Exploring Ligand Stability in Protein Crystal Structures Using Binding Pose Metadynamics
Fusani, Lucia, Palmer, David S, Somers, Don O, Wall, Ian D
Published in Journal of chemical information and modeling (23.03.2020)
Published in Journal of chemical information and modeling (23.03.2020)
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Journal Article
A knowledge-based, structural-aided discovery of a novel class of 2-phenylimidazo[1,2-a]pyridine-6-carboxamide H-PGDS inhibitors
Schulte, Christie A., Deaton, David N., Diaz, Elsie, Do, Young, Gampe, Robert T., Guss, Jeffrey H., Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Holt, Jason, Jeune, Michael R., Kahler, Kirsten M., Kramer, H. Fritz, Le, Joelle, Mortenson, Paul N., Musetti, Caterina, Nolte, Robert T., Orband-Miller, Lisa A., Peckham, Gregory E., Petrov, Kim G., Pietrak, Beth L., Poole, Chuck, Price, Daniel J., Saxty, Gordon, Shillings, Anthony, Smalley, Terrence L., Somers, Don O., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A.
Published in Bioorganic & medicinal chemistry letters (01.09.2021)
Published in Bioorganic & medicinal chemistry letters (01.09.2021)
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Journal Article
The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors
Deaton, David N., Do, Young, Holt, Jason, Jeune, Michael R., Kramer, H. Fritz, Larkin, Andrew L., Orband-Miller, Lisa A., Peckham, Gregory E., Poole, Chuck, Price, Daniel J., Schaller, Lee T., Shen, Ying, Shewchuk, Lisa M., Stewart, Eugene L., Stuart, J. Darren, Thomson, Stephen A., Ward, Paris, Wilson, Joseph W., Xu, Tianshun, Guss, Jeffrey H., Musetti, Caterina, Rendina, Alan R., Affleck, Karen, Anders, David, Hancock, Ashley P., Hobbs, Heather, Hodgson, Simon T., Hutchinson, Jonathan, Leveridge, Melanie V., Nicholls, Harry, Smith, Ian E.D., Somers, Don O., Sneddon, Helen F., Uddin, Sorif, Cleasby, Anne, Mortenson, Paul N., Richardson, Caroline, Saxty, Gordon
Published in Bioorganic & medicinal chemistry (15.04.2019)
Published in Bioorganic & medicinal chemistry (15.04.2019)
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Journal Article
Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2)
Woolford, Alison J.-A, Day, Philip J, Bénéton, Véronique, Berdini, Valerio, Coyle, Joseph E, Dudit, Yann, Grondin, Pascal, Huet, Pascal, Lee, Lydia Y. W, Manas, Eric S, McMenamin, Rachel L, Murray, Christopher W, Page, Lee W, Patel, Vipulkumar K, Potvain, Florent, Rich, Sharna J, Sang, Yingxia, Somers, Don O, Trottet, Lionel, Wan, Zehong, Zhang, Xiaomin
Published in Journal of medicinal chemistry (08.12.2016)
Published in Journal of medicinal chemistry (08.12.2016)
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Journal Article
Covalent targeting of non-cysteine residues in PI4KIIIβ
Cosgrove, Brett, Grant, Emma K, Bertrand, Sophie, Down, Kenneth D, Somers, Don O, Evans, John, Tomkinson, Nicholas C. O, Barker, Michael D
Published in RSC chemical biology (29.11.2023)
Published in RSC chemical biology (29.11.2023)
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Journal Article
Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode
Kranz, Michael, Wall, Michael, Evans, Brian, Miah, Afjal, Ballantine, Stuart, Delves, Chris, Dombroski, Brian, Gross, Jeffrey, Schneck, Jessica, Villa, James P., Neu, Margarete, Somers, Don O.
Published in Bioorganic & medicinal chemistry (15.07.2009)
Published in Bioorganic & medicinal chemistry (15.07.2009)
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Journal Article
Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors
Garton, Neil S., Barker, Michael D., Davis, Rob P., Douault, Clement, Hooper-Greenhill, Edward, Jones, Emma, Lewis, Huw D., Liddle, John, Lugo, Dave, McCleary, Scott, Preston, Alex G.S., Ramirez-Molina, Cesar, Neu, Margarete, Shipley, Tracy J., Somers, Don O., Watson, Robert J., Wilson, David M.
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
Published in Bioorganic & medicinal chemistry letters (01.10.2016)
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Journal Article
Biphenyl amide p38 kinase inhibitors 3: Improvement of cellular and in vivo activity
Angell, Richard, Aston, Nicola M., Bamborough, Paul, Buckton, Jacky B., Cockerill, Stuart, deBoeck, Suzanne J., Edwards, Chris D., Holmes, Duncan S., Jones, Katherine L., Laine, Dramane I., Patel, Shila, Smee, Penny A., Smith, Kathryn J., Somers, Don O., Walker, Ann L.
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Journal Article
Biphenyl amide p38 kinase inhibitors 4: DFG-in and DFG-out binding modes
Angell, Richard M., Angell, Tony D., Bamborough, Paul, Bamford, Mark J., Chung, Chun-wa, Cockerill, Stuart G., Flack, Stephen S., Jones, Katherine L., Laine, Dramane I., Longstaff, Timothy, Ludbrook, Steve, Pearson, Rosannah, Smith, Kathryn J., Smee, Penny A., Somers, Don O., Walker, Ann L.
