
Kumar, Dange V., Rai, Roopa, Brameld, Ken A., Riggs, Jennifer, Somoza, John R., Rajagopalan, Ravi, Janc, James W., Xia, Yu M., Ton, Tony L., Hu, Huiyong, Lehoux, Isabelle, Ho, Joseph D., Young, Wendy B., Hart, Barry, Green, Michael J.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Journal Article
Structural and kinetic analysis of Escherichia coli GDP-mannose 4,6 dehydratase provides insights into the enzyme’s catalytic mechanism and regulation by GDP-fucose
Somoza, John R, Menon, Saurabh, Schmidt, Holly, Joseph-McCarthy, Diane, Dessen, Andréa, Stahl, Mark L, Somers, William S, Sullivan, Francis X
Published in Structure (London) (15.02.2000)
Published in Structure (London) (15.02.2000)
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Journal Article
β-Substituted Cyclohexanecarboxamide: A Nonpeptidic Framework for the Design of Potent Inhibitors of Cathepsin K
Crane, Sheldon N, Black, W. Cameron, Palmer, James T, Davis, Dana E, Setti, Eduardo, Robichaud, Joel, Paquet, Julie, Oballa, Renata M, Bayly, Christopher I, McKay, Daniel J, Somoza, John R, Chauret, Natalie, Seto, Carmai, Scheigetz, John, Wesolowski, Greg, Massé, Frederic, Desmarais, Sylvie, Ouellet, Marc
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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Journal Article
Peptide Ketobenzoxazole Inhibitors Bound to Cathepsin K
McGrath, Mary E, Sprengeler, Paul A, Hill, Craig M, Martichonok, Valeri, Cheung, Harry, Somoza, John R, Palmer, James T, Janc, James W
Published in Biochemistry (Easton) (30.12.2003)
Published in Biochemistry (Easton) (30.12.2003)
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Journal Article
Dissecting and Designing Inhibitor Selectivity Determinants at the S1 Site Using an Artificial Ala190 Protease (Ala190 uPA)
Katz, Bradley A., Luong, Christine, Ho, Joseph D., Somoza, John R., Gjerstad, Erik, Tang, Jie, Williams, Steven R., Verner, Erik, Mackman, Richard L., Young, Wendy B., Sprengeler, Paul A., Chan, Hedy, Mortara, Kyle, Janc, James W., McGrath, Mary E.
Published in Journal of molecular biology (19.11.2004)
Published in Journal of molecular biology (19.11.2004)
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Journal Article
Structure-Guided Design of Peptide-Based Tryptase Inhibitors
McGrath, Mary E, Sprengeler, Paul A, Hirschbein, Bernard, Somoza, John R, Lehoux, Isabelle, Janc, James W, Gjerstad, Erik, Graupe, Michael, Estiarte, Angeles, Venkataramani, Chandru, Liu, Yang, Yee, Robb, Ho, Joseph D, Green, Michael J, Lee, Chang-Sun, Liu, Liang, Tai, Vincent, Spencer, Jeffrey, Sperandio, David, Katz, Bradley A
Published in Biochemistry (Easton) (16.05.2006)
Published in Biochemistry (Easton) (16.05.2006)
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Journal Article
Design of novel, potent, and selective human β-tryptase inhibitors based on α-keto-[1,2,4]-oxadiazoles
Lee, Chang-Sun, Liu, Weili, Sprengeler, Paul A., Somoza, John R., Janc, James W., Sperandio, David, Spencer, Jeffrey R., Green, Michael J., McGrath, Mary E.
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
Published in Bioorganic & medicinal chemistry letters (01.08.2006)
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Journal Article
Crystal Structure of Human Cathepsin V
Somoza, John R, Zhan, Hangjun, Bowman, Krista K, Yu, Lily, Mortara, Kyle D, Palmer, James T, Clark, James M, McGrath, Mary E
Published in Biochemistry (Easton) (17.10.2000)
Published in Biochemistry (Easton) (17.10.2000)
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Journal Article