Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia
Paris, Jasmin, Morgan, Marcos, Campos, Joana, Spencer, Gary J., Shmakova, Alena, Ivanova, Ivayla, Mapperley, Christopher, Lawson, Hannah, Wotherspoon, David A., Sepulveda, Catarina, Vukovic, Milica, Allen, Lewis, Sarapuu, Annika, Tavosanis, Andrea, Guitart, Amelie V., Villacreces, Arnaud, Much, Christian, Choe, Junho, Azar, Ali, van de Lagemaat, Louie N., Vernimmen, Douglas, Nehme, Ali, Mazurier, Frederic, Somervaille, Tim C.P., Gregory, Richard I., O’Carroll, Dónal, Kranc, Kamil R.
Published in Cell stem cell (03.07.2019)
Published in Cell stem cell (03.07.2019)
Get full text
Journal Article
ORY-1001, a Potent and Selective Covalent KDM1A Inhibitor, for the Treatment of Acute Leukemia
Maes, Tamara, Mascaró, Cristina, Tirapu, Iñigo, Estiarte, Angels, Ciceri, Filippo, Lunardi, Serena, Guibourt, Nathalie, Perdones, Alvaro, Lufino, Michele M.P., Somervaille, Tim C.P., Wiseman, Dan H., Duy, Cihangir, Melnick, Ari, Willekens, Christophe, Ortega, Alberto, Martinell, Marc, Valls, Nuria, Kurz, Guido, Fyfe, Matthew, Castro-Palomino, Julio Cesar, Buesa, Carlos
Published in Cancer cell (12.03.2018)
Published in Cancer cell (12.03.2018)
Get full text
Journal Article
The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
Harris, William J., Huang, Xu, Lynch, James T., Spencer, Gary J., Hitchin, James R., Li, Yaoyong, Ciceri, Filippo, Blaser, Julian G., Greystoke, Brigit F., Jordan, Allan M., Miller, Crispin J., Ogilvie, Donald J., Somervaille, Tim C.P.
Published in Cancer cell (17.04.2012)
Published in Cancer cell (17.04.2012)
Get full text
Journal Article
Enhancer Activation by Pharmacologic Displacement of LSD1 from GFI1 Induces Differentiation in Acute Myeloid Leukemia
Maiques-Diaz, Alba, Spencer, Gary J., Lynch, James T., Ciceri, Filippo, Williams, Emma L., Amaral, Fabio M.R., Wiseman, Daniel H., Harris, William J., Li, Yaoyong, Sahoo, Sudhakar, Hitchin, James R., Mould, Daniel P., Fairweather, Emma E., Waszkowycz, Bohdan, Jordan, Allan M., Smith, Duncan L., Somervaille, Tim C.P.
Published in Cell reports (Cambridge) (27.03.2018)
Published in Cell reports (Cambridge) (27.03.2018)
Get full text
Journal Article
The miR-17-92 microRNA Polycistron Regulates MLL Leukemia Stem Cell Potential by Modulating p21 Expression
PIU WONG, IWASAKI, Masayuki, SOMERVAILLE, Tim C. P, FICARA, Francesca, CARICO, Christine, ARNOLD, Christopher, CHEN, Chang-Zheng, CLEARY, Michael L
Published in Cancer research (Chicago, Ill.) (01.05.2010)
Published in Cancer research (Chicago, Ill.) (01.05.2010)
Get full text
Journal Article
The Histone Demethylase KDM1A Sustains the Oncogenic Potential of MLL-AF9 Leukemia Stem Cells
Harris, William J., Huang, Xu, Lynch, James T., Hitchin, James R., Li, Yaoyong, Ciceri, Filippo, Blaser, Julian G., Greystoke, Brigit F., Jordan, Allan M., Ogilvie, Donald J., Somervaille, Tim C.P.
