DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitochondrial Replicative Twinkle Helicase
Bharti, Sanjay Kumar, Sommers, Joshua A., Zhou, Jun, Kaplan, Daniel L., Spelbrink, Johannes N., Mergny, Jean-Louis, Brosh, Robert M.
Published in The Journal of biological chemistry (24.10.2014)
Published in The Journal of biological chemistry (24.10.2014)
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Journal Article
WRN helicase safeguards deprotected replication forks in BRCA2-mutated cancer cells
Datta, Arindam, Biswas, Kajal, Sommers, Joshua A., Thompson, Haley, Awate, Sanket, Nicolae, Claudia M., Thakar, Tanay, Moldovan, George-Lucian, Shoemaker, Robert H., Sharan, Shyam K., Brosh, Robert M.
Published in Nature communications (12.11.2021)
Published in Nature communications (12.11.2021)
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Journal Article
Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress
Aggarwal, Monika, Sommers, Joshua A, Shoemaker, Robert H, Brosh, Robert M. Jr
Published in Proceedings of the National Academy of Sciences - PNAS (25.01.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (25.01.2011)
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Journal Article
A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN)
Sommers, Joshua A, Kulikowicz, Tomasz, Croteau, Deborah L, Dexheimer, Thomas, Dorjsuren, Dorjbal, Jadhav, Ajit, Maloney, David J, Simeonov, Anton, Bohr, Vilhelm A, Brosh, Jr, Robert M
Published in PloS one (09.01.2019)
Published in PloS one (09.01.2019)
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Journal Article
CDK1 phosphorylates WRN at collapsed replication forks
Palermo, Valentina, Rinalducci, Sara, Sanchez, Massimo, Grillini, Francesca, Sommers, Joshua A., Brosh, Robert M., Zolla, Lello, Franchitto, Annapaola, Pichierri, Pietro
Published in Nature communications (16.09.2016)
Published in Nature communications (16.09.2016)
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Journal Article
Biochemical Characterization of Warsaw Breakage Syndrome Helicase
Wu, Yuliang, Sommers, Joshua A., Khan, Irfan, de Winter, Johan P., Brosh, Robert M.
Published in The Journal of biological chemistry (06.01.2012)
Published in The Journal of biological chemistry (06.01.2012)
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Journal Article
Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway
AGGARWAL, Monika, BANERJEE, Taraswi, SOMMERS, Joshua A, LANNASCOLI, Chiara, PICHIERRI, Pietro, SHOEMAKER, Robert H, BROSH, Robert M
Published in Cancer research (Chicago, Ill.) (01.09.2013)
Published in Cancer research (Chicago, Ill.) (01.09.2013)
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Journal Article
Molecular functions and cellular roles of the ChlR1 (DDX11) helicase defective in the rare cohesinopathy Warsaw breakage syndrome
Bharti, Sanjay Kumar, Khan, Irfan, Banerjee, Taraswi, Sommers, Joshua A, Wu, Yuliang, Brosh, Robert M., Jr
Published in Cellular and molecular life sciences : CMLS (01.07.2014)
Published in Cellular and molecular life sciences : CMLS (01.07.2014)
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Journal Article
Human RECQ1 interacts with Ku70/80 and modulates DNA end-joining of double-strand breaks
Parvathaneni, Swetha, Stortchevoi, Alexei, Sommers, Joshua A, Brosh, Jr, Robert M, Sharma, Sudha
Published in PloS one (01.05.2013)
Published in PloS one (01.05.2013)
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Journal Article
Impact of age-associated cyclopurine lesions on DNA repair helicases
Khan, Irfan, Suhasini, Avvaru N, Banerjee, Taraswi, Sommers, Joshua A, Kaplan, Daniel L, Kuper, Jochen, Kisker, Caroline, Brosh, Jr, Robert M
Published in PloS one (19.11.2014)
Published in PloS one (19.11.2014)
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Journal Article
Biochemical and cell biological assays to identify and characterize DNA helicase inhibitors
Banerjee, Taraswi, Aggarwal, Monika, Sommers, Joshua A., Brosh, Robert M.