Published in Bioorganic & medicinal chemistry (01.08.2008)
Published in Bioorganic & medicinal chemistry (01.08.2008)
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Journal Article
Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA 2 Inhibitor
Measom, Nicholas D, Down, Kenneth D, Hirst, David J, Jamieson, Craig, Manas, Eric S, Patel, Vipulkumar K, Somers, Don O
Published in ACS medicinal chemistry letters (12.01.2017)
Published in ACS medicinal chemistry letters (12.01.2017)
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Journal Article
Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration
Woodrow, Michael D., Ballantine, Stuart P., Barker, Michael D., Clarke, Beth J., Dawson, John, Dean, Tony W., Delves, Christopher J., Evans, Brian, Gough, Sharon L., Guntrip, Steven B., Holman, Stuart, Holmes, Duncan S., Kranz, Michael, Lindvaal, Mika K., Lucas, Fiona S., Neu, Margarete, Ranshaw, Lisa E., Solanke, Yemisi E., Somers, Don O., Ward, Peter, Wiseman, Joanne O.
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Journal Article
Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors
Hamblin, J. Nicole, Angell, Tony D.R., Ballantine, Stuart P., Cook, Caroline M., Cooper, Anthony W.J., Dawson, John, Delves, Christopher J., Jones, Paul S., Lindvall, Mika, Lucas, Fiona S., Mitchell, Charlotte J., Neu, Margarete Y., Ranshaw, Lisa E., Solanke, Yemisi E., Somers, Don O., Wiseman, Joanne O.
Published in Bioorganic & medicinal chemistry (15.07.2008)
Published in Bioorganic & medicinal chemistry (15.07.2008)
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Journal Article
Pyrazolopyridines as potent PDE4B inhibitors: 5-Heterocycle SAR
Mitchell, Charlotte J., Ballantine, Stuart P., Coe, Diane M., Cook, Caroline M., Delves, Christopher J., Dowle, Mike D., Edlin, Chris D., Hamblin, J. Nicole, Holman, Stuart, Johnson, Martin R., Jones, Paul S., Keeling, Sue E., Kranz, Michael, Lindvall, Mika, Lucas, Fiona S., Neu, Margarete, Solanke, Yemisi E., Somers, Don O., Trivedi, Naimisha A., Wiseman, Joanne O.
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
Published in Bioorganic & medicinal chemistry letters (01.10.2010)
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Journal Article
Quinolines as a novel structural class of potent and selective PDE4 inhibitors: Optimisation for oral administration
Lunniss, Christopher J., Cooper, Anthony W.J., Eldred, Colin D., Kranz, Michael, Lindvall, Mika, Lucas, Fiona S., Neu, Margarete, Preston, Alex G.S., Ranshaw, Lisa E., Redgrave, Alison J., Ed Robinson, J., Shipley, Tracy J., Solanke, Yemisi E., Somers, Don O., Wiseman, Joanne O.
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
Published in Bioorganic & medicinal chemistry letters (01.03.2009)
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Journal Article
Kinase array design, back to front: Biaryl amides
Baldwin, Ian, Bamborough, Paul, Haslam, Claudine G., Hunjan, Suchete S., Longstaff, Tim, Mooney, Christopher J., Patel, Shila, Quinn, Jo, Somers, Don O.
Published in Bioorganic & medicinal chemistry letters (01.10.2008)
Published in Bioorganic & medicinal chemistry letters (01.10.2008)
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Journal Article
Biphenyl amide p38 kinase inhibitors 2: Optimisation and SAR
Angell, Richard M., Angell, Tony D., Bamborough, Paul, Brown, David, Brown, Murray, Buckton, Jacky B., Cockerill, Stuart G., Edwards, Chris D., Jones, Katherine L., Longstaff, Tim, Smee, Penny A., Smith, Kathryn J., Somers, Don O., Walker, Ann L., Willson, Malcolm
Published in Bioorganic & medicinal chemistry (2008)
Published in Bioorganic & medicinal chemistry (2008)
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Journal Article
Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA(2) Inhibitor
Measom, Nicholas D., Down, Kenneth D., Hirst, David J., Jamieson, Craig, Manas, Eric S., Patel, Vipulkumar K., Somers, Don O.
Published in ACS medicinal chemistry letters (01.01.2017)
Published in ACS medicinal chemistry letters (01.01.2017)
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Journal Article
Design and Characterization of Protein E-PilA, a Candidate Fusion Antigen for Nontypeable Haemophilus influenzae Vaccine
Blais, Normand, Somers, Don, Faubert, Denis, Labbé, Steve, Castado, Cindy, Ysebaert, Carine, Gagnon, Louis-Patrick, Champagne, Josée, Gagné, Martin, Martin, Denis
Published in Infection and immunity (01.08.2019)
Published in Infection and immunity (01.08.2019)
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Journal Article
GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice
Pearce, Andrew C., Bamford, Mark J., Barber, Ruth, Bridges, Angela, Convery, Maire A., Demetriou, Constantinos, Evans, Sian, Gobbetti, Thomas, Hirst, David J., Holmes, Duncan S., Hutchinson, Jonathan P., Jayne, Sandrine, Lezina, Larissa, McCabe, Michael T., Messenger, Cassie, Morley, Joanne, Musso, Melissa C., Scott-Stevens, Paul, Manso, Ana Sousa, Schofield, Jennifer, Slocombe, Tom, Somers, Don, Walker, Ann L., Wyce, Anastasia, Zhang, Xi-Ping, Wagner, Simon D.
Published in The Journal of biological chemistry (01.08.2021)
Published in The Journal of biological chemistry (01.08.2021)
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