Published in Cancer cell (12.06.2012)
Published in Cancer cell (12.06.2012)
Get full text
Journal Article
Meis1 is an essential and rate-limiting regulator of MLL leukemia stem cell potential
Wong, Piu, Iwasaki, Masayuki, Somervaille, Tim C P, So, Chi Wai Eric, So, Chai Wai Eric, Cleary, Michael L
Published in Genes & development (01.11.2007)
Published in Genes & development (01.11.2007)
Get full text
Journal Article
Frequent Derepression of the Mesenchymal Transcription Factor Gene FOXC1 in Acute Myeloid Leukemia
Somerville, Tim D.D., Wiseman, Daniel H., Spencer, Gary J., Huang, Xu, Lynch, James T., Leong, Hui Sun, Williams, Emma L., Cheesman, Edmund, Somervaille, Tim C.P.
Published in Cancer cell (14.09.2015)
Published in Cancer cell (14.09.2015)
Get full text
Journal Article
CD86 expression as a surrogate cellular biomarker for pharmacological inhibition of the histone demethylase lysine-specific demethylase 1
Lynch, James T., Cockerill, Mark J., Hitchin, James R., Wiseman, Daniel H., Somervaille, Tim C.P.
Published in Analytical biochemistry (01.11.2013)
Published in Analytical biochemistry (01.11.2013)
Get full text
Journal Article
Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia
Simeoni, Fabrizio, Romero-Camarero, Isabel, Camera, Francesco, Amaral, Fabio M.R., Sinclair, Oliver J., Papachristou, Evangelia K., Spencer, Gary J., Lie-A-Ling, Michael, Lacaud, Georges, Wiseman, Daniel H., Carroll, Jason S., Somervaille, Tim C.P.
Published in Cell reports (Cambridge) (21.09.2021)
Published in Cell reports (Cambridge) (21.09.2021)
Get full text
Journal Article
Oligomeric self-association contributes to E2A-PBX1-mediated oncogenesis
Lin, Chiou-Hong, Wang, Zhong, Duque-Afonso, Jesús, Wong, Stephen Hon-Kit, Demeter, Janos, Loktev, Alexander V., Somervaille, Tim C. P., Jackson, Peter K., Cleary, Michael L.
Published in Scientific reports (20.03.2019)
Published in Scientific reports (20.03.2019)
Get full text
Journal Article
Derepression of the Iroquois Homeodomain Transcription Factor Gene IRX3 Confers Differentiation Block in Acute Leukemia
Somerville, Tim D.D., Simeoni, Fabrizio, Chadwick, John A., Williams, Emma L., Spencer, Gary J., Boros, Katalin, Wirth, Christopher, Tholouli, Eleni, Byers, Richard J., Somervaille, Tim C.P.
Published in Cell reports (Cambridge) (16.01.2018)
Published in Cell reports (Cambridge) (16.01.2018)
Get full text
Journal Article
Conserved role of FOXC1 in TNBC is parallel to FOXA1 in ER+ breast cancer
Ramachandran, Revathy, Ibragimova, Shakhzada, Woods, Laura M., AlHouqani, Tamader, Gomez, Roshna Lawrence, Simeoni, Fabrizio, Hachim, Mahmood Y., Somervaille, Tim C.P., Philpott, Anna, Carroll, Jason S., Ali, Fahad R.
Published in iScience (16.08.2024)
Published in iScience (16.08.2024)
Get full text
Journal Article
Differentiation block in acute myeloid leukemia regulated by intronic sequences of FTO
Camera, Francesco, Romero-Camarero, Isabel, Revell, Bradley H., Amaral, Fabio M.R., Sinclair, Oliver J., Simeoni, Fabrizio, Wiseman, Daniel H., Stojic, Lovorka, Somervaille, Tim C.P.
Published in iScience (18.08.2023)
Published in iScience (18.08.2023)
Get full text
Journal Article
LSD1 inhibitors disrupt the GFI1 transcription repressor complex
Maiques-Diaz, Alba, Lynch, James T., Spencer, Gary J., Somervaille, Tim C.P.
Published in Molecular & cellular oncology (04.07.2018)
Published in Molecular & cellular oncology (04.07.2018)
Get full text
Journal Article