Published in Methods (San Diego, Calif.) (01.10.2016)
Published in Methods (San Diego, Calif.) (01.10.2016)
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Journal Article
A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair
Bharti, Sanjay Kumar, Sommers, Joshua A, Awate, Sanket, Bellani, Marina A, Khan, Irfan, Bradley, Lynda, King, Graeme A, Seol, Yeonee, Vidhyasagar, Venkatasubramanian, Wu, Yuliang, Abe, Takuye, Kobayashi, Koji, Shin-ya, Kazuo, Kitao, Hiroyuki, Wold, Marc S, Branzei, Dana, Neuman, Keir C, Brosh, Robert M
Published in Nucleic acids research (06.07.2018)
Published in Nucleic acids research (06.07.2018)
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Journal Article
Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome
Suhasini, Avvaru N, Rawtani, Nina A, Wu, Yuliang, Sommers, Joshua A, Sharma, Sudha, Mosedale, Georgina, North, Phillip S, Cantor, Sharon B, Hickson, Ian D, Brosh Jr, Robert M
Published in The EMBO journal (16.02.2011)
Published in The EMBO journal (16.02.2011)
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Journal Article
Novel Function of the Fanconi Anemia Group J or RECQ1 Helicase to Disrupt Protein-DNA Complexes in a Replication Protein A-stimulated Manner
Sommers, Joshua A., Banerjee, Taraswi, Hinds, Twila, Wan, Bingbing, Wold, Marc S., Lei, Ming, Brosh, Robert M.
Published in The Journal of biological chemistry (18.07.2014)
Published in The Journal of biological chemistry (18.07.2014)
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Journal Article
Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes
Wu, Yuliang, Sommers, Joshua A., Suhasini, Avvaru N., Leonard, Thomas, Deakyne, Julianna S., Mazin, Alexander V., Shin-ya, Kazuo, Kitao, Hiroyuki, Brosh, Robert M.
Published in Blood (11.11.2010)
Published in Blood (11.11.2010)
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Journal Article
FANCJ Uses Its Motor ATPase to Destabilize Protein-DNA Complexes, Unwind Triplexes, and Inhibit RAD51 Strand Exchange
Sommers, Joshua A., Rawtani, Nina, Gupta, Rigu, Bugreev, Dmitry V., Mazin, Alexander V., Cantor, Sharon B., Brosh, Robert M.
Published in The Journal of biological chemistry (20.03.2009)
Published in The Journal of biological chemistry (20.03.2009)
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Journal Article
Fanconi Anemia Group J Helicase and MRE11 Nuclease Interact To Facilitate the DNA Damage Response
Suhasini, Avvaru N., Sommers, Joshua A., Muniandy, Parameswary A., Coulombe, Yan, Cantor, Sharon B., Masson, Jean-Yves, Seidman, Michael M., Brosh, Robert M.
Published in Molecular and Cellular Biology (01.06.2013)
Published in Molecular and Cellular Biology (01.06.2013)
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Journal Article
The Q Motif of Fanconi Anemia Group J Protein (FANCJ) DNA Helicase Regulates Its Dimerization, DNA Binding, and DNA Repair Function
Wu, Yuliang, Sommers, Joshua A., Loiland, Jason A., Kitao, Hiroyuki, Kuper, Jochen, Kisker, Caroline, Brosh, Robert M.
Published in The Journal of biological chemistry (22.06.2012)
Published in The Journal of biological chemistry (22.06.2012)
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Journal Article
Biochemical Analysis of the DNA Unwinding and Strand Annealing Activities Catalyzed by Human RECQ1[boxs]
Sharma, Sudha, Sommers, Joshua A., Choudhary, Saba, Faulkner, Jinnifer Korin, Cui, Sheng, Andreoli, Lucia, Muzzolini, Laura, Vindigni, Alessandro, Brosh, Robert M.
Published in The Journal of biological chemistry (29.07.2005)
Published in The Journal of biological chemistry (29.07.2005)
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Journal Article